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Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2014, Volume 207, Issue 2, pp. 283 - 297
Integrin-mediated force application induces a conformational change in latent TGF-β1 that leads to the release of the active form of the growth factor from the... 
Integrins - physiology | Rats, Wistar | Humans | Transforming Growth Factor beta1 - metabolism | Cells, Cultured | Extracellular Matrix - metabolism | Integrins - metabolism | Myofibroblasts - cytology | Myofibroblasts - metabolism | Mechanotransduction, Cellular | Animals | HEK293 Cells | Cell Differentiation | Index Medicus
Journal Article
Journal of Pathology, ISSN 0022-3417, 01/2013, Volume 229, Issue 2, pp. 298 - 309
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e39969 - e39969
Fibroblasts residing in connective tissues throughout the body are responsible for extracellular matrix (ECM) homeostasis and repair. In response to tissue... 
SMOOTH MUSCLE ACTIN | GROWTH-FACTOR-BETA | HEPATIC STELLATE CELLS | PHOTODEGRADABLE HYDROGELS | LUNG MYOFIBROBLASTS | GRANULATION-TISSUE | MULTIDISCIPLINARY SCIENCES | TRANSFORMING GROWTH-FACTOR-BETA-1 | EXTRACELLULAR-MATRIX | IDIOPATHIC PULMONARY-FIBROSIS | AORTIC-VALVE DISEASE | Aortic Valve - radiation effects | Gene Expression - drug effects | Hydrogels | Actins - metabolism | Aortic Valve - drug effects | Polyethylene Glycols - chemistry | Actins - genetics | Myofibroblasts - metabolism | Collagen Type I - genetics | Swine | Light | Myofibroblasts - radiation effects | Biomimetic Materials - chemistry | Transforming Growth Factor beta1 - pharmacology | Biomarkers - metabolism | Cell Differentiation - radiation effects | Oligopeptides - chemical synthesis | Collagen Type I - metabolism | Acrylates - chemistry | Cell Cycle - radiation effects | Aortic Valve - cytology | Myofibroblasts - drug effects | Aortic Valve - metabolism | Gene Expression - radiation effects | Fibronectins - metabolism | Elastic Modulus - radiation effects | Myofibroblasts - cytology | Animals | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Connective Tissue Growth Factor - genetics | Fibronectins - genetics | Primary Cell Culture | Cell Cycle - drug effects | Connective Tissue Growth Factor - metabolism | Cell Proliferation - radiation effects | Fibronectins | Collagen | Genes | Bone morphogenetic proteins | Transforming growth factors | Intermediate filament proteins | Apoptosis | Vimentin | Bioengineering | Collagens | Homeostasis | Smooth muscle | Kinases | Tissues | Fibronectin | Mimicry | Connective tissues | Proteins | Engineering | Genotype & phenotype | Reduction | Cell fate | Actin | Topography | Rodents | Cell cycle | Fibroblasts | Extracellular matrix | Stiffness | Repair | Growth factors | Heart diseases | Phenotypes | Developmental biology | Contractility | Organs | Muscles | Mechanical properties | Connective tissue growth factor | Modulus of elasticity | Stiffening | Muscle contraction | Substrates | Fibrosis | Stem cells | Molecular biology | Index Medicus
Journal Article
European Urology, ISSN 0302-2838, 02/2019, Volume 75, Issue 2, pp. 329 - 340
Journal Article
KIDNEY INTERNATIONAL, ISSN 0085-2538, 03/2019, Volume 95, Issue 3, pp. 487 - 489
Tubulointerstitial fibrosis is considered a hallmark of maladaptive repair processes after tubular injury leading to chronic kidney disease. Nakamura and... 
UROLOGY & NEPHROLOGY | MYOFIBROBLASTS
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2011, Volume 208, Issue 7, pp. 1459 - 1471
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 06/2013, Volume 172, Issue 3, pp. 410 - 416
Interleukin ( IL )‐37 is a member of the IL ‐1 cytokine family. We investigated IL ‐37b expression in the inflamed mucosa of inflammatory bowel disease ( IBD )... 
innate immunity | TNF | anti‐inflammatory cytokine | TNF-α | Innate immunity | Anti-inflammatory cytokine | CROHNS-DISEASE | TNF-alpha | IL-1 FAMILY | KAPPA-B | IMMUNOLOGY | PROTEIN-KINASE KINASE | IDENTIFICATION | COLONIC SUBEPITHELIAL MYOFIBROBLASTS | PATHOGENESIS | OVEREXPRESSION | INHIBITOR | anti-inflammatory cytokine | CELL | Crohn Disease - genetics | Interleukin-1 - genetics | Intestinal Mucosa - metabolism | Gene Expression - drug effects | Myofibroblasts - immunology | Humans | Inflammatory Bowel Diseases - immunology | Colitis, Ulcerative - genetics | Crohn Disease - metabolism | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | RNA, Messenger - metabolism | Colitis, Ulcerative - immunology | Inflammatory Bowel Diseases - metabolism | Transcription Factor AP-1 - metabolism | Case-Control Studies | Intestinal Mucosa - drug effects | MAP Kinase Signaling System | Myofibroblasts - metabolism | Intestinal Mucosa - immunology | Inflammatory Bowel Diseases - pathology | Inflammatory Bowel Diseases - genetics | Adaptive Immunity | Caco-2 Cells | Interleukin-1 - metabolism | Myofibroblasts - pathology | Colitis, Ulcerative - metabolism | RNA, Messenger - genetics | Cells, Cultured | Colitis, Ulcerative - pathology | Immunity, Innate | Myofibroblasts - drug effects | Crohn Disease - immunology | Tumor Necrosis Factor-alpha - pharmacology | Chemokine CXCL10 - genetics | Crohn Disease - pathology | Chemokine CXCL10 - metabolism | Intestinal Mucosa - pathology | Interleukins | Biological response modifiers | Gastrointestinal diseases | Inflammatory bowel disease | Proteins | Colon | Cytokines | Index Medicus | Original
Journal Article
Gastroenterology, ISSN 0016-5085, 2017, Volume 153, Issue 4, pp. 1054 - 1067
Abstract Background Intestinal fibrosis resulting in (sub)obstruction is a common complication of Crohn’s disease (CD). Rho kinases (ROCKs) play multiple roles... 
Gastroenterology and Hepatology | Stenosis | Epithelial-to-Mesenchymal Transition | Colitis | Mesenchymal Cells | APOPTOSIS | CROHNS-DISEASE | MOUSE | AUTOPHAGY | MODEL | PATHWAY | MYOFIBROBLASTS | GASTROENTEROLOGY & HEPATOLOGY | MATRIX-STIFFNESS | PULMONARY-FIBROSIS | Dextran Sulfate | Ileum - pathology | Intestinal Obstruction - enzymology | Myofibroblasts - immunology | Humans | Myofibroblasts - enzymology | Male | Adoptive Transfer | Intestinal Obstruction - chemically induced | Intestinal Obstruction - prevention & control | Ileum - immunology | Autophagy - drug effects | Case-Control Studies | T-Lymphocytes - transplantation | rho-Associated Kinases - antagonists & inhibitors | Ileum - enzymology | Ileum - drug effects | Time Factors | rho-Associated Kinases - metabolism | Inflammatory Bowel Diseases - enzymology | Inflammatory Bowel Diseases - pathology | Inflammatory Bowel Diseases - chemically induced | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-6 - metabolism | Disease Models, Animal | Myofibroblasts - pathology | Inflammatory Bowel Diseases - prevention & control | Tissue Culture Techniques | Mice, Inbred C57BL | Intestinal Obstruction - pathology | Myofibroblasts - drug effects | Collagen - metabolism | Animals | Signal Transduction - drug effects | Fibrosis | T-Lymphocytes - immunology | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Matrix Metalloproteinases - metabolism | Care and treatment | Transforming growth factors | Health aspects | Gastrointestinal diseases | Evaluation | Sulfates | T cells | Preventive health services | Dextran | Collagen | Analysis | Resveratrol | Stem cells | Interferon | Medicine, Preventive | Protein kinases | Ulcerative colitis | Index Medicus | Abridged Index Medicus
Journal Article
Cellular Signalling, ISSN 0898-6568, 07/2016, Volume 28, Issue 7, pp. 753 - 763
Phosphodiesterases 4 (PDE4) act as proinflammatory enzymes via degradation of cAMP, whereas PDE4 inhibitors play an anti-inflammatory role in vitro and in... 
Apremilast | Myofibroblasts | Psoriasis | CD271 | PBMC | PDE4 | FIBROSIS | HUMAN LUNG | TISSUE | CELL BIOLOGY | THERAPEUTIC TARGET | PDE4 INHIBITOR | NEUROTROPHINS | Immunohistochemistry | Inflammation - pathology | Leukocytes, Mononuclear - metabolism | Immunoprecipitation | Adapalene - metabolism | Humans | Male | Thalidomide - pharmacology | Inflammation - blood | Myofibroblasts - metabolism | Thalidomide - analogs & derivatives | Psoriasis - pathology | Isoenzymes - metabolism | Inflammation Mediators - metabolism | Adult | Female | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Psoriasis - blood | Cyclic AMP - metabolism | Myofibroblasts - pathology | Cytokines - metabolism | Isoenzymes - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Myofibroblasts - drug effects | Gene Expression Regulation, Enzymologic | Cell Movement - drug effects | Cell Differentiation - drug effects | Dermis - pathology | Psoriasis - enzymology | Inflammation - enzymology | Evaluation | RNA | Dermatology | Analysis | Formulae, receipts, prescriptions | Nerve growth factor | Bone morphogenetic proteins | Dermatologic agents | Cyclic adenylic acid | Arthritis | Transforming growth factors | Rheumatoid factor | Systemic lupus erythematosus | Skin | Interferon | Macrophage colony stimulating factor | Growth factors | Index Medicus
Journal Article
Cell Stem Cell, ISSN 1934-5909, 01/2015, Volume 16, Issue 1, pp. 51 - 66
Mesenchymal stem cells (MSCs) reside in the perivascular niche of many organs, including kidney, lung, liver, and heart, although their roles in these tissues... 
REGULATOR | ORIGIN | SONIC HEDGEHOG | PATHWAY | BONE-MARROW NICHE | MYOFIBROBLASTS | NG2 PROTEOGLYCAN | EXPRESSION | MESENCHYMAL STEM-CELLS | GROWTH FACTOR-AA | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Organ Specificity - drug effects | Diphtheria Toxin - pharmacology | Neovascularization, Physiologic - drug effects | Pericytes - drug effects | Blood Vessels - metabolism | Blood Vessels - pathology | Humans | Fibrosis - metabolism | Cell Lineage - drug effects | Myofibroblasts - metabolism | Mesenchymal Stromal Cells - cytology | Mesenchymal Stromal Cells - ultrastructure | Kruppel-Like Transcription Factors - metabolism | Pericytes - pathology | Bone Marrow Cells - drug effects | Colony-Forming Units Assay | Aorta - physiopathology | Homeostasis - drug effects | Heart Ventricles - pathology | Receptor, Platelet-Derived Growth Factor beta - metabolism | Mesenchymal Stromal Cells - drug effects | Endothelial Cells - metabolism | Aorta - drug effects | Pericytes - metabolism | Cells, Cultured | Proteoglycans - metabolism | Antigens - metabolism | Aorta - pathology | Myofibroblasts - cytology | Animals | Heart Ventricles - physiopathology | Cell Differentiation - drug effects | Endothelial Cells - cytology | Blood Vessels - drug effects | Mice | Stem Cell Niche - drug effects | Zinc Finger Protein GLI1 | Fibrosis - pathology | Bone Marrow Cells - metabolism | Endothelial Cells - drug effects | Heart Ventricles - drug effects | Index Medicus
Journal Article