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Journal Article
Journal Article
PLOS ONE, ISSN 1932-6203, 04/2019, Volume 14, Issue 4, pp. e0215018 - e0215018
p21((WAF1/CIP1/SDI1)) is a critical sentinel of the cell cycle that plays an important role in determining cell fate with respect to proliferation,... 
THERAPY | P21(WAF1/CIP1) | REGENERATION | MULTIDISCIPLINARY SCIENCES | OSTEOGENESIS | EXPRESSION | MESENCHYMAL STEM-CELLS | P21 | OSTEOPOROSIS | RESCUES
Journal Article
by Yi, C and Wang, Q and Wang, L and Huang, Y and Li, L and Liu, L and Zhou, X and Xie, G and Kang, T and Wang, H and Zeng, M and Ma, J and Zeng, Y and Yun, J.-P
Oncogene, ISSN 0950-9232, 10/2012, Volume 31, Issue 41, pp. 4421 - 4433
Journal Article
FEBS Letters, ISSN 0014-5793, 12/2014, Volume 588, Issue 24, pp. 4654 - 4664
We have previously reported that synthetic dsRNA can activate p21 expression by targeting the p21 promoter, thereby suppressing the proliferation of human... 
miRNA | RNA activation | Gene promoter | Bladder cancer | p21
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2014, Volume 171, Issue 13, pp. 3182 - 3195
Background and purpose Sorafenib, a potent inhibitor that targets several kinases associated with tumourigenesis and cell survival, has been approved for... 
combination therapy | cancer | ABT | sorafenib | 263 | ABT-263 | OXIDATIVE STRESS | DOWN-REGULATION | ANTITUMOR-ACTIVITY | ARRIVE GUIDELINES | MULTIKINASE INHIBITOR | RAF/MEK/ERK PATHWAY | LYMPHOCYTIC-LEUKEMIA CELLS | BCL-2 FAMILY INHIBITOR | IN-VIVO | PHARMACOLOGY & PHARMACY | HUMAN HEPATOCELLULAR-CARCINOMA | Niacinamide - analogs & derivatives | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Male | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Aniline Compounds - administration & dosage | bcl-2-Associated X Protein - genetics | In Situ Nick-End Labeling | Cell Survival - drug effects | Aniline Compounds - pharmacology | bcl-2-Associated X Protein - metabolism | Sulfonamides - pharmacology | Blotting, Western | Neoplasms - drug therapy | Niacinamide - administration & dosage | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Phenylurea Compounds - administration & dosage | Mice, Nude | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Neoplasms - pathology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Sulfonamides - administration & dosage | Antimitotic agents | Antineoplastic agents | Phosphotransferases | Analysis | Cancer | Apoptosis | Medical research | Index Medicus | Research Papers
Journal Article
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, ISSN 1357-2725, 2007, Volume 39, Issue 7-8, pp. 1367 - 1374
Chromatin-modifying enzymes such as histone deacetylases (HDAC) facilitate a closed chromatin structure and hence transcriptional repression. HDAC are commonly... 
CARCINOMA CELLS | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER-CELL-LINES | TRICHOSTATIN-A | epigenetics | CELL BIOLOGY | MYC REPRESSES | p21(cip1/waf1) | GENE | LEUKEMIA-CELLS | cancer biology | C-JUN | TRANSCRIPTIONAL REGULATION | histone deacetylase inhibitors | P21(WAF1) EXPRESSION
Journal Article
PLOS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6
We previously showed that p21(Cip1) transits through the nucleolus on its way from the nucleus to the cytoplasm and that DNA damage inhibits this transit and... 
RNA-POLYMERASE-I | PATHWAY | UBIQUITIN | MULTIDISCIPLINARY SCIENCES | DE-SUMOYLATION | NUCLEAR EXPORT | STRESS | CANCER | P21 | NUCLEOCYTOPLASMIC TRANSPORT | P53
Journal Article
The Journal of Pathology, ISSN 0022-3417, 04/2012, Volume 226, Issue 5, pp. 784 - 795
The peroxisome proliferator activated receptor‐γ (PPARγ) agonist, pioglitazone (PIO), exerts anti‐diabetic properties associated with increased fat mass,... 
nuclear receptors | cell cycle | RXR | obesity | p21 | p53 | METABOLIC SYNDROME | P21(WAF1/CIP1) | DIABETIC-NEPHROPATHY | KINASE INHIBITOR | PATHOLOGY | P27(KIP1) | HYPERTROPHY | ONCOLOGY | PPAR-GAMMA | DIFFERENTIATION | TARGET GENE | Up-Regulation | Obesity - drug therapy | PPAR gamma - drug effects | Humans | Male | Adipocytes - drug effects | Diabetes Mellitus, Type 2 - metabolism | PPAR gamma - metabolism | Obesity - genetics | Tumor Suppressor Protein p53 - genetics | Transfection | Biphenyl Compounds - pharmacology | RNA Interference | Time Factors | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Kidney Glomerulus - metabolism | Retinoid X Receptors - antagonists & inhibitors | Thiazolidinediones - pharmacology | Retinoid X Receptors - metabolism | Disease Models, Animal | Cell Size - drug effects | Kidney Glomerulus - drug effects | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Rats | Kidney Glomerulus - pathology | Adipocytes - pathology | Hypoglycemic Agents - pharmacology | Obesity - metabolism | Obesity - pathology | Rats, Inbred OLETF | Animals | Signal Transduction - drug effects | Adipocytes - metabolism | Benzoates - pharmacology | Resting Phase, Cell Cycle - drug effects | Cell Proliferation - drug effects | Diabetes Mellitus, Type 2 - pathology | Diabetes Mellitus, Type 2 - drug therapy | G1 Phase Cell Cycle Checkpoints - drug effects | Anti-Obesity Agents - pharmacology | Hypertrophy | Index Medicus
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 3/2013, Volume 33, Issue 3, pp. 351 - 355
Hypoxic preconditioning is thought to rely on gene products regulated by hypoxia-inducible factor (HIF)-1. Here, we show that the HIF-1 target gene... 
hypoxia | HIF-1 target genes | cyclin-dependent kinase inhibitor 1 (p2 | erythropoietin | ischemia | preconditioning | cyclin-dependent kinase inhibitor 1 (p21(WAF1/CIP1)) | APOPTOSIS | PHOSPHORYLATION | TOLERANCE | NEUROSCIENCES | NEUROPROTECTION | IN-VITRO | ENDOCRINOLOGY & METABOLISM | RESISTANCE | HEMATOLOGY | CEREBRAL-ISCHEMIA | EXPRESSION | BRAIN | Erythropoietin - pharmacology | Deferoxamine - pharmacology | Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis | Gene Expression Regulation - genetics | Ischemic Preconditioning | Hypoxia-Inducible Factor 1 - metabolism | Nerve Tissue Proteins - genetics | Siderophores - pharmacology | Hypoxia, Brain - metabolism | Hypoxia, Brain - pathology | Hypoxia-Inducible Factor 1 - genetics | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cell Death - genetics | Nerve Tissue Proteins - biosynthesis | Mice | Cell Death - drug effects | Mutation | Hypoxia, Brain - genetics | Index Medicus | Neuroprotection | Cyclin-dependent kinase inhibitor p21 | Hypoxia-inducible factor 1 | Erythropoietin | Cell death | Cerebral blood flow | Neurons | Cortex | Data processing | Hypoxia | cyclin-dependent kinase inhibitor 1 (p21WAF1 | CIP1 | Brief Communication | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin
Journal Article