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1. Full Text Azole-Resistant Aspergillosis: Epidemiology, Molecular Mechanisms, and Treatment
by Chowdhary, A and Sharma, C and Meis, J.F.G.M
The Journal of infectious diseases, ISSN 0022-1899, 2017, Volume 216, Issue suppl_3, pp. S436 - s444
Aspergillus fumigatis | Aspergillus | epidemiology | treatment | fumigatis | azole-esistant aspergillosis | cyp51 mutations | non cyp51 mutations | Azole-resistant aspergillosis | resistance mechanisms | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Antifungal Agents - pharmacology | Aspergillus fumigatus - drug effects | Invasive Pulmonary Aspergillosis - drug therapy | Bronchitis - epidemiology | Humans | Cytochrome P-450 Enzyme System - metabolism | Tandem Repeat Sequences | Fungal Proteins - genetics | Aspergillosis, Allergic Bronchopulmonary - drug therapy | Invasive Pulmonary Aspergillosis - diagnosis | Bronchitis - diagnosis | Triazoles - pharmacology | Point Mutation | Bronchitis - diet therapy | Cytochrome P-450 Enzyme System - genetics | Drug Resistance, Fungal | Aspergillosis, Allergic Bronchopulmonary - diagnosis | Aspergillosis, Allergic Bronchopulmonary - epidemiology | Fungal Proteins - metabolism | Invasive Pulmonary Aspergillosis - epidemiology | Index Medicus | Abridged Index Medicus
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2. Full Text Exploring the molecular mechanism of azole resistance in Aspergillus fumigatus
by Chen, P and Liu, J and Zeng, M and Sang, H
Journal de mycologie médicale, ISSN 1156-5233, 04/2020, Volume 30, Issue 1, pp. 100915 - 100915
Non-cyp51 mutation | cyp51 mutation | Pathogenic fungi | Aspergillus fumigatus | Azole resistance | Life Sciences & Biomedicine | Mycology | Science & Technology | Index Medicus
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3. Full Text Analysis of cytochrome b5 reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence
by Derbyshire, Mark C and Michaelson, Louise and Parker, Josie and Kelly, Steven and Thacker, Urvashi and Powers, Stephen J and Bailey, Andy and Hammond-Kosack, Kim and Courbot, Mikael and Rudd, Jason
Fungal genetics and biology, ISSN 1087-1845, 09/2015, Volume 82, pp. 69 - 84
Septoria tritici | Mycosphaerella graminicola | Dimorphic fungi | Fatty acids | Cytochrome P450 | CYP51 | WT, wild-type | CPR, cytochrome P450 reductase | Regular | DPI, days post inoculation | STB, Septoria tritici blotch | FPKM, fragments per kilobase per million mapped fragments | HPLC, high pressure liquid chromatography | FAME, fatty acid methyl ester | RNA-seq, RNA sequencing | b5, cytochrome b5 | LCB, sphingolipid long chain base | CBR, cytochrome b5 reductase | GC–MS, gas chromatography–mass spectrometry | CYP, cytochrome P450
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4. Full Text Antifungal resistance: current trends and future strategies to combat
by Wiederhold, Nathan P
Infection and drug resistance, ISSN 1178-6973, 08/2017, Volume 10, pp. 249 - 259
Candida albicans | Aspergillus | Candida auris | Azoles | Intrinsic resistance | Acquired resistance | Echinocandins | Investigational antifungals | Non-albicans Candida species | Pharmacology & Pharmacy | Infectious Diseases | Life Sciences & Biomedicine | Science & Technology | Complications and side effects | Drug resistance in microorganisms | Prognosis | Antifungal agents | Mycoses | Dosage and administration | Research | Drug therapy | Enzymes | Ergosterol | Fluconazole | Toxicity | Antimicrobial agents | Fungal infections | Patients | Chemotherapy | Side effects | Testing laboratories | Trends | Mutation | Species | echinocandins | investigational antifungals | azoles | Candida
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5. Full Text Non-cyp51A azole-resistant aspergillus fumigatus isolates with mutation in HMG-CoA reductase
by Hagiwara, Daisuke and Arai, Teppei and Takahashi, Hiroki and Kusuya, Yoko and Watanabe, Akira and Kamei, Katsuhiko
Emerging infectious diseases, ISSN 1080-6040, 10/2018, Volume 24, Issue 10, pp. 1889 - 1897
Infectious Diseases | Immunology | Life Sciences & Biomedicine | Science & Technology | Aspergillus fumigatus - drug effects | Ergosterol - metabolism | Humans | Fungal Proteins - genetics | Aspergillus fumigatus - genetics | Azoles - pharmacology | DNA, Fungal | Genotyping Techniques | Microbial Sensitivity Tests | Genome, Fungal | Aspergillus fumigatus - isolation & purification | Aspergillosis - microbiology | Cytochrome P-450 Enzyme System - genetics | Genes, Fungal | Aspergillus fumigatus - metabolism | Polymorphism, Single Nucleotide | Mutation | Drug Resistance, Fungal | Hydroxymethylglutaryl CoA Reductases - genetics | Microsatellite Repeats | Physiological aspects | Genetic aspects | Chromosomal proteins | Phytosterols | Index Medicus | azole resistance | Isolates with HMG-CoA Reductase Mutation in | Japan | non-cyp51A | Research | Non | Azole-Resistant | Gene Encoding | Hmg1 | mutation | HMG-CoA reductase | fungi | antimicrobial resistance | drug resistance | Aspergillus fumigatus
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6. Full Text Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study
by Arlt, Wiebke and Walker, Elizabeth A and Draper, Nicole and Ivison, Hannah E and Ride, Jon P and Hammer, Fabian and Chalder, Susan M and Borucka-Mankiewicz, Maria and Hauffa, Berthold P and Malunowicz, Ewa M and Stewart, Paul M and Shackleton, Cedric HL
The Lancet (British edition), ISSN 0140-6736, 06/2004, Volume 363, Issue 9427, pp. 2128 - 2135
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Adrenals. Adrenal axis. Renin-angiotensin system (diseases) | Biological and medical sciences | Endocrinopathies | Non tumoral diseases. Target tissue resistance. Benign neoplasms | Medical sciences | Cytochrome P-450 Enzyme System - chemistry | Humans | Adolescent | Adrenal Hyperplasia, Congenital - metabolism | Child, Preschool | Cytochrome P-450 Enzyme System - genetics | Androgens - biosynthesis | Female | Male | Adrenal Hyperplasia, Congenital - genetics | Mutation | Amino Acid Substitution | Pathology | Androgens | Medical disorders | Genomics | Girls | Cytochrome | Steroid 21-hydroxylase | Enzyme activity | Pathogenesis | Oxidoreductase | Hyperplasia | Parents | Electron transfer | Heterozygotes | Biosynthesis | Proteins | Design | Synthesis | Enzymatic activity | Metabolites | Children | NADP | Deoxyribonucleic acid--DNA | Age | Enzymes | Data analysis | Genitalia | Fetuses | Hydroxylase | Patients | Molecular chains | Studies | Pregnancy | Cytochrome c | Testosterone | Cysts | Steroids | Reductase | Index Medicus | Abridged Index Medicus
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7. Targeting UDP-galactopyranose mutases from eukaryotic human pathogens
by Kizjakina, Karina and Tanner, John J and Sobrado, Pablo
Current pharmaceutical design, ISSN 1381-6128, 2013, Volume 19, Issue 14, pp. 2561 - 2573
Galactofuranose | Inhibitors | Eukaryotic pathogens | Flavoenzyme | Enzyme drug target | Galactopyranose | Non-redox reaction | UDP-galactopyranose mutase | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Humans | Virulence | Molecular Sequence Data | Drug Discovery - methods | Protozoan Infections - drug therapy | Eukaryota - pathogenicity | Protozoan Infections - parasitology | Enzyme Inhibitors - chemistry | Intramolecular Transferases - chemistry | Eukaryota - enzymology | Binding Sites | Aspergillosis - drug therapy | Amino Acid Sequence | Enzyme Inhibitors - pharmacology | Models, Molecular | Enzyme Inhibitors - therapeutic use | Intramolecular Transferases - metabolism | Sequence Alignment | Animals | High-Throughput Screening Assays | Intramolecular Transferases - antagonists & inhibitors | Aspergillosis - microbiology | Bacteria - enzymology | Eukaryota - drug effects | Protein Conformation | Bacteria - pathogenicity | Amino acid sequence
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8. Exploring azole antifungal drug resistance in Aspergillus fumigatus with special reference to resistance mechanisms
by Chowdhary, Anuradha and Sharma, Cheshta and Hagen, Ferry and Meis, Jacques F
Future microbiology, ISSN 1746-0913, 2014, Volume 9, Issue 5, pp. 697 - 711
environment | resistance mechanism | Aspergillus fumigatus | non-cyp51A mutation | aspergillosis | Life Sciences & Biomedicine | Microbiology | Science & Technology | Aspergillus fumigatus - drug effects | Fungal Proteins - biosynthesis | Humans | Voriconazole - therapeutic use | Azoles - therapeutic use | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Aspergillus fumigatus - genetics | Cholesterol - metabolism | Aspergillus fumigatus - pathogenicity | Antifungal Agents - therapeutic use | Itraconazole - therapeutic use | Microbial Sensitivity Tests | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Mutation | Aspergillosis - drug therapy | Triazoles - therapeutic use
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9. Full Text Evaluation of cytotoxic effect of the combination of a pyridinyl carboxamide derivative and oxaliplatin on NCI-H1299 human non-small cell lung carcinoma cells
by Teixeira, Sarah Fernandes and de Azevedo, Ricardo Alexandre and Silva, Arthur Carvalho and Braga, Rodolpho Campos and Jorge, Salomão Dória and Barbuto, José Alexandre Marzagão and Andrade, Carolina Horta and Ferreira, Adilson Kleber, Dr
Biomedicine & pharmacotherapy, ISSN 0753-3322, 2016, Volume 84, pp. 1019 - 1028
Internal Medicine | Medical Education | Pyridinyl carboxamide derivative | Oxaliplatin | Synergism | Lung cancer | Apoptosis | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Amides - pharmacology | Carcinoma, Non-Small-Cell Lung - pathology | Cell Survival - drug effects | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Models, Molecular | Lung Neoplasms - pathology | Structure-Activity Relationship | Organoplatinum Compounds - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Drug Synergism | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Molecular Structure | Pyridines - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Antimitotic agents | Respiratory agents | Drug therapy, Combination | Lung cancer, Non-small cell | Antineoplastic agents | Analysis | Index Medicus
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