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Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2009, Volume 29, Issue 47, pp. 14741 - 14751
Alzheimer's disease (AD) is characterized by memory impairment, neurochemically by accumulation of beta-amyloid peptide (namely Abeta(1-42)) and... 
Memory Disorders - physiopathology | Presynaptic Terminals - pathology | Rats, Wistar | Peptide Fragments - toxicity | Nerve Degeneration - physiopathology | Male | Adenosine A2 Receptor Antagonists | Neuroprotective Agents - pharmacology | Nerve Degeneration - prevention & control | Caffeine - pharmacology | Receptor, Adenosine A2A - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Cell Survival - physiology | Cell Survival - drug effects | Alzheimer Disease - physiopathology | Maze Learning - physiology | Presynaptic Terminals - drug effects | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Cells, Cultured | Alzheimer Disease - drug therapy | Phosphodiesterase Inhibitors - pharmacology | Rats | Pyrimidines - pharmacology | Receptor, Adenosine A2A - metabolism | Maze Learning - drug effects | Down-Regulation - genetics | Mice, Knockout | Triazoles - pharmacology | Amyloid beta-Peptides - antagonists & inhibitors | Synaptic Membranes - drug effects | p38 Mitogen-Activated Protein Kinases - drug effects | Animals | Memory Disorders - drug therapy | Peptide Fragments - antagonists & inhibitors | Alzheimer Disease - metabolism | Presynaptic Terminals - metabolism | Mice | Synaptic Membranes - metabolism | Nerve Degeneration - drug therapy | Memory Disorders - chemically induced | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2004, Volume 24, Issue 13, pp. 3370 - 3378
The mechanisms of action of human synthetic and naturally secreted cell-derived amyloid beta-peptide (Abeta)(1-42) on the induction of long-term potentiation... 
Metabotropic glutamate receptors | Cdk5 | JNK | LTP | Amyloid β-protein | Alzheimer's disease | p38 MAPK | Hippocampus | NEURONAL APOPTOSIS | hippocampus | ALZHEIMERS-DISEASE | MAP KINASE | metabotropic glutamate receptors | amyloid beta-protein | SYNAPTIC PLASTICITY | FREQUENCY STIMULATION | AREA CA1 | NEUROSCIENCES | IN-VITRO | PATHWAY | MICE | PRECURSOR PROTEIN | Receptors, Metabotropic Glutamate - drug effects | Cyclin-Dependent Kinases - metabolism | Amyloid beta-Peptides - pharmacology | Humans | Amyloid beta-Peptides - secretion | Peptide Fragments - pharmacology | Receptors, Metabotropic Glutamate - metabolism | Hippocampus - drug effects | Ovary - cytology | Excitatory Postsynaptic Potentials - drug effects | Cyclin-Dependent Kinases - drug effects | Dose-Response Relationship, Drug | Excitatory Postsynaptic Potentials - physiology | Long-Term Potentiation - drug effects | Amyloid beta-Peptides - genetics | JNK Mitogen-Activated Protein Kinases | Long-Term Potentiation - physiology | Receptor, Metabotropic Glutamate 5 | Female | Electric Stimulation - methods | Peptide Fragments - genetics | p38 Mitogen-Activated Protein Kinases | CHO Cells | Ovary - metabolism | Cricetinae | Enzyme Inhibitors - pharmacology | Peptide Fragments - secretion | Rats | Excitatory Amino Acid Antagonists - pharmacology | Cyclin-Dependent Kinase 5 | Animals | Ovary - secretion | Hippocampus - physiology | In Vitro Techniques | Mitogen-Activated Protein Kinases - drug effects | Mitogen-Activated Protein Kinases - metabolism | Plasticity | Development | amyloid β-protein | Repair
Journal Article
Translational Research, ISSN 1931-5244, 2016, Volume 170, pp. 57 - 72
Stroke pathogenesis involves complex oxidative stress-related pathways. The nuclear factor erythroid-2–related factor 2 (Nrf2) and heme oxygenase 1 (HO-1)... 
Internal Medicine | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | REPERFUSION INJURY | GLUCOSE DEPRIVATION | BLOOD-BRAIN-BARRIER | NEUROPROTECTION | MEDICINE, GENERAL & INTERNAL | NRF2 | NEURONS | HEME OXYGENASE-1 | MEDICAL LABORATORY TECHNOLOGY | PLATELET ACTIVATION | MOLECULAR-MECHANISMS | Endothelium, Vascular - cytology | Cerebral Infarction - drug therapy | Heme Oxygenase-1 - metabolism | Rats, Wistar | Brain Ischemia - metabolism | Endothelium, Vascular - drug effects | Male | Stroke - pathology | Cerebral Infarction - metabolism | Neuroprotective Agents - pharmacology | Membrane Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Cerebral Infarction - pathology | Diterpenes - pharmacology | Reproducibility of Results | Stroke - prevention & control | Brain Edema - metabolism | Endothelial Cells - metabolism | Brain Edema - pathology | Mice, Inbred C57BL | Cells, Cultured | Stroke - metabolism | p38 Mitogen-Activated Protein Kinases - drug effects | Animals | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Brain Ischemia - drug therapy | NF-E2-Related Factor 2 - metabolism | Brain Ischemia - pathology | Brain Edema - drug therapy | Endothelial Cells - pathology | Endothelial Cells - drug effects | Medical colleges | Brain | Nervous system diseases | RNA | College graduates | Glucose | Dextrose | Endothelium | Stroke (Disease) | Ischemia | Heme | Health aspects | Mitogens | Protein kinases | Injuries
Journal Article
Journal Article
Bone, ISSN 8756-3282, 2001, Volume 28, Issue 5, pp. 491 - 498
Bone morphogenetic protein (BMP)-2, a member of the transforming growth factor-β (TGF-β) superfamily, is able to induce osteoblastic differentiation of C2C12... 
C2C12 | MAPK | Bone morphogenetic protein (BMP)-2 | Osteoblast differentiation | Gene Expression Regulation, Enzymologic - drug effects | MAP Kinase Signaling System - physiology | Mitogen-Activated Protein Kinase Kinases - genetics | Bone Development - physiology | Cells, Cultured - cytology | Osteocalcin - genetics | Stem Cells - cytology | Gene Expression Regulation, Enzymologic - physiology | MAP Kinase Kinase 3 | RNA, Messenger - metabolism | Stem Cells - metabolism | Bone Morphogenetic Proteins - metabolism | Protein-Tyrosine Kinases - genetics | Female | Osteoblasts - cytology | Bone Morphogenetic Proteins - pharmacology | Cell Differentiation - physiology | p38 Mitogen-Activated Protein Kinases | Transforming Growth Factor beta | RNA, Messenger - drug effects | Cells, Cultured - drug effects | Cricetinae | Alkaline Phosphatase - genetics | Bone Development - drug effects | Bone Morphogenetic Protein 2 | Osteoblasts - drug effects | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Flavonoids | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 8 | Cell Differentiation - drug effects | Stem Cells - drug effects | Cells, Cultured - metabolism | Mice | Pyridines - pharmacology | Osteoblasts - metabolism | Mitogen-Activated Protein Kinases - drug effects | Mitogen-Activated Protein Kinases - metabolism
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2016, Volume 311, Issue 4, pp. H871 - H880
We previously reported that endoplasmic reticulum (ER) stress is induced in the subfornical organ (SFO) and the hypothalamic paraventricular nucleus (PVN) of... 
Heart failure | Brain | Sympathetic activity | Hypothalamic paraventricular nucleus | Mitogen-activated protein kinase | Subfornical organ | Endoplasmic reticulum stress | heart failure | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | INDUCED PHOSPHORYLATION | MYOCARDIAL-INFARCTION | ER STRESS | subfornical organ | KINASE | RATS | sympathetic activity | KAPPA-B | brain | endoplasmic reticulum stress | hypothalamic paraventricular nucleus | mitogen-activated protein kinase | UNFOLDED PROTEIN RESPONSE | PERIPHERAL VASCULAR DISEASE | UP-REGULATION | Cholagogues and Choleretics - pharmacology | Tumor Necrosis Factor-alpha - genetics | Heart Failure - physiopathology | Male | NF-KappaB Inhibitor alpha - genetics | Peptidyl-Dipeptidase A - drug effects | Interleukin-1beta - genetics | Sympathetic Nervous System - physiopathology | RNA, Messenger - metabolism | Activating Transcription Factor 6 - genetics | Subfornical Organ - drug effects | Brain - metabolism | Heat-Shock Proteins - genetics | Inflammation - metabolism | Receptor, Angiotensin, Type 1 - genetics | Cyclooxygenase 2 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Real-Time Polymerase Chain Reaction | Echocardiography | Signal Transduction | Rats | Cyclooxygenase 2 - drug effects | Heart Failure - metabolism | Rats, Sprague-Dawley | Blotting, Western | Brain - drug effects | Tumor Necrosis Factor-alpha - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Endoplasmic Reticulum Stress | Paraventricular Hypothalamic Nucleus - metabolism | Infusions, Intraventricular | Mitogen-Activated Protein Kinases - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Interleukin-1beta - drug effects | Sympathetic Nervous System - drug effects | Mitogen-Activated Protein Kinase 1 - drug effects | X-Box Binding Protein 1 - drug effects | Sympathetic Nervous System - metabolism | Transcription Factor RelA - genetics | Activating Transcription Factor 6 - drug effects | Mitogen-Activated Protein Kinase 3 - drug effects | Taurochenodeoxycholic Acid - pharmacology | Peptidyl-Dipeptidase A - genetics | Renin-Angiotensin System | Receptor, Angiotensin, Type 1 - drug effects | RNA, Messenger - drug effects | Subfornical Organ - metabolism | Heat-Shock Proteins - drug effects | Activating Transcription Factor 4 - genetics | Activating Transcription Factor 4 - drug effects | NF-KappaB Inhibitor alpha - drug effects | Paraventricular Hypothalamic Nucleus - drug effects | p38 Mitogen-Activated Protein Kinases - drug effects | Animals | Transcription Factor RelA - drug effects | X-Box Binding Protein 1 - genetics | Mitogen-Activated Protein Kinases - metabolism | Physiological aspects | Cellular signal transduction | Endoplasmic reticulum | Health aspects | Mitogen-activated protein kinases | Cardiovascular Neurohormonal Regulation
Journal Article
Journal Article
MOLECULAR BIOLOGY OF THE CELL, ISSN 1059-1524, 05/2003, Volume 14, Issue 5, pp. 2071 - 2087
Activation of the mitotic checkpoint by chemotherapeutic drugs such as taxol causes mammalian cells to arrest in mitosis and then undergo apoptosis. However,... 
PATHWAYS | BREAST-CANCER CELLS | HELA-CELLS | INDUCED APOPTOSIS | BAX | SPINDLE ASSEMBLY CHECKPOINT | JUN KINASE | CYTOCHROME-C RELEASE | MICROTUBULE DYNAMICS | CASPASE ACTIVATION | CELL BIOLOGY
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 08/2016, Volume 311, Issue 2, pp. E530 - E541
To better understand the role of irisin in humans, we examined the effects of irisin in human primary adipocytes and fresh human subcutaneous white adipose... 
Irisin | Thermogenesis | Human white adipose tissue | Brown adipose tissue | Adipocytes browning | Osteogenesis | Adipogenesis | Immunohistochemistry | Thermogenesis - genetics | Up-Regulation | Phosphoproteins - drug effects | Extracellular Signal-Regulated MAP Kinases - drug effects | Adipocytes, Brown - metabolism | Adipogenesis - drug effects | Humans | Middle Aged | Extracellular Signal-Regulated MAP Kinases - metabolism | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Young Adult | Adipocytes, White - drug effects | Exercise | Cell Respiration - drug effects | Adult | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Adipogenesis - genetics | Real-Time Polymerase Chain Reaction | Osteogenesis - genetics | STAT3 Transcription Factor - metabolism | RNA, Messenger - drug effects | Uncoupling Protein 1 - drug effects | Fibronectins - pharmacology | Signal Transduction | Adipocytes, Brown - drug effects | Uncoupling Protein 1 - metabolism | Osteoblasts - drug effects | Osteogenesis - drug effects | Cells, Cultured | Mitochondria - metabolism | Mitochondria - drug effects | Subcutaneous Fat - cytology | Blotting, Western | Obesity - metabolism | p38 Mitogen-Activated Protein Kinases - drug effects | Cell Differentiation - drug effects | STAT3 Transcription Factor - drug effects | Adolescent | Aged | Thermogenesis - drug effects | Osteoblasts - metabolism | Adipocytes, White - metabolism | Fat cells | Growth | Physiological aspects | Bones | Physiological research | Research
Journal Article