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1. Full Text Cancer enzyme affects Parkinson's disease New insights identify a possible target for slowing neurodegeneration
by Brundin, P and Wyse, R
SCIENCE, ISSN 0036-8075, 11/2018, Volume 362, Issue 6414, pp. 521 - 522
PARTHANATOS | MULTIDISCIPLINARY SCIENCES | Care and treatment | Parkinson's disease
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2. Full Text Mitochondrial mechanisms of neuronal cell death: Potential the rapeutics
by Dawson, Ted M and Dawson, Valina L
Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 01/2017, Volume 57, pp. 437 - 454
Poly (ADP-ribose) polymerase | Stroke | Neurodegeneration | Apoptosis-inducing factor | Parthanatos | Apoptosis
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3. Full Text Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012
by Galluzzi, L and Vitale, I and Abrams, J.M and Alnemri, E.S and Baehrecke, E.H and Blagosklonny, M.V and Dawson, T.M and Dawson, V.L and El-Deiry, W.S and Fulda, S and Gottlieb, E and Green, D.R and Hengartner, M.O and Kepp, O and Knight, R.A and Kumar, S and Lipton, S.A and Lu, X and Madeo, F and Malorni, W and Mehlen, P and Nũez, G and Peter, M.E and Piacentini, M and Rubinsztein, D.C and Shi, Y and Simon, H.-U and Vandenabeele, P and White, E and Yuan, J and Zhivotovsky, B and Melino, G and Kroemer, G
Cell Death and Differentiation, ISSN 1350-9047, 01/2012, Volume 19, Issue 1, pp. 107 - 120
In 2009, the Nomenclature Committee on Cell Death (NCCD) proposed a set of recommendations for the definition of distinct cell death morphologies and for the... 
autophagy | parthanatos | TP53 | mitochondrial membrane permeabilization | necroptosis | TNFR1 | APOPTOSIS-INDUCING FACTOR | POLY(ADP-RIBOSE) PAR POLYMER | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOTIC CATASTROPHE | STRESS-INDUCED APOPTOSIS | CELL BIOLOGY | CYTOCHROME-C | MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | BREAST-CANCER CELLS | NEUTROPHIL EXTRACELLULAR TRAPS | NECROSIS-FACTOR TNF | CASPASE-MEDIATED CLEAVAGE | Animals | Caspases - metabolism | Mitosis | Humans | Cells - metabolism | Terminology as Topic | Autophagy | Apoptosis | Cells - pathology | Necrosis | Review
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4. Full Text Iduna protects HT22 cells by inhibiting parthanatos: The role of the p53-MDM2 pathway
by Xu, Haoxiang and Li, Xin and Wu, Xiuquan and Yang, Yuefan and Dai, Shuhui and Lei, Tao and Jing, Da and Luo, Erping and Luo, Peng
Experimental Cell Research, ISSN 0014-4827, 11/2019, Volume 384, Issue 1, p. 111547
Traumatic brain injury (TBI) is common and often fatal in current times. The role of poly(adenosine diphosphate-ribose) polymerase (PARP)-induced cell death... 
PARP | Traumatic brain injury | p53-MDM2 pathway | Parthanatos | Iduna | AIF | OXIDATIVE STRESS | ACTIVATION | HIPPOCAMPAL | DEATH | MESSENGER | P53 | CELL BIOLOGY | INTERACT | TRAUMATIC BRAIN-INJURY | ONCOLOGY | DEGRADATION | EXPRESSION
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5. Full Text Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis
by Shaida A. Andrabi and George K. E. Umanah and Calvin Chang and Daniel A. Stevens and Senthilkumar S. Karuppagounder and Jean-Philippe Gagné and Guy G. Poirier and Valina L. Dawson and Ted M. Dawson
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2014, Volume 111, Issue 28, pp. 10209 - 10214
Excessive poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) activation kills cells via a cell-death process designated "parthanatos" in which PAR induces the... 
Lactates | Enzymes | Energy metabolism | Neurons | Cell death | Glycolysis | Antibodies | Cultured cells | Respiration | Oligomycins | APOPTOSIS-INDUCING FACTOR | POLYMERASE-1-DEPENDENT CELL-DEATH | PATHWAY | MULTIDISCIPLINARY SCIENCES | PAR POLYMER | PARTHANATOS | NEURONS | ISCHEMIA | HEXOKINASE II | BRAIN | Mitochondria - enzymology | Cerebral Cortex - enzymology | Cells, Cultured | Neurons - cytology | Enzyme Activation - drug effects | Cerebral Cortex - cytology | Glycolysis - drug effects | Nerve Tissue Proteins - metabolism | Glycolysis - physiology | Methylnitronitrosoguanidine - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Animals | Piperidines - pharmacology | Neurons - enzymology | Glucose - metabolism | Mice | Poly (ADP-Ribose) Polymerase-1 | Hexokinase - metabolism | Acrylamides - pharmacology | Enzyme Activation - physiology | Glucose-6-Phosphate - metabolism | NAD - metabolism | Glucose metabolism | Protein research | Research | Glutamate | Health aspects | Biological Sciences
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6. Full Text Astragaloside IV reduces neuronal apoptosis and parthanatos in ischemic injury by preserving mitochondrial hexokinase-II
by Li, Ying and Yang, Yilin and Zhao, Yunpeng and Zhang, Xiaojian and Zhang, Jingmin and Liu, Baolin and Jiao, Shujie
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2019, Volume 131, pp. 251 - 263
Cerebral ischemia induces neuronal cell death in different ways and mitochondrial dysfunction is an important cause. Astragaloside IV (AIV) is a natural... 
Cerebral ischemia | Astragaloside IV | Hexokinase-II | Parthanatos | Apoptosis | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-DEATH | EXCITOTOXICITY | PATHWAY | ENDOCRINOLOGY & METABOLISM | DYSFUNCTION | ENERGY-METABOLISM
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7. Full Text Roles of Poly(ADP-Ribose) Glycohydrolase in DNA Damage and Apoptosis
by Feng, Xiaoxing and Koh, David W
2013, International Review of Cell and Molecular Biology, ISBN 0124076963, Volume 304, 55
Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme that catalyzes the hydrolysis of poly(ADP-ribose) (PAR), an essential biopolymer that is... 
DNA-damage repair | PARG | Cell death | Poly(ADP-ribose) | PARsylation | PARP | Parthanatos | ADENOSINE-DIPHOSPHATE (HYDROXYMETHYL)PYRROLIDINEDIOL | STRAND BREAK REPAIR | BASE EXCISION-REPAIR | MITOCHONDRIAL MU-CALPAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROGRAMMED NECROSIS | CELL-DEATH PARTHANATOS | TANNIC-ACID | ADP-RIBOSE | ZINC-FINGER MOTIFS | COLON-CARCINOMA CELLS | CELL BIOLOGY | Hydrolysis | Animals | DNA Repair | Humans | DNA Damage | Glycoside Hydrolases - metabolism | Apoptosis | Poly Adenosine Diphosphate Ribose - biosynthesis | Poly Adenosine Diphosphate Ribose - chemistry
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8. Full Text Parthanatos: mitochondrial‐linked mechanisms and therapeutic opportunities
by Fatokun, Amos A and Dawson, Valina L and Dawson, Ted M
British Journal of Pharmacology, ISSN 0007-1188, 04/2014, Volume 171, Issue 8, pp. 2000 - 2016
Cells die by a variety of mechanisms. Terminally differentiated cells such as neurones die in a variety of disorders, in part, via parthanatos, a process... 
PARP‐1 | parthanatos | cell death | mitochondria | therapy | AIF | PARP-1 | POLY(ADP-RIBOSE) POLYMERASE INHIBITORS | APOPTOSIS-INDUCING-FACTOR | NITRIC-OXIDE SYNTHASE | FOCAL CEREBRAL-ISCHEMIA | DNA-DAMAGE | NEURONAL CELL-DEATH | SPINAL-CORD | ADP-RIBOSE POLYMERASE | PHARMACOLOGY & PHARMACY | PARP INHIBITORS | IN-VIVO MODELS | Poly Adenosine Diphosphate Ribose - physiology | Active Transport, Cell Nucleus - physiology | Glycoside Hydrolases - physiology | Humans | Neurodegenerative Diseases - drug therapy | Poly(ADP-ribose) Polymerases - physiology | Poly Adenosine Diphosphate Ribose - metabolism | Animals | Neurodegenerative Diseases - physiopathology | Cell Death - physiology | Apoptosis Inducing Factor - physiology | Models, Biological | Poly (ADP-Ribose) Polymerase-1 | Mitochondria - physiology | Cell Survival - physiology | Molecular Targeted Therapy - methods | Apoptosis Inducing Factor - metabolism | Mitochondrial DNA | Health aspects | Sugars | Monosaccharides | Energy, Injury & Beyond | Mitochondrial Pharmacology | Themed Issue
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9. Full Text Resveratrol protects photoreceptors by blocking caspase- and PARP-dependent cell death pathways
by Liu, Shu-Yan and Song, Jing-Yao and Fan, Bin and Wang, Ying and Pan, Yi-Ran and Che, Lin and Sun, Ying-Jian and Li, Guang-Yu
Free Radical Biology and Medicine, ISSN 0891-5849, 12/2018, Volume 129, pp. 569 - 581
Retinal degeneration is a major cause of severe vision loss and irreversible blindness and is characterized by progressive damage to retinal photoreceptor... 
PATHOGENESIS | APOPTOSIS | OXIDATIVE STRESS | PIGMENT EPITHELIAL-CELLS | MITOCHONDRIAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | PARTHANATOS | FACTOR-KAPPA-B | MECHANISMS | SIRT1 | DAMAGE | Macular degeneration | Biochemistry | Cell death | Resveratrol | Heme | Blindness
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10. Full Text Flow Cytometry Reveals the Nature of Oncotic Cells
by Vossenkamper, A and Warnes, G
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 09/2019, Volume 20, Issue 18, p. 4379
The term necrosis is commonly applied to cells that have died via a non-specific pathway or mechanism but strictly is the description of the degradation... 
APOPTOSIS | oncosis | NECROPTOSIS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | CHEMISTRY, MULTIDISCIPLINARY | accidental cell death | DDR | NECROSIS | parthanatos | flow cytometry | NECROBIOLOGY | DEATH RECOMMENDATIONS
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11. Full Text A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
by Wang, Yingfei and An, Ran and Umanah, George K and Park, Hyejin and Nambiar, Kalyani and Eacker, Stephen M and Kim, Bongwoo and Bao, Lei and Harraz, Maged M and Chang, Calvin and Chen, Rong and Wang, Jennifer E and Kam, Tae-In and Jeong, Jun Seop and Xie, Zhi and Neifert, Stewart and Qian, Jiang and Andrabi, Shaida A and Blackshaw, Seth and Zhu, Heng and Song, Hongjun and Ming, Guo-Li and Dawson, Valina L and Dawson, Ted M
Science, ISSN 0036-8075, 10/2016, Volume 354, Issue 6308, pp. aad6872 - aad6872
Inhibition or genetic deletion of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) is protective against toxic insults in many organ systems. The molecular... 
APOPTOSIS | MIGRATION-INHIBITORY FACTOR | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | FACTOR MIF | PARTHANATOS | CYTOKINE | ENZYMATIC-ACTIVITY | TAUTOMERASE | IDENTIFICATION | ENDONUCLEASE-G | Chromatin - metabolism | Mitochondria - enzymology | Oxidative Stress | Glutamic Acid - genetics | Humans | Apoptosis - genetics | Macrophage Migration-Inhibitory Factors - metabolism | Deoxyribonucleases - metabolism | Stroke - genetics | Cell Nucleus - enzymology | Macrophage Migration-Inhibitory Factors - genetics | Base Sequence | DNA Fragmentation | DNA Damage - genetics | Macrophage Migration-Inhibitory Factors - chemistry | Active Transport, Cell Nucleus | Intramolecular Oxidoreductases - metabolism | Nucleic Acid Conformation | Apoptosis Inducing Factor - metabolism | Deoxyribonucleases - chemistry | Amino Acid Sequence | Catalytic Domain | Intramolecular Oxidoreductases - chemistry | DNA, Single-Stranded - metabolism | Poly (ADP-Ribose) Polymerase-1 - metabolism | Apoptosis Inducing Factor - genetics | Mice, Knockout | Stroke - enzymology | Deoxyribonucleases - genetics | Animals | Intramolecular Oxidoreductases - genetics | Neurons - enzymology | Mice | HeLa Cells | Mutation | Glutamic Acid - toxicity | DNA Cleavage | Glutamic Acid - chemistry | Polymerase chain reaction | DNA damage | Cells | Cell death | Deoxyribonucleic acid | Activation | Nuclease | Inhibition | Damage accumulation | Nuclei | Diseases
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12. Full Text LPS protects macrophages from AIF-independent parthanatos by downregulation of PARP1 expression, induction of SOD2 expression, and a metabolic shift to aerobic glycolysis
by Regdon, Zsolt and Robaszkiewicz, Agnieszka and Kovács, Katalin and Rygielska, Żaneta and Hegedűs, Csaba and Bodoor, Khaldon and Szabó, Éva and Virág, László
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2019, Volume 131, pp. 184 - 196
In inflamed tissues or during ischemia-reperfusion episodes, activated macrophages produce large amounts of reactive species and are, thus, exposed to the... 
Hydrogen peroxide | Cell death | Lipopolysaccharide | Parthanatos | Macrophage | Necrosis | Apoptosis | Warburg effect | OXIDATIVE-STRESS | PEROXYNITRITE | MITOCHONDRIAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | PEROXIREDOXIN | TRANSCRIPTION | CANCER | CELL-DEATH | THIOREDOXIN | ENDOCRINOLOGY & METABOLISM | INDUCED CYTOTOXICITY
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13. Full Text New Synaptic and Molecular Targets for Neuroprotection in Parkinson’s Disease
by Calabresi, Paolo and Di Filippo, Massimiliano and Gallina, Antongiulio and Wang, Yingfei and Stankowski, Jeannette N and Picconi, Barbara and Dawson, Valina L and Dawson, Ted M
Movement disorders : official journal of the Movement Disorder Society, ISSN 0885-3185, 1/2013, Volume 28, Issue 1, pp. 51 - 60
The defining anatomical feature of Parkinson’s disease (PD) is the degeneration of substantia nigra pars compacta (SNc) neurons, resulting in striatal dopamine... 
dopamine receptors | LRRK2 | synaptic plasticity | NMDA receptors | Parthanatos
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14. Full Text Poly(ADP-ribose): A signaling molecule in different paradigms of cell death
by Aredia, Francesca and Scovassi, Anna Ivana
Biochemical Pharmacology, ISSN 0006-2952, 11/2014, Volume 92, Issue 1, pp. 157 - 163
Poly(ADP-ribosylation) results from the conversion of NAD into ADP-ribose and the following addition of ADP-ribose units to form polymers, further bound to... 
PAR | PARP | Necroptosis | Autophagy | Parthanatos | Apoptosis | POLYMERASE 3 PARP3 | RIP KINASES | APOPTOSIS-INDUCING FACTOR | OXIDATIVE STRESS | MITOCHONDRIAL | DNA-DAMAGE | CROSS-TALK | ROLES | PHARMACOLOGY & PHARMACY | TANKYRASE | Signal Transduction - physiology | Poly Adenosine Diphosphate Ribose - metabolism | Animals | Cell Death - physiology | Humans | Cell death | Sugars | Monosaccharides
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