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Publication DateBrain Research, ISSN 0006-8993, 2006, Volume 1091, Issue 1, pp. 113 - 121
Inner ear dysfunction is often associated with defective hair cells. Therefore, hair cells are the focus of study in many of the mouse mutants showing auditory...
Otology | Gel electrophoresis | Mass spectrometry | Proteomics | TECTORIAL MEMBRANE | proteomics | INBRED STRAINS | 2-DIMENSIONAL ELECTROPHORESIS | otology | DIFFERENCE GEL-ELECTROPHORESIS | GENETIC-MODIFICATION | NEUROSCIENCES | MASS-SPECTROMETRY | VESTIBULAR DYSFUNCTION | HEARING-LOSS | HAIR-CELLS | mass spectrometry | gel electrophoresis | OTOCONIAL AGENESIS | Ear, Inner - metabolism | Animals | Deafness - genetics | Deafness - metabolism | Mice, Mutant Strains | Humans | Mice | Ear, Inner - physiopathology | Disease Models, Animal | Discovery and exploration | Proteins | Deafness | Cell research
Otology | Gel electrophoresis | Mass spectrometry | Proteomics | TECTORIAL MEMBRANE | proteomics | INBRED STRAINS | 2-DIMENSIONAL ELECTROPHORESIS | otology | DIFFERENCE GEL-ELECTROPHORESIS | GENETIC-MODIFICATION | NEUROSCIENCES | MASS-SPECTROMETRY | VESTIBULAR DYSFUNCTION | HEARING-LOSS | HAIR-CELLS | mass spectrometry | gel electrophoresis | OTOCONIAL AGENESIS | Ear, Inner - metabolism | Animals | Deafness - genetics | Deafness - metabolism | Mice, Mutant Strains | Humans | Mice | Ear, Inner - physiopathology | Disease Models, Animal | Discovery and exploration | Proteins | Deafness | Cell research
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Loading RightsNature Reviews Cancer, ISSN 1474-175X, 11/2005, Volume 5, Issue 11, pp. 876 - 885
Apoptosis is deregulated in many cancers, making it difficult to kill tumours. Drugs that restore the normal apoptotic pathways have the potential for...
CELL LUNG-CANCER | BCL-X-L | FORKHEAD TRANSCRIPTION FACTOR | ONCOLOGY | STRUCTURAL BASIS | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | TRAIL-INDUCED APOPTOSIS | GROWTH IN-VIVO | PROTEIN-KINASE B | STRUCTURE-BASED DESIGN | Tumor Necrosis Factor-alpha - metabolism | Membrane Glycoproteins - metabolism | Apoptosis - drug effects | Humans | Antineoplastic Agents - therapeutic use | Proto-Oncogene Proteins c-mdm2 - chemistry | Apoptosis Regulatory Proteins - metabolism | Neoplasms - drug therapy | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | TNF-Related Apoptosis-Inducing Ligand | Inhibitor of Apoptosis Proteins - chemistry | Proto-Oncogene Proteins c-bcl-2 - chemistry | Inhibitor of Apoptosis Proteins - metabolism | Apoptosis - physiology | Proto-Oncogene Proteins c-mdm2 - metabolism | Antimitotic agents | Complications and side effects | Gene mutations | Physiological aspects | Dosage and administration | Research | Antineoplastic agents | Apoptosis
CELL LUNG-CANCER | BCL-X-L | FORKHEAD TRANSCRIPTION FACTOR | ONCOLOGY | STRUCTURAL BASIS | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | TRAIL-INDUCED APOPTOSIS | GROWTH IN-VIVO | PROTEIN-KINASE B | STRUCTURE-BASED DESIGN | Tumor Necrosis Factor-alpha - metabolism | Membrane Glycoproteins - metabolism | Apoptosis - drug effects | Humans | Antineoplastic Agents - therapeutic use | Proto-Oncogene Proteins c-mdm2 - chemistry | Apoptosis Regulatory Proteins - metabolism | Neoplasms - drug therapy | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | TNF-Related Apoptosis-Inducing Ligand | Inhibitor of Apoptosis Proteins - chemistry | Proto-Oncogene Proteins c-bcl-2 - chemistry | Inhibitor of Apoptosis Proteins - metabolism | Apoptosis - physiology | Proto-Oncogene Proteins c-mdm2 - metabolism | Antimitotic agents | Complications and side effects | Gene mutations | Physiological aspects | Dosage and administration | Research | Antineoplastic agents | Apoptosis
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Loading RightsGenome Biology, ISSN 1474-7596, 01/2015, Volume 16, Issue 1, pp. 6 - 6
While advances in genome sequencing technology make population- scale genomics a possibility, current approaches for analysis of these data rely upon...
SNP | GENOTYPE | FORMAT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CLOUD | GENETICS & HEREDITY | FRAMEWORK | PIPELINE | LEUKEMIA | SEQUENCING DATA | RESOURCE | Genetic Variation | Genetics, Population | Haplotypes - genetics | Cloud Computing | Time Factors | Humans | Software | Genome, Human | Genomics - methods | Cloud computing | Data analysis | Leukemia | Genomics | Data processing | Genomes | Genetic diversity | Boundaries | Artificial chromosomes | Consortia | Data integrity | Workloads | Mutation | Bioinformatics | Method
SNP | GENOTYPE | FORMAT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CLOUD | GENETICS & HEREDITY | FRAMEWORK | PIPELINE | LEUKEMIA | SEQUENCING DATA | RESOURCE | Genetic Variation | Genetics, Population | Haplotypes - genetics | Cloud Computing | Time Factors | Humans | Software | Genome, Human | Genomics - methods | Cloud computing | Data analysis | Leukemia | Genomics | Data processing | Genomes | Genetic diversity | Boundaries | Artificial chromosomes | Consortia | Data integrity | Workloads | Mutation | Bioinformatics | Method
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Loading RightsLancet, The, ISSN 0140-6736, 2007, Volume 369, Issue 9574, pp. 1742 - 1757
Summary Most cancer deaths are due to the development of metastases, hence the most important improvements in morbidity and mortality will result from...
Internal Medicine | EPITHELIAL-MESENCHYMAL TRANSITION | GENE-EXPRESSION SIGNATURE | DISSEMINATED TUMOR-CELLS | MEDICINE, GENERAL & INTERNAL | LYMPH-NODE METASTASIS | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | MATRIX-METALLOPROTEINASE INHIBITORS | BREAST-CANCER METASTASIS | CENTRAL-NERVOUS-SYSTEM | HISTONE DEACETYLASE INHIBITORS | ENDOTHELIAL GROWTH-FACTOR | Neoplasm Metastasis - genetics | Molecular Biology - trends | Neoplasm Metastasis - drug therapy | Oligonucleotide Array Sequence Analysis | Neoplasm Metastasis - pathology | Genes, Tumor Suppressor - physiology | Humans | Neovascularization, Pathologic | Adult | Anoikis - drug effects | Anoikis - physiology | Antineoplastic Agents - therapeutic use | Care and treatment | Metastasis | Methods | Cancer | Genotype & phenotype | Medical treatment | Stem cells | Genetic engineering | Mutation | Drug therapy | DNA repair | Apoptosis | Tumors
Internal Medicine | EPITHELIAL-MESENCHYMAL TRANSITION | GENE-EXPRESSION SIGNATURE | DISSEMINATED TUMOR-CELLS | MEDICINE, GENERAL & INTERNAL | LYMPH-NODE METASTASIS | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | MATRIX-METALLOPROTEINASE INHIBITORS | BREAST-CANCER METASTASIS | CENTRAL-NERVOUS-SYSTEM | HISTONE DEACETYLASE INHIBITORS | ENDOTHELIAL GROWTH-FACTOR | Neoplasm Metastasis - genetics | Molecular Biology - trends | Neoplasm Metastasis - drug therapy | Oligonucleotide Array Sequence Analysis | Neoplasm Metastasis - pathology | Genes, Tumor Suppressor - physiology | Humans | Neovascularization, Pathologic | Adult | Anoikis - drug effects | Anoikis - physiology | Antineoplastic Agents - therapeutic use | Care and treatment | Metastasis | Methods | Cancer | Genotype & phenotype | Medical treatment | Stem cells | Genetic engineering | Mutation | Drug therapy | DNA repair | Apoptosis | Tumors
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Loading RightsJOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 09/2016, Volume 59, Issue 17, pp. 7818 - 7839
The majority of potent and selective hNa(V)1.7 inhibitors possess common pharmacophoric features that include a heteroaryl sulfonamide headgroup and a...
TARGET | CLEARANCE | PRIMARY ERYTHERMALGIA | CHEMISTRY, MEDICINAL | PAIN | GATED SODIUM-CHANNELS | DISORDER | SCN9A MUTATIONS | GAIN
TARGET | CLEARANCE | PRIMARY ERYTHERMALGIA | CHEMISTRY, MEDICINAL | PAIN | GATED SODIUM-CHANNELS | DISORDER | SCN9A MUTATIONS | GAIN
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Loading RightsAnnual Review of Microbiology, ISSN 0066-4227, 2008, Volume 62, Issue 1, pp. 53 - 70
Genetically monomorphic bacteria contain so little sequence diversity that sequencing a few gene fragments yields little or no information. As a result, our...
Biogeography | Genomic comparison | Single nucleotide polymorphism | Mutation discovery strategy | NUMBER TANDEM REPEATS | single nucleotide polymorphism | biogeography | genomic comparison | ESCHERICHIA-COLI | ANCIENT DNA | SALMONELLA-TYPHI | MICROBIOLOGY | TRANSMISSION DYNAMICS | MYCOBACTERIUM-TUBERCULOSIS COMPLEX | YERSINIA-PESTIS DNA | GENOME-WIDE ANALYSIS | BACILLUS-ANTHRACIS | mutation discovery strategy | SINGLE-NUCLEOTIDE POLYMORPHISMS | Genome, Bacterial | Humans | Phylogeny | Bacteria - genetics | Mycobacterium tuberculosis - pathogenicity | Salmonella typhi - pathogenicity | Animals | DNA, Bacterial - genetics | Yersinia pestis - genetics | Base Sequence | Bacteria - pathogenicity | Polymorphism, Single Nucleotide | Mutation | Salmonella typhi - genetics | Yersinia pestis - pathogenicity | Evolution, Molecular | Mycobacterium tuberculosis - genetics | Genetic aspects | Diagnosis | Single nucleotide polymorphisms | Bacteria, Pathogenic | Abnormalities | Microbial mutation
Biogeography | Genomic comparison | Single nucleotide polymorphism | Mutation discovery strategy | NUMBER TANDEM REPEATS | single nucleotide polymorphism | biogeography | genomic comparison | ESCHERICHIA-COLI | ANCIENT DNA | SALMONELLA-TYPHI | MICROBIOLOGY | TRANSMISSION DYNAMICS | MYCOBACTERIUM-TUBERCULOSIS COMPLEX | YERSINIA-PESTIS DNA | GENOME-WIDE ANALYSIS | BACILLUS-ANTHRACIS | mutation discovery strategy | SINGLE-NUCLEOTIDE POLYMORPHISMS | Genome, Bacterial | Humans | Phylogeny | Bacteria - genetics | Mycobacterium tuberculosis - pathogenicity | Salmonella typhi - pathogenicity | Animals | DNA, Bacterial - genetics | Yersinia pestis - genetics | Base Sequence | Bacteria - pathogenicity | Polymorphism, Single Nucleotide | Mutation | Salmonella typhi - genetics | Yersinia pestis - pathogenicity | Evolution, Molecular | Mycobacterium tuberculosis - genetics | Genetic aspects | Diagnosis | Single nucleotide polymorphisms | Bacteria, Pathogenic | Abnormalities | Microbial mutation
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Loading RightsOMICS: A Journal of Integrative Biology, ISSN 1536-2310, 11/2014, Volume 18, Issue 11, pp. 75 - 710
Mutations in the GJB2 gene, encoding connexin 26, could account for 50% of congenital, nonsyndromic, recessive deafness cases in some Caucasian/Asian...
Original Articles | AMERICAN | HEARING-LOSS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CONNEXIN 26 GENE | GENETICS & HEREDITY | FOUNDER | MUTATIONS | Cameroon | Deafness - genetics | Gene Frequency | Humans | Computational Biology | Connexins - genetics | Genotype | Male | Hearing Loss, Sensorineural - genetics | Phylogeny | Connexin 26 | Genetic Variation | Base Sequence | Adolescent | Female | Heterozygote | South Africa | African Continental Ancestry Group - genetics | Mutation | Deafness - congenital | Original
Original Articles | AMERICAN | HEARING-LOSS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CONNEXIN 26 GENE | GENETICS & HEREDITY | FOUNDER | MUTATIONS | Cameroon | Deafness - genetics | Gene Frequency | Humans | Computational Biology | Connexins - genetics | Genotype | Male | Hearing Loss, Sensorineural - genetics | Phylogeny | Connexin 26 | Genetic Variation | Base Sequence | Adolescent | Female | Heterozygote | South Africa | African Continental Ancestry Group - genetics | Mutation | Deafness - congenital | Original
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Loading RightsJournal of Proteome Research, ISSN 1535-3893, 05/2017, Volume 16, Issue 5, pp. 1936 - 1943
Proteogenomic studies aiming at identification of variant peptides using customized database searches of mass spectrometry data are facing a dilemma of...
variant peptides | false discovery rate | proteogenomics | cancer proteome | shotgun proteomics | TANDEM | SEARCH | PROTEOME | BIOCHEMICAL RESEARCH METHODS | COLON | LEVEL | CANCER | MASS-SPECTROMETRY | Mutant Proteins | Proteogenomics - methods | Escherichia coli Proteins | Proteogenomics - standards | Databases, Protein | Humans | Mass Spectrometry | Sensitivity and Specificity | Peptides - genetics | Databases, Factual
variant peptides | false discovery rate | proteogenomics | cancer proteome | shotgun proteomics | TANDEM | SEARCH | PROTEOME | BIOCHEMICAL RESEARCH METHODS | COLON | LEVEL | CANCER | MASS-SPECTROMETRY | Mutant Proteins | Proteogenomics - methods | Escherichia coli Proteins | Proteogenomics - standards | Databases, Protein | Humans | Mass Spectrometry | Sensitivity and Specificity | Peptides - genetics | Databases, Factual
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Loading RightsExpert Opinion on Drug Discovery, ISSN 1746-0441, 04/2017, Volume 12, Issue 4, pp. 317 - 319
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Loading RightsCurrent Topics in Microbiology and Immunology, ISSN 0070-217X, 12/2016, Volume 398, pp. 339 - 363
Natural products continue to be a predominant source for new anti-infective agents. Research at the Helmholtz Institute for Pharmaceutical Research Saarland...
PLATFORM | COMBINATORIAL BIOSYNTHESIS | MECHANISM | DRUGS | MUTATION | POLYKETIDE | RESISTANCE | ALBICIDIN | MICROBIOLOGY | IMMUNOLOGY | INHIBITOR | DNA-REPLICATION | Antitubercular Agents - chemistry | Anti-Bacterial Agents - chemistry | Humans | Antitubercular Agents - pharmacology | Anti-Bacterial Agents - pharmacology | Biological Products - pharmacology | Drug Discovery | Mycobacterium tuberculosis - drug effects
PLATFORM | COMBINATORIAL BIOSYNTHESIS | MECHANISM | DRUGS | MUTATION | POLYKETIDE | RESISTANCE | ALBICIDIN | MICROBIOLOGY | IMMUNOLOGY | INHIBITOR | DNA-REPLICATION | Antitubercular Agents - chemistry | Anti-Bacterial Agents - chemistry | Humans | Antitubercular Agents - pharmacology | Anti-Bacterial Agents - pharmacology | Biological Products - pharmacology | Drug Discovery | Mycobacterium tuberculosis - drug effects
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PROTEOMICS – Clinical Applications, ISSN 1862-8346, 11/2018, Volume 12, Issue 6, pp. 1800065 - n/a
Purpose The Brugada syndrome (BrS) is a severe inherited cardiac disorder. Given the high genetic and phenotypic heterogeneity of this disease, three different...
brugada syndrome | genomics | proteomics | MiRNA | reactive oxygen species | personalized medicine | Deregulation | Genomic analysis | Transcription | Pathogenesis | Data processing | Coronary artery disease | Proteins | Heterogeneity | Molecular modelling | Experimental design | Point mutation | Biomarkers | Diagnostic systems | Heart diseases | Design of experiments
brugada syndrome | genomics | proteomics | MiRNA | reactive oxygen species | personalized medicine | Deregulation | Genomic analysis | Transcription | Pathogenesis | Data processing | Coronary artery disease | Proteins | Heterogeneity | Molecular modelling | Experimental design | Point mutation | Biomarkers | Diagnostic systems | Heart diseases | Design of experiments
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