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Journal Article
by Park, SE and Sapkota, K and Kim, S and Kim, H and Kim, SJ
British Journal of Pharmacology, ISSN 0007-1188, 10/2011, Volume 164, Issue 3, pp. 1008 - 1025
BACKGROUND AND PURPOSE Kaempferol, a dietary flavonoid and phyto‐oestrogen, is known to have anti‐inflammatory properties. Microglial activation has been... 
mitogen‐activated protein kinases | NF‐κB | kaempferol | neuroinflammation | AKT | lipopolysaccharide | microglia | NF-κB | mitogen-activated protein kinases | NITRIC-OXIDE SYNTHASE | ALZHEIMERS-DISEASE | NEURODEGENERATIVE DISEASES | MATRIX METALLOPROTEINASES | NF-kappa B | TOLL-LIKE RECEPTORS | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | NF-KAPPA-B | INNATE IMMUNITY | PARKINSONS-DISEASE | Microglia - metabolism | Reactive Oxygen Species - metabolism | Dinoprostone - biosynthesis | NF-kappa B - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Cyclooxygenase 2 - genetics | Nitric Oxide Synthase Type II - antagonists & inhibitors | Protein Binding - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Toll-Like Receptor 4 - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-1beta - antagonists & inhibitors | Cell Survival - drug effects | Nitric Oxide - biosynthesis | NF-kappa B - antagonists & inhibitors | Phagocytosis - drug effects | Microglia - drug effects | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Nitric Oxide - antagonists & inhibitors | Cells, Cultured | Microglia - enzymology | Matrix Metalloproteinase 3 - metabolism | Toll-Like Receptor 4 - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Animals | Nitric Oxide Synthase Type II - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | Matrix Metalloproteinase Inhibitors | Kaempferols - pharmacology | Mice | Dinoprostone - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Kinases | Index Medicus | Research Papers
Journal Article
Lancet, The, ISSN 0140-6736, 2014, Volume 384, Issue 9949, pp. 1187 - 1195
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 05/2011, Volume 300, Issue 5, pp. 1181 - 1192
Enhanced vascular arginase activity impairs endothelium-dependent vasorelaxation by decreasing l-arginine availability to endothelial nitric oxide (NO)... 
Endothelial nitric oxide synthase dysfunction | PHYSIOLOGY | BLOOD-PRESSURE | P38 MAP KINASE | CELL BIOLOGY | INCREASED ARGINASE ACTIVITY | NITRIC-OXIDE PRODUCTION | INHIBITION | MOUSE MODEL | endothelial nitric oxide synthase dysfunction | CARDIOVASCULAR-DISEASE | SMOOTH-MUSCLE-CELLS | HYPERTENSIVE-RATS | CONTRIBUTES | Phosphorylation | Endothelial Cells | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Endothelium, Vascular - drug effects | Endothelium, Vascular - enzymology | GTP-Binding Protein alpha Subunits, G12-G13 - antagonists & inhibitors | Simvastatin - pharmacology | Angiotensin II Type 1 Receptor Blockers - pharmacology | rho-Associated Kinases - antagonists & inhibitors | Cattle | Arginase - antagonists & inhibitors | Amides - pharmacology | Cell Line | rho-Associated Kinases - physiology | Angiotensin II - pharmacology | p38 Mitogen-Activated Protein Kinases - physiology | RNA, Small Interfering - pharmacology | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | GTP-Binding Protein alpha Subunits, Gq-G11 - antagonists & inhibitors | Imidazoles - pharmacology | Animals | Signal Transduction - drug effects | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction - physiology | Mice | Pyridines - pharmacology | Arginase - physiology | Angiotensin II - physiology | Boronic Acids - pharmacology | Abnormalities | Angiotensin | Physiological aspects | Vascular endothelium | Genetic aspects | Research | Mitogen-activated protein kinases | Proteins | Signal transduction | Nitric oxide | Rodents | Cardiovascular disease | ACE inhibitors | Cells | Index Medicus | Vascular Biology
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2004, Volume 24, Issue 45, pp. 10211 - 10222
To investigate whether activation of mitogen-activated protein kinase ( MAPK) in damaged and/or undamaged primary afferents participates in neuropathic pain... 
Brain-derived neurotrophic factor | p38 mitogen-activated protein kinase | TRPV1 | Extracellular signal-regulated protein kinase | C-Jun N-terminal kinase/stress-activated protein kinase | Neuropathic pain | c-Jun N-terminal kinase/stress-activated protein kinase | NEUROTROPHIC FACTOR | WALLERIAN DEGENERATION | DRG NEURONS | NECROSIS-FACTOR-ALPHA | DORSAL-ROOT GANGLION | NEUROSCIENCES | RAT MODEL | neuropathic pain | MESSENGER-RNA | SCIATIC-NERVE | brain-derived neurotrophic factor | PRIMARY SENSORY NEURONS | extracellular signal-regulated protein kinase | Brain-Derived Neurotrophic Factor - genetics | MAP Kinase Signaling System - physiology | Nitriles - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Ion Channels - genetics | Stress, Mechanical | Male | Ganglia, Spinal - cytology | Ion Channels - physiology | Ganglia, Spinal - enzymology | Ligation | Brain-Derived Neurotrophic Factor - physiology | Brain-Derived Neurotrophic Factor - biosynthesis | Spinal Nerves - injuries | Pyrazoles - pharmacology | Butadienes - pharmacology | Ion Channels - biosynthesis | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Hot Temperature - adverse effects | Mitogen-Activated Protein Kinase 1 - physiology | p38 Mitogen-Activated Protein Kinases - physiology | TRPV Cation Channels | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation - physiology | Rats | Imidazoles - pharmacology | Neurons, Afferent - physiology | Rats, Sprague-Dawley | Anthracenes - pharmacology | Mitogen-Activated Protein Kinase 3 - physiology | Hyperalgesia - physiopathology | Animals | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - physiology | Hyperalgesia - etiology | Pyridines - pharmacology | Rhizotomy | Enzyme Activation | Lumbar Vertebrae | Physical Stimulation - adverse effects | Index Medicus | c-Jun N-terminal kinase | Cellular | stress-activated protein kinase | Molecular
Journal Article
Cancer Research, ISSN 0008-5472, 01/2010, Volume 70, Issue 2, pp. 832 - 841
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2007, Volume 282, Issue 21, pp. 15439 - 15450
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, pp. e0127885 - e0127885
Recent studies have suggested that 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) increases macrophage phagocytosis through adenosine... 
TGF-BETA | 5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBOSIDE | SIGNALING PATHWAY | MAP KINASE | MULTIDISCIPLINARY SCIENCES | INHIBITS EFFEROCYTOSIS | ACUTE LUNG INJURY | SAURURUS-CHINENSIS | BACTERIAL PHAGOCYTOSIS | MUSCLE-CELLS | EXPRESSION | AMP-Activated Protein Kinases - metabolism | Apoptosis - drug effects | Apoptosis - genetics | Male | Phagocytosis - genetics | Aminoimidazole Carboxamide - pharmacology | Gene Knockdown Techniques | Ribonucleotides - pharmacology | Phosphorylation - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Phagocytosis - drug effects | MAP Kinase Kinase Kinases - genetics | AMP-Activated Protein Kinases - antagonists & inhibitors | Macrophages, Peritoneal - enzymology | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | MAP Kinase Kinase Kinases - metabolism | Enzyme Activation - drug effects | Animals | Aminoimidazole Carboxamide - analogs & derivatives | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mice | Mice, Inbred BALB C | Pyridines - pharmacology | Enzyme Activation - genetics | AMP-Activated Protein Kinases - genetics | Bone morphogenetic proteins | Inflammation | Adenylic acid | Macrophages | Transforming growth factors | Mitogens | Protein kinases | Apoptosis | Phosphorylation | Transforming growth factor-b | Homeostasis | AKT protein | Activation | Kinases | AMP-activated protein kinase | Medical schools | Proteins | Phagocytes | Cell activation | Pain | Penicillin | Cell cycle | Inhibition | Growth factors | Adenosine | Adenosine monophosphate | AMP | TAK1 protein | Neutrophils | Dipyridamole | MAP kinase | Leukocytes (neutrophilic) | siRNA | 1-Phosphatidylinositol 3-kinase | Medicine | Studies | Inhibitors | Thymocytes | Lungs | Adenosine kinase | Stem cells | Anesthesiology | Laboratory animals | Transporter | Phagocytosis | Index Medicus
Journal Article