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Food and Chemical Toxicology, ISSN 0278-6915, 10/2015, Volume 84, pp. 125 - 132
We investigated apoptosis induced by the green tea component the epigallocatechin-3-gallate (EGCG) and the pathways underlying its activity in a colon cancer... 
p38γ/p38δ | Colon cancer | Akt | EGCG | Apoptosis | ERK | P38γ/p38δ | TRANSFORMATION | ACTIVATED PROTEIN-KINASE | P38-GAMMA | P38-DELTA | FOOD SCIENCE & TECHNOLOGY | TRAIL-MEDIATED APOPTOSIS | MECHANISMS | p38 gamma/p38 delta | POLYPHENOLS | COLORECTAL-CANCER | INFLAMMATION | TOXICOLOGY | STRESS | Apoptosis - drug effects | Colonic Neoplasms - prevention & control | Antioxidants - metabolism | Humans | Colonic Neoplasms - chemically induced | Isoenzymes - chemistry | Anticarcinogenic Agents - metabolism | Colonic Neoplasms - metabolism | Osmolar Concentration | Protein Processing, Post-Translational - drug effects | RNA Interference | Isoenzymes - metabolism | HEK293 Cells | p38 Mitogen-Activated Protein Kinases - metabolism | Food Handling | Phosphorylation - drug effects | Catechin - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Isoenzymes - genetics | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Signaling System - drug effects | Proto-Oncogene Proteins c-akt - agonists | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Catechin - analogs & derivatives | Colonic Neoplasms - enzymology | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | p38 Mitogen-Activated Protein Kinases - chemistry | Isoenzymes - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Tea - chemistry | Chemotherapy | Catechin | Green tea | Cancer | Index Medicus
Journal Article
2004, Methods in molecular biology, ISBN 9781592596713, Volume 250., xi, 332
Mitogen-activated protein kinase (MAPK) signaling cascades initiate highly significant cellular processes and are involved in a large number of diseases,... 
Transduction du signal cellulaire | Protéine kinase | Methodology | Cellular signal transduction | Research | Recherche | Protein kinases | Méthodologie | Biochemistry, general | Biochemistry | Life Sciences
Book
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2009, Volume 9, Issue 11, pp. 1038 - 1048
The p38 kinase plays a central role in inflammation, and it has been the subject of extensive efforts in both basic research and drug discovery. This review... 
C-REACTIVE PROTEIN | RHEUMATOID-ARTHRITIS | SKELETAL-MUSCLE | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | MONOCYTE-CHEMOATTRACTANT PROTEIN-1 | SPINAL NERVE LIGATION | SMOOTH-MUSCLE-CELLS | PRIMARY SENSORY NEURONS | NF-KAPPA-B | P38 MAP KINASE
Journal Article
The Journal of Pathology, ISSN 0022-3417, 06/2010, Volume 221, Issue 2, pp. 210 - 220
Water channel aquaporin 5 (AQP5) is highly expressed at the apical membrane of alveolar type I epithelial cells and confers high osmotic water permeability.... 
p38 mitogen‐activated protein kinase (p38 MAPK) | extracellular signal‐regulated protein kinase (ERK) | proliferating cell nuclear antigen (PCNA) | epidermal growth factor receptor (EGFR) | aquaporin 5 | MUC5AC | Extracellular signal-regulated protein kinase (ERK) | Aquaporin 5 | Proliferating cell nuclear antigen (PCNA) | p38 mitogen-activated protein kinase (p38 MAPK) | Epidermal growth factor receptor (EGFR) | ACTIVATED PROTEIN-KINASE | COLORECTAL CARCINOGENESIS | MUCIN | WATER CHANNELS | PATHOLOGY | TUMORS | BRAIN EDEMA | ONCOLOGY | SIGNALING PATHWAY | EPIDERMAL-GROWTH-FACTOR | SQUAMOUS-CELL CARCINOMA | GENE DISRUPTION | extracellular signal-regulated protein kinase (ERK) | Receptor, Epidermal Growth Factor - genetics | Up-Regulation | Cell Proliferation | Humans | Lung Neoplasms - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | Lung Neoplasms - pathology | Male | Signal Transduction - genetics | Aquaporin 5 - genetics | Permeability | Neoplasm Proteins - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Receptor, Epidermal Growth Factor - metabolism | Animals | Aquaporin 5 - metabolism | Proliferating Cell Nuclear Antigen - genetics | Lung Neoplasms - etiology | Mitogen-Activated Protein Kinase 3 - metabolism | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | Proliferating Cell Nuclear Antigen - metabolism | Cell Movement | Index Medicus
Journal Article
Biomaterials, ISSN 0142-9612, 2013, Volume 34, Issue 38, pp. 10028 - 10042
Abstract The regeneration capacity of the osteoporotic bones is generally lower than that of the normal bones. Current methods of bone defect treatment for... 
Advanced Basic Science | Dentistry | Osteoclastogenesis | Bioceramics | Angiogenesis | Osteogenesis | ERK/p38 signaling pathways | Strontium-substituted calcium silicate | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | PROMOTES OSTEOGENIC DIFFERENTIATION | HYDROXYAPATITE | APATITE | OVARIECTOMIZED RATS | MESENCHYMAL STEM-CELLS | KINASE PATHWAYS | RANELATE | IN-VIVO | MARROW STROMAL CELLS | Bone Regeneration - physiology | Endothelial Growth Factors - metabolism | Humans | Rats, Inbred F344 | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Silicates - chemistry | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Female | Flavonoids - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Real-Time Polymerase Chain Reaction | Calcium Compounds - chemistry | Bone Regeneration - drug effects | Cell Line | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | Strontium - chemistry | Blotting, Western | Animals | Ceramics - chemistry | Endothelial Growth Factors - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Pyridines - pharmacology | Strontium | Osteoporosis | Biological products | Analysis | Stem cells | Ceramics | Vascular endothelial growth factor | Ceramic materials | Phosphotransferases | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2013, Volume 21, Issue 21, pp. 6708 - 6717
Design, synthesis and biological evaluation of a novel series of 1,2,4-triazine derivatives coupled to the hydrazone as cytokine (IL-1β and TNF-α) production... 
1,2,4-Triazine | Anti-inflammatory activity | TNF-α | IL-1β | p38 MAPK | MAPK 1,2,4-Triazine | TNF-α p38 | ANTIINFLAMMATORY ACTIVITY | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | ACID HYDRAZIDES | TNF-alpha | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | IL-1 beta | ANALGESIC ACTIVITY | ARTHRITIS | P38 MAP KINASE | INTERLEUKIN-1-BETA IL-1-BETA PRODUCTION | AGENTS | INHIBITORS | BIOACTIVITIES | Tumor Necrosis Factor-alpha - metabolism | Triazines - therapeutic use | Humans | Structure-Activity Relationship | Triazines - toxicity | MCF-7 Cells | Interleukin-1beta - metabolism | Drug Design | Triazines - chemistry | p38 Mitogen-Activated Protein Kinases - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Binding Sites | Carrageenan - toxicity | Interleukin-1beta - antagonists & inhibitors | Protein Structure, Tertiary | Cell Survival - drug effects | Leukocytes, Mononuclear - drug effects | Cells, Cultured | Rats | Edema - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - toxicity | Hydrazones - chemistry | Animals | Signal Transduction - drug effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Leukocytes, Mononuclear - cytology | Molecular Docking Simulation | Edema - chemically induced | p38 Mitogen-Activated Protein Kinases - chemistry | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 12/2012, Volume 72, Issue 24, pp. 6393 - 6402
Journal Article
Circulation, ISSN 0009-7322, 04/2017, Volume 135, Issue 21, pp. 2041 - 2057
BACKGROUND—Hypertensive ventricular remodeling is a common cause of heart failure. However, the molecular mechanisms regulating ventricular remodeling remain... 
Heart failure | Fibroblast | P38 mitogenactivated protein kinases | Activating transcription factor 3 | FIBROSIS | heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIOMYOPATHY | p38 mitogen-activated protein kinases | BETA | HYPERTROPHY | fibroblast | INHIBITION | INFLAMMATION | DISEASE | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | CELL | activating transcription factor 3 | ATF3 | Fibroblasts - enzymology | Hypertrophy, Left Ventricular - enzymology | Ventricular Function, Left | Heart Failure - enzymology | Humans | Heart Failure - physiopathology | Male | MAP Kinase Kinase 3 - genetics | Heart Failure - prevention & control | Ventricular Remodeling | Time Factors | Hypertension - chemically induced | p38 Mitogen-Activated Protein Kinases - metabolism | Acetylation | Angiotensin II | Binding Sites | Heart Failure - etiology | Activating Transcription Factor 3 - genetics | Disease Models, Animal | Promoter Regions, Genetic | Genetic Predisposition to Disease | Signal Transduction | Hypertrophy, Left Ventricular - etiology | Hypertrophy, Left Ventricular - prevention & control | Activating Transcription Factor 3 - deficiency | Cells, Cultured | Myocardium - pathology | Fibroblasts - pathology | Activating Transcription Factor 3 - metabolism | MAP Kinase Kinase 3 - metabolism | Mice, Knockout | Myocardium - enzymology | Phenotype | Animals | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Fibrosis | Protein Kinase Inhibitors - pharmacology | Histones - metabolism | Hypertrophy, Left Ventricular - physiopathology | Transforming Growth Factor beta - metabolism | Histone Deacetylase 1 - metabolism | Index Medicus | Abridged Index Medicus | p38 MAPK | cardiac fibroblast
Journal Article
Oncogene, ISSN 0950-9232, 03/2008, Volume 27, Issue 13, pp. 1916 - 1929
Photodynamic therapy (PDT) is an anticancer approach utilizing a light-absorbing molecule and visible light irradiation to generate, in the presence of O-2,... 
p38 | Microarrays | Photodynamic therapy | p38(MAPK) | SIGNALING PATHWAYS | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | INDUCED APOPTOSIS | photodynamic therapy | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MESSENGER-RNA STABILIZATION | ENDOPLASMIC-RETICULUM STRESS | microarrays | P38 MAP KINASE | CELL BIOLOGY | EPITHELIAL-CELLS | ONCOLOGY | GENETICS & HEREDITY | Oligonucleotide Array Sequence Analysis | Oxidative Stress | Photosensitizing Agents - therapeutic use | Humans | Gene Expression Profiling | RNA, Messenger - metabolism | Photochemotherapy | Perylene - therapeutic use | Radiation-Sensitizing Agents - therapeutic use | Urinary Bladder Neoplasms - genetics | Urinary Bladder Neoplasms - pathology | Biomarkers, Tumor - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Cell Death - drug effects | Perylene - analogs & derivatives | Signal Transduction | RNA, Small Interfering - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | Protein Kinase C - antagonists & inhibitors | Urinary Bladder Neoplasms - drug therapy | Reverse Transcriptase Polymerase Chain Reaction | Cell Movement - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Apoptosis | Genetics | Cellular biology | Molecular biology | Gene expression | Cancer | Tumors | Index Medicus
Journal Article