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Molecular Cell, ISSN 1097-2765, 01/2008, Volume 29, Issue 1, pp. 92 - 101
Transcriptional activators, several different coactivators, and general transcription factors are necessary to access specific loci in the dense chromatin... 
DNA | UBIQUITINATION | COMPLEX | ACTIVATION | UBP8 | CHROMATIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | UBIQUITYLATION | DEUBIQUITYLATION | MESSENGER-RNA EXPORT | SAGA | CELL BIOLOGY | Transcription Factors - chemistry | p300-CBP Transcription Factors - physiology | Histone Acetyltransferases - chemistry | Humans | Recombinant Fusion Proteins - physiology | Molecular Sequence Data | Trans-Activators - chemistry | Drosophila melanogaster - genetics | Promoter Regions, Genetic - genetics | Trans-Activators - physiology | Drosophila melanogaster - metabolism | Drosophila Proteins - physiology | Endopeptidases - chemistry | Conserved Sequence | Ubiquitination - physiology | p300-CBP Transcription Factors - chemistry | Amino Acid Sequence | Cell Line | Transcription Factors - physiology | Transcription Factors, General - chemistry | Animals, Genetically Modified | Gene Silencing | Thiolester Hydrolases - physiology | RNA Polymerase II - physiology | Drosophila Proteins - chemistry | Transcription Factors - genetics | Histone Acetyltransferases - physiology | Multiprotein Complexes - physiology | Protein Interaction Mapping | Sequence Homology, Amino Acid | Transcription Factors, General - physiology | Multiprotein Complexes - chemistry | Sequence Alignment | Animals | Endopeptidases - genetics | Heterochromatin - genetics | Receptors, Androgen - genetics | Drosophila Proteins - genetics | Thiolester Hydrolases - chemistry | Transcription, Genetic - genetics | Endopeptidases - physiology | Histones | Index Medicus | p300-CBP Transcription Factors | Histone Acetyltransferases | Multiprotein Complexes | Receptors, Androgen | Recombinant Fusion Proteins | Life Sciences | Ubiquitination | Heterochromatin | Transcription, Genetic | Promoter Regions (Genetics) | Drosophila Proteins | Transcription Factors, General | Trans-Activators | Biochemistry, Molecular Biology | Thiolester Hydrolases | Transcription Factors | RNA Polymerase II | Drosophila melanogaster | Endopeptidases
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2008, Volume 29, Issue 1, pp. 102 - 111
Polycomb genes encode critical regulators of both normal stem cells and cancer stem cells. A gene signature that includes Polycomb genes and additional genes... 
DNA | METASTATIC CANCER | HISTONE H2B | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | C-MYC | GENE-EXPRESSION | BINDING DOMAIN | MYC TRANSGENIC MICE | PROTEIN COMPLEXES | SACCHAROMYCES-CEREVISIAE | MASS-SPECTROMETRY | CELL BIOLOGY | Protein Subunits | Neoplastic Stem Cells - cytology | Nuclear Proteins - analysis | Transcription Factors - chemistry | p300-CBP Transcription Factors - physiology | Humans | Recombinant Fusion Proteins - physiology | Lung Neoplasms - pathology | Gene Expression Profiling | Promoter Regions, Genetic - genetics | Trans-Activators - physiology | Proto-Oncogene Proteins c-myc - physiology | Neoplastic Stem Cells - metabolism | Ubiquitination - physiology | Cell Line, Tumor - metabolism | Cell Line, Transformed - cytology | Carcinoma, Non-Small-Cell Lung - pathology | Transcription Factors - physiology | Thiolester Hydrolases - physiology | Histone Acetyltransferases - physiology | Protein Processing, Post-Translational - physiology | Adaptor Proteins, Signal Transducing - analysis | Adaptor Proteins, Signal Transducing - physiology | Transcription, Genetic - physiology | Cell Line, Tumor - cytology | Histone Acetyltransferases - analysis | Cell Line, Transformed - metabolism | Biomarkers | Cell Cycle - physiology | p300-CBP Transcription Factors - analysis | Nuclear Proteins - physiology | Stem cells | Cancer | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2012, Volume 122, Issue 12, pp. 4727 - 4731
Journal Article
Neuron, ISSN 0896-6273, 2010, Volume 67, Issue 6, pp. 953 - 966
Neurodegenerative tauopathies characterized by hyperphosphorylated tau include frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) and... 
UBIQUITINATION | APOPTOSIS | ALZHEIMERS-DISEASE | MOUSE MODEL | PHOSPHORYLATED TAU | NEURODEGENERATION | LYSINE ACETYLATION | DEACETYLASE SIRT1 | SIRTUINS | NEUROSCIENCES | CALORIE RESTRICTION | Phosphorylation - physiology | Sirtuin 1 - metabolism | p300-CBP Transcription Factors - physiology | Tauopathies - genetics | Humans | tau Proteins - metabolism | Cerebral Cortex - cytology | Sirtuin 1 - genetics | Tauopathies - etiology | Transfection - methods | Ubiquitination - drug effects | tau Proteins - genetics | Time Factors | Neurons - metabolism | Phosphorylation - drug effects | Protein Synthesis Inhibitors - pharmacology | Neurons - drug effects | Disease Models, Animal | Animals, Newborn | Immunoprecipitation - methods | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Mice, Transgenic | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods | Mutation - genetics | Rats, Sprague-Dawley | Cycloheximide - pharmacology | Gene Expression Regulation - drug effects | Acetylation - drug effects | Tauopathies - metabolism | Animals | Analysis of Variance | Models, Biological | Mice | Carbazoles - pharmacology | Viral antibodies | Neurosciences | Nervous system diseases | Neurons | Analysis | Antibodies | Histones | Acetates | Alzheimer's disease | Proteins | Enzymes | Amino acids | Grants | Neurodegeneration | Rodents | Index Medicus | Acetylation | proteasome-mediated degradation | tauopathy | sirtuin | ubiquitine | FTDP-17 | post-translational modification | deacetylase | tau phosphorylation | acetyltransferase | protein degradation
Journal Article
Cell, ISSN 0092-8674, 09/2018, Volume 175, Issue 1, pp. 186 - 199.e19
Mutations or aberrant upregulation of EZH2 occur frequently in human cancers, yet clinical benefits of EZH2 inhibitor (EZH2i) remain unsatisfactory and limited... 
MLL1 | acetylation | crosstalk | methylation | therapy | cancer | histone | H3K27 | MAPK | EZH2 | STEM-CELLS | EZH2 INHIBITION | ERK1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | H3K27 ACETYLATION | TRANSCRIPTIONAL REGULATION | CANCER | EXPRESSION | NERVE SHEATH TUMORS | SOMATIC MUTATIONS | REVEALS | CELL BIOLOGY | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | p300-CBP Transcription Factors - physiology | Humans | Transcriptional Activation | Male | MAP Kinase Signaling System | Epigenomics - methods | Histone Code - drug effects | Myeloid-Lymphoid Leukemia Protein - physiology | Female | Gene Expression Regulation, Neoplastic - genetics | Enhancer of Zeste Homolog 2 Protein - genetics | Histone-Lysine N-Methyltransferase - genetics | Transcription Factors - physiology | Carcinogenesis - genetics | Nuclear Proteins - metabolism | Mice, SCID | Xenograft Model Antitumor Assays - methods | Transcription Factors - metabolism | Animals | Histones - genetics | Epigenesis, Genetic - genetics | Myeloid-Lymphoid Leukemia Protein - genetics | Histones - physiology | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Nuclear Proteins - physiology | Mutation | Polycomb Repressive Complex 2 - metabolism | Histone Code - genetics | Histone-Lysine N-Methyltransferase - physiology | Epigenetic inheritance | Methylation | Health aspects | Analysis | Cancer | Index Medicus
Journal Article