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Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2008, Volume 121, Issue 4, pp. 893 - 902.e2
.... Objectives We sought to study the activation of the mitogen-activated protein kinase (MAPK) signaling pathway in airway cells... 
Allergy and Immunology | mitogen-activated protein kinase | chemokines | epithelial function | bronchial biopsy | Asthma | LUNG | BRONCHIAL EPITHELIAL-CELLS | MAP KINASE | asthma | PROLIFERATION | IMMUNOLOGY | ALLERGY | GM-CSF | PATHWAY | INFLAMMATION | SMOOTH-MUSCLE-CELLS | DIFFERENTIATION | EXPRESSION | Phosphorylation | Bronchi - enzymology | Humans | Middle Aged | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Enzyme Induction - immunology | MAP Kinase Signaling System - immunology | Enzyme Activation - immunology | Respiratory Mucosa - pathology | Chemokines - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - biosynthesis | Adult | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Bronchi - pathology | Respiratory Mucosa - secretion | Chemokines - biosynthesis | Chemokines - secretion | Mitogen-Activated Protein Kinase 1 - physiology | p38 Mitogen-Activated Protein Kinases - physiology | Asthma - enzymology | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Respiratory Mucosa - enzymology | Mitogen-Activated Protein Kinase 3 - physiology | Mitogen-Activated Protein Kinase 1 - biosynthesis | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinases - physiology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Asthma - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Protein kinases | Proteins | Studies | Signal transduction | Cell culture | Rodents | Cloning | Smooth muscle | Kinases
Journal Article
Journal of clinical immunology, ISSN 1573-2592, 2011, Volume 31, Issue 3, pp. 472 - 478
...), signal transducer and activator of transcription 3 (STAT3), p38 mitogen-activated protein kinase (p38MAPK... 
Medical Microbiology | Biomedicine | Immunology | Internal Medicine | Infectious Diseases | activation markers | cytokines | B cells | PROTEIN-KINASE | TRANSDUCER | RECEPTOR | PROLIFERATION | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | DEFICIENCY | PI3K/AKT | IMMUNE-RESPONSES | T-CELLS | Autoimmunity | Interleukin-6 - analysis | Janus Kinase 2 - biosynthesis | Mitogen-Activated Protein Kinase 3 - analysis | Humans | p38 Mitogen-Activated Protein Kinases - biosynthesis | p38 Mitogen-Activated Protein Kinases - analysis | Dose-Response Relationship, Drug | Signal Transduction - immunology | Inflammation - metabolism | Mitogen-Activated Protein Kinases - analysis | Mitogen-Activated Protein Kinase 3 - biosynthesis | Mitogen-Activated Protein Kinase 6 - analysis | Leptin - pharmacology | Phosphorylation - drug effects | Interleukin-10 - analysis | B-Lymphocytes - metabolism | Janus Kinase 2 - analysis | Enzyme-Linked Immunosorbent Assay | Lymphocyte Activation | Cells, Cultured | Mitogen-Activated Protein Kinases - biosynthesis | Receptors, Leptin - immunology | STAT3 Transcription Factor - analysis | Inflammation - immunology | Tumor Necrosis Factor-alpha - analysis | STAT3 Transcription Factor - biosynthesis | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Mitogen-Activated Protein Kinase 6 - biosynthesis | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Receptors, Leptin - metabolism | Tumor Necrosis Factor-alpha - biosynthesis
Journal Article
Scientific reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 1480 - 11
.... In normal retinas, intravitreal injection of BaCl2 significantly increased GFAP expression in Muller cells, which was eliminated by co-injecting mitogen-activated protein kinase (MAPK) inhibitor U0126... 
ACTIVATED PROTEIN-KINASE | MESSENGER-RNA | POTASSIUM CHANNELS | MULTIDISCIPLINARY SCIENCES | GANGLION-CELLS | MEMBRANE CONDUCTANCE | INTRAOCULAR-PRESSURE | OCULAR HYPERTENSION MODEL | GLIAL-CELLS | EXPERIMENTAL GLAUCOMA | NUCLEUS-ACCUMBENS | Retina - drug effects | Glial Fibrillary Acidic Protein - genetics | Retina - metabolism | Nitriles - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Ependymoglial Cells - metabolism | Gliosis - chemically induced | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Ocular Hypertension - metabolism | Glial Fibrillary Acidic Protein - metabolism | Ocular Hypertension - drug therapy | Gliosis - pathology | Mitogen-Activated Protein Kinase 1 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Ependymoglial Cells - pathology | Disease Models, Animal | Barium Compounds - administration & dosage | Butadienes - pharmacology | Gliosis - genetics | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Ocular Hypertension - pathology | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | Proto-Oncogene Proteins c-fos - metabolism | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Potassium Channels, Inwardly Rectifying - genetics | Ependymoglial Cells - drug effects | Rats, Sprague-Dawley | Ocular Hypertension - genetics | Cyclic AMP Response Element-Binding Protein - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Chlorides - administration & dosage | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cyclic AMP Response Element-Binding Protein - metabolism | Proto-Oncogene Proteins c-fos - genetics | Gliosis - drug therapy | Protein Kinase Inhibitors - pharmacology | Chronic Disease | Potassium Channels, Inwardly Rectifying - metabolism | Retina - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Transcription factors | Potassium channels (inwardly-rectifying) | P elements | Glial fibrillary acidic protein | c-Jun protein | Extracellular signal-regulated kinase | MAP kinase | Retina | Injection | Cyclic AMP response element-binding protein | Kinases | Proteins | Signal transduction | Gliosis | Protein kinase | Rodents | c-Fos protein | Glutamic acid receptors (metabotropic)
Journal Article
by Li, H and Xu, H and Zhou, Y and Zhang, J and Long, C and Li, S and Chen, S and Zhou, J.-M and Shao, F
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2007, Volume 315, Issue 5814, pp. 1000 - 1003
Journal Article
Applied Biochemistry and Biotechnology, ISSN 0273-2289, 1/2015, Volume 175, Issue 2, pp. 657 - 665
.... These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2... 
Biochemistry, general | Biotechnology | Chemistry | Inflammation | Extract from Grateloupia lanceolata | Macrophage | MAPK signaling | GAMMA | RAW264.7 CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPOPOLYSACCHARIDE | CYTOKINE | MICE | Plant Extracts - chemistry | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Plant Extracts - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | Mitogen-Activated Protein Kinase 9 - genetics | Interleukin-1beta - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-1beta - antagonists & inhibitors | Cell Line | Nitric Oxide - biosynthesis | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Mitogen-Activated Protein Kinase 9 - metabolism | Nitric Oxide - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - metabolism | Gene Expression Regulation | Rhodophyta - chemistry | p38 Mitogen-Activated Protein Kinases - genetics | Macrophages - cytology | Macrophages - metabolism | Animals | Anti-Inflammatory Agents - chemistry | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 2016, Volume 36, Issue 6, pp. 1122 - 1131
OBJECTIVE—The c-Jun NH2-terminal kinases (JNK) are regulated by a wide variety of cellular stresses and have been implicated in apoptotic signaling... 
atherosclerosis | apoptosis | macrophages | MAP kinase signaling system | endoplasmic reticulum stress | SURVIVAL | ACTIVATION | PHOSPHORYLATION | BAD | SIGNAL-TRANSDUCTION | OBESITY | NH2-TERMINAL KINASE (JNK)1 | INSULIN-RESISTANCE | INFLAMMATION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | REQUIREMENT | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Apoptosis - drug effects | Bone Marrow Cells - enzymology | Atherosclerosis - genetics | Mitogen-Activated Protein Kinase 9 - genetics | PTEN Phosphohydrolase - antagonists & inhibitors | Atherosclerosis - enzymology | Hypercholesterolemia - enzymology | Diet, High-Fat | Bone Marrow Transplantation | Receptors, LDL - deficiency | bcl-Associated Death Protein - metabolism | Bone Marrow Cells - drug effects | Mitogen-Activated Protein Kinase 8 - genetics | Aortic Diseases - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Aorta - enzymology | Aortic Diseases - pathology | Disease Models, Animal | Receptors, LDL - genetics | Atherosclerosis - pathology | Genetic Predisposition to Disease | Macrophages - pathology | Signal Transduction | Cell Survival | Aorta - drug effects | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Cells, Cultured | PTEN Phosphohydrolase - metabolism | Plaque, Atherosclerotic | Mitogen-Activated Protein Kinase 9 - deficiency | Macrophages - enzymology | Mice, Knockout | Aorta - pathology | Mitogen-Activated Protein Kinase 8 - deficiency | Aortic Diseases - genetics | Phenotype | Animals | Endoplasmic Reticulum Stress | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | Macrophages - drug effects | Protein Kinase Inhibitors - pharmacology | Hypercholesterolemia - genetics
Journal Article
PloS one, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0167071
...) in podocytes, cDNAs and cell lysate of cultured human podocytes were used for the expression of nAChR mRNAs and proteins, respectively... 
ACETYLCHOLINE-RECEPTORS | CIGARETTE-SMOKING | NMDA RECEPTORS | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | RENAL-FUNCTION | INJURY | DIABETIC-NEPHROPATHY | CHRONIC KIDNEY-DISEASE | CARDIOVASCULAR MORBIDITY | ROS PRODUCTION | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Apoptosis - genetics | Male | Nicotinic Antagonists - pharmacology | Spin Labels | Reactive Oxygen Species - agonists | Nicotine - pharmacology | MAP Kinase Kinase 4 - metabolism | Cyclic N-Oxides - pharmacology | Mitogen-Activated Protein Kinase 1 - genetics | Female | MAP Kinase Kinase 4 - antagonists & inhibitors | Membrane Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Receptors, Nicotinic - metabolism | Podocytes - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Membrane Proteins - genetics | Tissue Culture Techniques | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Nicotine - antagonists & inhibitors | Podocytes - cytology | Reactive Oxygen Species - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Podocytes - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Acetylcysteine - pharmacology | MAP Kinase Kinase 4 - genetics | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Oxidative Stress - drug effects | Receptors, Nicotinic - genetics | Cell Line, Transformed | Mitogen-Activated Protein Kinase 1 - metabolism | Oxidative stress | Physiological aspects | Research | Health aspects | Health/Alcohol and other Drugs/Information/Nicotine and Tobacco | Nicotine | Smoking | Apoptosis | Cell proliferation | Reactive oxygen species | Phosphorylation | Laboratories | Syngeneic grafts | Downstream effects | Tempol | Acetylcysteine | Superoxide dismutase | mRNA | Medical schools | Antioxidants | Proteins | Receptors | Rodents | Mesangial cells | Localization | Medical research | Oxygen | Extracellular signal-regulated kinase | JNK protein | Permeability | Gene expression | Cigarette smoking | Signaling | Molecular modelling | Inhibitors | Acetylcholine receptors (nicotinic) | In vivo methods and tests | Kidney diseases | Diabetes | Kidney transplantation
Journal Article
by Park, SE and Sapkota, K and Kim, S and Kim, H and Kim, SJ
British Journal of Pharmacology, ISSN 0007-1188, 10/2011, Volume 164, Issue 3, pp. 1008 - 1025
BACKGROUND AND PURPOSE Kaempferol, a dietary flavonoid and phyto‐oestrogen, is known to have anti‐inflammatory properties. Microglial activation has been... 
mitogen‐activated protein kinases | NF‐κB | kaempferol | neuroinflammation | AKT | lipopolysaccharide | microglia | NF-κB | mitogen-activated protein kinases | NITRIC-OXIDE SYNTHASE | ALZHEIMERS-DISEASE | NEURODEGENERATIVE DISEASES | MATRIX METALLOPROTEINASES | NF-kappa B | TOLL-LIKE RECEPTORS | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | NF-KAPPA-B | INNATE IMMUNITY | PARKINSONS-DISEASE | Microglia - metabolism | Reactive Oxygen Species - metabolism | Dinoprostone - biosynthesis | NF-kappa B - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Cyclooxygenase 2 - genetics | Nitric Oxide Synthase Type II - antagonists & inhibitors | Protein Binding - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Toll-Like Receptor 4 - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-1beta - antagonists & inhibitors | Cell Survival - drug effects | Nitric Oxide - biosynthesis | NF-kappa B - antagonists & inhibitors | Phagocytosis - drug effects | Microglia - drug effects | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Nitric Oxide - antagonists & inhibitors | Cells, Cultured | Microglia - enzymology | Matrix Metalloproteinase 3 - metabolism | Toll-Like Receptor 4 - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Animals | Nitric Oxide Synthase Type II - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | Matrix Metalloproteinase Inhibitors | Kaempferols - pharmacology | Mice | Dinoprostone - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Kinases | Research Papers
Journal Article
Cell death & disease, ISSN 2041-4889, 2016, Volume 7, Issue 2, pp. e2119 - e2119
.... P38 mitogen-activated protein kinase (MAPK) activity is also dysregulated in advanced prostate cancer... 
MULTIPLE-MYELOMA | BREAST-CANCER | APOPTOSIS | ACTIVATED PROTEIN-KINASE | OSTEOBLAST DIFFERENTIATION | BONE METASTASES | PATHWAY | ANTAGONIST DKK1 | STRESS-RESPONSE | EXPRESSION | CELL BIOLOGY | Wnt3A Protein - metabolism | Mitogen-Activated Protein Kinase 14 - antagonists & inhibitors | Humans | Male | RNA, Messenger - metabolism | Mitogen-Activated Protein Kinase 12 - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Mitogen-Activated Protein Kinase 11 - metabolism | Prostatic Neoplasms | Antibodies, Neutralizing - immunology | Mitogen-Activated Protein Kinase 12 - metabolism | Mitogen-Activated Protein Kinase 14 - metabolism | RNA Interference | Cell Differentiation | p38 Mitogen-Activated Protein Kinases - metabolism | Pyrazoles - pharmacology | Mitogen-Activated Protein Kinase 11 - genetics | Mitogen-Activated Protein Kinase 12 - antagonists & inhibitors | Wnt3A Protein - genetics | Intercellular Signaling Peptides and Proteins - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | Mitogen-Activated Protein Kinase 11 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 14 - genetics | Down-Regulation - drug effects | Naphthalenes - pharmacology | Signal Transduction - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Pyridines - pharmacology | RNA, Small Interfering | Intercellular Signaling Peptides and Proteins - immunology | Proteins | Metastasis | Cellular biology | Kinases | Prostate cancer | Original
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2009, Volume 284, Issue 19, pp. 13165 - 13173
Journal Article
Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
... (mitogen-activated protein kinase) isoforms, PI-103 and wortmannin to be used in parallel to inhibit phosphatidylinositol (phosphoinositide... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2