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Antioxidants & redox signaling, ISSN 1523-0864, 11/2017, Volume 27, Issue 14, pp. 127 - 1047
Aims: Organismal aging can be delayed by mutations that either activate stress responses or reduce the nutrient-sensing pathway signaling; thus, by using... 
Original Research Communications | Pdpk1 | OXIDATIVE STRESS | STEM-CELLS | 6-bromoindirubin-3'-oxime | DROSOPHILA-MELANOGASTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | Nrf-2 | GLYCOGEN-SYNTHASE KINASE-3 | DEATH | FACTOR-I | proteostasis | CAENORHABDITIS-ELEGANS | INHIBITION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | aging | Gsk-3 | LITHIUM | Administration, Oral | Humans | Aging - drug effects | Oximes - administration & dosage | Male | Drosophila Proteins - metabolism | Glycogen Synthase Kinase 3 - metabolism | Drosophila melanogaster - drug effects | Indoles - administration & dosage | Drosophila melanogaster - metabolism | Animals | NF-E2-Related Factor 2 - metabolism | Oximes - pharmacology | Female | Indoles - pharmacology | Metabolic Networks and Pathways - drug effects | Proteostasis - drug effects | Energy Metabolism - drug effects | Aging - metabolism | Disease Models, Animal | Aging | Energy metabolism | Reactive oxygen species | Cellular signal transduction | Research | Bioenergetics | Stresses | Insulin-like growth factor I | Glycogen | Modules | Drosophila | Oral administration | Innovations | Glycogen synthase kinase 3 | Longevity | Kinases | Tissues | Insulin | Stress | Antioxidants | Signal transduction | Life span | Pathways | GA-binding protein | Insects | Protein kinase | Nutrients | Mutation | 6-bromoindirubin-3′-oxime
Journal Article
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 2014, Volume 53, Issue 16, pp. 4205 - 4208
Sulfone derivatives are important synthetic intermediates. However, the general method for their preparation is through traditional coupling reaction... 
CH activation | copper | sulfone derivatives | cleavage reactions | C-H activation | OXIDATION | BETA-KETO SULFONES | INTERNAL ALKYNES | CHEMISTRY, MULTIDISCIPLINARY | FUNCTIONALIZATION | CYCLOADDITION | SULFOXIDES | ALKENES | CH activation | BONDS | REGIOSELECTIVE SYNTHESIS | ARYL | Copper | Acetates | Sodium | Derivatives | Oximes | Oxidants | Oxidizing agents | Joining | Bonding | Sulfones
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2010, Volume 53, Issue 16, pp. 6164 - 6179
Journal Article
Advanced synthesis & catalysis, ISSN 1615-4150, 2017, Volume 359, Issue 14, pp. 2339 - 2344
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e70198
Oral cancer is the fourth most common cause of death from cancer in Taiwanese men. Indirubin-3'-monoxime (I3M), a potent cyclin-dependent kinase inhibitor, has... 
HEAD | INVASION | INHIBITION | CYCLOOXYGENASE-2 | MULTIDISCIPLINARY SCIENCES | KINASE | SQUAMOUS-CELL CARCINOMA | SERUM | INDUCE APOPTOSIS | TUMOR-GROWTH | NECK-CANCER | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Gene Expression Regulation, Neoplastic | Male | Mouth Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cell Transformation, Neoplastic - genetics | Cyclooxygenase 2 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Mouth Neoplasms - genetics | Disease Models, Animal | Tumor Suppressor Protein p53 - metabolism | Down-Regulation - drug effects | Cell Transformation, Neoplastic - metabolism | Cell Movement - drug effects | Animals | Tumor Burden - drug effects | Cell Cycle Checkpoints - drug effects | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Mouth Neoplasms - pathology | Oximes - pharmacology | Cell Proliferation - drug effects | Mice | Cell Transformation, Neoplastic - drug effects | Cytochrome c | Immunohistochemistry | Health aspects | Mouth cancer | Apoptosis | Cytochrome | Target recognition | Oral cancer | Immunoblotting | mRNA | Metastasis | Matrix metalloproteinase | Kinases | Cancer therapies | Alcohols | Proteins | Cyclin-dependent kinase | Urokinase | Cell growth | Rodents | Animal tissues | Penicillin | Cell cycle | Tumorigenesis | Metalloproteinase | Research & development--R&D | Cell division | Breast cancer | Survivin | Tumor cell lines | Gene expression | U-Plasminogen activator | Studies | Inhibitors | Medical prognosis | Topical application | Focal adhesion kinase | In vitro methods and tests | Cell migration | Cancer | Research & development | R&D
Journal Article
RSC advances, ISSN 2046-2069, 2017, Volume 7, Issue 22, pp. 13123 - 13129
...(sp )–N bond cleavage of primary amines to provide nitrogen sources for the assembly of pyridine derivatives in high yields with excellent functional group... 
FUNCTIONALIZED PYRIDINES | NITRILE | ONE-POT SYNTHESIS | REGIOSELECTIVE SYNTHESIS | TERMINAL ALKYNES | 2+2+2 CYCLOADDITION | POLYSUBSTITUTED PYRIDINES | C-H ACTIVATION | OXIME ESTERS | CHEMISTRY, MULTIDISCIPLINARY | SUBSTITUTED PYRIDINES
Journal Article
Current Organic Chemistry, ISSN 1385-2728, 2018, Volume 22, Issue 4, pp. 345 - 361
Background: For more than one hundred years, it has been known that some 2- isoxazolines can be experimentally obtained by the addition of hydroxylamine or its derivatives to α,β... 
Hydroxylamine | Enal | Isoxazole | Oxime | Enone | Isoxazolidine | Isoxazoline | PYRYLIUM-SALTS | ENANTIOSELECTIVE SYNTHESIS | hydroxylamine | ORGANIC-REACTIONS | isoxazolidine | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | isoxazoline | OXYGEN NUCLEOPHILE | oxime | IN-VITRO | ISOXAZOLINE DERIVATIVES | ANTIMICROBIAL EVALUATION | BIOLOGICAL EVALUATION | isoxazole | VERSATILE SYNTHONS | enone
Journal Article