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Molecular cell, ISSN 1097-2765, 2018, Volume 69, Issue 6, pp. 993 - 1004.e3
The molecular mechanism of transmembrane proton translocation in rotary motor ATPases is not fully understood. Here, we report the 3.5-Å resolution cryoEM... 
Voa1 | reversible disassembly | cryoEM | proton pumping | vacuolar H+-ATPase | Vo proton channel | lipid nanodisc | membrane protein structure | V-ATPase assembly | proton channel | ATPase | vacuolar H | Vo proton channelcryo | EMlipid nanodisc | BASIC BIOLOGICAL SCIENCES | Vacuolar H+-ATPase
Journal Article
Structure (London), ISSN 0969-2126, 2018, Volume 26, Issue 10, pp. 1303 - 1313.e4
Understanding gating principles of ion channels at high resolution is of great importance. Here we investigate the conformational transition from closed to... 
ryanodine receptor | ion channel gating | cryo-EM | lipid mimetic | calcium signaling | lipid nanodiscs | ACTIVATION | CA2+ RELEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | SARCOPLASMIC-RETICULUM | CELL BIOLOGY | CALCIUM-RELEASE CHANNEL | BIOPHYSICS | STRUCTURAL BASIS | PURIFICATION | MEMBRANE-PROTEINS | RECONSTITUTION | INSIGHTS | Physiological aspects | Membrane lipids | Protein binding
Journal Article
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 07/2018, Volume 592, Issue 13, pp. 2282 - 2288
Cytochrome P450 17A1 (CYP17A1) catalyzes the synthesis of androgens from the steroid precursors pregnenolone and progesterone in a two‐step reaction process:... 
Nanodisc | cytochrome b5 | cytochrome P450 | androgen biosynthesis
Journal Article
Angewandte Chemie (International ed. in English), ISSN 1433-7851, 1/2018, Volume 57, Issue 5, pp. 1342 - 1345
Polymer lipid nanodiscs have provided an invaluable system for structural and functional studies of membrane proteins in their near-native environment. In... 
pH tolerance | lipid bilayer | magnetic-alignment | polymer nanodisc | SMA
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2017, Volume 487, Issue 2, pp. 351 - 355
KRas4b is a small G-protein whose constitutively active oncogenic mutants are present in 90% of pancreatic cancers. Using fully post-translationally modified... 
Nanodisc | Lipid specificity | KRas4b | Cancer signaling | PIP2 | PHOSPHOLIPID-BILAYER NANODISCS | MOLECULAR-DYNAMICS | ACTIVATION | RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MIMETIC MODEL | METHYLATED KRAS4B | BIOPHYSICS | STRUCTURAL BASIS | PROTEINS
Journal Article
Journal Article