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native chemical ligation (523) 523
science & technology (328) 328
life sciences & biomedicine (214) 214
biochemistry & molecular biology (175) 175
chemistry (175) 175
peptides (175) 175
physical sciences (171) 171
proteins (158) 158
humans (111) 111
chemical synthesis (103) 103
amino acid sequence (99) 99
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chemistry, multidisciplinary (85) 85
peptides - chemical synthesis (80) 80
molecular sequence data (77) 77
pharmacology & pharmacy (65) 65
animals (64) 64
protein synthesis (62) 62
chemistry, medicinal (57) 57
native chemische ligation (56) 56
models, molecular (54) 54
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proteins - chemistry (47) 47
thioester (47) 47
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synthesis (44) 44
protein conformation (42) 42
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chemical protein synthesis (40) 40
chromatography, high pressure liquid (39) 39
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cysteine - chemistry (38) 38
proteins - chemical synthesis (38) 38
amino acids (36) 36
biophysics (33) 33
chemistry, analytical (33) 33
peptide (32) 32
peptide synthesis (31) 31
analysis (30) 30
expressed protein ligation (30) 30
proteinsynthese (30) 30
desulfurization (29) 29
enzymes (28) 28
protein binding (28) 28
kinetics (27) 27
solid phase peptide synthesis (27) 27
solid-phase synthesis (25) 25
sulfhydryl compounds - chemistry (24) 24
ubiquitin (24) 24
protein-synthesis (23) 23
life sciences (22) 22
mass spectrometry (22) 22
protein structure, secondary (22) 22
solid-phase peptide synthesis (22) 22
biochemistry (21) 21
peptide thioester (21) 21
protein structure, tertiary (21) 21
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cystein (20) 20
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protein engineering (20) 20
thiols (20) 20
circular dichroism (19) 19
glycoproteins (19) 19
protein chemical synthesis (19) 19
chemical-synthesis (18) 18
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peptid (18) 18
solid‐phase synthesis (18) 18
biology (17) 17
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peptide:organic-acid (17) 17
binding sites (16) 16
esters - chemistry (16) 16
methods (16) 16
protein processing, post-translational (16) 16
science & technology - other topics (16) 16
biochemistry, general (15) 15
crystallography, x-ray (15) 15
dna (15) 15
fluorescence (15) 15
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catalysis (14) 14
cystine (14) 14
entschwefelung (14) 14
glycopeptides - chemical synthesis (14) 14
ligation (14) 14
organic compounds (14) 14
peptides - metabolism (14) 14
protein engineering - methods (14) 14
proteins - metabolism (14) 14
recombinant proteins - chemistry (14) 14
selenocysteine (14) 14
amino acids - chemistry (13) 13
drug discovery (13) 13
esters (13) 13
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Angewandte Chemie (International ed.), ISSN 1521-3773, 08/2008, Volume 47, Issue 36, pp. 6851 - 6855
Journal Article
Chemistry : a European journal, ISSN 0947-6539, 01/2017, Volume 23, Issue 4, pp. 946 - 952
The use of native chemical ligation at selenocysteine (Sec) residues with peptide thioesters and additive... 
synthesis | peptides | glycopeptides | native chemical ligation | oxidative deselenization | Peptides | Amino acids | Mucins | Index Medicus | Residues | Phenyls | Thioesters | Efficiency | Concerts | Glycopeptides | Bearing
Journal Article
Royal Society open science, ISSN 2054-5703, 06/2018, Volume 5, Issue 6, pp. 172455 - 172455
Sequential peptide ligation strategy becomes more and more important in large protein or long peptides chemical synthesis due to the limited peptide/protein size obtained by solid phase synthesis... 
Native chemical ligation | Thioacid capture ligation | Protein chemical synthesis | Sequential peptide ligation | thioacid capture ligation | protein chemical synthesis | native chemical ligation | sequential peptide ligation
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 08/2011, Volume 50, Issue 33, pp. 7645 - 7649
pH determines selectivity: The ligation of peptide hydrazides is a new method for protein chemical synthesis that is complementary to native chemical ligation... 
peptide hydrazides | protein chemical synthesis | native chemical ligation | protein design | proteins | Hydrazines - chemistry | Oligopeptides - chemical synthesis | Hydrazines - chemical synthesis | Molecular Structure | Oligopeptides - chemistry | Index Medicus
Journal Article
Tetrahedron letters, ISSN 0040-4039, 06/2017, Volume 58, Issue 25, pp. 2448 - 2455
....•Efficient sequential native chemical ligation using three peptidic segments.•Only five steps, simple reaction conditions and broad scope... 
Native chemical ligation | Human Growth Hormone analog | Microwave-assisted SPPS | N-Acyl-N′-methylacylurea linker | Selective desulfurization | Physical Sciences | Chemistry | Chemistry, Organic | Science & Technology
Journal Article
Angewandte Chemie (International ed.), ISSN 1521-3773, 08/2008, Volume 47, Issue 36, pp. 6807 - 6810
...‐dimethylcysteine peptides reacted surprisingly fast in native chemical ligation reactions. Even the sterically crowded and unpolar Leu... 
penicillamine | peptide ligation | valine | native chemical ligation | Native chemical ligation | Penicillamine | Valine | Peptide ligation | Valine - chemistry | Molecular Sequence Data | Amino Acid Sequence | Peptides - chemical synthesis | Peptides - chemistry | Penicillamine - chemistry | Index Medicus
Journal Article
Chemistry : a European journal, ISSN 0947-6539, 01/2016, Volume 22, Issue 3, pp. 1146 - 1151
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 07/2016, Volume 55, Issue 28, pp. 8108 - 8112
.... We show, for the first time, the assembly of three peptide fragments in a one‐pot fashion by native chemical ligation where the Acm moiety was used to protect the N... 
palladium | protein synthesis | desulfurization | native chemical ligation | cysteine | Ubiquitin | Cysteine | Thiols | Peptides | Protein biosynthesis | Palladium | Chemical synthesis | Cystine | Proteins | Desulfurization | Semisynthesis | Protein synthesis | Fragments | Acetamidomethyl | Desulfurizing | Index Medicus
Journal Article
Israel journal of chemistry, ISSN 0021-2148, 11/2011, Volume 51, Issue 8‐9, pp. 885 - 899
... and their analogues using convergent coupling strategies. 2 Native Chemical Ligation (NCL) 2b has proved particularly useful, since it provides access to native proteins... 
peptides | acyl‐transfer | protein modifications | thioester | native chemical ligation | acyl-transfer | Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Peptides | Reviews
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 03/2016, Volume 26, Issue 5, pp. 1434 - 1437
[Display omitted] Native chemical ligation (NCL) proceeds via a S–N acyl shift and, therefore, requires N-terminal cysteine. Nα... 
Extending NCL | Auxiliary assisted NCL | Dermicidine | Total chemical protein synthesis | Native chemical ligation | Radicals | Peptide coupling
Journal Article
Angewandte Chemie (International ed.), ISSN 1521-3773, 12/2008, Volume 47, Issue 52, pp. 10030 - 10074
The investigation of biological processes by chemical methods, commonly referred to as chemical biology, often requires chemical access to biologically relevant macromolecules such as peptides and proteins... 
semisynthesis | chemoselectivity | peptides | native chemical ligation | protein ligation | Native chemical ligation | Protein ligation | Semisynthesis | Peptides | Chemoselectivity | Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Proteins - genetics | Peptides - chemical synthesis | Proteins - chemistry | Peptides - chemistry | Proteins - chemical synthesis | Peptides - genetics | Index Medicus
Journal Article