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Seminars in cell & developmental biology, ISSN 1084-9521, 05/2019
Succinate dehydrogenase (SDH) has been classically considered a mitochondrial enzyme with the unique property to participate in both the citric acid cycle and... 
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2018, Volume 24, Issue 24, pp. 6433 - 6446
Purpose: Elevation of L-2-hydroxylgutarate (L-2-HG) in renal cell carcinoma (RCC) is due in part to reduced expression of L-2-HG dehydrogenase (L2HGDH).... 
IDH2 MUTATIONS | GENE | ONCOLOGY | ACIDURIA | ALPHA-KETOGLUTARATE | ACUTE MYELOID-LEUKEMIA | ONCOMETABOLITE 2-HYDROXYGLUTARATE | PUTATIVE ONCOMETABOLITE | CELL CARCINOMA | DEHYDROGENASE | HISTONE
Journal Article
Cancer and Metabolism, ISSN 2049-3002, 05/2014, Volume 2, Issue 1, pp. 10 - 10
Cancer is a heterogeneous set of diseases characterized by different molecular and cellular features. Over the past decades, researchers have attempted to... 
Mitochondria | TCA cycle | Evolution | mtDNA mutations | Oncometabolites | Metabolism | Cancer | Genetic aspects | Research | Oncology, Experimental
Journal Article
BLOOD, ISSN 0006-4971, 10/2015, Volume 126, Issue 15, pp. 1741 - 1752
Angioimmunoblastic T-cell lymphoma (AITL) is a common subtype of peripheral T-cell lymphoma (PTCL) with a poor prognosis. We performed targeted resequencing on... 
IDH2 MUTATIONS | FREQUENT | LANDSCAPE | TET2 | UTX | ACUTE MYELOID-LEUKEMIA | HEMATOLOGY | ONCOMETABOLITE 2-HYDROXYGLUTARATE | RHOA | FOLLICULAR HELPER-CELLS
Journal Article
CELL, ISSN 0092-8674, 01/2018, Volume 172, Issue 1-2, pp. 90 - 90
R-2-hydroxyglutarate (R-2HG), produced at high levels by mutant isocitrate dehydrogenase 1/2 (IDH1/2) enzymes, was reported as an oncometabolite. We show here... 
GLIOMA-CELLS | RNA METHYLATION | INHIBITION | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDH MUTATION | C-MYC | HEMATOPOIETIC DIFFERENTIATION | ACUTE MYELOID-LEUKEMIA | NUCLEAR-RNA | ONCOMETABOLITE 2-HYDROXYGLUTARATE | CELL BIOLOGY
Journal Article
CANCER CELL, ISSN 1535-6108, 12/2015, Volume 28, Issue 6, pp. 773 - 784
Heterozygous mutation of IDH1 in cancers modifies IDH1 enzymatic activity, reprogramming metabolite flux and markedly elevating 2-hydroxyglutarate (2-HG).... 
ISOCITRATE DEHYDROGENASE 1 | GLIOMA-CELLS | ONCOLOGY | PROMOTES DIFFERENTIATION | PATHWAY MUTATIONS | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE | ALPHA-KETOGLUTARATE | ACUTE MYELOID-LEUKEMIA | ONCOMETABOLITE 2-HYDROXYGLUTARATE | GLUTAMINE-METABOLISM | REDUCTIVE CARBOXYLATION | CELL BIOLOGY
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 6/2017, Volume 86, Issue 1, pp. 305 - 331
The identification of heterozygous mutations in the metabolic enzyme isocitrate dehydrogenase (IDH) in subsets of cancers, including secondary glioblastoma,... 
cancer therapeutics | allosteric inhibition | metabolism | oncometabolite | Allosteric inhibition | Cancer therapeutics | Metabolism | Oncometabolite | GLIOMA-CELLS | SELECTIVE-INHIBITION | RAT-LIVER | MUTANT IDH1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | REDUCTIVE CARBOXYLATION | POTENT INHIBITOR | ISOTOPOMER ANALYSIS | ONCOMETABOLITE 2-HYDROXYGLUTARATE | CARBON-DIOXIDE | Glutarates - analysis | Antineoplastic Agents - chemical synthesis | Humans | Antineoplastic Agents - therapeutic use | Enzyme Inhibitors - chemical synthesis | Isocitrate Dehydrogenase - antagonists & inhibitors | Benzeneacetamides - chemical synthesis | Acetamides - chemical synthesis | Leukemia, Myeloid, Acute - enzymology | Benzeneacetamides - therapeutic use | Acetamides - therapeutic use | Isoenzymes - metabolism | Biomarkers, Tumor - metabolism | Leukemia, Myeloid, Acute - drug therapy | Imidazoles - chemical synthesis | Imidazoles - therapeutic use | Benzimidazoles - therapeutic use | Gene Expression | Biomarkers, Tumor - analysis | Isoenzymes - genetics | Leukemia, Myeloid, Acute - pathology | Benzimidazoles - chemical synthesis | Translational Medical Research | Small Molecule Libraries - therapeutic use | Models, Molecular | Small Molecule Libraries - chemical synthesis | Isocitrate Dehydrogenase - genetics | Drug Discovery | Enzyme Inhibitors - therapeutic use | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mutation | Isoenzymes - antagonists & inhibitors | Leukemia, Myeloid, Acute - genetics | Antimitotic agents | Gene mutations | Physiological aspects | Genetic aspects | Oxidoreductases | Research | Antineoplastic agents
Journal Article
Cancer Cell, ISSN 1535-6108, 03/2013, Volume 23, Issue 3, pp. 274 - 276
The tumor-associated isocitrate dehydrogenase (IDH) mutants are unique in that they have lost their normal catalytic activity and gained a novel function to... 
ONCOLOGY | ONCOMETABOLITE 2-HYDROXYGLUTARATE | DEMETHYLASES | HISTONE | CELL BIOLOGY
Journal Article