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Cell, ISSN 0092-8674, 04/2019, Volume 177, Issue 2, pp. 414 - 427.e13
PD-L1 on the surface of tumor cells binds its receptor PD-1 on effector T cells, thereby suppressing their activity. Antibody blockade of PD-L1 can activate an... 
SMPD3 | CD274 | NSMASE2 | abscopal | exosomes | immune checkpoint | PD-L1 | RAB27A | cancer | T cells | PROMOTE TUMOR-GROWTH | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROSTATE-CANCER | BIOLOGY | CMTM6 | LYSOSOME | IDENTIFICATION | EXPRESSION | CANCER-IMMUNITY | CELL-DEATH | CELL BIOLOGY | Viral antibodies | Antibodies | Analysis | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 6, pp. 3455 - 3467
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 05/2019, Volume 294, Issue 18, pp. 7488 - 7502
Neutral sphingomyelinase 2 (nSMase2) produces the bioactive lipid ceramide and has important roles in neurodegeneration, cancer, and exosome formation.... 
NSMASE2 | PROTEIN | MECHANISM | sphingolipid | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | IDENTIFICATION | lipid | PREDICTION | ceramide | AMYLOID-BETA | sphingomyelinase | SECRETION | enzyme mechanism | STRESS
Journal Article
Journal Article
Artificial Cells, Nanomedicine, and Biotechnology, ISSN 2169-1401, 11/2018, Volume 46, Issue 8, pp. 1659 - 1670
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2018, Volume 499, Issue 4, pp. 751 - 757
Journal Article
Acta Pharmacologica Sinica, ISSN 1671-4083, 04/2018, Volume 39, Issue 4, pp. 569 - 578
Journal Article
Journal Article
Journal of Neuroinflammation, ISSN 1742-2094, 09/2013, Volume 10, Issue 1, pp. 109 - 109
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 7/2018, Volume 55, Issue 7, pp. 5741 - 5756
Sphingomyelinases are a family of enzymes that hydrolyze sphingomyelin to generate phosphocholine and ceramide. The brain distribution and function of neutral... 
Neurosciences | Antisense knockdown | Neurobiology | Lipidomics | Lipid rafts | Sphingolipids | Startle reflex | Microdomains | Cell Biology | Neurology | Membrane lipids | Biomedicine | Proteomics | Motor function | nSMase2 | GW4869 | SOMATOTOPOGRAPHICAL DISTRIBUTION | ACID SPHINGOMYELINASES | NECROSIS-FACTOR-ALPHA | CERAMIDE | PLASMA-MEMBRANE | NEUROSCIENCES | RECEPTOR LOCALIZATION | CELL-DEATH | SPHINGOLIPID METABOLISM | INHIBITION | BRAIN | Sphingomyelin Phosphodiesterase - genetics | Rats, Wistar | Isoenzymes - genetics | Membrane Microdomains - metabolism | RNA, Messenger - genetics | Male | Sphingolipids - metabolism | Motor Activity | RNA, Messenger - metabolism | Corpus Striatum - cytology | Prepulse Inhibition | Corpus Striatum - ultrastructure | Gene Knockdown Techniques | Reflex, Acoustic | Gene Expression Regulation, Enzymologic | Rotarod Performance Test | Animals | Isoenzymes - metabolism | Sphingomyelin Phosphodiesterase - metabolism | Reflex, Startle | Corpus Striatum - enzymology | Proteome - metabolism | Proteins | Analysis | Presynapse | Cerebellum | Cortex (olfactory) | Brain stem | Lipids | Antisense | Caudate-putamen | Dendritic spines | Startle response | Neostriatum | Ceramide | Thalamus | Dendrites | Inhibition | Cortex (prefrontal) | Cortex | Electron microscopy | Gene expression | Putamen | Phosphocholine | Sphingomyelin phosphodiesterase | Axons | Sphingomyelin | Olfactory bulb | Glutamatergic transmission | Hippocampus | Index Medicus
Journal Article
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 02/2016, Volume 1861, Issue 2, pp. 78 - 90
Increased synthesis of hyaluronic acid (HA) is often associated with increased metastatic potential and invasivity of tumor cells. 4-Methylumbelliferone (MU)... 
Ceramide | 4-Methylumbelliforone | NSMase2 | Hyaluronic acid | Anticancer | CANCER-CELLS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIRT1 | CELL BIOLOGY | ADHESION DYNAMICS | IN-VITRO | BIOPHYSICS | CALPAIN-MEDIATED PROTEOLYSIS | NEUTRAL SPHINGOMYELINASE 2 | PROSTATE-CANCER | MELANOMA-CELLS | EXPRESSION | Sirtuin 1 - metabolism | Sphingomyelin Phosphodiesterase - genetics | Calpain - metabolism | Apoptosis - drug effects | Neuroglia - pathology | Humans | Caspase 3 - metabolism | Gene Expression Regulation, Neoplastic | Calpain - genetics | Sirtuin 1 - genetics | Ceramides - biosynthesis | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Neuroglia - drug effects | Glucuronosyltransferase - genetics | Sphingomyelin Phosphodiesterase - metabolism | Caspase 3 - genetics | Antineoplastic Agents - pharmacology | Hyaluronan Synthases | Hymecromone - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Signal Transduction | Protein Phosphatase 2 - genetics | Tumor Suppressor Protein p53 - metabolism | Hyaluronic Acid - antagonists & inhibitors | Cell Movement - drug effects | Animals | Glucuronosyltransferase - metabolism | Hyaluronic Acid - metabolism | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Neuroglia - metabolism | Mice | Enzyme Activation | Ceramides | Calpain | Plant lipids | Tumor proteins | Tumors | Phosphatases | Metastasis | Mass spectrometry
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2011, Volume 435, Issue 2, pp. 381 - 390
Journal Article