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Journal of Surgical Research, ISSN 0022-4804, 09/2019, Volume 241, pp. 254 - 263
Clinically, liver fibrosis and cholestasis are two major disease entities, ultimately leading to hepatic failure. Although autophagy plays a substantial role... 
Liver fibrosis | Cholestatic liver disease | p-JNK | Autophagy | Necrosis | PATHWAYS | SIGNAL | SURGERY | APOPTOSIS | REACTIVE OXYGEN | Immunohistochemistry | Liver diseases | Cell death | Analysis | Liver
Journal Article
International Journal of Oncology, ISSN 1019-6439, 09/2015, Volume 47, Issue 3, pp. 1054 - 1060
Although the anticancer effects of Huaier extract have been widely investigated, including anti-proliferate, anti-angiogenic and anti-metastatic activities,... 
Huaier | Proliferation | P-JNK | Cervical cancer | Cell cycle | INACTIVATION | APOPTOSIS | proliferation | ONCOLOGY | cell cycle | p-JNK | JNK | KINASE | cervical cancer
Journal Article
NATURAL PRODUCT COMMUNICATIONS, ISSN 1934-578X, 06/2019, Volume 14, Issue 6
Melanin plays a role in determining human skin color of a person, and a large amount of melanin makes the skin color look darkened. The proper amount of... 
ECTOINE | CHEMISTRY, MEDICINAL | PROTEIN | ACID | melanin | FOOD SCIENCE & TECHNOLOGY | INVOLVEMENT | melanogenesis | MITF | hydroxyectoine | tyrosinase | whitening | TRP-1 | B16F10 melanoma cell | p-AKT | p-JNK | p-p38 | SKIN | PIGMENTATION
Journal Article
BBA - Gene Regulatory Mechanisms, ISSN 1874-9399, 11/2016, Volume 1859, Issue 11, pp. 1429 - 1439
Matrix metalloproteinases (MMPs) are zinc-containing endopeptidases that play roles in cell proliferation, migration, differentiation, angiogenesis, and... 
c-Jun | Zbtb7c (Kr-pok) | NCoR | p-Jnk | Mmps | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | FAMILY | PATHOGENESIS | MATRIX METALLOPROTEINASES | REPRESSES | BIOPHYSICS | EXTRACELLULAR-MATRIX | MICE | EXPRESSION | BINDING | Ubiquitin | Genetic aspects | Genetic transcription | Genes | Protein binding
Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 6/2015, Volume 404, Issue 1, pp. 143 - 159
Journal Article
Phytomedicine, ISSN 0944-7113, 03/2018, Volume 42, pp. 18 - 24
Injection of snakegourd peel (SP), an herb used in traditional Chinese medicine, is used to treat coronary artery disease and stable angina in China. However,... 
Myocardial infarction | p-p38MAPK | Snakegourd peel | p-JNK | Apoptosis | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | INDUCED APOPTOSIS | JNK | MURINE MACROPHAGES | P38 MAPK | MAP KINASES | VENTRICULAR MYOCYTES | ARSENIC TRIOXIDE | PLANT SCIENCES | CARDIOMYOCYTE APOPTOSIS | INTEGRATIVE & COMPLEMENTARY MEDICINE | CALCIUM | PHARMACOLOGY & PHARMACY
Journal Article
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 48, pp. 78455 - 78472
We assumed that diabetic encephalopathy (DEP) may be induced by endoplasmic reticulum (ER)-mediated inflammation and apoptosis in central nervous system. To... 
ER stress | Inflammation | Diabetes | p-JNK | Apoptosis | OXIDATIVE STRESS | ACTIVATION | RAT | MEMORY IMPAIRMENT | apoptosis | C-KIT | BETA-CELL FUNCTION | CELL BIOLOGY | COGNITIVE DYSFUNCTION | HIPPOCAMPUS | INHIBITION | HYPERGLYCEMIA | inflammation | diabetes | Tumor Necrosis Factor-alpha - metabolism | Brain Diseases - metabolism | Neurons - pathology | Diabetes Mellitus, Experimental - drug therapy | Phosphorylation | Apoptosis - drug effects | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Cognition | Diabetes Mellitus, Type 2 - metabolism | Hippocampus - drug effects | Behavior, Animal | Dose-Response Relationship, Drug | Transfection | Time Factors | Diabetes Mellitus, Experimental - complications | Neurons - metabolism | Brain Diseases - etiology | JNK Mitogen-Activated Protein Kinases - genetics | Diabetes Mellitus, Experimental - metabolism | Neurons - drug effects | Interleukin-6 - metabolism | Diabetes Mellitus, Type 2 - complications | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Endoplasmic Reticulum Stress - drug effects | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Heat-Shock Proteins - metabolism | Cells, Cultured | Hippocampus - pathology | Rats, Sprague-Dawley | Hippocampus - metabolism | Activating Transcription Factor 6 - metabolism | Animals | Brain Diseases - pathology | Brain Diseases - prevention & control | X-Box Binding Protein 1 - metabolism | Diabetes Mellitus, Experimental - pathology | Protein Kinase Inhibitors - pharmacology | Diabetes Mellitus, Type 2 - pathology | Diabetes Mellitus, Type 2 - drug therapy | Transcription Factor CHOP - metabolism
Journal Article
Acta Pharmacologica Sinica, ISSN 1671-4083, 04/2011, Volume 32, Issue 4, pp. 519 - 527
To investigate the effect of genipin on apoptosis in human leukemia K562 cells in vitro and elucidate the underlying mechanisms. The effect of genipin on K562... 
K562 cells | cell cycle | p-JNK | genipin | Bax | apoptosis | dicoumarol | cytochrome c | p63 | Fas-L | Iridoids | Leukemia - pathology | Apoptosis - drug effects | Cell Division | Humans | Iridoid Glycosides - pharmacology | K562 Cells | G2 Phase | JNK Mitogen-Activated Protein Kinases - metabolism | Original
Journal Article
Human Pathology, ISSN 0046-8177, 2010, Volume 41, Issue 3, pp. 401 - 406
Summary Basal-like carcinomas and human epidermal growth factor receptor 2 (HER-2/neu) overexpression carcinomas are the subgroups of breast cancers that have... 
Pathology | Breast cancer | Basal-like phenotype | p-JNK | “Triple-negative” phenotype
Journal Article
Journal of Central South University (Medical Sciences), ISSN 1672-7347, 2014, Volume 39, Issue 4, pp. 371 - 378
Journal Article
JAAD Case Reports, ISSN 2352-5126, 05/2018, Volume 4, Issue 4, pp. 355 - 358
Journal Article
Journal of Cancer Research and Clinical Oncology, ISSN 0171-5216, 2/2013, Volume 139, Issue 2, pp. 287 - 295
Journal Article
中国药理学报:英文版, ISSN 1671-4083, 2011, Volume 32, Issue 4, pp. 519 - 527
Aim: To investigate the effect of genipin on apoptosis in human leukemia K562 cells in vitro and elucidate the underlying mechanisms. Methods: The effect of... 
细胞凋亡 | K562细胞 | M期 | Fas配体 | 激酶 | 诱导形成 | Bax蛋白 | 白血病 | ACTIVATION | cell cycle | genipin | JNK | apoptosis | dicoumarol | DEATH | p63 | CANCER | CHEMISTRY, MULTIDISCIPLINARY | PROTEIN-KINASES | K562 cells | p-JNK | PATHWAY | Bax | NITRIC-OXIDE | GENIPOSIDE | GARDENIA | PHARMACOLOGY & PHARMACY | cytochrome c | Fas-L
Journal Article