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1. Full Text Developmental basis for filamin-A-associated myxomatous mitral valve disease
by Sauls, Kimberly and De Vlaming, Annemarieke and Harris, Brett S and Williams, Katherine and Wessels, Andy and Levine, Robert A and Slaugenhaupt, Susan A and Goodwin, Richard L and Pavone, Luigi Michele and Merot, Jean and Schott, Jean-Jacques and Le Tourneau, Thierry and Dix, Thomas and Jesinkey, Sean and Feng, Yuanyi and Walsh, Christopher and Zhou, Bin and Baldwin, Scott and Markwald, Roger R and Norris, Russell A
Cardiovascular Research, ISSN 0008-6363, 10/2012, Volume 96, Issue 1, pp. 109 - 119
We hypothesized that the structure and function of the mature valves is largely dependent upon how these tissues are built during development, and defects in... 
Valve maturation | Filamin-A | Myxomatous valve disease | Serotonin | Transglutaminase-2 | SEROTONYLATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN | 5-HYDROXYTRYPTAMINE | VALVULAR HEART-DISEASE | PREVALENCE | VALVULOPATHY | DEFICIENCY | SIGNAL-TRANSDUCTION | GENE | Contractile Proteins - genetics | Heart Defects, Congenital - embryology | Myxoma - embryology | Male | Mitral Valve Prolapse - embryology | Myxoma - genetics | Mitral Valve Prolapse - genetics | Filamins | Mice, Knockout | Serotonin Plasma Membrane Transport Proteins - metabolism | Heart Defects, Congenital - genetics | Genetic Diseases, X-Linked - embryology | Animals | Serotonin - metabolism | Transglutaminases - metabolism | Mitral Valve - embryology | Genetic Diseases, X-Linked - genetics | Mice | Microfilament Proteins - metabolism | Contractile Proteins - metabolism | Microfilament Proteins - genetics | Tryptophan Hydroxylase - metabolism | GTP-Binding Proteins - metabolism | Original
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2. Full Text Filamin A mitral valve disease: prolapse, dystrophy, or dysplasia?
by Thiene, Gaetano and Basso, Cristina
European Heart Journal, ISSN 0195-668X, 04/2018, Volume 39, Issue 15, pp. 1278 - 1280
CARDIAC & CARDIOVASCULAR SYSTEMS | GENE | MYXOMATOUS VALVULAR DYSTROPHY | XQ28 | MUTATION
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3. Full Text Echocardiographic indices and severity of mitral regurgitation in dogs with preclinical degenerative mitral valve disease
by Larouche‐Lebel, Éva and Loughran, Kerry A and Oyama, Mark A
Journal of Veterinary Internal Medicine, ISSN 0891-6640, 03/2019, Volume 33, Issue 2, pp. 489 - 498
Background Describing severity of mitral regurgitation (MR) in dogs with degenerative mitral valve disease (DMVD) is challenging. Hypothesis/Objectives Mitral... 
degenerative mitral valve disease | regurgitant fraction | heart disease | myxomatous degeneration | MANAGEMENT | QUANTIFICATION | MECHANISMS | FLOW | MATHEMATIC MODELS | ORIFICE AREA | VETERINARY SCIENCES | CROSS-SECTIONAL ECHOCARDIOGRAPHY | CONGESTIVE-HEART-FAILURE | QUANTIFYING VOLUME | ENALAPRIL | Analysis | Mitral valve insufficiency | Heart | Diastole | Population studies | Standard error | Goodness of fit | Mathematical analysis | Orifices | Regurgitation | Aorta | Blood pressure | Rheumatic heart disease | Atria | Heart failure | Atrium | Stroke | Mitral valve | Dimensional measurement | Velocity | Heart valves | Studies | Coronary vessels | Dogs | Ventricle | Surface area | Methods | Standard | SMALL ANIMAL
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4. Full Text Survival of activated myofibroblasts in canine myxomatous mitral valve disease and the role of apoptosis
by Blake, Rachel R and Markby, Greg R and Culshaw, Geoff J and Martinez-Pereira, Yolanda and Lu, Chi-Chien and Corcoran, Brendan M
Research in Veterinary Science, ISSN 0034-5288, 02/2020, Volume 128, pp. 99 - 106
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5. Full Text Myxomatous mitral valve disease in the miniature poodle: A retrospective study
by Meurs, K.M and Adin, D and O’Donnell, K and Keene, B.W and Atkins, C.E and DeFrancesco, T and Tou, S
The Veterinary Journal, ISSN 1090-0233, 02/2019, Volume 244, pp. 94 - 97
Myxomatous mitral valve disease (MMVD) is the most common cardiovascular disease in the dog. The natural history of the disease is wide ranging and includes... 
Genetic | Mitral valve | Myxomatous valve | Canine | Miniature poodle | DOGS | PROLAPSE | VETERINARY SCIENCES | NATURAL-HISTORY | EPIDEMIOLOGY | Hypertension | Heart | Medical records | Heart valve diseases | Fainting | Development and progression
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6. Full Text Evaluation of genes associated with human myxomatous mitral valve disease in dogs with familial myxomatous mitral valve degeneration
by Meurs, K.M and Friedenberg, S.G and Williams, B and Keene, B.W and Atkins, C.E and Adin, D and Aona, B and DeFrancesco, T and Tou, S and Mackay, T
The Veterinary Journal, ISSN 1090-0233, 02/2018, Volume 232, pp. 16 - 19
Myxomatous mitral valve disease (MMVD) is the most common heart disease in the dog. It is believed to be heritable in Cavalier King Charles spaniels (CKCS) and... 
Genetic | Dachshund | Mitral valve | Cavalier King Charles spaniel | Myxomatous valve | Canine | VARIANTS | RISK | POLYMORPHISM | MODEL | GENETICS | SEQUENCE | FRAMEWORK | PROLAPSE | VETERINARY SCIENCES | Mitral Valve | Animals | Species Specificity | Heart Valve Diseases - veterinary | Humans | Dogs | Heart Valve Diseases - genetics | Dog Diseases - genetics | Mutation | Whole Genome Sequencing - veterinary | Mitral Valve Prolapse - genetics | DNA - blood
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7. Full Text Iron status in dogs with myxomatous mitral valve disease
by Savarese, A and Probo, M and Locatelli, C and Gazzonis, A.L and Zanzani, S.A and Traini, G and Vitiello, T and Brambilla, P.G
Polish Journal of Veterinary Sciences, ISSN 1505-1773, 2018, Volume 21, Issue 3, pp. 507 - 515
In humans, iron deficiency represents a relevant occurrence in heart failure (HF), with or without anaemia, and is associated with the worst outcome. Moreover,... 
myxomatous mitral valve disease | iron | cardiovascular-renal disorder | dog | cardiorenal syndrome | KIDNEY-DISEASE | CHRONIC HEART-FAILURE | BLUNTED ERYTHROPOIETIN PRODUCTION | DISORDERS | VETERINARY SCIENCES | ANEMIA | DEFICIENCY
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8. Full Text Expression profiling of circulating microRNAs in canine myxomatous mitral valve disease
by Li, Qinghong and Freeman, Lisa M and Rush, John E and Laflamme, Dorothy P
International Journal of Molecular Sciences, ISSN 1661-6596, 06/2015, Volume 16, Issue 6, pp. 14098 - 14108
MicroRNAs (miRNAs) are small non-coding RNAs that have shown promise as noninvasive biomarkers in cardiac disease. This study was undertaken to investigate the... 
Myxomatous mitral valve disease | Biomarker | MicroRNA | Congestive heart failure | Dog | RT-qPCR | BIOMARKERS | CANCER | CHEMISTRY, MULTIDISCIPLINARY | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | DOGS | Biomarkers - metabolism | Heart Valve Diseases - blood | Mitral Valve Prolapse - blood | Mitral Valve Prolapse - veterinary | Dog Diseases - genetics | Male | Mitral Valve Prolapse - genetics | Dog Diseases - pathology | Dog Diseases - blood | Mitral Valve Prolapse - diagnosis | Animals | Heart Valve Diseases - veterinary | Dogs | Heart Valve Diseases - genetics | Female | Heart Valve Diseases - diagnosis | MicroRNAs - blood | MicroRNAs - genetics | Real-Time Polymerase Chain Reaction | Heart failure | Disease | Gene expression | Ribonucleic acid--RNA | myxomatous mitral valve disease | microRNA | congestive heart failure | biomarker | dog
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9. Full Text Developmental pathways and endothelial to mesenchymal transition in canine myxomatous mitral valve disease
by Lu, Chi-Chien and Liu, Meng-Meng and Clinton, Michael and Culshaw, Geoff and Argyle, David J and Corcoran, Brendan M
The Veterinary Journal, ISSN 1090-0233, 12/2015, Volume 206, Issue 3, pp. 377 - 384
Epithelial to mesenchymal transition (EMT) and the cardiovascular equivalent, endothelial to mesenchymal transition (EndoMT), contribute to a range of chronic... 
Endothelial to mesenchymal transition | Myxomatous mitral valve disease | Transcriptomics | Canine | TRANSFORMATION | CELLS | ACTIVATION | HYALURONAN | VALVULAR DISEASE | DEGENERATION | HEART | MATRIX METALLOPROTEINASES | DOGS | VETERINARY SCIENCES | EXPRESSION | Heart Valve Diseases - pathology | Oligonucleotide Array Sequence Analysis - veterinary | Signal Transduction | Antigens, CD - biosynthesis | Transcriptome | Snail Family Transcription Factors - biosynthesis | Cadherins - biosynthesis | Dog Diseases - pathology | Real-Time Polymerase Chain Reaction - veterinary | Animals | Heart Valve Diseases - veterinary | Dogs | Heart Valve Diseases - genetics | Cell Differentiation | Endothelial Cells - pathology | Glucuronosyltransferase - biosynthesis | Mesoderm - pathology | Heart valve diseases | Stem cells | Endothelium
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10. Canine degenerative myxomatous mitral valve disease: Natural history, clinical presentation and therapy
by Borgarelli Michele, M and Haggstrom, Jens
Veterinary Clinics of North America - Small Animal Practice, ISSN 0195-5616, 2010, Volume 40, Issue 4, pp. 651 - 663
Myxomatous mitral valve disease is a common condition in geriatric dogs. Most dogs affected are clinically asymptomatic for a long time. However, about 30% of... 
Therapy | Mitral valve | Myxomatous degeneration | Canine | SURVIVAL | ENALAPRIL MALEATE | NATRIURETIC PEPTIDE | KING CHARLES SPANIELS | REGURGITATION | ARTERIAL-HYPERTENSION | DOGS | CHRONIC VALVULAR DISEASE | PROLAPSE | VETERINARY SCIENCES | CONGESTIVE-HEART-FAILURE | Risk Factors | Male | Mitral Valve - surgery | Treatment Outcome | Mitral Valve Insufficiency - therapy | Mitral Valve Insufficiency - veterinary | Mitral Valve Insufficiency - diagnosis | Heart Failure - therapy | Animals | Dog Diseases - therapy | Dogs | Mitral Valve Insufficiency - complications | Female | Heart Failure - diagnosis | Heart Failure - veterinary | Mitral Valve - pathology | Dog Diseases - diagnosis | Heart Failure - etiology
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11. Full Text Serotonin Concentrations in Platelets, Plasma, Mitral Valve Leaflet, and Left Ventricular Myocardial Tissue in Dogs with Myxomatous Mitral Valve Disease
by Cremer, S.E and Singletary, G.E and Olsen, L.H and Wallace, K and Häggström, J and Ljungvall, I and Höglund, K and Reynolds, C.A and Pizzinat, N and Oyama, M.A and Sveriges lantbruksuniversitet
Journal of Veterinary Internal Medicine, ISSN 0891-6640, 09/2014, Volume 28, Issue 5, pp. 1534 - 1540
Hypothesis/Objectives Altered serotonin (5‐hydroxytryptamine, 5HT) signaling is postulated in development and progression of canine myxomatous mitral valve... 
Myxomatous mitral valve disease | Cavalier King Charles Spaniels | Heart disease | 5‐Hydroxytryptamine | 5-Hydroxytryptamine | SIGNALING PATHWAYS | HEART-FAILURE | RECEPTOR | VALVULOPATHY | INTERSTITIAL-CELLS | REGURGITATION | KING-CHARLES SPANIELS | VETERINARY SCIENCES | ECHOCARDIOGRAPHY | AGGREGATION | Heart Valve Diseases - blood | Echocardiography - veterinary | Serotonin - analysis | Dog Diseases - metabolism | Blood Platelets - chemistry | Mitral Valve - chemistry | Male | Heart Ventricles - chemistry | Serotonin - blood | Dog Diseases - blood | Animals | Heart Valve Diseases - metabolism | Heart Valve Diseases - veterinary | Dogs | Female | Platelet Count - veterinary | Phenols | Development and progression | Serotonin | Heart diseases | Standard | Kardiologi | Cardiac and Cardiovascular Systems | Klinisk vetenskap | Clinical Science
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12. Full Text Blood lactate increases with the progression of mitral valve disease in dogs
by Silva-Filho, Jorge Cardoso and Sousa, Marlos G and Pereira, Evandro Zacché and Ortiz, Edna M.G and Franco, Rodrigo P and Rosa, Fernando A and Camacho, Aparecido Antonio
Pesquisa Veterinária Brasileira, ISSN 0100-736X, 09/2018, Volume 38, Issue 9, pp. 1781 - 1786
In dogs with congestive heart failure, the upregulated sympathetic tone causes vasoconstriction that impairs peripheral blood supply, therefore causing the... 
myxomatous mitral valve disease | hyperlactatemia | endocardiosis | dogs | mitral valve disease | congestive heart failure | Blood lactate | hypoperfusion
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13. Full Text Blood lactate increases with the progression of mitral valve disease in dogs
by Silva, JC and Sousa, MG and Pereira, EZ and Ortiz, EMG and Franco, RP and Rosa, FA and Camacho, AA
PESQUISA VETERINARIA BRASILEIRA, ISSN 0100-736X, 09/2018, Volume 39, Issue 9, pp. 1781 - 1786
In dogs with congestive heart failure, the upregulated sympathetic tone causes vasoconstriction that impairs peripheral blood supply, therefore causing the... 
myxomatous mitral valve disease | hyperlactatemia | MARKERS | Blood lactate | hypoperfusion | PROGNOSTIC VALUE | FAILURE | BIOMARKERS | THERAPY | endocardiosis | dogs | mitral valve disease | congestive heart failure | VETERINARY SCIENCES | CRITICALLY-ILL PATIENTS | CLINICAL-PRACTICE
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14. Full Text Historical review, epidemiology and natural history of degenerative mitral valve disease
by Borgarelli, Michele and Buchanan, James W
Journal of Veterinary Cardiology, ISSN 1760-2734, 03/2012, Volume 14, Issue 1, pp. 93 - 101
Chronic mitral valve disease due to myxomatous degeneration (MMVD) is the most common cardiovascular disease in dogs and has been known to cause congestive... 
Dog | Mitral valve | Myxomatous degeneration | VETERINARY SCIENCES | Dog Diseases - epidemiology | Mitral Valve Insufficiency - pathology | Animals | Dogs | Aging | Dog Diseases - genetics | Mitral Valve Insufficiency - epidemiology | Dog Diseases - pathology | Mitral Valve Insufficiency - veterinary | Mitral Valve Insufficiency - genetics | Heart valve diseases | Epidemiology
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15. Full Text Serum Serotonin Concentration Is Associated with Severity of Myxomatous Mitral Valve Disease in Dogs
by Ljungvall, I and Höglund, K and Lilliehöök, I and Oyama, M.A and Tidholm, A and Tvedten, H and Häggström, J and Sveriges lantbruksuniversitet
Journal of Veterinary Internal Medicine, ISSN 0891-6640, 09/2013, Volume 27, Issue 5, pp. 1105 - 1112
Background The neurotransmitter serotonin (5‐hydroxytryptamine, 5‐HT) has recently been suggested to play a role in the development of naturally acquired... 
Valvular disease | Canine myxomatous disease | Cardiology | Platelet function | 5-HYDROXYTRYPTAMINE | ABNORMALITIES | PHENOTYPE | KING-CHARLES-SPANIELS | DACHSHUNDS | INTERSTITIAL-CELLS | CARCINOID HEART-DISEASE | CHRONIC VALVULAR DISEASE | PROLAPSE | VETERINARY SCIENCES | ECHOCARDIOGRAPHY | Mitral Valve Prolapse - blood | Predictive Value of Tests | Serotonin - blood | Dog Diseases - blood | Animals | Mitral Valve Prolapse - veterinary | Dogs | Female | Male | Biomarkers - blood | Phenols | Heart valve diseases | Heart beat | Serotonin | Analysis | Kardiologi | Cardiac and Cardiovascular Systems
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16. Full Text Pharmacologic management of myxomatous mitral valve disease in dogs
by Atkins, Clarke E and Häggström, Jens and Sveriges lantbruksuniversitet
Journal of Veterinary Cardiology, ISSN 1760-2734, 03/2012, Volume 14, Issue 1, pp. 165 - 184
Myxomatous mitral valve disease (MMVD) causing mitral regurgitation is the most important disease of the heart in small animal cardiovascular medicine. Because... 
Myxomatous mitral valve disease | Treatment heart disease | Canine | LONG-TERM MONOTHERAPY | SILDENAFIL CITRATE | TREATMENT RAMIPRIL VASOTOP(R) | ANGIOTENSIN-CONVERTING ENZYME | BOLUS INJECTION | ALDOSTERONE SYSTEM | PROSPECTIVE MULTICENTER TRIAL | LEFT-VENTRICULAR DYSFUNCTION | ASSOCIATION TASK-FORCE | VETERINARY SCIENCES | CONGESTIVE-HEART-FAILURE | Cardiovascular Agents - therapeutic use | Animals | Dog Diseases - drug therapy | Mitral Valve Insufficiency - drug therapy | Mitral Valve Insufficiency - veterinary | Dogs | Heart valve diseases | Klinisk vetenskap | Clinical Science
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