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PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e53343
Kunitz-type serine protease inhibitors are involved in various physiological processes, such as ion channel blocking, blood coagulation, fibrinolysis, and... 
VENOM | KING COBRA | MULTIDISCIPLINARY SCIENCES | PSEUDONAJA-TEXTILIS | SILK PROTEIN | CHYMOTRYPSIN INHIBITOR | MOLECULAR-CLONING | BOOPHILUS-MICROPLUS | EXPRESSION | ARANEUS-VENTRICOSUS | PEPTIDE | Factor Xa - chemistry | Chymotrypsin - metabolism | Molecular Sequence Data | Baculoviridae - genetics | Tissue Plasminogen Activator - chemistry | Pancreatic Elastase - antagonists & inhibitors | Antifibrinolytic Agents - metabolism | Trypsin Inhibitors - chemistry | Serine Proteinase Inhibitors - chemistry | Spiders - metabolism | Aprotinin - genetics | Conserved Sequence | Antifibrinolytic Agents - chemistry | Spiders - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Gene Expression | Fibrinolysin - antagonists & inhibitors | Recombinant Proteins - chemistry | Arthropod Proteins - genetics | Recombinant Proteins - genetics | Trypsin - metabolism | Arthropod Proteins - chemistry | Fibrinolysin - chemistry | Sequence Alignment | Animals | Thrombin - chemistry | Trypsin Inhibitors - genetics | Chymotrypsin - antagonists & inhibitors | Pancreatic Elastase - chemistry | Aprotinin - chemistry | Serine Proteinase Inhibitors - genetics | Enzymes | Care and treatment | Protease inhibitors | Physiological aspects | Hydrolases | Inflammation | Research | Health aspects | Risk factors | Blood coagulation | Serine | Thrombin | Amino acids | Baculovirus | Plasmin | t-Plasminogen activator | Proteins | Protease | Ion channels | Elastase | Recombinant | Natural resources | Proteinase inhibitors | Potassium channels | Fibrinolysis | Chymotrypsin | Trypsin | Insects | Proteases | Lysine | Venom | Insect cells | Serine proteinase
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 3/2016, Volume 73, Issue 5, pp. 985 - 1001
Journal Article
Medicinal Research Reviews, ISSN 0198-6325, 01/2013, Volume 33, Issue 1, pp. 139 - 189
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes an overwhelming health, social, economic, and political problem to... 
antioxidant drugs | CDK5 inhibitors | anti‐inflammatory drugs | AChE peripheral anionic site | CK‐1 inhibitors | ERK2‐inhibitors | Ca2+ dyshomeostasis | BACE‐1 inhibitors | amyloid–β antiaggregating agents | NSAIDs | neuroprotection | multitarget drugs | GSK‐3β inhibitors | dual AChE inhibitors | metal chelators | Alzheimer's disease | Ca2+ overload | oxidative stress | multiactive compounds | 1,4‐dihydropyridines | voltage‐dependent calcium channels | Neuroprotection | Oxidative stress | Dual AChE inhibitors | Anti-inflammatory drugs | GSK-3β inhibitors | Antioxidant drugs | overload | Metal chelators | Multitarget drugs | Voltage-dependent calcium channels | CK-1 inhibitors | BACE-1 inhibitors | dyshomeostasis | 1,4-dihydropyridines | ERK2-inhibitors | Multiactive compounds | Amyloid-β antiaggregating agents | GSK-3 ss inhibitors | anti-inflammatory drugs | voltage-dependent calcium channels | TYROSINE KINASE INHIBITOR | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | POTENT ACETYLCHOLINESTERASE INHIBITORS | amyloid-ss antiaggregating agents | M1 MUSCARINIC AGONISTS | CHEMISTRY, MEDICINAL | AMYLOID PRECURSOR PROTEIN | MOLECULAR MODELING INVESTIGATIONS | HERPES-SIMPLEX-VIRUS | TACRINE-DIHYDROPYRIDINE HYBRIDS | PERIPHERAL ANIONIC SITE | HISTAMINE H-3 RECEPTOR | Calcium Channels - metabolism | Humans | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | tau Proteins - metabolism | Receptors, N-Methyl-D-Aspartate | Alzheimer Disease - enzymology | Enzyme Inhibitors - therapeutic use | Disease Progression | Alzheimer Disease - pathology | Amyloid Precursor Protein Secretases - metabolism | Butyrylcholinesterase - metabolism | Amyloid beta-Peptides - metabolism | Ligands | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Binding Sites | Acetylcholinesterase - metabolism | Care and treatment | Calcium channels | Glycogen | Development and progression | Glutamate | Target marketing | Antioxidants | Methyl aspartate | Enzyme inhibitors | Synthesis | Surface active agents | Drug therapy | Cancer
Journal Article
Expert Opinion on Drug Discovery, ISSN 1746-0441, 09/2013, Volume 8, Issue 9, pp. 1095 - 1116
Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) have been on the increase during the past decade, due to the steady growth of the elderly and... 
acyl t-RNA synthase inhibitor | Clp protease inhibitor | methicillin-resistant Staphylococcus aureus | two-component system inhibitor | elongation factor G inhibitor | linezolid | antibacterial agents | combination therapy | daptomycin | vancomycin | β-lactamase inhibitor | antibacterial vaccine | dihydropteroate synthase inhibitor | peptidoglycan biosynthesis inhibitor | Pol IIIC inhibitor | electron transport inhibitor | RNA-polymerase inhibitor | phage therapy | peptide deformylase inhibitor | menaquinone biosynthesis inhibitor | Gram-positive pathogens | antibiotics | antimicrobial peptides | dihydrofolate reductase inhibitor | FAS II inhibitor | Linezolid | Peptide deformylase inhibitor | Daptomycin | Dihydropteroate synthase inhibitor | Vancomycin | Combination therapy | Antimicrobial peptides | Menaquinone biosynthesis inhibitor | Antibacterial vaccine | Dihydrofolate reductase inhibitor | Acyl t-RNA synthase inhibitor | Elongation factor G inhibitor | Antibacterial agents | Electron transport inhibitor | Peptidoglycan biosynthesis inhibitor | Antibiotics | Methicillin-resistant Staphylococcus aureus | Phage therapy | Two-component system inhibitor | SOFT-TISSUE INFECTIONS | INTENSIVE-CARE UNITS | beta-lactamase inhibitor | RESISTANT STAPHYLOCOCCUS-AUREUS | PHARMACOLOGY & PHARMACY | IN-VITRO ACTIVITY | TOREZOLID PHOSPHATE TR-701 | BRIDGED BICYCLIC MACROLIDE | DIHYDROFOLATE-REDUCTASE INHIBITOR | QUALITY-CONTROL RANGES | Anti-Bacterial Agents - therapeutic use | Animals | Bacterial Infections - drug therapy | Drug Resistance, Multiple, Bacterial | Humans | Drug Discovery | Methicillin-Resistant Staphylococcus aureus | elongation factor G (EF-G) inhibitor | peptide deformylase (PDF) inhibitor | methicillin-resistant Staphylococcus aureus (MRSA) | PolIIC inhibitor | β5 -lactamase inhibitor
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2013, Volume 110, Issue 36, pp. E3445 - E3454
Journal Article
CA: A Cancer Journal for Clinicians, ISSN 0007-9235, 07/2010, Volume 60, Issue 4, pp. 222 - 243
Angiogenesis has become an attractive target for drug therapy because of its key role in tumor growth. An extensive array of compounds is currently in... 
TYROSINE KINASE INHIBITORS | CELL LUNG-CANCER | PHASE-III TRIAL | FARNESYL-PROTEIN TRANSFERASE | FACTOR 1-ALPHA | ONCOLOGY | ENDOTHELIAL-GROWTH-FACTOR | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | FACTOR EXPRESSION | VASCULAR-PERMEABILITY FACTOR | TUMOR-GROWTH | Neoplasms - metabolism | Nucleic Acid Synthesis Inhibitors - pharmacology | Humans | Receptor Protein-Tyrosine Kinases - physiology | Antibodies, Monoclonal - therapeutic use | Receptors, Notch - antagonists & inhibitors | Protein Binding - drug effects | Angiogenesis Inhibitors - therapeutic use | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Neovascularization, Pathologic - prevention & control | Farnesyltranstransferase - antagonists & inhibitors | Thioredoxins - antagonists & inhibitors | Nucleic Acid Synthesis Inhibitors - therapeutic use | Basic Helix-Loop-Helix Transcription Factors - physiology | Antibodies, Monoclonal - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Angiogenesis Inhibitors - pharmacology | Receptors, Notch - physiology | Neoplasms - blood supply | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Neoplasms - drug therapy | Signal Transduction - drug effects | Cell Transformation, Neoplastic | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - physiology | Complications and side effects | Care and treatment | Ligands (Biochemistry) | Physiological aspects | Development and progression | Dosage and administration | Angiogenesis inhibitors | Neovascularization | Identification and classification | Growth factors | Cancer | Angiogenesis | Pharmacology | FDA approval | Drug therapy | Kinases | Tumors | hypoxia inducible factor (HIF) | kinase inhibitors | growth factors | angiogenesis inhibitors | VEGF | anti-angiogenesis
Journal Article