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The Journal of clinical investigation, ISSN 0021-9738, 2010, Volume 120, Issue 7, pp. 2457 - 2473
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 1480 - 11
.... In normal retinas, intravitreal injection of BaCl2 significantly increased GFAP expression in Muller cells, which was eliminated by co-injecting mitogen-activated protein kinase (MAPK) inhibitor U0126... 
ACTIVATED PROTEIN-KINASE | MESSENGER-RNA | POTASSIUM CHANNELS | MULTIDISCIPLINARY SCIENCES | GANGLION-CELLS | MEMBRANE CONDUCTANCE | INTRAOCULAR-PRESSURE | OCULAR HYPERTENSION MODEL | GLIAL-CELLS | EXPERIMENTAL GLAUCOMA | NUCLEUS-ACCUMBENS | Retina - drug effects | Glial Fibrillary Acidic Protein - genetics | Retina - metabolism | Nitriles - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Ependymoglial Cells - metabolism | Gliosis - chemically induced | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Ocular Hypertension - metabolism | Glial Fibrillary Acidic Protein - metabolism | Ocular Hypertension - drug therapy | Gliosis - pathology | Mitogen-Activated Protein Kinase 1 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Ependymoglial Cells - pathology | Disease Models, Animal | Barium Compounds - administration & dosage | Butadienes - pharmacology | Gliosis - genetics | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Ocular Hypertension - pathology | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | Proto-Oncogene Proteins c-fos - metabolism | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Potassium Channels, Inwardly Rectifying - genetics | Ependymoglial Cells - drug effects | Rats, Sprague-Dawley | Ocular Hypertension - genetics | Cyclic AMP Response Element-Binding Protein - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Chlorides - administration & dosage | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cyclic AMP Response Element-Binding Protein - metabolism | Proto-Oncogene Proteins c-fos - genetics | Gliosis - drug therapy | Protein Kinase Inhibitors - pharmacology | Chronic Disease | Potassium Channels, Inwardly Rectifying - metabolism | Retina - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Transcription factors | Potassium channels (inwardly-rectifying) | P elements | Glial fibrillary acidic protein | c-Jun protein | Extracellular signal-regulated kinase | MAP kinase | Retina | Injection | Cyclic AMP response element-binding protein | Kinases | Proteins | Signal transduction | Gliosis | Protein kinase | Rodents | c-Fos protein | Glutamic acid receptors (metabotropic)
Journal Article
by Zhang, Y and Li, R and Meng, Y and Li, S and Donelan, W and Zhao, Y and Qi, L and Zhang, M and Wang, X and Cui, T and Yang, L.-J and Tang, D
Diabetes (New York, N.Y.), ISSN 1939-327X, 2013, Volume 63, Issue 2, pp. 514 - 525
.... This effect was possibly mediated by irisin-induced phosphorylation of the p38 mitogen-activated protein kinase (p38 MAPK... 
OBESITY | GENE | ENDOCRINOLOGY & METABOLISM | MUSCLE | RECEPTOR | PROLIFERATION | DIFFERENTIATION | EXPRESSION | FAT-CELL | EXERCISE | ADIPOSE-TISSUE | MAP Kinase Signaling System - physiology | Nitriles - pharmacology | Adipose Tissue, White - metabolism | Caenorhabditis elegans Proteins - metabolism | Adipocytes - cytology | Male | Adipocytes - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | Recombinant Proteins | Extracellular Signal-Regulated MAP Kinases - genetics | Pichia - metabolism | Membrane Transport Proteins - genetics | Dietary Fats | Membrane Transport Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Butadienes - pharmacology | Fibronectins - pharmacology | Fibronectins - administration & dosage | Mice, Inbred C57BL | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | 3T3-L1 Cells | Rats, Sprague-Dawley | Animals | Adipocytes - metabolism | Pichia - genetics | Protein Binding | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Fibronectins - genetics | Mice | Pyridines - pharmacology | Mutation | Mitochondrial Uncoupling Proteins | Caenorhabditis elegans Proteins - genetics | Adipose Tissue, White - drug effects | Physiological research | Cellular signal transduction | Research | Identification and classification | Membrane proteins
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 39, pp. 16161 - 16173
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association, ISSN 1079-5642, 05/2003, Volume 23, Issue 5, pp. 795 - 801
OBJECTIVE—We investigated the comparative roles of mitogen-activated protein (MAP) kinases, including c-Jun NH2-terminal kinase... 
Vascular smooth muscle cell | Platelet-derived growth factor | Proliferation | Gene transfer | Gene expression | PATHWAYS | FACTOR-BETA | gene transfer | proliferation | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | platelet-derived growth factor | RAT MODEL | PDGF | DISEASE | PERIPHERAL VASCULAR DISEASE | vascular smooth muscle cell | ACTIVATED PROTEIN-KINASES | C-JUN | HEMATOLOGY | SIGNAL-REGULATED KINASE | gene expression | SMOOTH-MUSCLE CELLS | Mitogen-Activated Protein Kinase Kinases - genetics | Hyperplasia | Cyclins - genetics | Mitogen-Activated Protein Kinase Kinases - physiology | Recombinant Fusion Proteins - physiology | Mitogen-Activated Protein Kinase 1 - deficiency | Male | Transforming Growth Factor beta - biosynthesis | Cyclins - biosynthesis | MAP Kinase Kinase 4 | Mitogen-Activated Protein Kinase 1 - genetics | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | JNK Mitogen-Activated Protein Kinases | Plasminogen Activator Inhibitor 1 - genetics | p38 Mitogen-Activated Protein Kinases | Carotid Artery Injuries - pathology | Muscle, Smooth, Vascular - drug effects | Transforming Growth Factor beta1 | Transduction, Genetic | Mitogen-Activated Protein Kinase 1 - physiology | Cyclin-Dependent Kinase Inhibitor p21 | Proto-Oncogene Proteins c-sis | Rats | Chemokine CCL2 - genetics | Cell Cycle Proteins - biosynthesis | Mitogen-Activated Protein Kinase Kinases - deficiency | Platelet-Derived Growth Factor - pharmacology | Muscle, Smooth, Vascular - cytology | Rats, Sprague-Dawley | Cell Division - drug effects | Cyclin-Dependent Kinase Inhibitor p27 | Gene Expression Regulation - drug effects | Mitogen-Activated Protein Kinases - deficiency | Cell Movement - drug effects | Plasminogen Activator Inhibitor 1 - biosynthesis | Animals | Transforming Growth Factor beta - genetics | Tunica Intima - pathology | Mitogen-Activated Protein Kinases - physiology | Chemokine CCL2 - biosynthesis | Mitogen-Activated Protein Kinases - genetics | Tumor Suppressor Proteins - biosynthesis | Muscle, Smooth, Vascular - enzymology | Mitogen-Activated Protein Kinase 3
Journal Article
Hypertension, ISSN 0194-911X, 02/2011, Volume 57, Issue 2, pp. 245 - 254
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 2016, Volume 36, Issue 6, pp. 1122 - 1131
OBJECTIVE—The c-Jun NH2-terminal kinases (JNK) are regulated by a wide variety of cellular stresses and have been implicated in apoptotic signaling... 
atherosclerosis | apoptosis | macrophages | MAP kinase signaling system | endoplasmic reticulum stress | SURVIVAL | ACTIVATION | PHOSPHORYLATION | BAD | SIGNAL-TRANSDUCTION | OBESITY | NH2-TERMINAL KINASE (JNK)1 | INSULIN-RESISTANCE | INFLAMMATION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | REQUIREMENT | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Apoptosis - drug effects | Bone Marrow Cells - enzymology | Atherosclerosis - genetics | Mitogen-Activated Protein Kinase 9 - genetics | PTEN Phosphohydrolase - antagonists & inhibitors | Atherosclerosis - enzymology | Hypercholesterolemia - enzymology | Diet, High-Fat | Bone Marrow Transplantation | Receptors, LDL - deficiency | bcl-Associated Death Protein - metabolism | Bone Marrow Cells - drug effects | Mitogen-Activated Protein Kinase 8 - genetics | Aortic Diseases - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Aorta - enzymology | Aortic Diseases - pathology | Disease Models, Animal | Receptors, LDL - genetics | Atherosclerosis - pathology | Genetic Predisposition to Disease | Macrophages - pathology | Signal Transduction | Cell Survival | Aorta - drug effects | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Cells, Cultured | PTEN Phosphohydrolase - metabolism | Plaque, Atherosclerotic | Mitogen-Activated Protein Kinase 9 - deficiency | Macrophages - enzymology | Mice, Knockout | Aorta - pathology | Mitogen-Activated Protein Kinase 8 - deficiency | Aortic Diseases - genetics | Phenotype | Animals | Endoplasmic Reticulum Stress | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | Macrophages - drug effects | Protein Kinase Inhibitors - pharmacology | Hypercholesterolemia - genetics
Journal Article
Applied Biochemistry and Biotechnology, ISSN 0273-2289, 1/2015, Volume 175, Issue 2, pp. 657 - 665
.... These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2... 
Biochemistry, general | Biotechnology | Chemistry | Inflammation | Extract from Grateloupia lanceolata | Macrophage | MAPK signaling | GAMMA | RAW264.7 CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPOPOLYSACCHARIDE | CYTOKINE | MICE | Plant Extracts - chemistry | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Plant Extracts - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | Mitogen-Activated Protein Kinase 9 - genetics | Interleukin-1beta - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-1beta - antagonists & inhibitors | Cell Line | Nitric Oxide - biosynthesis | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Mitogen-Activated Protein Kinase 9 - metabolism | Nitric Oxide - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - metabolism | Gene Expression Regulation | Rhodophyta - chemistry | p38 Mitogen-Activated Protein Kinases - genetics | Macrophages - cytology | Macrophages - metabolism | Animals | Anti-Inflammatory Agents - chemistry | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2008, Volume 283, Issue 45, pp. 31246 - 31255
The strength and duration of mitogen-activated protein kinase signaling is regulated through phosphorylation and dephosphorylation by dedicated dual-specificity kinases and phosphatases, respectively... 
SIGNAL-REGULATED KINASE-2 | OVEREXPRESSION | ACTIVATED PROTEIN-KINASE | PHOSPHATASE 2A | ERK2 | SPECIFICITY | GENETIC INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC-HYPERTROPHY | P38 MAPK | MUSCLE CELL-PROLIFERATION | Dual Specificity Phosphatase 6 - genetics | Fibroblasts - enzymology | Cell Proliferation | Cell Survival - genetics | Apoptosis - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | Cardiomyopathy, Hypertrophic - enzymology | Myocytes, Cardiac - enzymology | Phosphorylation - genetics | MAP Kinase Signaling System - genetics | Mice, Mutant Strains | Mitogen-Activated Protein Kinase 1 - genetics | Embryo, Mammalian - enzymology | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Embryo, Mammalian - pathology | Mitogen-Activated Protein Kinase 3 - genetics | Disease Susceptibility - enzymology | p38 Mitogen-Activated Protein Kinases - genetics | Myocardium - pathology | Mitogen-Activated Protein Kinase 7 - genetics | Mitogen-Activated Protein Kinase 7 - metabolism | Fibroblasts - pathology | Dual Specificity Phosphatase 6 - metabolism | Myocytes, Cardiac - pathology | Myocardium - enzymology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Mice | Cardiomyopathy, Hypertrophic - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Mechanisms of Signal Transduction
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2016, Volume 311, Issue 4, pp. H871 - H880
...) and the hypothalamic paraventricular nucleus (PVN) of heart failure (HF) rats and is reduced by inhibition of mitogen-activated protein kinase (MAPK) signaling... 
Heart failure | Brain | Sympathetic activity | Hypothalamic paraventricular nucleus | Mitogen-activated protein kinase | Subfornical organ | Endoplasmic reticulum stress | heart failure | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | INDUCED PHOSPHORYLATION | MYOCARDIAL-INFARCTION | ER STRESS | subfornical organ | KINASE | RATS | sympathetic activity | KAPPA-B | brain | endoplasmic reticulum stress | hypothalamic paraventricular nucleus | mitogen-activated protein kinase | UNFOLDED PROTEIN RESPONSE | PERIPHERAL VASCULAR DISEASE | UP-REGULATION | Cholagogues and Choleretics - pharmacology | Tumor Necrosis Factor-alpha - genetics | Heart Failure - physiopathology | Male | NF-KappaB Inhibitor alpha - genetics | Peptidyl-Dipeptidase A - drug effects | Interleukin-1beta - genetics | Sympathetic Nervous System - physiopathology | RNA, Messenger - metabolism | Activating Transcription Factor 6 - genetics | Subfornical Organ - drug effects | Brain - metabolism | Heat-Shock Proteins - genetics | Inflammation - metabolism | Receptor, Angiotensin, Type 1 - genetics | Cyclooxygenase 2 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Real-Time Polymerase Chain Reaction | Echocardiography | Signal Transduction | Rats | Cyclooxygenase 2 - drug effects | Heart Failure - metabolism | Rats, Sprague-Dawley | Blotting, Western | Brain - drug effects | Tumor Necrosis Factor-alpha - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Endoplasmic Reticulum Stress | Paraventricular Hypothalamic Nucleus - metabolism | Infusions, Intraventricular | Mitogen-Activated Protein Kinases - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Interleukin-1beta - drug effects | Sympathetic Nervous System - drug effects | Mitogen-Activated Protein Kinase 1 - drug effects | X-Box Binding Protein 1 - drug effects | Sympathetic Nervous System - metabolism | Transcription Factor RelA - genetics | Activating Transcription Factor 6 - drug effects | Mitogen-Activated Protein Kinase 3 - drug effects | Taurochenodeoxycholic Acid - pharmacology | Peptidyl-Dipeptidase A - genetics | Renin-Angiotensin System | Receptor, Angiotensin, Type 1 - drug effects | RNA, Messenger - drug effects | Subfornical Organ - metabolism | Heat-Shock Proteins - drug effects | Activating Transcription Factor 4 - genetics | Activating Transcription Factor 4 - drug effects | NF-KappaB Inhibitor alpha - drug effects | Paraventricular Hypothalamic Nucleus - drug effects | p38 Mitogen-Activated Protein Kinases - drug effects | Animals | Transcription Factor RelA - drug effects | X-Box Binding Protein 1 - genetics | Mitogen-Activated Protein Kinases - metabolism | Physiological aspects | Cellular signal transduction | Endoplasmic reticulum | Health aspects | Mitogen-activated protein kinases | Cardiovascular Neurohormonal Regulation
Journal Article
BMC Genomics, ISSN 1471-2164, 11/2011, Volume 12, Issue 1, pp. 574 - 574
Journal Article