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PLOS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, p. e0131735
Inhibiting the synthesis of endogenous prostaglandins with nonsteroidal anti-inflammatory drugs exacerbates arterial hypertension. We hypothesized that the... 
PRIMARY HYPERTROPHIC OSTEOARTHROPATHY | HORMONE INTERACTIONS | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | RENAL MEDULLA | MULTIDISCIPLINARY SCIENCES | CYCLOOXYGENASE-2 INHIBITORS | ENDOTHELIAL-CELLS | DAHL RATS | ANGIOTENSIN-II | CONVERTING ENZYME-INHIBITORS | SLCO2A1 GENE | Organic Anion Transporters - antagonists & inhibitors | Triazines - pharmacology | para-Aminobenzoates - pharmacology | Rats | Hypertension - drug therapy | Sodium - metabolism | Hypertension - physiopathology | Organic Anion Transporters - metabolism | Hypertension - metabolism | para-Aminobenzoates - administration & dosage | Animals | Sodium - urine | Thromboxanes - metabolism | Triazines - administration & dosage | Blood Pressure - drug effects | Mice | Vasodilation - drug effects | Disease Models, Animal | Prostaglandins - metabolism | Hypertension | Prostaglandins | Blood pressure | Drinking water | Prostaglandin E2 | Biochemistry | Arachidonic acid | Drug development | Inactivation | Blood | Vasodilation | Metabolites | Rodents | Physiology | Inhibition | Bathing | Urine | Excretion | Antiinflammatory agents | Deactivation | Serotonin | Therapeutic applications | Vasoconstriction | Pharmacology | Inflammation | Metabolism | Gene expression | Fatty acids | Medicine | Sodium | Womens health | Coronary vessels | Mutation | Laboratory animals | Transporter
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0133615
Peripheral ischemia, resulting from diminished arterial flow and defective local vascularization, is one of the main causes of impaired wound healing in... 
LIMB | IN-VITRO | KERATINOCYTE PROLIFERATION | ENDOTHELIAL DYSFUNCTION | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | FOOT ULCERS | MODEL | BLOOD-FLOW | EXPRESSION | CD34-POSITIVE CELLS | Neovascularization, Physiologic - drug effects | Antigens, CD34 - metabolism | Skin - metabolism | para-Aminobenzoates - pharmacology | Humans | Male | Re-Epithelialization - physiology | Regional Blood Flow - drug effects | Bone Marrow Cells - drug effects | Diabetes Mellitus, Experimental - metabolism | Wound Healing - drug effects | Endothelial Progenitor Cells - metabolism | Cell Line | Organic Anion Transporters - antagonists & inhibitors | Triazines - pharmacology | Endothelial Progenitor Cells - drug effects | Rats | Re-Epithelialization - drug effects | Rats, Sprague-Dawley | Streptozocin - pharmacology | Skin - blood supply | Neovascularization, Physiologic - physiology | Animals | Keratinocytes - drug effects | Hindlimb - blood supply | Keratinocytes - metabolism | Wound Healing - physiology | Hindlimb - metabolism | Bone Marrow Cells - metabolism | Skin - drug effects | Prostaglandins - metabolism | Streptozocin | Prostaglandin E2 | Diabetic neuropathy | Experiments | Blood | Vascularization | Degradation | Angiogenesis | Prostaglandins | Ischemia | Rodents | Animal tissues | Bone marrow | Inhibition | Vascular endothelial growth factor | CD34 antigen | Medical research | Wound healing | Diabetes mellitus | Keratinocytes | Blood vessels | Gene expression | Progenitor cells | Blood flow | Flow | Medicine | Blood circulation | Perfusion | Ulcers | Cell lines | Stem cells | Cells (biology) | Healing | Diabetes | Transporter | Cell migration | Veins & arteries
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 1/2013, Volume 71, Issue 1, pp. 73 - 83
Benzaldehyde dimethane sulfonate (BEN, DMS612, NSC281612) is an alkylating agent with activity against renal cell carcinoma and is being evaluated clinically.... 
Stability | Alkylators | Oncology | Metabolism | Aldehyde dehydrogenase | Degradation | Medicine & Public Health | Renal cell carcinoma | BEN metabolism | Cell lines | Cancer Research | Pharmacology/Toxicology | Mass spectrometry | HPLC | Cancer | PHARMACOKINETICS | ONCOLOGY | PHARMACOLOGY & PHARMACY | AGENTS | Temperature | para-Aminobenzoates - pharmacology | Humans | Half-Life | Mesylates - pharmacokinetics | Antineoplastic Agents, Alkylating - pharmacology | Antineoplastic Agents, Alkylating - administration & dosage | Glucuronides - blood | Time Factors | Inhibitory Concentration 50 | Female | Benzaldehydes - pharmacokinetics | Carcinoma, Renal Cell - drug therapy | Aldehyde Dehydrogenase - metabolism | Tandem Mass Spectrometry - methods | para-Aminobenzoates - pharmacokinetics | Reproducibility of Results | Carcinoma, Renal Cell - pathology | Mesylates - administration & dosage | Benzaldehydes - pharmacology | Antineoplastic Agents, Alkylating - pharmacokinetics | para-Aminobenzoates - administration & dosage | Animals | Benzaldehydes - administration & dosage | Mesylates - pharmacology | Cell Line, Tumor | Kidney Neoplasms - pathology | Mice | Chromatography, Liquid - methods | In Vitro Techniques | Kidney Neoplasms - drug therapy | Hydrogen-Ion Concentration | Benzoic acid | Medical colleges | Drugstores | Carcinoma, Renal cell | Aldehydes | Organic acids
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2017, Volume 60, Issue 23, pp. 9703 - 9723
Journal Article
Journal Article
Journal of Hematology and Oncology, ISSN 1756-8722, 07/2017, Volume 10, Issue 1, pp. 133 - 17
The two murine double minute (MDM) family members MDM2 and MDMX are at the center of an intense clinical assessment as molecular target for the management of... 
MDM2 | Pediatric tumors | Clinical studies | Leukemia | MDMX | Pharmacological inhibitor | MULTIPLE-MYELOMA | GENE-MUTATIONS | ACUTE MYELOID-LEUKEMIA | P53 PATHWAY | TP53 MUTATIONS | B-CELL LYMPHOMA | ONCOLOGY | PHASE-I TRIAL | CHRONIC LYMPHOCYTIC-LEUKEMIA | HIGHLY POTENT | HEMATOLOGY | CHROMOSOMAL-ABERRATIONS | Proto-Oncogene Proteins c-mdm2 - genetics | Protein Interaction Maps - drug effects | para-Aminobenzoates - pharmacology | Humans | Spiro Compounds - therapeutic use | Antineoplastic Agents - therapeutic use | Hematologic Neoplasms - pathology | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Imidazolines - therapeutic use | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Child | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Hematologic Neoplasms - metabolism | Molecular Targeted Therapy - methods | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Suppressor Protein p53 - metabolism | Imidazolines - pharmacology | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Animals | Signal Transduction - drug effects | Nuclear Proteins - antagonists & inhibitors | para-Aminobenzoates - therapeutic use | Hematologic Neoplasms - drug therapy | Indoles - therapeutic use | Hematologic Neoplasms - genetics | Spiro Compounds - pharmacology | Pediatrics | Medical research | Clinical trials | Medicine, Experimental | Development and progression | Tumor proteins | Cancer | Cell proliferation | MDM2 protein | Animal models | Hematology | Medical innovations | p53 Protein | Genomics | Multiple myeloma | Genomes | Proteins | Side effects | Chemotherapy | Cell cycle | Lymphomas | Mutation | Chromosomes | Regulatory proteins | Tumors
Journal Article
RESPIRATORY RESEARCH, ISSN 1465-993X, 08/2019, Volume 20, Issue 1, pp. 180 - 12
Journal Article
Journal of Hematology and Oncology, ISSN 1756-8722, 06/2017, Volume 10, Issue 1, pp. 123 - 10
Purpose: MDM2 and CDK4 are frequently co-amplified in well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS). We aimed to determine whether combined... 
MDM2 | CDK4 | Well-differentiated/dedifferentiated liposarcomas | SURVIVAL | APOPTOSIS | P53 PATHWAY | BREAST-CANCER | PALBOCICLIB | ONCOLOGY | NUTLIN-3A | CHRONIC LYMPHOCYTIC-LEUKEMIA | RETROPERITONEAL LIPOSARCOMA | INHIBITORS | ANTAGONISTS | HEMATOLOGY | Apoptosis - drug effects | para-Aminobenzoates - pharmacology | Humans | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Liposarcoma - metabolism | Female | Antineoplastic Agents - pharmacology | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Pyridines - therapeutic use | Liposarcoma - drug therapy | Liposarcoma - pathology | Piperazines - therapeutic use | Cyclin-Dependent Kinase 4 - metabolism | Piperazines - pharmacology | Drug Synergism | Animals | Cell Cycle Checkpoints - drug effects | para-Aminobenzoates - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Pyridines - pharmacology | Liposarcoma | Physiological aspects | Development and progression | Genetic aspects | Research | Drug therapy | Gene expression | Flow cytometry | MDM2 protein | Animal models | Growth rate | Clinical trials | Antagonists | Breast cancer | Patients | Cancer therapies | Survival | Cyclin-dependent kinase 4 | Western blotting | Signal transduction | Gene amplification | Cell cycle | Xenografts | Chromosomes | Apoptosis | Tumors
Journal Article
Journal Article