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Journal Article
Structure, ISSN 0969-2126, 01/2018, Volume 26, Issue 1, pp. 7 - 19.e5
Orexin peptides in the brain regulate physiological functions such as the sleep-wake cycle, and are thus drug targets for the treatment of insomnia. Using... 
X-ray crystallography | GPCR | subtype selective ligand | X-ray free-electron laser | serial femtosecond crystallography | orexin receptor | ACTIVATION | SODIUM | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATOMIC CHARGES | X-RAY-DIFFRACTION | FREE-ENERGIES | DISCOVERY | FAMILY | CELL BIOLOGY | BIOPHYSICS | SERIAL FEMTOSECOND CRYSTALLOGRAPHY | PROTEINS | Baculoviridae - metabolism | Triazoles - chemistry | Humans | Crystallography - methods | Baculoviridae - genetics | Aminopyridines - metabolism | Spodoptera | Aminopyridines - chemistry | Orexin Receptor Antagonists - metabolism | Thermodynamics | Sf9 Cells | Azepines - chemistry | Synchrotrons | Cloning, Molecular | Orexin Receptors - genetics | Orexin Receptor Antagonists - chemistry | Protein Interaction Domains and Motifs | Orexin Receptors - chemistry | Binding Sites | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | Orexin Receptors - metabolism | Genetic Vectors - chemistry | Orexins - metabolism | Sulfonamides - chemistry | Genetic Vectors - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Molecular Dynamics Simulation | Triazoles - metabolism | Animals | Hydrogen Bonding | Protein Conformation, beta-Strand | Azepines - metabolism | Sulfonamides - metabolism | Orexins - chemistry | Protein Binding | Kinetics | Peptides | Lasers | Analysis | Crystals | Physiological aspects | Drug discovery | Structure
Journal Article
Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 1/2017, Volume 57, Issue 1, pp. 509 - 533
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 09/2012, Volume 37, Issue 10, pp. 2210 - 2221
Growing evidence indicates that an increase of orexin (or hypocretin) signaling is involved in the pathophysiology of major depression, but little is known... 
hypothalamic-pituitary-adrenal axis | orexin/hypocretin | depression | antidepressant | dual orexin/hypocretin receptor antagonist | hippocampal neurogenesis | ADULT HIPPOCAMPUS | PSYCHIATRY | CHRONIC MILD STRESS | CELL-PROLIFERATION | OREXIN/HYPOCRETIN NEURONS | REWARD-SEEKING | MAJOR DEPRESSION | CEREBROSPINAL-FLUID | NEUROSCIENCES | PHARMACOLOGY & PHARMACY | ANIMAL-MODEL | RAT-BRAIN | Cell Proliferation | Neuropeptides - physiology | Depression - drug therapy | Acetamides - therapeutic use | Behavior, Animal - drug effects | Fluoxetine - therapeutic use | Disease Models, Animal | Neuropeptides - analysis | Hypothalamo-Hypophyseal System - drug effects | Microtubule-Associated Proteins - analysis | Orexins | Pituitary-Adrenal System - drug effects | Receptors, Neuropeptide - antagonists & inhibitors | Orexin Receptors | Antidepressive Agents - therapeutic use | Animals | Ki-67 Antigen - analysis | Neurogenesis - physiology | Bromodeoxyuridine - analysis | Receptors, G-Protein-Coupled - antagonists & inhibitors | Biomarkers | Isoquinolines - therapeutic use | Mice | Mice, Inbred BALB C | Intracellular Signaling Peptides and Proteins - physiology | Cell proliferation | Neonates | Animal models | Dexamethasone | Fluoxetine | Bromodeoxyuridine | Depression | Hypothalamic-pituitary-adrenal axis | Neurogenesis | Stress | Antidepressants | Feedback | Orexin receptors | Doublecortin protein | Hippocampus | animal models | dual orexin | hypocretin receptor antagonist | neuropeptides | unipolar | psychopharmacology | hypocretin | bipolar | orexin | Original
Journal Article