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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, ISSN 0021-972X, 08/2007, Volume 92, Issue 8, pp. 3321 - 3325
Context: Germline mutations in the MEN1 gene predispose to multiple endocrine neoplasia type 1 (MEN1) syndrome, but in up to 20-25% of clinical MEN1 cases, no... 
GENE-MUTATIONS | EXPRESSION ANALYSIS | MEN1 GENE | CYCLE INHIBITOR P27(KIP1) | LINE MUTATIONS | ENDOCRINOLOGY & METABOLISM | CLINICAL-FEATURES | TYPE-1 | TUMORS | P27(KIP1)-DEFICIENT MICE | PITUITARY-ADENOMAS
Journal Article
EMBO JOURNAL, ISSN 0261-4189, 08/2007, Volume 26, Issue 15, pp. 3699 - 3708
Journal Article
CELL CYCLE, ISSN 1538-4101, 08/2007, Volume 6, Issue 16, pp. 2005 - 2009
Levels of p27(Kip1), a key negative regulator of the cell cycle, are often decreased in cancer. In most cancers, levels of p27(Kip1) mRNA are unchanged and... 
miRNA 221 | p27(Kip1) | CELLS | cell cycle | TRANSLATION | CANCER | CELL BIOLOGY | glioblastoma | P27 | PATHWAY | MiRNA 222 | GROWTH | GENES | dicer | microRNA | TARGETS | MICRORNA EXPRESSION | MODULATION
Journal Article
JOURNAL OF PATHOLOGY, ISSN 0022-3417, 01/2019, Volume 247, Issue 1, pp. 60 - 71
The cell cycle inhibitor p27(Kip1) is a tumor suppressor via the inhibition of CDK complexes in the nucleus. However, p27 also plays other functions in the... 
MIGRATION | CELLS | RAS | PHOSPHORYLATION | STABILITY | PATHOLOGY | non-small cell lung carcinoma | CONFERS RESISTANCE | RhoB | lung cancer | LUNG-CANCER | INHIBITION | transgenic mice | P27 | ONCOLOGY | p27/Kip1 | EXPRESSION
Journal Article
JOURNAL OF PATHOLOGY, ISSN 0022-3417, 05/2019, Volume 248, Issue 1, pp. 3 - 5
Lung cancer is the leading cause of cancer mortality worldwide, with adenocarcinomas of the non-small cell lung carcinoma (NSCLC) subtype accounting for the... 
lung cancer | p27(Kip1) | CDKN1B | NSCLC | ONCOLOGY | RAS | PATHOLOGY | CYTOPLASMIC P27 | EXPRESSION | RhoB
Journal Article
Journal of Pathology, ISSN 0022-3417, 01/2019, Volume 247, Issue 1, pp. 60 - 71
The cell cycle inhibitor p27 is a tumor suppressor via the inhibition of CDK complexes in the nucleus. However, p27 also plays other functions in the cell and... 
lung cancer | transgenic mice | non-small cell lung carcinoma | p27/Kip1 | RhoB
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, ISSN 0167-4889, 11/2018, Volume 1865, Issue 11, pp. 1630 - 1639
Cytokinesis begins in anaphase with the formation of the central spindle. PRC1 is a microtubule associated protein that plays an essential role in central... 
p27(KiP1) | PROTEIN | SPINDLE MIDZONE FORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-CYCLE PROGRESSION | Mitotic spindle | CHROMOSOMAL INSTABILITY | CELL BIOLOGY | HEPATOCELLULAR-CARCINOMA | CYTOKINESIS | PRC1 | Cell cycle | EARLY RECURRENCE | Multinucleation | Microtubule | CATENIN SIGNALING PATHWAY | PROMOTES | BINDING
Journal Article
GENES & DEVELOPMENT, ISSN 0890-9369, 04/2004, Volume 18, Issue 8, pp. 862 - 876
The tumor suppressor p27(Kip1) is an inhibitor of cyclin/cyclin-dependent kinase (CDK) complexes and plays a crucial role in cell cycle regulation. However,... 
p27(Kip1) | ROCK | Ras | MEMBRANE PROTRUSION | PHOSPHATIDYLINOSITOL 3-KINASE | KINASE INHIBITOR P27(KIP1) | actin stress fibers | DEVELOPMENTAL BIOLOGY | FOCAL ADHESIONS | BINDING PROTEIN RHO | P27 | GTPASES | GENETICS & HEREDITY | Rho | migration | EXPRESSION
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 12/2004, Volume 6, Issue 12, pp. 1229 - 1235
The cyclin-dependent kinase inhibitor p27(Kip1) is degraded at the G0-G1 transition of the cell cycle by the ubiquitin proteasome pathway(1,2). Although the... 
LOCALIZATION | COMPLEX | P27 | PHOSPHORYLATION | KINASE INHIBITOR P27(KIP1) | MEDIATED DEGRADATION | NUCLEAR EXPORT | S-PHASE | SCFSKP2 | PROGRESSION | CELL BIOLOGY | NIH 3T3 Cells | Peptide Hydrolases - genetics | Humans | DNA, Complementary - genetics | Ubiquitin - metabolism | Molecular Sequence Data | Cytoplasm - metabolism | Amino Acid Sequence - genetics | Protein Subunits - metabolism | Protein Subunits - isolation & purification | RNA Interference | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cytoplasm - genetics | G1 Phase - genetics | Active Transport, Cell Nucleus - genetics | Peptide Hydrolases - metabolism | Protein Subunits - genetics | DNA, Complementary - analysis | Rabbits | Base Sequence - genetics | Tumor Suppressor Proteins - metabolism | Macromolecular Substances - isolation & purification | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Protein Structure, Tertiary - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Mutation - genetics | Down-Regulation - genetics | Cyclin-Dependent Kinase Inhibitor p27 | Animals | Karyopherins - metabolism | Peptide Hydrolases - isolation & purification | Karyopherins - genetics | Ubiquitin-Protein Ligases - isolation & purification | Mice | Ubiquitin-Protein Ligases - genetics | Macromolecular Substances - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
GENES & DEVELOPMENT, ISSN 0890-9369, 01/2006, Volume 20, Issue 1, pp. 47 - 64
We have created two knock-in mouse models to study the mechanisms that regulate p27 in normal cells and cause misregulation of p27 in tumors: p27(S10A), in... 
p27(Kip1) | cyclin | Ras | PHOSPHORYLATION | CYTOPLASMIC LOCALIZATION | tumor suppressor | NUCLEAR EXPORT | CYCLIN-DEPENDENT KINASE | DEVELOPMENTAL BIOLOGY | CDK | MICE LACKING | CELL BIOLOGY | lung cancer | UBIQUITINATION | CDK INHIBITOR P27 | GROWTH | GENETICS & HEREDITY | DEGRADATION | tumorigenesis | PROGRESSION | Allelomorphism | Tumor suppressor genes | Genetic aspects | Research | Cell fractionation
Journal Article
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