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Journal of Clinical Investigation, ISSN 0021-9738, 04/2012, Volume 122, Issue 4, pp. 1519 - 1528
Genetic mutations that give rise to active mutant forms of Ras are oncogenic and found in several types of tumor. However, such mutations are not clear... 
SIGNAL-TRANSDUCTION | PROTEASE INHIBITOR | MEDICINE, RESEARCH & EXPERIMENTAL | PANCREATIC DUCTAL ADENOCARCINOMA | ACTIVATION | K-RAS | ONCOGENIC KRAS | MOUSE MODEL | IN-VIVO | ACINAR-CELLS | CANCER | Inflammation - chemically induced | Pancreatic Neoplasms - metabolism | Pancreatic Neoplasms - etiology | Humans | Carcinoma, Pancreatic Ductal - metabolism | Sincalide - toxicity | Pancreatitis, Chronic - chemically induced | Proto-Oncogene Proteins p21(ras) - physiology | Gabexate - toxicity | I-kappa B Kinase - physiology | Carcinoma, Pancreatic Ductal - genetics | Cyclooxygenase 2 - biosynthesis | Inflammation - complications | Inflammation - metabolism | Cell Transformation, Neoplastic - genetics | Inflammation Mediators - metabolism | Carcinoma, Pancreatic Ductal - etiology | Gene Expression Regulation, Neoplastic - physiology | I-kappa B Kinase - deficiency | Lipopolysaccharides - toxicity | Cyclooxygenase 2 Inhibitors - pharmacology | Neoplasm Proteins - biosynthesis | Pancreatic Neoplasms - pathology | Ceruletide - toxicity | Enzyme Induction | Cyclooxygenase 2 - physiology | Gabexate - analogs & derivatives | Mice, Transgenic | Pancreatic Neoplasms - genetics | I-kappa B Kinase - genetics | Pancreas - metabolism | Pancreatitis, Chronic - genetics | Carcinoma, Pancreatic Ductal - pathology | Precancerous Conditions - genetics | Proto-Oncogene Proteins p21(ras) - biosynthesis | Gene Knock-In Techniques | Animals | NF-kappa B - physiology | Inflammation - genetics | Mice | Feedback, Physiological - physiology | Precancerous Conditions - chemically induced | Genes, ras | Pancreatitis, Chronic - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 1/2002, Volume 156, Issue 2, pp. 299 - 313
Multistep carcinogenesis involves more than six discrete events also important in normal development and cell behavior. Of these, local invasion and metastasis... 
Gels | Hepatocytes | Epithelial cells | Collagens | Cell lines | Cadherins | Metastasis | Cells | Tumors | Apoptosis | TGFβ | PI3K | MAPK | EMT | PHOSPHATIDYLINOSITOL 3-KINASE | E-CADHERIN EXPRESSION | TUMOR-SUPPRESSOR GENE | CELL BIOLOGY | GROWTH-FACTOR-BETA | ONCOGENIC RAS | metastasis | MESENCHYMAL TRANSITIONS | MOUSE EMBRYOS LACKING | MICE | TGF beta | MESODERM INDUCTION | N-CADHERIN | PI3K; MAPK; TGFβ; EMT; metastasis
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2014, Volume 124, Issue 1, pp. 285 - 296
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2016, Volume 126, Issue 11, pp. 4088 - 4102
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 9, pp. 7018 - 7026
The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by phosphorylating them for cytoplasmic sequestration or degradation. In... 
YES-ASSOCIATED PROTEIN | EPITHELIAL-MESENCHYMAL TRANSITION | CELL CONTACT INHIBITION | WW DOMAIN | GROWTH-CONTROL | ORGAN SIZE CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ONCOGENIC TRANSFORMATION | BINDING | CANCER | Adaptor Proteins, Signal Transducing - chemistry | Protein Interaction Domains and Motifs - physiology | Humans | Intercellular Signaling Peptides and Proteins - chemistry | Cytoplasm - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Intercellular Signaling Peptides and Proteins - metabolism | HEK293 Cells | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein Structure, Tertiary | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Phosphoproteins - genetics | Cell Division - physiology | Transcription, Genetic - physiology | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Connective Tissue Growth Factor - genetics | Adaptor Proteins, Signal Transducing - metabolism | Connective Tissue Growth Factor - metabolism | Index Medicus | Gene Transcription | Transcription Coactivators | Signal Transduction | AmotL1 | YAP | Transcription Factors | Serine Threonine Protein Kinase | Hippo Pathway | TAZ | Amot
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2015, Volume 112, Issue 6, pp. 1785 - 1790
Adherens junctions (AJs) and cell polarity complexes are key players in the establishment and maintenance of apical–basal cell polarity. Loss of AJs or... 
adherens junction | Hippo pathway | basolateral protein | apical–basal cell polarity | Drosophila imaginal discs | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | E-CADHERIN | ESTABLISHMENT | ORGANIZATION | apical-basal cell polarity | TISSUE OVERGROWTH | ONCOGENIC RAS | SIGNALING-PATHWAY | ALPHA-CATENIN | GROWTH | TUMOR-SUPPRESSOR | RNA, Small Interfering - genetics | Cell Adhesion Molecules - genetics | Humans | DNA Primers - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Adherens Junctions - metabolism | Gene Knockdown Techniques | RNA Interference | Tumor Suppressor Proteins - genetics | Imaginal Discs - growth & development | Madin Darby Canine Kidney Cells | Cadherins - genetics | Real-Time Polymerase Chain Reaction | Protein-Serine-Threonine Kinases - metabolism | Caco-2 Cells | Tumor Suppressor Proteins - metabolism | Drosophila | Nuclear Proteins - metabolism | Animals | Dogs | Cell Polarity - physiology | Signal Transduction - physiology | Trans-Activators - metabolism | alpha Catenin - genetics | Drosophila Proteins - genetics | Morphogenesis - physiology | Crosses, Genetic | Junctional complexes (Epithelium) | Cell junctions | Physiological aspects | Cell interaction | Observations | Binding sites (Biochemistry) | Proteins | Signal transduction | Metastasis | Insects | Cells | Tumors | Index Medicus | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, pp. e90275 - e90275
Journal Article
Journal Article