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Journal of Biological Chemistry, ISSN 0021-9258, 06/2013, Volume 288, Issue 23, pp. 16761 - 16774
The objective of the study was to investigate how inflammatory cytokines, IL-1 beta, and TNF-alpha control NOTCH signaling activity in nucleus pulposus (NP)... 
MATRIX METALLOPROTEINASES | BACK-PAIN | TUMOR-NECROSIS-FACTOR | KAPPA-B ACTIVATION | BASIC SCIENCE | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEGRADATION | TNF-ALPHA | EXPRESSION | FACTOR-ALPHA | Tumor Necrosis Factor-alpha - metabolism | Transcription Factor HES-1 | Homeodomain Proteins - metabolism | Humans | Middle Aged | Tumor Necrosis Factor-alpha - genetics | Male | Receptor, Notch2 - genetics | Interleukin-1beta - genetics | Promoter Regions, Genetic - genetics | Transcription Factor RelA - genetics | Intervertebral Disc Degeneration - metabolism | MAP Kinase Signaling System | Intervertebral Disc Degeneration - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Interleukin-1beta - metabolism | Cell Cycle Proteins - genetics | Adult | Female | Intervertebral Disc - pathology | Repressor Proteins - metabolism | Intervertebral Disc Degeneration - genetics | Cell Line | Basic Helix-Loop-Helix Transcription Factors - genetics | Cell Cycle Proteins - metabolism | Receptor, Notch2 - metabolism | Rats | Repressor Proteins - genetics | Intervertebral Disc - metabolism | Receptor, Notch1 - metabolism | Homeodomain Proteins - genetics | Animals | Transcription Factor RelA - metabolism | Aged | Receptor, Notch1 - genetics | Index Medicus | Intervertebral Disc | Nucleus Pulposus | Chondrocytes | Cytokine | Glycobiology and Extracellular Matrices | NF-kappa B (NF-KB) | Notch Pathway | Osteoarthritis
Journal Article
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 12/2017, Volume 118, Issue 12, pp. 4862 - 4871
Journal Article
Journal Article
Spine, ISSN 0362-2436, 09/2005, Volume 30, Issue 17, pp. 1940 - 1948
Study Design. This study examines changes in the production of extracellular matrix molecules as well as the induction of tissue degradation in in vitro formed... 
Proteoglycan | Tumor necrosis factor-alpha | Matrix metalloproteinases | Extracellular matrix degradation | Collagen | Intervertebral disc | Aggrecanase | Nucleus pulposus | intervertebral disc | aggrecanase | HUMAN INTERVERTEBRAL DISC | HERNIATED DISC | collagen | METALLOPROTEINASES | extracellular matrix degradation | CLINICAL NEUROLOGY | proteoglycan | DEGENERATION | tumor necrosis factor-alpha | IN-VITRO | MESSENGER-RNA | ARTICULAR-CARTILAGE | BASIC SCIENCE | nucleus pulposus | GENE-EXPRESSION | NITRIC-OXIDE | ORTHOPEDICS | matrix metalloproteinases | Extracellular Matrix Proteins - biosynthesis | Gene Expression - drug effects | Humans | Extracellular Matrix - metabolism | Dose-Response Relationship, Drug | Chondroitin Sulfate Proteoglycans - drug effects | Lectins, C-Type - metabolism | Cattle | Aggrecans | Intervertebral Disc - pathology | Extracellular Matrix Proteins - metabolism | Lectins, C-Type - drug effects | Tissue Culture Techniques | Extracellular Matrix Proteins - genetics | Chondroitin Sulfate Proteoglycans - metabolism | Proteoglycans - metabolism | Intervertebral Disc - metabolism | Recombinant Proteins - pharmacology | Extracellular Matrix Proteins - drug effects | Recombinant Proteins - administration & dosage | Tissue Inhibitor of Metalloproteinases - metabolism | Collagen - metabolism | Tumor Necrosis Factor-alpha - pharmacology | ADAM Proteins - metabolism | Animals | Tumor Necrosis Factor-alpha - physiology | Tumor Necrosis Factor-alpha - administration & dosage | Matrix Metalloproteinases - metabolism | Index Medicus
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Journal Article
Journal Article
Journal Article