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humans (163) 163
p300-cbp transcription factors - metabolism (145) 145
index medicus (136) 136
animals (116) 116
acetylation (95) 95
mice (85) 85
biochemistry & molecular biology (81) 81
p300-cbp transcription factors - genetics (68) 68
cell line (57) 57
histones - metabolism (52) 52
cell line, tumor (47) 47
cell biology (45) 45
transcription factors - metabolism (44) 44
gene-expression (42) 42
promoter regions, genetic (40) 40
p300-cbp transcription factors (39) 39
p300 (37) 37
transcription factors (37) 37
protein binding (36) 36
expression (34) 34
transcription (33) 33
histone acetyltransferases (32) 32
phosphorylation (32) 32
transcription, genetic (32) 32
transcriptional activation (32) 32
chromatin (31) 31
signal transduction (31) 31
activation (30) 30
gene expression (30) 30
oncology (30) 30
female (28) 28
gene expression regulation (28) 28
cells, cultured (27) 27
male (27) 27
p300-cbp transcription factors - biosynthesis (27) 27
histone acetyltransferase (26) 26
cell cycle proteins - metabolism (25) 25
cancer (24) 24
transcription factors - genetics (24) 24
article (23) 23
apoptosis (22) 22
dna-binding proteins - metabolism (22) 22
histones (22) 22
immunology (22) 22
in-vivo (21) 21
protein (21) 21
transfection (21) 21
creb-binding protein (20) 20
gene expression regulation, neoplastic (20) 20
acetyltransferases - metabolism (19) 19
binding sites (19) 19
chromatin - metabolism (19) 19
genetic aspects (19) 19
p300-cbp transcription factors - antagonists & inhibitors (19) 19
differentiation (18) 18
down-regulation (18) 18
mutation (18) 18
proteins (18) 18
cells (17) 17
histone acetyltransferases - metabolism (17) 17
binding (16) 16
molecular sequence data (16) 16
amino acid sequence (15) 15
chromatin immunoprecipitation (15) 15
event-related potentials (15) 15
hela cells (15) 15
immunoprecipitation (15) 15
multidisciplinary sciences (15) 15
nf-kappa b - metabolism (15) 15
nf-kappa-b (15) 15
research article (15) 15
analysis (14) 14
blotting, western (14) 14
cbp (14) 14
enzymes (14) 14
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histone deacetylases - metabolism (14) 14
histones - genetics (14) 14
protein processing, post-translational (14) 14
trans-activators - metabolism (14) 14
transcription factors - biosynthesis (14) 14
acetylation - drug effects (13) 13
dna-binding proteins - genetics (13) 13
endocrinology & metabolism (13) 13
lysine (13) 13
medicine (13) 13
molecular biology (13) 13
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science (13) 13
abridged index medicus (12) 12
cell proliferation (12) 12
dna methylation (12) 12
gene regulation (12) 12
genetics & heredity (12) 12
mice, knockout (12) 12
response elements - physiology (12) 12
rna, messenger - genetics (12) 12
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1. Full Text Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner
by Xiong, Yuning and Khannas, Sahil and Grzenda, Adrienne L and Sarmento, Olga F and Svingen, Phyllis A and Lomberk, Gwen A and Urrutia, Raul A and Faubion Jr, William A
Journal of Biological Chemistry, ISSN 0021-9258, 10/2012, Volume 287, Issue 41, pp. 34372 - 34385
Inducible gene expression underlies the epigenetically inherited differentiation program of most immune cells. We report that the promoter of the FOXP3 gene... 
RESPONSE ELEMENT | INTESTINAL INFLAMMATION | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR FOXP3 | TRANSFORMING GROWTH-FACTOR-BETA-1 | IN-VIVO | REGULATORY T-CELLS | HISTONE ACETYLTRANSFERASE | BINDING PROTEIN | EXPRESSION | Forkhead Transcription Factors - immunology | T-Lymphocytes, Regulatory - metabolism | p300-CBP Transcription Factors - immunology | Polycomb Repressive Complex 2 - genetics | p300-CBP Transcription Factors - antagonists & inhibitors | Early Growth Response Transcription Factors - biosynthesis | Male | Polycomb-Group Proteins - metabolism | T-Lymphocytes, Regulatory - immunology | p300-CBP Transcription Factors - genetics | Early Growth Response Transcription Factors - genetics | Polycomb Repressive Complex 2 - immunology | T-Lymphocytes, Regulatory - cytology | Response Elements - physiology | Forkhead Transcription Factors - biosynthesis | Kruppel-Like Transcription Factors - biosynthesis | Polycomb-Group Proteins - immunology | Early Growth Response Transcription Factors - immunology | Forkhead Transcription Factors - genetics | Enhancer of Zeste Homolog 2 Protein | Mice, Knockout | p300-CBP Transcription Factors - metabolism | Animals | Polycomb-Group Proteins - genetics | Mice | Polycomb Repressive Complex 2 - metabolism | Gene Silencing - physiology | Kruppel-Like Transcription Factors - genetics | Kruppel-Like Transcription Factors - immunology | Chromatin Assembly and Disassembly - physiology | DNA and Chromosomes | Histone Modification | Epigenetics | Polycomb | T Cell Biology | FOXP3 | Kruppel-like Factor (KLF) | T Regulatory Cell
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2. Full Text Simultaneous modulation of COX‐2, p300, Akt, and Apaf‐1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells
by Wang, Jingshu and Xiao, Xiangsheng and Zhang, Yun and Shi, Dingbo and Chen, Wangbing and Fu, Lingyi and Liu, Liqun and Xie, Fangyun and Kang, Tiebang and Huang, Wenlin and Deng, Wuguo
Journal of Pineal Research, ISSN 0742-3098, 08/2012, Volume 53, Issue 1, pp. 77 - 90
:  Melatonin exhibits anti‐inflammatory and anticancer effects and could be a chemopreventive and chemotherapeutic agent against cancers, but the precise... 
p300 | breast cancer | Apaf‐1 | Akt | melatonin | COX‐2 | Melatonin | Apaf-1 | Breast cancer | COX-2 | TARGET | OXIDATIVE STRESS | ACTIVATION | PHYSIOLOGY | CYCLOOXYGENASE-2 | C/EBP-BETA | ACETYLATION | RECEPTOR | NEUROSCIENCES | SYNTHASE | ENDOCRINOLOGY & METABOLISM | CELLULAR MECHANISMS | EXPRESSION | Apoptosis - drug effects | Caspases - genetics | Dinoprostone - biosynthesis | Humans | Antioxidants - pharmacology | Apoptotic Protease-Activating Factor 1 - genetics | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Cyclooxygenase 2 - biosynthesis | Proto-Oncogene Proteins c-akt - biosynthesis | Breast Neoplasms - genetics | Caspases - metabolism | p300-CBP Transcription Factors - genetics | Breast Neoplasms - pathology | Cyclooxygenase 2 - genetics | p300-CBP Transcription Factors - biosynthesis | Cell Line, Tumor | Apoptotic Protease-Activating Factor 1 - biosynthesis | Female | Cell Proliferation - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Melatonin - pharmacology
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3. Full Text Identifying targets for the restoration and reactivation of BRM
by Kahali, B and Gramling, S.J.B and Marquez, S.B and Thompson, K and Lu, L and Reisman, D
Oncogene, ISSN 0950-9232, 01/2014, Volume 33, Issue 5, pp. 653 - 664
Brahma (BRM) is a novel anticancer gene, which is frequently inactivated in a variety of tumor types. Unlike many anticancer genes, BRM is not mutated, but... 
Histone Transferase | Brahma | Histone Deacetylase Complex | Epigenetic | SWI/SNF | Tumor Suppressor | histone transferase | TRANSCRIPTIONAL ACTIVITY | DNA-BINDING | CHROMATIN-REMODELING FACTOR | SWI/SNF COMPLEX | brahma | epigenetic | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN LUNG-CANCER | tumor suppressor | histone deacetylase complex | CELL-LINES | CELL BIOLOGY | BREAST-CANCER | ONCOLOGY | RAS MUTATIONS | GENETICS & HEREDITY | GENE-EXPRESSION | II HISTONE DEACETYLASES | GATA3 Transcription Factor - genetics | MEF2 Transcription Factors - genetics | Cell Proliferation | Histone Deacetylases - biosynthesis | Humans | MAP Kinase Signaling System | RNA Interference | Histone Acetyltransferases - metabolism | Acetylation | GATA3 Transcription Factor - metabolism | Repressor Proteins - metabolism | Cell Line | Histone Deacetylase 2 - genetics | Gene Expression | Histone Deacetylases - genetics | Down-Regulation | Gene Expression Regulation | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Transcription Factors - biosynthesis | Transcription Factors - genetics | Transcription Factors - metabolism | p300-CBP Transcription Factors - metabolism | Repressor Proteins - biosynthesis | Mitogen-Activated Protein Kinases - antagonists & inhibitors | MEF2 Transcription Factors - metabolism | RNA, Small Interfering | Histone Deacetylase 2 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Oncology, Experimental | Drug targeting | Tumor suppressor genes | Genetic aspects | Research | Health aspects | Tumors | Cancer | Studies | Epigenetics | Oncology | Gene therapy
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4. Full Text FGF8, c-Abl and p300 participate in a pathway that controls stability and function of the ΔNp63α protein
by Restelli, Michela and Molinari, Elisa and Marinari, Barbara and Conte, Daniele and Gnesutta, Nerina and Costanzo, Antonio and Merlo, Giorgio Roberto and Guerrini, Luisa
Human Molecular Genetics, ISSN 0964-6906, 08/2015, Volume 24, Issue 15, pp. 4185 - 4197
The p63 transcription factor, homolog to the p53 tumor suppressor gene, plays a crucial role in epidermal and limb development, as its mutations are associated... 
P63 GENE | LIMB | DNA-BINDING | ACTIVATION | ACETYLATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | P53 FAMILY | DIFFERENTIATION | IDENTIFICATION | P73 | Limb Deformities, Congenital - genetics | Humans | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins c-abl - biosynthesis | Fibroblast Growth Factor 8 - metabolism | Congenital Abnormalities - genetics | p300-CBP Transcription Factors - genetics | Tumor Suppressor Proteins - genetics | p300-CBP Transcription Factors - biosynthesis | Fibroblast Growth Factor 8 - biosynthesis | Fibroblast Growth Factor 8 - genetics | Cell Line | Promoter Regions, Genetic | Proto-Oncogene Proteins c-abl - genetics | Tumor Suppressor Proteins - metabolism | Signal Transduction | Embryonic Development - genetics | Congenital Abnormalities - embryology | Transcription Factors - biosynthesis | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Congenital Abnormalities - pathology | Transcription Factors - metabolism | p300-CBP Transcription Factors - metabolism | Animals | Protein Binding | Proto-Oncogene Proteins c-abl - metabolism | Mice | Mutation | Tumor Suppressor Proteins - biosynthesis | Limb Deformities, Congenital - pathology
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5. Full Text Poly(ADP-ribosyl)ation affects histone acetylation and transcription
by Verdone, Loredana and La Fortezza, Marco and Ciccarone, Fabio and Caiafa, Paola and Zampieri, Michele and Caserta, Micaela
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0144287
Poly(ADP-ribosyl) ation (PARylation) is a posttranslational protein modification catalyzed by members of the poly(ADP-ribose) polymerase (PARP) enzyme family.... 
RECRUITMENT | ACTIVATION | INTERPLAY | CHROMATIN-STRUCTURE | POLY(ADENOSINE DIPHOSPHATE RIBOSYLATION) | MULTIDISCIPLINARY SCIENCES | COACTIVATION | GENE-EXPRESSION | POSTTRANSLATIONAL MODIFICATIONS | PARP-1 | MODULATION | E1A-Associated p300 Protein - biosynthesis | Genomic Instability | NIH 3T3 Cells | DNA (Cytosine-5-)-Methyltransferase 1 | Phenanthrenes - pharmacology | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | p300-CBP Transcription Factors - biosynthesis | Benzimidazoles - pharmacology | Transcription, Genetic | Mice | Acetylation | Histones - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | DNA (Cytosine-5-)-Methyltransferases - biosynthesis | Energy metabolism | Chromatin | Immunoprecipitation | Transcription | Structural stability | Poly(ADP-ribose) | Event-related potentials | ADP | Nuclei | Proteins | Ribose | Rodents | DNA methylation | Acetyltransferase | Deoxyribonucleic acid--DNA | ADP-ribosylation | DNMT1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Metabolism | Gene expression | Biological activity | Polymerase | Insects | Cell death | Poly(ADP-ribose) glycohydrolase | Methylation | Histone H3 | Deoxyribonucleic acid | DNA
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6. Full Text Peptidomimetic blockade of MYB in acute myeloid leukemia
by Ramaswamy, Kavitha and Forbes, Lauren and Minuesa, Gerard and Gindin, Tatyana and Brown, Fiona and Kharas, Michael G and Krivtsov, Andrei V and Armstrong, Scott A and Still, Eric and De Stanchina, Elisa and Knoechel, Birgit and Koche, Richard and Kentsis, Alex
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 110 - 13
Aberrant gene expression is a hallmark of acute leukemias. MYB-driven transcriptional coactivation with CREB-binding protein (CBP)/P300 is required for acute... 
H3K79 METHYLATION | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | KIX DOMAIN | C-MYB | CELL-PENETRATING PEPTIDES | PARTICLE MESH EWALD | TRANSACTIVATION DOMAIN | TRANSCRIPTION-FACTOR-BINDING | SMALL-MOLECULE INHIBITOR | MLL-REARRANGED LEUKEMIA | Peptidomimetics - pharmacology | Transcriptional Activation - genetics | Apoptosis - drug effects | Humans | Mice, Inbred C57BL | Proto-Oncogene Proteins c-myb - genetics | Down-Regulation - drug effects | Proto-Oncogene Proteins c-myb - biosynthesis | Xenograft Model Antitumor Assays - methods | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Molecular Dynamics Simulation | Biomimetic Materials - pharmacology | Animals | p300-CBP Transcription Factors - genetics | Binding Sites - physiology | p300-CBP Transcription Factors - biosynthesis | Cell Line, Tumor | HL-60 Cells | Leukemia, Myeloid, Acute - drug therapy | Female | Mice, Inbred NOD | Mice | Leukemia, Myeloid, Acute - genetics | Cell survival | Molecular structure | Transcription | Myeloid leukemia | Leukemia | Immunodeficiency | Event-related potentials | Pharmacology | Myc protein | Cyclic AMP response element-binding protein | Gene expression | Nuclei | CREB-binding protein | Enhancers | Mitochondria | Rodents | Nuclei (cytology) | Aberration | Acute myeloid leukemia | Binding sites | Apoptosis
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7. An inhibitor of the acetyltransferases CBP/p300 exerts antineoplastic effects on gastrointestinal stromal tumor cells
by Gu, Meng-Li and Wang, Ya-Mei and Zhou, Xin-Xin and Yao, Hang-Ping and Zheng, Song and Xiang, Zun and Ji, Feng
Oncology Reports, ISSN 1021-335X, 11/2016, Volume 36, Issue 5, pp. 2763 - 2770
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm featured by activated mutations of KIT and PDGFRA. Although overall survival... 
CREB-binding protein | Signaling pathway | Antineoplastic | P300 | C646 | Acetylation | Gastrointestinal stromal tumor | signaling pathway | BINDING-PROTEIN | DOWN-REGULATION | PROLIFERATION | antineoplastic | p300 | acetylation | CBP | gastrointestinal stromal tumor | ONCOLOGY | PROSTATE-CANCER | KIT | GENE-EXPRESSION | MUTATIONS | IMATINIB RESISTANCE | CREB-Binding Protein - biosynthesis | p300-CBP Transcription Factors - antagonists & inhibitors | Apoptosis - drug effects | Histone Acetyltransferases - biosynthesis | Humans | Histone Acetyltransferases - genetics | Proto-Oncogene Proteins c-kit - biosynthesis | Receptor, Platelet-Derived Growth Factor beta - genetics | CREB-Binding Protein - antagonists & inhibitors | CREB-Binding Protein - genetics | p300-CBP Transcription Factors - genetics | Gastrointestinal Stromal Tumors - pathology | p300-CBP Transcription Factors - biosynthesis | Proto-Oncogene Proteins c-kit - genetics | Gene Expression Regulation, Neoplastic - drug effects | Gastrointestinal Stromal Tumors - genetics | Cell Survival - drug effects | Transcription Factors - biosynthesis | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Benzoates - administration & dosage | Pyrazoles - administration & dosage | Gastrointestinal Stromal Tumors - drug therapy | Histone Acetyltransferases - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | DNA-Binding Proteins - biosynthesis
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8. Full Text Spatial Memory Consolidation is Associated with Induction of Several Lysine-Acetyltransferase (Histone Acetyltransferase) Expression Levels and H2B H4 Acetylation-Dependent Transcriptional Events in the Rat Hippocampus
by Bousiges, Olivier and Vasconcelos, Anne Pereira De and Neidl, Romain and Cosquer, Brigitte and Herbeaux, Karine and Panteleeva, Irina and Loeffler, Jean-Philippe and Cassel, Jean-Christophe and Boutillier, Anne-Laurence
Neuropsychopharmacology, ISSN 0893-133X, 12/2010, Volume 35, Issue 13, pp. 2521 - 2537
Numerous genetic studies have shown that the CREB-binding protein (CBP) is an essential component of long-term memory formation, through its histone... 
H2B histone | Morris water maze | memory consolidation | CREB-binding protein CBP | histone acetyltransferase | hippocampus-dependent memory | LONG-TERM-MEMORY | RUBINSTEIN-TAYBI-SYNDROME | PSYCHIATRY | ALZHEIMERS-DISEASE | COACTIVATOR CBP | SYNAPTIC PLASTICITY | NEUROSCIENCES | CHROMATIN-MODIFYING ENZYMES | MOUSE MODEL | DEACETYLASE INHIBITORS | CREB-BINDING-PROTEIN | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | E1A-Associated p300 Protein - biosynthesis | CREB-Binding Protein - biosynthesis | Maze Learning - physiology | Histone Acetyltransferases - biosynthesis | Rats, Long-Evans | Gene Expression Regulation - physiology | Rats | Spatial Behavior - physiology | Male | Hippocampus - metabolism | Animals | p300-CBP Transcription Factors - biosynthesis | Acetylation | Histones - metabolism | Hippocampus - physiology | Memory - physiology | learning & memory | hippocampus | signal transduction | neurodegeneration | histone acetylase | CREB-binding protein | Alzheimer's Disease | molecular & cellular neurobiology | Original
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9. Full Text Histone acetyltransferase PCAF accelerates apoptosis by repressing a GLI1/BCL2/BAX axis in hepatocellular carcinoma
by Gai, X and Tu, K and Li, C and Lu, Z and Roberts, L.R and Zheng, X
Cell Death and Disease, ISSN 2041-4889, 04/2015, Volume 6, Issue 4, pp. e1712 - e1712
P300/CBP-associated factor (PCAF), a histone acetyltransferase (HAT), has been found to regulate numerous cell signaling pathways controlling cell fate by... 
THERAPY | ACETYLATION | RESECTION | PATHWAY | INTERACTS | OUTCOMES | PROTEINS | BINDING | EXPRESSION | TRANSPLANTATION | CELL BIOLOGY | Humans | bcl-2-Associated X Protein - biosynthesis | Cytoplasm - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | p300-CBP Transcription Factors - genetics | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - pathology | Acetylation | bcl-2-Associated X Protein - genetics | Liver Neoplasms - genetics | Signal Transduction | Down-Regulation | bcl-2-Associated X Protein - metabolism | Transcription Factors - biosynthesis | Transcription Factors - genetics | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Transcription Factors - metabolism | p300-CBP Transcription Factors - metabolism | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Zinc Finger Protein GLI1 | Apoptosis - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | Carcinoma, Hepatocellular - metabolism | Original
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10. Full Text Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress
by Jeon, Bu-Nam and Jeon, Bu-Nam and Jeon, Bu-Nam and Kim, Min-Kyeong and Kim, Min-Kyeong and Yoon, Jae-Hyeon and Yoon, Jae-Hyeon and Kim, Min-Young and Kim, Min-Young and An, Haemin and An, Haemin and Noh, Hee-Jin and Noh, Hee-Jin and Choi, Won-Il and Choi, Won-Il and Koh, Dong-In and Koh, Dong-In and Hur, Man-Wook and Hur, Man-Wook
Nucleic Acids Research, ISSN 0305-1048, 10/2014, Volume 42, Issue 18, pp. 11447 - 11461
ZNF509 is unique among POK family proteins in that four isoforms are generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain... 
CENTER B-CELLS | PROTEIN INTERACTION MOTIF | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | TUMOR-SUPPRESSOR | HUMAN CANCER-CELLS | P53 PATHWAY | EXPRESSION | P21 | REPRESSES TRANSCRIPTION | Neoplasms - metabolism | Cell Proliferation | Transcription Factors - chemistry | Humans | Transcriptional Activation | DNA-Binding Proteins - metabolism | Retinoblastoma Protein - biosynthesis | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Protein Isoforms - metabolism | Kruppel-Like Transcription Factors - metabolism | Protein Isoforms - chemistry | HEK293 Cells | Cell Line | Promoter Regions, Genetic | Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis | Zinc Fingers | Stress, Physiological - genetics | Tumor Suppressor Protein p53 - metabolism | Transcription Factors - biosynthesis | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | p300-CBP Transcription Factors - metabolism | Cell Cycle Checkpoints | Protein Isoforms - biosynthesis | Retinoblastoma Protein - genetics | DNA Damage | DNA-Binding Proteins - biosynthesis | Protein Isoforms - genetics | Gene regulation, Chromatin and Epigenetics
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11. Full Text The methionine transamination pathway controls hepatic glucose metabolism through regulation of the GCN5 acetyltransferase and the PGC-1α transcriptional coactivator
by Tavares, Clint D.J and Sharabi, Kfir and Dominy, John E and Lee, Yoonjin and Isasa, Marta and Orozco, Jose M and Jedrychowski, Mark P and Kamenecka, Theodore M and Griffin, Patrick R and Gygi, Steven P and Puigserver, Pere
Journal of Biological Chemistry, ISSN 0021-9258, 05/2016, Volume 291, Issue 20, pp. 10635 - 10645
Methionine is an essential sulfur amino acid that is engaged in key cellular functions such as protein synthesis and is a precursor for critical metabolites... 
AMINO-ACID-METABOLISM | HOMOCYSTEINE | HOMEOSTASIS | PROTEIN | GLUCONEOGENESIS | REPRESSION | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | HISTONE ACETYLTRANSFERASE | RESTRICTION | EXPRESSION | Gene Expression Regulation, Enzymologic - drug effects | Gluconeogenesis - drug effects | Histone Acetyltransferases - biosynthesis | Humans | Liver - metabolism | Histone Acetyltransferases - genetics | Methionine - pharmacology | Transcription Factors - genetics | Hep G2 Cells | Transcription Factors - metabolism | Acetylation - drug effects | Animals | Gluconeogenesis - genetics | p300-CBP Transcription Factors - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | p300-CBP Transcription Factors - biosynthesis | Mice | acetylation | glucose-6-phosphatase (G6pc) | methionine | phosphoenolpyruvate carboxykinase (Pck1) | transcription coactivator | methionine transamination | Metabolism | gluconeogenesis | methylthiopropionic acid (MTP) | acetyltransferase | peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) (PPARGC1α)
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12. Full Text E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin κ locus
by Sakamoto, Shuji and Wakae, Kousho and Anzai, Yuki and Murai, Kiyohito and Tamaki, Nobuyuki and Miyazaki, Masaki and Miyazaki, Kazuko and Romanow, William J and Ikawa, Tomokatsu and Kitamura, Daisuke and Yanagihara, Itaru and Minato, Nagahiro and Murre, Cornelis and Agata, Yasutoshi
Journal of Immunology, ISSN 0022-1767, 06/2012, Volume 188, Issue 11, pp. 5547 - 5560
V(D)J recombination of Ig and TCR genes is strictly regulated in a lineage- and stage-specific manner by the accessibility of target gene chromatin to the... 
LOOP-HELIX PROTEINS | LIGHT-CHAIN RECOMBINATION | TRANSCRIPTION | B-LYMPHOCYTE DEVELOPMENT | V(D)J RECOMBINATION | GENE REARRANGEMENT | NONLYMPHOID CELLS | IMMUNOLOGY | INTRONIC ENHANCER | HISTONE ACETYLATION | EXPRESSION | Cell Line | Chromatin - metabolism | Basic Helix-Loop-Helix Transcription Factors - physiology | Basic Helix-Loop-Helix Transcription Factors - genetics | p300-CBP Transcription Factors - physiology | Humans | Histone Deacetylases - metabolism | Enhancer Elements, Genetic - immunology | Immunoglobulin kappa-Chains - metabolism | Germ Cells - enzymology | Drug Synergism | V(D)J Recombination - genetics | Immunoglobulin kappa-Chains - genetics | Animals | p300-CBP Transcription Factors - genetics | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | p300-CBP Transcription Factors - biosynthesis | Enhancer Elements, Genetic - genetics | Mice | Germ Cells - metabolism | Chromatin - genetics | Germ Cells - immunology
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13. Full Text Elevated SP-1 transcription factor expression and activity drives basal and hypoxia-induced Vascular Endothelial Growth Factor (VEGF) expression in non-small cell lung cancer
by Deacon, Karl and Onion, David and Kumari, Rajendra and Watson, Susan A and Knox, Alan J
Journal of Biological Chemistry, ISSN 0021-9258, 11/2012, Volume 287, Issue 47, pp. 39967 - 39981
VEGF plays a central role in angiogenesis in cancer. Non-small cell lung cancer (NSCLC) tumors have increased microvascular density, localized hypoxia, and... 
MESSENGER-RNA | SP1 ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GENE-EXPRESSION | SMOOTH-MUSCLE-CELLS | TUMOR ANGIOGENESIS | HUMAN GLIOMA | PATIENT SURVIVAL | HIF-ALPHA | BINDING | Vascular Endothelial Growth Factor A - biosynthesis | Nucleic Acid Synthesis Inhibitors - pharmacology | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Male | Vascular Endothelial Growth Factor A - genetics | Promoter Regions, Genetic - genetics | Sp1 Transcription Factor - biosynthesis | Hypoxia - metabolism | Neovascularization, Pathologic - pathology | Cell Hypoxia | p300-CBP Transcription Factors - genetics | Female | Neoplasm Proteins - genetics | Lung Neoplasms - blood supply | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - blood supply | Carcinoma, Non-Small-Cell Lung - genetics | Neoplasm Proteins - biosynthesis | Carcinoma, Non-Small-Cell Lung - metabolism | p300-CBP Transcription Factors - metabolism | Hypoxia - genetics | Histones - genetics | Sp1 Transcription Factor - genetics | Hypoxia - pathology | Cell Line, Tumor | Protein Binding | Neovascularization, Pathologic - genetics | Neovascularization, Pathologic - metabolism | Histones - metabolism | Dactinomycin - pharmacology | Gene Regulation | Angiogenesis | Vascular Endothelial Growth Factor (VEGF) | Transcription Factors | Lung Cancer | Sp1
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