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1. Full Text Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading
by You, Lidan and Temiyasathit, Sara and Lee, Peling and Kim, Chi Hyun and Tummala, Padmaja and Yao, Wei and Kingery, Wade and Malone, Amanda M and Kwon, Ronald Y and Jacobs, Christopher R
Bone, ISSN 8756-3282, 2007, Volume 42, Issue 1, pp. 172 - 179
Abstract Bone has the ability to adjust its structure to meet its mechanical environment. The prevailing view of bone mechanobiology is that osteocytes are... 
Orthopedics | RANKL | Osteoclast | Mechanotransduction | Osteocyte | OPG | mechanotransduction | OSTEOCLAST DIFFERENTIATION FACTOR | osteocyte | OSTEOBLAST-LIKE CELLS | OSCILLATORY FLUID-FLOW | GROWTH-FACTOR-BETA | IN-VITRO | GAP-JUNCTIONS | OSTEOPROTEGERIN LIGAND | ENDOCRINOLOGY & METABOLISM | RECEPTOR ACTIVATOR | osteoclast | RANKL ISOFORMS | KAPPA-B LIGAND | Cell Line | RANK Ligand - metabolism | Osteocytes - metabolism | Signal Transduction | Coculture Techniques | Osteocytes - cytology | RNA, Messenger - genetics | Solubility | Cell Communication | Osteoprotegerin - secretion | RANK Ligand - genetics | Animals | RANK Ligand - secretion | Osteoprotegerin - genetics | Bone Resorption - metabolism | Cell Differentiation | Mice | Osteoprotegerin - metabolism | Mechanical engineering | Biological products | Index Medicus
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2. Full Text Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice
by Morony, Sean and Tintut, Yin and Zhang, Zina and Cattley, Russell C and Van, Gwyneth and Dwyer, Denise and Stolina, Marina and Kostenuik, Paul J and Demer, Linda L
Circulation, ISSN 0009-7322, 01/2008, Volume 117, Issue 3, pp. 411 - 420
Background-The role of osteoprotegerin in vascular disease is unclear. Recent observational studies show that serum osteoprotegerin levels are associated with... 
Calcification | RANK ligand | Atherosclerosis | Osteoprotegerin | atherosclerosis | CARDIAC & CARDIOVASCULAR SYSTEMS | MONCKEBERGS SCLEROSIS | RECEPTOR-DEFICIENT MICE | PLASMA OSTEOPROTEGERIN | APOPTOSIS-INDUCING LIGAND | BONE-FORMATION | ARTERIAL CALCIFICATION | ENDOTHELIAL-CELLS | HEMODIALYSIS-PATIENTS | PERIPHERAL VASCULAR DISEASE | calcification | HEMATOLOGY | osteoprotegerin | OSTEOCLAST DIFFERENTIATION | KAPPA-B LIGAND | Atherosclerosis - pathology | Calcinosis - drug therapy | Vascular Diseases - pathology | Vascular Diseases - etiology | Osteoprotegerin - pharmacology | Recombinant Proteins | Endothelium, Vascular - chemistry | Mice, Knockout | Atherosclerosis - etiology | RANK Ligand - blood | Animals | RNA, Messenger - blood | Osteoprotegerin - blood | Receptors, LDL - deficiency | Aorta | Mice | Prevention | Blood circulation disorders | Cytokines | Physiological aspects | Development and progression | Research | Index Medicus | Abridged Index Medicus
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3. Full Text Circulating osteoprotegerin is increased in the metabolic syndrome and associates with subclinical atherosclerosis and coronary arterial calcification
by Pérez de Ciriza, Carmen and Moreno, María and Restituto, Patricia and Bastarrika, Gorka and Simón, Isabel and Colina, Inmaculada and Varo, Nerea
Clinical Biochemistry, ISSN 0009-9120, 12/2014, Volume 47, Issue 18, pp. 272 - 278
The relationship between osteoprotegerin (OPG) a glycoprotein related to bone metabolism and the metabolic syndrome (MS) has not been established. The aim of... 
Coronary calcification | Adipose tissue | Metabolic syndrome | Atherosclerosis | Osteoprotegerin | SERUM OSTEOPROTEGERIN | VASCULAR CALCIFICATION | INCIDENT CARDIOVASCULAR-DISEASE | BIOMARKERS | GENERAL-POPULATION | OSTEOPONTIN | RISK-FACTOR | EARLY-ONSET | BONE | MEDICAL LABORATORY TECHNOLOGY | ADIPOSE-TISSUE | Carotid Artery, Common - diagnostic imaging | Immunohistochemistry | Gene Expression | Carotid Intima-Media Thickness | Humans | Middle Aged | Vascular Calcification - blood | Atherosclerosis - complications | Male | Biomarkers - blood | Reverse Transcriptase Polymerase Chain Reaction | Coronary Artery Disease - blood | Metabolic Syndrome - complications | Atherosclerosis - blood | Adipose Tissue - metabolism | Metabolic Syndrome - blood | Coronary Artery Disease - complications | Osteoprotegerin - blood | Osteoprotegerin - genetics | Vascular Calcification - complications | Female | Aged | Osteoprotegerin - metabolism | Index Medicus
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4. Full Text Osteoprotegerin Deficiency Limits Angiotensin II–Induced Aortic Dilatation and Rupture in the Apolipoprotein E–Knockout Mouse
by Moran, Corey S and Jose, Roby J and Biros, Erik and Golledge, Jonathan
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 12/2014, Volume 34, Issue 12, pp. 2609 - 2616
OBJECTIVE—Mounting evidence links osteoprotegerin with cardiovascular disease. Elevated serum and aortic tissue osteoprotegerin are associated with the... 
Matrix metalloproteinase 2 | Cathepsin S | Aneurysm | Osteoprotegerin | SERUM OSTEOPROTEGERIN | aneurysm | ACTIVATED RECEPTOR-GAMMA | PROTEIN-KINASE | matrix metalloproteinase 2 | cathepsin S | MARFAN-SYNDROME | DISEASE | GENE-EXPRESSION | PPAR-GAMMA | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | osteoprotegerin | ANEURYSM PROGRESSION | Osteoprotegerin - deficiency | Apolipoproteins E - deficiency | Humans | Male | Aortic Rupture - metabolism | Aortic Aneurysm, Abdominal - metabolism | Dilatation, Pathologic - metabolism | Dilatation, Pathologic - pathology | Matrix Metalloproteinase 9 - metabolism | Proteolysis | Osteoprotegerin - genetics | Blood Pressure - physiology | Myocytes, Smooth Muscle - metabolism | Aortic Aneurysm, Abdominal - pathology | Dilatation, Pathologic - etiology | Disease Models, Animal | Angiotensin II - metabolism | Aortic Rupture - etiology | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | Inflammation Mediators - blood | Aortic Rupture - pathology | Pancreatic Elastase - metabolism | Mice, Knockout | Animals | Cathepsins - metabolism | Apolipoproteins E - genetics | Mice | Osteoprotegerin - metabolism | Aortic Aneurysm, Abdominal - etiology | Index Medicus | matrix metalloproteinase | vascular smooth muscle cells | apolipoprotein E-null mouse
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5. Full Text Association of OPG–RANKL ratio with left ventricular hypertrophy and geometric remodeling in male overweight/obese youths
by Zampetti, S and Lucantoni, F and Pacifico, L and Campagna, G and Versacci, P and Pierimarchi, P and Buzzetti, R
Journal of Endocrinological Investigation, ISSN 0391-4097, 04/2019, Volume 42, Issue 4, pp. 427 - 434
PurposeReceptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin (RANKL/RANK/OPG) axis has been... 
Receptor activator of nuclear factor kappa B | Pediatric obesity | Receptor activator of nuclear factor kappa B ligand | Left ventricular hypertrophy | Osteoprotegerin | SERUM OSTEOPROTEGERIN | RISK-FACTORS | GENERAL-POPULATION | INSULIN-RESISTANCE | CARDIAC-HYPERTROPHY | ENDOCRINOLOGY & METABOLISM | SOLUBLE RECEPTOR ACTIVATOR | ELEVATED BLOOD-PRESSURE | CARDIOVASCULAR-DISEASE | CIRCULATING OSTEOPROTEGERIN | KAPPA-B LIGAND | Overweight - complications | Prognosis | Hypertrophy, Left Ventricular - blood | Obesity - complications | Humans | Hypertrophy, Left Ventricular - etiology | Hypertrophy, Left Ventricular - diagnosis | Male | Biomarkers - blood | RANK Ligand - blood | Adolescent | Osteoprotegerin - blood | Sex Factors | Female | Child | Heart | Serum levels | Adolescence | Obesity | Echocardiography | Body weight | Ventricle | Children | TRANCE protein | Hypertrophy | Children & youth
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6. Full Text Osteoprotegerin increases in metabolic syndrome and promotes adipose tissue proinflammatory changes
by Bernardi, Stella and Fabris, Bruno and Thomas, Merlin and Toffoli, Barbara and Tikellis, Christos and Candido, Riccardo and Catena, Cristiana and Mulatero, Paolo and Barbone, Fabio and Radillo, Oriano and Zauli, Giorgio and Secchiero, Paola
Molecular and Cellular Endocrinology, ISSN 0303-7207, 08/2014, Volume 394, Issue 1-2, pp. 13 - 20
Inflammation is believed to link obesity to insulin resistance, as in the setting of metabolic syndrome (MetS). Osteoprotegerin (OPG) is a soluble protein that... 
Inflammation | Adipose tissue | Metabolic syndrome | High-fat diet | Osteoprotegerin | WEIGHT-LOSS | NECROSIS-FACTOR-ALPHA | FULL-LENGTH OSTEOPROTEGERIN | CELL BIOLOGY | DIABETES-MELLITUS | HEPATIC INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | RECEPTOR ACTIVATOR | SMOOTH-MUSCLE-CELLS | CIRCULATING OSTEOPROTEGERIN | KAPPA-B LIGAND | Inflammation - pathology | Metabolic Syndrome - etiology | Humans | Middle Aged | Diet, High-Fat - adverse effects | Male | Insulin - blood | Obesity - blood | Case-Control Studies | Inflammation - blood | Osteoprotegerin - administration & dosage | Adipose Tissue - metabolism | Metabolic Syndrome - blood | C-Reactive Protein - metabolism | Osteoprotegerin - blood | Adult | Cholesterol, LDL - blood | Female | Obesity - etiology | Body Mass Index | Mice, Inbred C57BL | Adipose Tissue - pathology | Insulin Resistance | Inflammation - etiology | Obesity - pathology | Animals | Triglycerides - blood | Cholesterol, HDL - blood | Mice | Metabolic Syndrome - pathology | Blood Glucose - metabolism | Adipose tissues | Analysis | Index Medicus
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7. Full Text Dimerization interface of osteoprotegerin revealed by hydrogen-deuterium exchange mass spectrometry
by Xiao, Yiming and Li, Miaomiao and Larocque, Rinzhi and Zhang, Fuming and Malhotra, Anju and Chen, Jianle and Linhardt, Robert J and Konermann, Lars and Xu, Ding
The Journal of biological chemistry, ISSN 0021-9258, 11/2018, Volume 293, Issue 45, pp. 17523 - 17535
Previous structural studies of osteoprotegerin (OPG), a crucial negative regulator of bone remodeling and osteoclastogenesis, were mostly limited to the... 
hydrogen-deuterium exchange | hydrogen exchange mass spectrometry | RANKL | heparan sulfate | heparin-binding protein | dimerization | osteoclastogenesis | osteoporosis | osteoprotegerin | bone loss | CRYSTAL-STRUCTURE | DECOY RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYDROGEN/DEUTERIUM EXCHANGE | PROTEIN INTERACTIONS | REDUCTION | DYNAMICS | HEPARAN-SULFATE | BINDING | RANK Ligand - metabolism | Protein Multimerization | Osteoprotegerin - chemistry | Heparitin Sulfate - metabolism | RANK Ligand - genetics | Deuterium Exchange Measurement | Animals | Heparitin Sulfate - chemistry | Heparitin Sulfate - genetics | Mass Spectrometry | Osteoprotegerin - genetics | Protein Domains | Mice | Osteoprotegerin - metabolism | RANK Ligand - chemistry | Index Medicus
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8. Full Text Cortical bone loss caused by glucocorticoid excess requires RANKL production by osteocytes and is associated with reduced OPG expression in mice
by Piemontese, Marilina and Xiong, Jinhu and Fujiwara, Yuko and Thostenson, Jeff D and O’Brien, Charles A
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 09/2016, Volume 311, Issue 3, pp. E587 - E593
Glucocorticoid excess is a major cause of low bone mass and fractures. Glucocorticoid administration decreases cortical thickness and increases cortical... 
Osteoclasts | Osteocytes | Glucocorticoids | Receptor activator of nuclear factor-κB ligand | Osteoprotegerin | INDUCED OSTEOPOROSIS | CELLS | PHYSIOLOGY | receptor activator of nuclear factor-kappa\B ligand | STIMULATION | OSTEOCLAST FORMATION | osteoclasts | OSTEOPROTEGERIN LIGAND | IN-VIVO | ENDOCRINOLOGY & METABOLISM | glucocorticoids | osteocytes | osteoprotegerin | Osteocytes - drug effects | Osteocytes - metabolism | Cell Count | Mice, Inbred C57BL | Osteoprotegerin - biosynthesis | Cells, Cultured | RANK Ligand - biosynthesis | Prednisolone - pharmacology | Mice, Knockout | RANK Ligand - genetics | Animals | Dexamethasone - pharmacology | Bone Resorption - genetics | Osteoprotegerin - genetics | Glucocorticoids - pharmacology | Bone Resorption - chemically induced | Mice | Porosity - drug effects | Osteoclasts - drug effects | Measurement | Corticosteroids | Messenger RNA | Physiological aspects | Compact bone | Bone cells | Genetic aspects | Prednisolone | Ligands | Rodents | Fractures | Index Medicus | receptor activator of nuclear factor-κB ligand
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9. Full Text OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice
by Munehisa Shimamura and Hironori Nakagami and Mariana K. Osako and Hitomi Kurinami and Hiroshi Koriyama and Pang Zhengda and Hideki Tomioka and Akiko Tenma and Kouji Wakayama and Ryuichi Morishita
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 22, pp. 8191 - 8196
Osteoprotegerin (OPG) is a soluble secreted protein and a decoy receptor, which inhibits a receptor activator of nuclear factor κB (NF-κB) ligand (RANKL)/the... 
Brain | Receptors | Messenger RNA | Cytokines | Neurons | Body temperature | Strokes | Brain edema | Inflammation | Microglia | Immune cells | Neuroprotection | Cerebral ischemia | RANKL | PROTEIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | VASCULAR CALCIFICATION | immune cells | OSTEOPROTEGERIN | STROKE | OSTEOCLASTOGENESIS | cerebral ischemia | neuroprotection | RECEPTOR ACTIVATOR | EXPRESSION | KAPPA-B LIGAND | Microglia - metabolism | RANK Ligand - metabolism | Coculture Techniques | Cell Death - immunology | Brain Ischemia - metabolism | Brain Ischemia - immunology | RNA, Messenger - metabolism | Brain - metabolism | RANK Ligand - immunology | Signal Transduction - immunology | Microglia - immunology | Encephalitis - metabolism | Osteoprotegerin - genetics | Neurons - metabolism | Cell Death - drug effects | Receptor Activator of Nuclear Factor-kappa B - metabolism | Brain Edema - immunology | Macrophages - immunology | Cytokines - immunology | Brain Edema - metabolism | Cytokines - metabolism | Brain Edema - pathology | Mice, Inbred C57BL | Cells, Cultured | Neurons - immunology | Encephalitis - pathology | Osteoprotegerin - immunology | Encephalitis - immunology | Mice, Knockout | RANK Ligand - genetics | Macrophages - metabolism | Animals | Brain Ischemia - pathology | Lipopolysaccharides - pharmacology | Receptor Activator of Nuclear Factor-kappa B - genetics | Brain - pathology | Mice | Osteoprotegerin - metabolism | Receptor Activator of Nuclear Factor-kappa B - immunology | Brain - immunology | Medicine, Experimental | Medical research | Research | Ligands (Biochemistry) | Proteins | Stroke | Ischemia | Rodents | Index Medicus | Biological Sciences
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10. Full Text Serum calcium concentration is maintained when bone resorption is suppressed by osteoprotegerin in young growing male rats
by Hohman, Emily E and Hodges, Joanna K and Wastney, Meryl E and Lachcik, Pamela J and Han, Chun-Ya and Dwyer, Denise and Peacock, Munro and Kostenuik, Paul J and Weaver, Connie M
Bone, ISSN 8756-3282, 11/2018, Volume 116, pp. 162 - 170
Serum calcium (Ca) is maintained in a narrow range through regulation of Ca metabolism in the intestine, kidney, and bone. Calcium is incorporated and resorbed... 
RANKL | Bone | Calcium | Osteoprotegerin | HOMEOSTASIS | PHYSIOLOGICALLY-BASED MODELS | HUMORAL HYPERCALCEMIA | SEEKING ELEMENTS | INHIBITION | KINETICS | HUMAN RANKL | THYROCALCITONIN | ENDOCRINOLOGY & METABOLISM | MICE | ABSORPTION | Bone Resorption - urine | Bone Resorption - blood | Osteoprotegerin - pharmacology | Body Weight - drug effects | Male | RANK Ligand - administration & dosage | Calcium - urine | Rats, Sprague-Dawley | Osteoprotegerin - administration & dosage | Calcium - blood | RANK Ligand - pharmacology | Animals | Models, Biological | Tartrate-Resistant Acid Phosphatase - metabolism | Growth and Development | Osteoprotegerin - metabolism | Bone resorption | Tracers (Biology) | Index Medicus
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11. Full Text Quantitative proteomic profiling of human articular cartilage degradation in osteoarthritis
by Lourido, Lucía and Calamia, Valentina and Mateos, Jesús and Fernández-Puente, Patricia and Fernández-Tajes, Juan and Blanco, Francisco J and Ruiz-Romero, Cristina
Journal of Proteome Research, ISSN 1535-3893, 12/2014, Volume 13, Issue 12, pp. 6096 - 6106
Osteoarthritis (OA) is the most common rheumatic pathology and is characterized primarily by articular cartilage degradation. Despite its high prevalence,... 
proteomics | secretome | biomarkers | osteoarthritis | cartilage | RHEUMATOID-ARTHRITIS | RECEPTOR-ACTIVATOR | RANKL | SYNOVIAL-FLUID | BIOCHEMICAL RESEARCH METHODS | CLASSIFICATION | SERUM | OSTEOPROTEGERIN | GENE-EXPRESSION | KAPPA-B-LIGAND | BONE | Multivariate Analysis | Cell Adhesion Molecules - genetics | Proteome - genetics | Humans | Middle Aged | Synovial Fluid - metabolism | Male | Tandem Mass Spectrometry | Cartilage, Articular - metabolism | Osteoprotegerin - genetics | Aged, 80 and over | Chromatography, Liquid | Female | Proteomics - methods | Biomarkers - metabolism | Signal Transduction | Tissue Culture Techniques | Osteoarthritis - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion Molecules - metabolism | Osteoarthritis - diagnosis | Blotting, Western | Osteoarthritis - genetics | Osteoprotegerin - secretion | Cartilage, Articular - pathology | Proteome - secretion | Aged | Osteoprotegerin - metabolism | Cell Adhesion Molecules - secretion | Proteome - metabolism | Index Medicus
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12. Full Text Heparin enhances osteoclastic bone resorption by inhibiting osteoprotegerin activity
by Irie, Atsushi and Takami, Masamichi and Kubo, Hideo and Sekino-Suzuki, Naoko and Kasahara, Kohji and Sanai, Yutaka
Bone, ISSN 8756-3282, 2007, Volume 41, Issue 2, pp. 165 - 174
Abstract Heparin is a highly sulfated glycosaminoglycan and has been shown to activate osteoclastic bone resorption though how is not yet clear. Here we... 
Orthopedics | Glycosaminoglycan | Osteoclast | Heparin | Osteoprotegerin | CELLS | ACTIVATION | PREGNANCY | heparin | FIBROBLAST GROWTH | GROWTH-FACTOR VEGF | SULFATE | RANK LIGAND | ENDOCRINOLOGY & METABOLISM | CIRCULATING OSTEOPROTEGERIN | DIFFERENTIATION | osteoclast | glycosaminoglycan | osteoprotegerin | BINDING | Bone Resorption | Heparin - metabolism | RANK Ligand - metabolism | Bone Marrow Cells - cytology | Coculture Techniques | Humans | Mice, Inbred C57BL | Cells, Cultured | Osteoclasts - cytology | Osteoclasts - metabolism | Mice, Knockout | Osteoprotegerin - antagonists & inhibitors | Animals | Osteoprotegerin - genetics | Mice | Molecular Structure | Cell Culture Techniques | Osteoprotegerin - metabolism | Receptor Activator of Nuclear Factor-kappa B - metabolism | Osteoblasts - metabolism | Bone Marrow Cells - metabolism | Heparin - chemistry | Bone resorption | Cytokines | Index Medicus
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13. Full Text Bone Formation Is Coupled to Resorption Via Suppression of Sclerostin Expression by Osteoclasts
by Koide, Masanori and Kobayashi, Yasuhiro and Yamashita, Teruhito and Uehara, Shunsuke and Nakamura, Midori and Hiraoka, B. Yukihiro and Ozaki, Yuki and Iimura, Tadahiro and Yasuda, Hisataka and Takahashi, Naoyuki and Udagawa, Nobuyuki
Journal of Bone and Mineral Research, ISSN 0884-0431, 10/2017, Volume 32, Issue 10, pp. 2074 - 2086
Bone formation is coupled to bone resorption throughout life. However, the coupling mechanisms are not fully elucidated. Using Tnfrsf11b-deficient (OPG(-/-))... 
OSTEOCYTES | WNT/BETA‐CATENIN/LRPS | OSTEOCLASTS | OSTEOBLASTS | MOLECULAR PATHWAYS‐REMODELING | WNT/BETA-CATENIN/LRPS | MOLECULAR PATHWAYS-REMODELING | DENOSUMAB | LEUKEMIA INHIBITORY FACTOR | MESENCHYMAL STEM-CELLS | OSTEOBLASTIC CELLS | OSTEOPROTEGERIN-DEFICIENT MICE | POSTMENOPAUSAL OSTEOPOROSIS | IN-VIVO | MASS | ENDOCRINOLOGY & METABOLISM | SERUM SCLEROSTIN | DIFFERENTIATION | Animals, Newborn | Osteoprotegerin - deficiency | RANK Ligand - metabolism | Mice, Inbred C57BL | Osteogenesis - drug effects | Glycoproteins - metabolism | Rats | Male | Mice, Transgenic | Down-Regulation - drug effects | Leukemia Inhibitory Factor - pharmacology | Osteoclasts - metabolism | Antibodies - pharmacology | Animals | Wnt Signaling Pathway - drug effects | Bone Resorption - pathology | Bone Resorption - metabolism | Glycoproteins - deficiency | Osteoprotegerin - metabolism | Osteoclasts - drug effects | Viral antibodies | Antibodies | Genetic engineering | Leukemia | Bone resorption | Bone growth | Wnt protein | Vitamin D | Leukemia inhibitory factor | Transgenic mice | Osteoclasts | SOST protein | Bone turnover | TRANCE protein | Osteogenesis | Osteoprotegerin | Index Medicus
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