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phosphatidylinositol 3-kinase (152) 152
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cell biology (131) 131
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phosphatidylinositol 3-kinases - metabolism (117) 117
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p85 alpha (34) 34
cells (33) 33
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molecular sequence data (32) 32
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phosphatidylinositol 3-kinases - chemistry (32) 32
amino acid sequence (31) 31
apoptosis (30) 30
class ia phosphatidylinositol 3-kinase - metabolism (29) 29
phosphatidylinositol 3-kinases (29) 29
phosphoproteins - metabolism (29) 29
proto-oncogene proteins c-akt - metabolism (29) 29
transfection (29) 29
kinases (28) 28
endocrinology & metabolism (26) 26
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1-phosphatidylinositol 3-kinase (24) 24
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insulin receptor substrate proteins (24) 24
phosphatidylinositol 3'-kinase (24) 24
pi 3-kinase (24) 24
sh2 domains (24) 24
signal-transduction (24) 24
tyrosine phosphorylation (24) 24
protein subunits - metabolism (23) 23
pten (23) 23
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ras (19) 19
block-copolymers (18) 18
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Development, ISSN 0950-1991, 2008, Volume 135, Issue 24, pp. 3989 - 3993
Journal Article
FEBS Journal, ISSN 1742-464X, 02/2015, Volume 282, Issue 3, pp. 579 - 594
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2016, Volume 113, Issue 42, pp. E6418 - E6426
Journal Article
by Zhao, L and Vogt, PK
ONCOGENE, ISSN 0950-9232, 09/2008, Volume 27, Issue 41, pp. 5486 - 5496
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2008, Volume 105, Issue 7, pp. 2652 - 2657
Journal Article
Biomaterials, ISSN 0142-9612, 2013, Volume 34, Issue 37, pp. 9602 - 9614
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 07/2019, Volume 855, pp. 137 - 148
Selective pharmacologic targeting of cell cycle regulators is a potent anti-cancer therapeutic strategy. Here, we show that caspase-3-mediated p21 cleavage... 
PTEN | Akt | S phase arrest | Triptolide | p85α | RNA-POLYMERASE-II | APOPTOSIS | PHOSPHORYLATION | TRANSCRIPTION | p85 alpha | PHOSPHOINOSITIDE 3-KINASE | CANCER | CYCLIN-DEPENDENT KINASES | TFIIH | TUMOR-SUPPRESSOR | PHARMACOLOGY & PHARMACY | CASPASE
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 1, pp. 210 - 218.e9
Journal Article
Experimental Cell Research, ISSN 0014-4827, 01/2019, Volume 374, Issue 1, pp. 231 - 248
Retinal pigment epithelial cells (RPEs), a pigmented cell layer in the outer retina, are constantly exposed to photo-oxidative stress. Autophagy relieves the... 
Protein aggregation | Drusen | LAMPTOR1/p18 | Age-related macular degeneration | p85α | mTOR | TFEB | Autophagy | Neurodegenerative disorders | OXIDATIVE STRESS | ACTIVATION | PROTEIN | MECHANISM | MACULAR DEGENERATION | p85 alpha | CELL BIOLOGY | MITOCHONDRIAL-DNA DAMAGE | PATHOGENESIS | MTORC1 | ONCOLOGY | EXPRESSION
Journal Article
International Journal of Molecular Sciences, ISSN 1422-0067, 04/2019, Volume 20, Issue 9, p. 2105
Citrate is a key intermediate of the tricarboxylic acid cycle and acts as an allosteric signal to regulate the production of cellular ATP. An elevated... 
citrate | p85α | cyclin B1 | CDK1 | PTEN | G2/M | Akt
Journal Article
Oncotarget, ISSN 1949-2553, 12/2018, Volume 9, Issue 97, pp. 36975 - 36992
The phosphatidylinositol 3-kinase (PI3K) pathway plays a key role in regulating cell growth and cell survival and is frequently deregulated in cancer cells.... 
PTEN | P85α | Structure | Lipid binding | Regulatory mechanism
Journal Article
Cell, ISSN 0092-8674, 2006, Volume 125, Issue 4, pp. 733 - 747
Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe... 
CATALYTIC SUBUNIT | ACTIVATION | P85 REGULATORY SUBUNIT | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | EMBRYONIC LETHALITY | MICE | ATM | PHOSPHOINOSITIDE 3-KINASE INHIBITORS | INSIGHTS | CELL BIOLOGY
Journal Article