X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (7085) 7085
Publication (779) 779
Book Review (27) 27
Book Chapter (16) 16
Dissertation (12) 12
Conference Proceeding (5) 5
Magazine Article (3) 3
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (4461) 4461
p16 (3846) 3846
index medicus (2593) 2593
female (2376) 2376
oncology (2243) 2243
cancer (1799) 1799
cyclin-dependent kinase inhibitor p16 - genetics (1760) 1760
male (1749) 1749
cyclin-dependent kinase inhibitor p16 - metabolism (1609) 1609
middle aged (1594) 1594
animals (1533) 1533
expression (1429) 1429
adult (1367) 1367
aged (1304) 1304
immunohistochemistry (1259) 1259
mice (1199) 1199
cell biology (1158) 1158
dna methylation (1031) 1031
pathology (989) 989
p53 (979) 979
methylation (819) 819
biochemistry & molecular biology (811) 811
cell cycle (811) 811
senescence (797) 797
prognosis (766) 766
tumors (684) 684
aged, 80 and over (667) 667
mutation (645) 645
cellular senescence (642) 642
human papillomavirus (641) 641
genes, p16 (635) 635
gene expression (624) 624
research (608) 608
polymerase chain reaction (604) 604
proteins (590) 590
gene (564) 564
p16 protein (558) 558
apoptosis (537) 537
genetic aspects (525) 525
cell line, tumor (506) 506
cell proliferation (494) 494
gene expression regulation, neoplastic (488) 488
tumor suppressor protein p53 - metabolism (471) 471
genetics & heredity (469) 469
cells, cultured (460) 460
analysis (457) 457
cyclin-dependent kinase inhibitor p16 (448) 448
hpv (427) 427
carcinoma (412) 412
ink4a protein (402) 402
mutations (401) 401
inactivation (387) 387
dna (386) 386
squamous-cell carcinoma (386) 386
promoter regions, genetic (384) 384
cells (377) 377
squamous cell carcinoma (376) 376
article (374) 374
genes (374) 374
tumor-suppressor (371) 371
neoplasms (365) 365
tumor-suppressor gene (361) 361
cyclin-dependent kinase inhibitor p16 - biosynthesis (360) 360
p16 expression (360) 360
carcinoma, squamous cell - pathology (351) 351
hypermethylation (349) 349
protein (341) 341
p16ink4a (336) 336
gene deletion (332) 332
risk factors (331) 331
cyclin-dependent kinase inhibitor p16 - analysis (328) 328
head (328) 328
survival (324) 324
tumor suppressor protein p14arf - genetics (323) 323
tumor suppressor protein p53 - genetics (321) 321
research article (319) 319
human-papillomavirus (318) 318
multidisciplinary sciences (316) 316
aging (315) 315
diagnosis (312) 312
deoxyribonucleic acid--dna (311) 311
adolescent (310) 310
health aspects (308) 308
tumor cells, cultured (308) 308
papillomavirus infections (307) 307
reverse transcriptase polymerase chain reaction (306) 306
ink4a (304) 304
cervical cancer (303) 303
biomarkers, tumor - analysis (298) 298
signal transduction (297) 297
carcinoma, squamous cell - virology (294) 294
kinases (292) 292
carcinoma, squamous cell - metabolism (288) 288
in-vivo (287) 287
medicine (286) 286
retinoblastoma protein - metabolism (286) 286
melanoma (284) 284
overexpression (282) 282
cell line (279) 279
uterine cervical neoplasms - pathology (279) 279
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (6944) 6944
Chinese (41) 41
German (41) 41
French (27) 27
Korean (21) 21
Spanish (12) 12
Japanese (11) 11
Russian (5) 5
Portuguese (4) 4
Polish (3) 3
Bulgarian (2) 2
Turkish (2) 2
Romanian (1) 1
Serbian (1) 1
Slovak (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Pigment Cell & Melanoma Research, ISSN 1755-1471, 01/2013, Volume 26, Issue 1, pp. 136 - 142
To date, there are no effective therapies for tumors bearing NRAS mutations, which are present in 15–20% of human melanomas. Here we extend our earlier studies... 
melanoma | melanoma model | ras/Ink4a | ras | 69A11 | small molecule inhibitor | BI-69A11 | Nras melanoma | Melanoma model | Small molecule inhibitor | Nras/Ink4a | TARGETED THERAPY | CELLS | AKT | Ink4a | MALIGNANT-MELANOMA | CANCER | CHEMOTHERAPY | CELL BIOLOGY | DERMATOLOGY | METASTATIC MELANOMA | REPAIR | Nras | ONCOLOGY | GENETICS | RESISTANCE | Small Molecule Libraries - pharmacology | ras Proteins - genetics | Leukocyte Common Antigens - metabolism | Skin Neoplasms - drug therapy | Humans | Ki-67 Antigen - metabolism | Quinolones - pharmacology | Precancerous Conditions - drug therapy | Benzimidazoles - administration & dosage | Melanoma - genetics | Quinolones - therapeutic use | Precancerous Conditions - pathology | Gene Expression Regulation, Neoplastic - drug effects | Benzimidazoles - therapeutic use | Disease Models, Animal | Skin Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | Injections, Intraperitoneal | Small Molecule Libraries - therapeutic use | Melanoma - pathology | Precancerous Conditions - genetics | Xenograft Model Antitumor Assays | Quinolones - administration & dosage | Animals | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Skin Neoplasms - genetics | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Amino Acid Substitution - genetics | Benzimidazoles - pharmacology | Cell Proliferation - drug effects | Mice | Prevention | Sarcoma | Analysis | Melanoma | Genetically modified organisms | Models | Biological response modifiers | Gene expression | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2004, Volume 279, Issue 23, pp. 24745 - 24756
Journal Article
Epigenetics, ISSN 1559-2294, 11/2010, Volume 5, Issue 8, pp. 685 - 690
The INK4b-ARF-INK4a locus encodes for two cyclin-dependent kinase inhibitors, p15 INK4b and p16 INK4a and a regulator of the p53 pathway, ARF. In addition... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | ANRIL | DNA methylation | Polycomb | Histone demethylases | Senescence | ARF | INK4A-ARF LOCUS | EMBRYONIC FIBROBLASTS | histone demethylases | BIOCHEMISTRY & MOLECULAR BIOLOGY | METHYLATED HISTONE H3 | METHYLTRANSFERASE ACTIVITY | CELL-PROLIFERATION | senescence | polycomb | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | p16(INK4a) | p15(INK4b) | TARGETED DELETION | DEMETHYLASE JMJD3 CONTRIBUTES | POLYCOMB-GROUP | GENOME-WIDE ASSOCIATION | Chromatin - metabolism | Proto-Oncogene Proteins c-mdm2 - genetics | Cyclin-Dependent Kinase 4 - genetics | Diabetes Mellitus, Type 2 - genetics | Epigenesis, Genetic | Humans | Diabetes Mellitus, Type 2 - metabolism | Genetic Loci | Cardiovascular Diseases - genetics | Cyclin-Dependent Kinase Inhibitor p15 - biosynthesis | RNA, Untranslated - genetics | Tumor Suppressor Protein p53 - genetics | Cyclin-Dependent Kinase Inhibitor p15 - genetics | ADP-Ribosylation Factors - biosynthesis | DNA Modification Methylases | Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis | G1 Phase - genetics | ADP-Ribosylation Factors - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Repressor Proteins - metabolism | Cardiovascular Diseases - metabolism | Cyclin-Dependent Kinase 6 - genetics | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Repressor Proteins - genetics | Cyclin-Dependent Kinase 6 - metabolism | Signal Transduction - genetics | Polycomb-Group Proteins | Cyclin-Dependent Kinase 4 - metabolism | Animals | Histone Demethylases | RNA, Untranslated - biosynthesis | Alzheimer Disease - metabolism | Transcription, Genetic - genetics | Alzheimer Disease - genetics | Chromatin - genetics | p16INK4a | Point-of-View | p15INK4b
Journal Article
Current Opinion in Genetics & Development, ISSN 0959-437X, 2003, Volume 13, Issue 1, pp. 77 - 83
Journal Article
PLOS ONE, ISSN 1932-6203, 03/2008, Volume 3, Issue 3, pp. e1864 - e1864
Background: Expression of the tumor suppressor p16(INK4a) increases during aging and replicative senescence. Methodology/Principal Findings: Here, we report... 
BIOLOGY | Protein Biosynthesis | Mutagenesis, Site-Directed | Base Sequence | Humans | Cyclin-Dependent Kinase Inhibitor p16 - genetics | HeLa Cells | MicroRNAs - physiology | DNA Primers | Index Medicus
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 11/2004, Volume 114, Issue 9, pp. 1299 - 1307
The Ink4a/Arflocus encodes 2 tumor suppressor molecules, p16(INK4a) and Arf, which are principal mediators of cellular senescence. To study the links between... 
TRANSCRIPTION FACTORS | MEDICINE, RESEARCH & EXPERIMENTAL | LIFE-SPAN | P16(INK4A) EXPRESSION | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | IN-VIVO | TELOMERASE ACTIVITY | TUMOR-SUPPRESSOR | SIRT1 DEACETYLASE | CELLULAR SENESCENCE
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 10/2001, Volume 2, Issue 10, pp. 731 - 737
Journal Article
Journal Article
Journal Article