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Circulation, ISSN 0009-7322, 09/2010, Volume 122, Issue 10, pp. 958 - 966
Background-Endothelin (ET-1) is one of the most potent vasoconstrictors and plays a seminal role in the pathogenesis of atherosclerosis. The present study was... 
coronary disease | endothelin | endothelium | blood flow | CONTROLLED-TRIAL | CARDIAC & CARDIOVASCULAR SYSTEMS | EXPERIMENTAL HYPERCHOLESTEROLEMIA | ENDOGENOUS ENDOTHELIN | FLOW VELOCITY | REFRACTORY PROSTATE-CANCER | MESSENGER-RNA | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | ESSENTIAL-HYPERTENSION | EX-VIVO | HEMATOLOGY | HUMAN ARTERIES | Endothelin-1 - antagonists & inhibitors | Follow-Up Studies | Humans | Middle Aged | Pyrrolidines - administration & dosage | Pyrrolidines - adverse effects | Endothelium, Vascular - drug effects | Male | Microcirculation - drug effects | Enzyme Inhibitors - administration & dosage | Heart Rate - drug effects | Adult | Female | Blood Pressure - drug effects | Uric Acid - blood | Lipoprotein(a) - blood | Kidney - drug effects | Coronary Artery Disease - metabolism | Coronary Artery Disease - drug therapy | Blood Glucose - drug effects | omega-N-Methylarginine - administration & dosage | Endothelium, Vascular - metabolism | Triglycerides - blood | Receptor, Endothelin A - metabolism | Coronary Circulation - drug effects | Nitric Oxide - metabolism | Antagonists (Biochemistry) | Endothelin | Patient outcomes | Atherosclerosis | Dosage and administration | Drug therapy | Health aspects | endothelium independent coronary flow reserve | endothelin-1 (ET-1) | coronary artery diameter | Atrasentan | endothelium dependent coronary blood flow
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 10/2000, Volume 36, Issue 4, pp. 1233 - 1238
OBJECTIVES The goal of this study was to investigate the mechanism of reduced vasoconstrictor sensitivity to norepinephrine in women compared with men.... 
MENSTRUAL-CYCLE | NOREPINEPHRINE SPILLOVER | MEDIATED RELAXATION | SMOOTH-MUSCLE | HEART-DISEASE | CARDIAC & CARDIOVASCULAR SYSTEMS | CANINE CORONARY-ARTERIES | ENDOTHELIAL-CELLS | NITRIC-OXIDE | PERIMENOPAUSAL WOMEN | SEX-DIFFERENCES | Humans | Nitric Oxide Synthase - antagonists & inhibitors | Norepinephrine - administration & dosage | Male | Reference Values | Receptors, Adrenergic, beta-2 - drug effects | Verapamil - administration & dosage | Vascular Resistance - physiology | Enzyme Inhibitors - administration & dosage | Adrenergic alpha-Agonists - administration & dosage | Propranolol - administration & dosage | Adrenergic beta-Agonists - administration & dosage | Albuterol - administration & dosage | Forearm - blood supply | Vascular Resistance - drug effects | Adult | Female | Brachial Artery - drug effects | Adrenergic beta-Antagonists - administration & dosage | Nitroprusside - administration & dosage | Sex Characteristics | omega-N-Methylarginine - administration & dosage | Vasodilation - drug effects | Vasodilator Agents - administration & dosage | Plethysmography | Blood Flow Velocity - drug effects | Brachial Artery - physiology | Injections, Intra-Arterial | Substance P - administration & dosage | Propranolol hydrochloride | Dilatation | Analysis | Vasodilators | Nitric oxide | Sympathomimetic agents | Blood vessels | Noradrenaline
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 06/2001, Volume 280, Issue 6, pp. 2470 - 2477
The identity of endothelium-dependent hyperpolarizing factor (EDHF) in the human circulation remains controversial. We investigated whether EDHF contributes to... 
endothelium | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | potassium | DEPENDENT RELAXATION | CA2+-ACTIVATED K+ CHANNELS | bradykinin | miconazole | cytochrome P-450 | VASCULAR SMOOTH-MUSCLE | vascular tone | sodium nitroprusside | IN-VIVO | CORONARY ARTERIOLAR DILATION | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | ARACHIDONIC-ACID METABOLITE | EPOXYEICOSATRIENOIC ACIDS | Microcirculation - metabolism | Cytochrome P-450 Enzyme Inhibitors | Humans | Middle Aged | Vasomotor System - drug effects | Cytochrome P-450 Enzyme System - metabolism | Microcirculation - drug effects | Aspirin - administration & dosage | Phenylephrine - administration & dosage | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Forearm - blood supply | Adult | Potassium Chloride - administration & dosage | Forearm - physiology | Biological Factors - metabolism | Vasoconstrictor Agents - administration & dosage | Vasomotor System - metabolism | Administration, Oral | Nitroprusside - administration & dosage | Cyclooxygenase Inhibitors - administration & dosage | Miconazole - administration & dosage | omega-N-Methylarginine - administration & dosage | Bradykinin - administration & dosage | Blood Flow Velocity - physiology | Vasodilator Agents - administration & dosage | Plethysmography | Blood Flow Velocity - drug effects | Brachial Artery - physiology | Infusions, Intra-Arterial | Sodium nitroprusside | Vascular tone | Bradykinin | Cytochrome P-450 | Miconazole | Potassium | Endothelium
Journal Article
Circulation, ISSN 0009-7322, 05/2011, Volume 123, Issue 20, pp. 2244 - 2253
Background-We assessed the contribution of endothelium-derived hyperpolarizing factors to resting and agonist-stimulated vasodilator tone in health and... 
endothelium-derived vasoconstrictor factors | endothelium | nitric oxide | vasodilation | CARDIAC & CARDIOVASCULAR SYSTEMS | DEPENDENT VASODILATION | CA2+-ACTIVATED K+ CHANNELS | NITRIC-OXIDE ACTIVITY | ACTIVATED POTASSIUM CHANNELS | HYPERCHOLESTEROLEMIC PATIENTS | RADIAL ARTERY | TETRAETHYLAMMONIUM IONS | HUMAN CORONARY-CIRCULATION | PERIPHERAL VASCULAR DISEASE | ESSENTIAL-HYPERTENSION | HEMATOLOGY | EPOXYEICOSATRIENOIC ACIDS | Humans | Middle Aged | Potassium Channels - physiology | Endothelium, Vascular - drug effects | Male | Endothelium, Vascular - physiology | Enzyme Inhibitors - administration & dosage | Young Adult | Regional Blood Flow - drug effects | Forearm - blood supply | Adult | Female | Vasodilation - physiology | Cytochrome P-450 Enzyme System - physiology | Hypercholesterolemia - epidemiology | Potassium Channel Blockers - administration & dosage | Tetraethylammonium - administration & dosage | Biological Factors - physiology | Risk Factors | Nitric Oxide - physiology | omega-N-Methylarginine - administration & dosage | Acetylcholine - administration & dosage | Hypercholesterolemia - physiopathology | Vasodilation - drug effects | Bradykinin - administration & dosage | Regional Blood Flow - physiology | Plethysmography | Blood vessels | Influence | Research | Endothelium-derived relaxing factors | Dilatation | endothelium-derived factors | endothelial function | endothelium-derived hyperpolarizing factor
Journal Article
Journal Article
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 08/2005, Volume 112, Issue 8, pp. 1106 - 1112
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 02/2016, Volume 18, Issue 2, pp. 178 - 185
Aims To determine the acute effect of glucagon‐like peptide‐1 (GLP‐1) receptor agonist exenatide and the involvement of nitric oxide (NO) on renal... 
nitric oxide | GLP-1 receptor agonist | L-NMMA | exenatide | renal haemodynamics | GLP‐1 receptor agonist | L‐NMMA | Renal haemodynamics | Exenatide | Nitric oxide | RAT CONDUIT ARTERIES | GLP-1 | HUMANS | DIABETES-MELLITUS | HYPERFILTRATION | NATRIURESIS | PLASMA | INHIBITION | ENDOCRINOLOGY & METABOLISM | NITRIC-OXIDE | ASSOCIATION | Kidney Tubules - physiopathology | Kidney - blood supply | Peptides - antagonists & inhibitors | Hypoglycemic Agents - antagonists & inhibitors | Humans | Nitric Oxide Synthase - antagonists & inhibitors | Male | Overweight - urine | omega-N-Methylarginine - pharmacology | Kidney Tubules - blood supply | Peptides - administration & dosage | Enzyme Inhibitors - administration & dosage | Young Adult | Heart Rate - drug effects | Overweight - metabolism | Glomerular Filtration Rate - drug effects | Glucagon-Like Peptide-1 Receptor - metabolism | Kidney - metabolism | Hypoglycemic Agents - administration & dosage | Vascular Resistance - drug effects | Venoms - administration & dosage | Adult | Renal Circulation - drug effects | Kidney Tubules - metabolism | Kidney - physiopathology | Body Mass Index | Kidney - drug effects | Kidney Tubules - drug effects | Enzyme Inhibitors - pharmacology | Overweight - physiopathology | Hypoglycemic Agents - pharmacology | Peptides - pharmacology | omega-N-Methylarginine - administration & dosage | Metabolic Clearance Rate - drug effects | Nitric Oxide Synthase - metabolism | Venoms - pharmacology | Infusions, Intravenous | Glucagon-Like Peptide-1 Receptor - agonists | Obesity | Hypoglycemic agents | Glucagon | Analysis
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 12/2005, Volume 25, Issue 12, pp. 2630 - 2635
OBJECTIVE—Smoking is associated with endothelial dysfunction and activated Rho-kinase in vascular smooth muscle cells (VSMCs) in humans. The purpose of this... 
Rho-kinase | Vascular smooth muscle cell | Healthy young man | Endothelial function | Smoking | endothelial function | NITRIC-OXIDE SYNTHASE | PROTEIN-KINASE | LONG-TERM INHIBITION | HEALTHY-YOUNG ADULTS | SIGNAL-TRANSDUCTION | DEPENDENT DILATION | smoking | healthy young man | IN-VIVO | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | vascular smooth muscle cell | HEMATOLOGY | CORONARY-ARTERY SPASM | MYOSIN PHOSPHATASE | Smoking - adverse effects | Muscle, Smooth, Vascular - metabolism | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Male | Endothelium, Vascular - enzymology | Enzyme Inhibitors - administration & dosage | Regional Blood Flow - drug effects | rho-Associated Kinases | Forearm - blood supply | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Adult | Protein-Serine-Threonine Kinases - metabolism | Nitroprusside - administration & dosage | Endothelium, Vascular - physiopathology | Intracellular Signaling Peptides and Proteins | Ascorbic Acid - administration & dosage | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - administration & dosage | omega-N-Methylarginine - administration & dosage | Protein Kinase Inhibitors - administration & dosage | Smoking - metabolism | Acetylcholine - administration & dosage | Antioxidants - administration & dosage | Regional Blood Flow - physiology | Vasodilator Agents - administration & dosage | Plethysmography
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 09/2011, Volume 301, Issue 3, pp. H1118 - H1126
Parker BA, Tschakovsky ME, Augeri AL, Polk DM, Thompson PD, Kiernan FJ. Heterogenous vasodilator pathways underlie flow-mediated dilation in men and women. Am... 
Shear stress | Prostaglandins | Nitric oxide | Vasodilation | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | ENDOTHELIAL DYSFUNCTION | vasodilation | NITRIC-OXIDE SYNTHASE | HEART-FAILURE | PERIPHERAL CONDUIT ARTERIES | BLOOD-FLOW | RADIAL ARTERY | PROSTAGLANDIN PRODUCTION | shear stress | HYPERPOLARIZING FACTOR | IN-VIVO | prostaglandins | PERIPHERAL VASCULAR DISEASE | GENDER-DIFFERENCES | Hyperemia - metabolism | Humans | Nitric Oxide Synthase - antagonists & inhibitors | Male | Radial Artery - metabolism | Enzyme Inhibitors - administration & dosage | Radial Artery - physiopathology | Young Adult | Hyperemia - diagnostic imaging | Nitroglycerin - administration & dosage | Ultrasonography | Adult | Female | Cyclooxygenase Inhibitors - administration & dosage | Laser-Doppler Flowmetry | Regional Blood Flow | omega-N-Methylarginine - administration & dosage | Analysis of Variance | Prostaglandin-Endoperoxide Synthases - metabolism | Hyperemia - physiopathology | Blood Flow Velocity | Sex Factors | Radial Artery - drug effects | Nitric Oxide Synthase - metabolism | Vasodilation - drug effects | Ketorolac - administration & dosage | Nitric Oxide - metabolism | Vasodilator Agents - administration & dosage | Infusions, Intra-Arterial | Prostaglandins - metabolism | Radial Artery - diagnostic imaging | Physiological aspects | Research | Blood flow | Integrative Cardiovascular Physiology and Pathophysiology
Journal Article
Hypertension, ISSN 0194-911X, 03/2010, Volume 55, Issue 3, pp. 674 - 680
Cytochrome-derived epoxyeicosatrienoic acids may be important endothelium-derived hyperpolarizing factors, opening calcium-activated potassium channels, but... 
Cytochrome epoxygenases | Arterial stiffness | Endothelium-derived hyperpolarizing factor | Endothelium | arterial stiffness | endothelium | AUGMENTATION INDEX | BKCA CHANNELS | PULSE-WAVE VELOCITY | ACTIVATED POTASSIUM CHANNELS | PERIPHERAL CONDUIT ARTERIES | cytochrome epoxygenases | endothelium-derived hyperpolarizing factor | VASCULAR SMOOTH-MUSCLE | SOLUBLE EPOXIDE HYDROLASE | MECHANICS | IN-VIVO | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | Humans | Fluconazole - administration & dosage | Endothelium, Vascular - drug effects | Male | Elasticity - physiology | Enzyme Inhibitors - administration & dosage | Young Adult | Regional Blood Flow - drug effects | Adult | Indoles - pharmacology | Blood Pressure - drug effects | Blood Pressure - physiology | Vasodilation - physiology | Biological Factors - metabolism | Radial Artery - physiology | Potassium Channel Blockers - administration & dosage | Tetraethylammonium - administration & dosage | Hot Temperature | Mice, Inbred Strains | Hypertension - physiopathology | Hypertension - metabolism | omega-N-Methylarginine - administration & dosage | Animals | Endothelium, Vascular - metabolism | Oximes - pharmacology | Benzimidazoles - pharmacology | Radial Artery - drug effects | Mice | Vasodilation - drug effects | Nitric Oxide - metabolism | Regional Blood Flow - physiology
Journal Article
Journal Article