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Immunity, ISSN 1074-7613, 10/2017, Volume 47, Issue 4, pp. 776 - 788.e5
Antiretroviral therapy (ART) suppresses viral replication in HIV-infected individuals but does not eliminate the reservoir of latently infected cells. Recent... 
SIV | animal models | HIV | latent viral reservoir | regulatory T cells | co-inhibitory receptors | CTLA-4 | T follicular helper cells | PD-1 | regulatory T cells | TGF-BETA | REPLICATION | RESERVOIR | REGULATORY CELLS | IMMUNE ACTIVATION | GENE-EXPRESSION | IMMUNODEFICIENCY VIRUS-INFECTION | IMMUNOLOGY | CHRONIC HIV-INFECTION | FOLLICULAR HELPER-CELLS | Humans | Host-Pathogen Interactions - drug effects | Macaca mulatta | Immunologic Memory - drug effects | Host-Pathogen Interactions - immunology | T-Lymphocytes, Helper-Inducer - virology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | T-Lymphocytes, Helper-Inducer - drug effects | HIV Infections - immunology | Simian Acquired Immunodeficiency Syndrome - virology | HIV-1 - physiology | In Situ Hybridization | T-Lymphocytes, Helper-Inducer - immunology | Lymph Nodes - drug effects | CD4-Positive T-Lymphocytes - virology | Immunologic Memory - immunology | Simian Immunodeficiency Virus - immunology | Anti-Retroviral Agents - therapeutic use | HIV-1 - drug effects | HIV Infections - virology | CTLA-4 Antigen - metabolism | Programmed Cell Death 1 Receptor - metabolism | Lymph Nodes - virology | Lymph Nodes - immunology | CTLA-4 Antigen - immunology | Simian Immunodeficiency Virus - physiology | Microscopy, Confocal | HIV-1 - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Simian Acquired Immunodeficiency Syndrome - drug therapy | Simian Acquired Immunodeficiency Syndrome - immunology | HIV Infections - drug therapy | Programmed Cell Death 1 Receptor - immunology | Simian Immunodeficiency Virus - drug effects | CD4-Positive T-Lymphocytes - drug effects | T-Lymphocytes, Regulatory - virology | Therapy | PD-1 protein | Memory | Viruses | Infections | Lymphocytes T | Lymph nodes | CTLA-4 protein | Lymphocytes | Antiretroviral agents | Immunotherapy | Human immunodeficiency virus--HIV | Drug therapy | Deoxyribonucleic acid--DNA | Spleen | Antiretroviral drugs | Immunological memory | Memory cells | Immunoregulation | Latent infection | Monkeys & apes | Antiretroviral therapy | CD4 antigen | Lymphocytes B | Replication
Journal Article
European Journal of Immunology, ISSN 0014-2980, 12/2017, Volume 47, Issue 12, pp. 2113 - 2123
We and others have demonstrated that adipose tissue is a reservoir for HIV. Evaluation of the mechanisms responsible for viral persistence may lead to ways of... 
CD4 T cell | Fat | Adipose tissue | HIV | PD‐1 | HIV persistence | PD-1 | IMMUNE CELLS | RESIDENT | REG CELLS | IMMUNOLOGY | OBESITY | INSULIN-RESISTANCE | INFLAMMATION | REGULATORY T-CELLS | PPAR-GAMMA | ACCUMULATION | LYMPHOCYTE-ACTIVATION | Disease Reservoirs - virology | Humans | Middle Aged | Male | Adipose Tissue - immunology | Host-Pathogen Interactions - immunology | CD4-Positive T-Lymphocytes - immunology | Adipose Tissue - metabolism | HIV Infections - immunology | Flow Cytometry | Aged, 80 and over | Adult | Female | CD4-Positive T-Lymphocytes - virology | Antiviral Agents - therapeutic use | HIV-1 - drug effects | Adipose Tissue - virology | HIV Infections - virology | CD4-Positive T-Lymphocytes - metabolism | Programmed Cell Death 1 Receptor - metabolism | Cellular Microenvironment - immunology | HIV-1 - immunology | Aged | Programmed Cell Death 1 Receptor - immunology | HIV Infections - metabolism | Adipose tissues | Highly active antiretroviral therapy | Antiviral agents | Medical research | Medicine, Experimental | T cells | HIV (Viruses) | HIV infection | Antiretroviral drugs | Memory cells | Immunological memory | PD-1 protein | Immunomodulation | CD8 antigen | Helper cells | Activation | Lymphocytes T | Infections | Patients | Antiretroviral therapy | CD4 antigen | CD69 antigen | Cell activation | Antiretroviral agents | Lymphocytes | Human immunodeficiency virus--HIV | Histocompatibility antigen HLA | Programmed Cell Death 1 Receptor/immunology | CD4-Positive T-Lymphocytes/metabolism | HIV-1/immunology | Adipose Tissue/immunology | HIV Infections/immunology | HIV-1/drug effects | Life Sciences | Host-Pathogen Interactions/immunology | HIV Infections/metabolism | Immunology | Adipose Tissue/metabolism | Cellular Microenvironment/immunology | Adipose Tissue/virology | Virology | Disease Reservoirs/virology | Microbiology and Parasitology | Antiviral Agents/therapeutic use | CD4-Positive T-Lymphocytes/immunology | HIV Infections/virology | CD4-Positive T-Lymphocytes/virology | Programmed Cell Death 1 Receptor/metabolism
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 10/2017, Volume 47, Issue 4, pp. 723 - 738.e5
Noroviruses can establish chronic infections with active viral shedding in healthy humans but whether persistence is associated with adaptive immune... 
T cell exhaustion | tissue-resident memory T cells | T cell inflation | norovirus | enteric viral persistence | tissue-resident memory T cells | ACTIVATION | REPLICATION | MEMORY | RESIDENT | GENES | CYTOMEGALOVIRUS-INFECTION | ABSENCE | COSTIMULATION | IMMUNOLOGY | EXHAUSTION | REVEALS | Caliciviridae Infections - virology | Caliciviridae Infections - genetics | Humans | Gastroenteritis - virology | Host-Pathogen Interactions - immunology | Cell Differentiation - genetics | HEK293 Cells | CD8-Positive T-Lymphocytes - metabolism | Gastroenteritis - immunology | Caliciviridae Infections - immunology | Gene Ontology | Immunologic Memory - genetics | Immunologic Memory - immunology | Norovirus - physiology | Cell Line | Oligonucleotide Array Sequence Analysis - methods | Mice, Inbred C57BL | Gene Expression Profiling - methods | Norovirus - immunology | Cellular Microenvironment - immunology | Cell Differentiation - immunology | Animals | CD8-Positive T-Lymphocytes - virology | Gastroenteritis - genetics | Cellular Microenvironment - genetics | CD8-Positive T-Lymphocytes - immunology | Shedding | Antigens | Cytomegalovirus | Immunological memory | Memory cells | CD8 antigen | Differentiation (biology) | Chronic infection | Viruses | Infections | Lymphocytes T | T cell receptors | Cell differentiation | Cells | Studies | Lymphocytes | Exhaustion | Replication | Immune privilege | Genetic engineering | Immune system | Norovirus
Journal Article
Trends in Microbiology, ISSN 0966-842X, 2008, Volume 17, Issue 2, pp. 59 - 65
Journal Article