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Neurobiology of Disease, ISSN 0969-9961, 2017, Volume 103, pp. 32 - 44
Abstract The serpinopathies are human pathologies caused by mutations that promote polymerisation and intracellular deposition of proteins of the serpin... 
Neurology | Oxidative stress | Neurodegeneration | Neurons | Familial encephalopathy with neuroserpin inclusion bodies | Neural progenitor cells | Neuroserpin | Protein conformational disease | Serpin polymers | HUMAN BRAIN | PROTEIN | NEUROSCIENCES | ENCEPHALOPATHY | GENE | GLUTATHIONE | PATHWAY | DISEASE | DEGRADATION | ACCUMULATION | ASSOCIATION | Neurons - pathology | Heredodegenerative Disorders, Nervous System - pathology | Humans | Oxidative Stress - physiology | Cerebral Cortex - pathology | Epilepsies, Myoclonic - metabolism | Epilepsies, Myoclonic - pathology | Cerebral Cortex - metabolism | Dementia - metabolism | Neuropeptides - toxicity | Neurons - metabolism | Cerebral Cortex - drug effects | Neurons - drug effects | Cell Survival - physiology | Cell Survival - drug effects | Dementia - pathology | Cells, Cultured | Mice, Transgenic | Epilepsies, Myoclonic - chemically induced | Animals | Dementia - chemically induced | Serpins - toxicity | Polymers - toxicity | Mice | Heredodegenerative Disorders, Nervous System - chemically induced | Heredodegenerative Disorders, Nervous System - metabolism | Oxidative Stress - drug effects | Proteins | RNA sequencing | Fluorescence | Genetic engineering | Polymer industry | Dementia | Analysis | Index Medicus | NFκB, nuclear factor κB | A1AT, alpha1 antitrypsin | unfolded protein response, UPR | Aldh, aldehyde dehydrogenase | Prdx6, peroxiredoxin 6 | NS, neuroserpin | FENIB, familial encephalopathy with neuroserpin inclusion bodies | SOD, superoxide dismutase | HRP, horseradish peroxidase | GPx, glutathione peroxidase | wild type, WT | GST, glutathione transferase | ER, endoplasmic reticulum | MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide | ApoE, apolipoprotein E | Scara, scavenger receptor class A
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 05/2002, Volume 30, Issue 10, pp. 2202 - 2211
Neuroserpin is an axonally secreted serine protease inhibitor expressed in the nervous system that protects neurons from ischemia-induced apoptosis. Mutant... 
neuroserpin
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2019, Volume 517, Issue 3, pp. 421 - 426
Antithrombin (AT3) is one of the most important inhibitors of blood coagulation proteases that belong to the serpin family of protease inhibitors. In this... 
Alternative splicing | Neuroserpin | Antithrombin | Reactive centre loop | Novel isoform | Index Medicus
Journal Article
Journal of Neuropathology & Experimental Neurology, ISSN 0022-3069, 02/2016, Volume 75, Issue 2, pp. 121 - 133
Journal Article
Journal Article
Genetics, ISSN 0016-6731, 2013, Volume 193, Issue 3, pp. 865 - 876
Journal Article
HEPATOLOGY, ISSN 0270-9139, 09/2010, Volume 52, Issue 3, pp. 1078 - 1088
Alpha(1)-antitrypsin is the most abundant circulating protease inhibitor. The severe Z deficiency allele (G1u342Lys) causes the protein to undergo a... 
REACTIVE LOOP | DEMENTIA | NEUROSERPIN | FLUORESCENCE | MECHANISM | PIZ-ALPHA-1-ANTITRYPSIN VARIANT | ALPHA-1-ANTITRYPSIN | ACCUMULATION | CONFORMATION | GASTROENTEROLOGY & HEPATOLOGY | SERPIN POLYMERIZATION
Journal Article
Neurobiology of Stress, ISSN 2352-2895, 11/2019, Volume 11, pp. 100188 - 100188
Tissue plasminogen activator (tPA) is a serine protease involved in cleavage of neurotrophic factors. In addition, tPA and neuroserpin can also directly bind... 
PAI-1 | Depression | Neuroserpin | tPA | LRP1
Journal Article
Brain Research, ISSN 0006-8993, 03/2019, Volume 1707, pp. 107 - 116
General anesthesia with sevoflurane is associated with an increased incidence of postoperative cognitive dysfunction. Previous studies have shown that... 
Sevoflurane | Nerve growth factor | Basal forebrain cholinergic neurons | Postoperative cognitive dysfunction | NEUROSERPIN | ACETYLCHOLINE | NEURODEGENERATION | NGF | NEUROSCIENCES | HIPPOCAMPUS | RESPONSES | MOUSE MODEL | ANESTHETICS | DEFICITS | EXPRESSION
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0123932
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2019, Volume 129, Issue 1, pp. 388 - 405
Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent edema attacks associated with morbidity and mortality. HAE results from... 
MEDICINE, RESEARCH & EXPERIMENTAL | ALPHA-ANTITRYPSIN | MUTANTS | ANGIONEUROTIC EDEMA | GENE | MECHANISM | NEUROSERPIN | MUTATION | SUPERFAMILY | POLYMERIZATION | PROTEINS | Angioneurotic edema | Care and treatment | Research | Genetic variation | Patient outcomes | Risk factors
Journal Article
Cardiovascular and Hematological Disorders - Drug Targets, ISSN 1871-529X, 2013, Volume 13, Issue 2, pp. 123 - 132
Journal Article