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Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 2, pp. 523 - 540
Reactive oxygen and nitrogen species change cellular responses through diverse mechanisms that are now being defined. At low levels, they are signalling... 
Mitochondrion | Oxidative stress | Redox signalling | Neurodegeneration | Autophagy | Nitrative stress | autophagy | CHAPERONE-MEDIATED AUTOPHAGY | ANTIOXIDANT RESPONSIVE ELEMENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPOFUSCINOSES BATTEN-DISEASE | neurodegeneration | AMYOTROPHIC-LATERAL-SCLEROSIS | mitochondrion | redox signalling | MOTOR-NEURON DEGENERATION | MANGANESE SUPEROXIDE-DISMUTASE | nitrative stress | SMOOTH-MUSCLE-CELLS | PATHOGENIC DJ-1 MUTATIONS | HYPOXIA-INDUCED AUTOPHAGY | oxidative stress | COMPLEX-I DEFICIENCY | Protein Kinases - metabolism | Transcription, Genetic - drug effects | Cardiovascular Diseases - physiopathology | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Reactive Nitrogen Species - metabolism | Humans | Oxidative Stress - physiology | Hydrogen Peroxide - pharmacology | Oncogene Proteins - metabolism | Nitric Oxide - physiology | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Parkinson Disease - physiopathology | Lysosomes - physiology | Protein Deglycase DJ-1 | Animals | Signal Transduction - physiology | TOR Serine-Threonine Kinases - physiology | Neoplasms - physiopathology | AMPK, 5′-AMP-activated protein kinase | NBR1, neighbour of BRCA1 (breast cancer early-onset 1) | NGF, nerve growth factor | LC3, light chain 3 | NOX, NADPH oxidase | EM, electron microscopy | TOR, target of rapamycin | ULK, unc (unco-ordinated family member)-51-like kinase | mtDNA, mitochondrial DNA | mTOR, mammalian target of rapamycin | IKKβ, IκB kinase β | LRRK2, leucine-rich repeat kinase 2 | NAC, N-acetyl-L-cysteine | Nrf2, nuclear factor-erythroid 2-related factor 2 | PI3P, phosphatidylinositol 3-phosphate | ECH, enoyl-CoA hydratase | BNIP3L, BNIP3-like | Drp1, dynamin-related protein 1 | tfLC3, tandem fluorescently tagged LC3 | NF-κB, nuclear factor κB | BAG, Bcl-2-associated athanogene | Keap1, Kelch-like ECH-associated protein 1 | PE, phosphatidylethanolamine | 3-MA, 3-methyladenine | UCP, uncoupling protein | IκB, inhibitor of nuclear factor κB | FIP200, focal adhesion kinase family-interacting protein of 200 kDa | PI3K, phosphoinositide 3-kinase | HNE, 4-hydroxynonenal | Review | ALS, amyotrophic lateral sclerosis | ATG, AuTophaGy-related | adenovirus E18 19-kDa-interacting protein | Tzb, trastuzumab | mETC, mitochondrial electron-transport chain | Rubicon, RUN domain- and cysteine-rich domain-containing beclin-1-interacting protein | VDAC, voltage-dependent anion channel | IP3, inositol 1,4,5-trisphosphate | RFP, red fluorescent protein | ROS, reactive oxygen species | TNFα, tumour necrosis factor α | PINK1, PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced kinase 1 | GFP, green fluorescent protein | LAMP, lysosome-associated membrane protein | JNK1, c-Jun N-terminal kinase 1 | TAC, transverse aortic constriction | GABARAP, GABAA (γ-aminobutyric acid type A)-receptor-associated protein | HIF-1, hypoxia-inducible factor 1 | NOS, nitric oxide synthase | siRNA, small interfering RNA | SOD, superoxide dismutase | RLS, reactive lipid species | RNS, reactive nitrogen species | ER, endoplasmic reticulum | TIGAR, TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator | Vps34, vacuolar protein sorting 34 | BNIP, Bcl-2
Journal Article
Autophagy, ISSN 1554-8627, 01/2015, Volume 11, Issue 1, pp. 145 - 154
The autophagy-related proteins ATG12 and ATG5 form a covalent complex essential for autophagy. Here, we demonstrate that ATG12 has distinct functions from ATG5... 
UBL, ubiquitin-like molecule | POMC/ACTH, pro-opiomelanocortin-α (in mice), proopiomelanocortin (in humans) | DEXA, dual energy X-ray absorptiometry | AGRP, agouti-related peptide | NPY, neuropeptide Y | LEP, leptin | BafA, bafilomycin A | PBS, phosphate-buffered saline | CLAMS, Comprehensive Lab Animal Monitoring System | HBSS, Hank's balanced salt solution | HFD, high-fat diet | MAP1LC3, microtubule-associated protein 1 light chain 3 | BMD, bone mineral density | NBR1, neighbor of BRCA1 gene 1 | BAC, bacterial artificial chromosome | ATG5 | pSTAT3, phosphorylated form of signal transducer and activator of transcription 3 (acute-phase response factor) | autophagy | LC3-II, phosphatidylethanolamine conjugated isoform of microtubule-associated protein 1 light chain 3 | SQSTM1/p62, sequestosome 1 | PE, phosphatidylethanolamine | leptin | ATG12 | diet-induced obesity | POMC | SV40Tag, simian virus 40 T antigen | MEFs, mouse embryonic fibroblasts | hypothalamus | Diet-induced obesity | Leptin | Hypothalamus | Autophagy | POMC NEURONS | ACTIVATION | HOMEOSTASIS | CONJUGATION SYSTEM | CELL BIOLOGY | INACTIVATION | PROTEIN LIPIDATION | MICE | LEPTIN RECEPTOR | LONG | Animals, Newborn | Autophagy-Related Protein 12 | Gene Targeting | Body Weight | Microtubule-Associated Proteins - metabolism | Leptin - metabolism | Mice, Inbred C57BL | Feeding Behavior | Obesity - metabolism | Obesity - pathology | Pro-Opiomelanocortin - metabolism | Animals | Proteins - metabolism | Adiposity | Autophagy-Related Protein 5 | Energy Metabolism | Diet, High-Fat | Gene Deletion | Integrases - metabolism | Neurons - metabolism
Journal Article
Autophagy, ISSN 1554-8627, 12/2014, Volume 10, Issue 12, pp. 2297 - 2309
Journal Article
FEBS Letters, ISSN 0014-5793, 2010, Volume 584, Issue 12, pp. 2635 - 2645
Ubiquitinated protein aggregates are hallmarks of a range of human diseases, including neurodegenerative, liver and muscle disorders. These protein aggregates... 
Aggregate-prone protein | Huntingtin | Neurodegeneration | Autophagy | p62 | Proteinopathies | aggresome-like inducible structure | APP | Parkinson's disease | Alzheimer disease | ALS | frontotemporal dementia | MDB | ALIS | amyotrophic lateral sclerosis | CREB-binding protein | PI3P | PI3K | ULK | CMA | autophagy-related | blue cheese | mTOR | UPS | unc-51-like kinase | LC3 | MTOC | phosphatidylinositol 3-kinase | TAR DNA binding protein-43 | chaperone-mediated autophagy | ESCRT | DOR | amyloid-β | mammalian Target of Rapamycin | coat protein complex I | LC3-interacting region | Bchs | intermediate filament | TDP-43 | FTD | ROS | MVB | Cvt | Alfy | phospatidylinositol-3-phosphate | microtubule-organizing centre | autophagy-linked FYVE protein | SCA1 | nuclear localization signal | diabetes- and obesity-regulated gene | HDAC6 | CBP | NLS | amyloid precursor protein | UBA | ubiquitin-associated domain | multivesicular body | reactive oxygen species | cytoplasm to vacuole targeting | spinocerebellar ataxia 1 | endosomal sorting complex required for transport | MAP1 light chain 3 | Histone deacetylase 6 | nuclear export signal | Huntington's disease | PML | neighbour of BRCA1 gene 1 | ubiquitin-proteasome system | phosphatidylethanolamine | LIR | Atg | NBR1 | promyelocytic leukemia | COPI | Mallory-Denk body | NES | P62 | POLYGLUTAMINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTANT HUNTINGTIN | FRONTOTEMPORAL DEMENTIA | ALPHA-SYNUCLEIN | INCLUSION-BODY FORMATION | CELL BIOLOGY | BIOPHYSICS | MULTIVESICULAR BODIES | DEGRADATION | HUNTINGTONS-DISEASE | MEDIATED CLEARANCE | MALLORY-DENK-BODIES | Adaptor Proteins, Signal Transducing - chemistry | Phosphorylation | Transcription Factors - chemistry | Neurodegenerative Diseases - etiology | Sequestosome-1 Protein | Humans | Autophagy - physiology | Multiprotein Complexes - metabolism | Ubiquitination | Membrane Proteins - metabolism | Acetylation | Active Transport, Cell Nucleus | Ubiquitinated Proteins - metabolism | Ubiquitinated Proteins - chemistry | Histone Deacetylase 6 | Histone Deacetylases - chemistry | Histone Deacetylases - metabolism | Neurodegenerative Diseases - therapy | Neurodegenerative Diseases - metabolism | Unfolded Protein Response | Protein Transport | Transcription Factors - metabolism | Multiprotein Complexes - chemistry | Proteins - metabolism | Membrane Proteins - chemistry | Models, Biological | Proteasome Endopeptidase Complex - metabolism | Proteins - chemistry | Adaptor Proteins, Signal Transducing - metabolism
Journal Article