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Journal Article
by Sun, P and Huang, W and Kang, L and Jin, MJ and Fan, B and Jin, HY and Wang, QM and Gao, ZG
INTERNATIONAL JOURNAL OF NANOMEDICINE, ISSN 1178-2013, 2017, Volume 12, pp. 3221 - 3234
An ideal carrier that delivers small interfering RNA (siRNA) should be designed based on two criteria: cellular-mediated internalization and endosomal escape.... 
poly(histidine-arginine)-peptide-modified chitosan nanoparticle | SURVIVIN | COMPLEXES | NANOSCIENCE & NANOTECHNOLOGY | COMBINATION | ANTITUMOR | endosome/lysosome escape | CANCER-THERAPY | DELIVERY | CPPS | gene delivery | INHIBITION | cell-penetrating peptides | breast carcinoma | HISTIDINE | IN-VIVO | PHARMACOLOGY & PHARMACY
Journal Article
Journal Article
by Shen, Y and Hu, GX and Zhang, HX and Qi, LL and Luo, CC
ACTA CHIMICA SINICA, ISSN 0567-7351, 03/2013, Volume 71, Issue 3, pp. 323 - 333
Gene therapy shows promise as a potentially revolutionizing strategy for treatment of many genetically-related diseases, such as cancer. However, the lack of... 
gene therapy | FUSOGENIC PEPTIDE | SIRNA DELIVERY | CHEMISTRY, MULTIDISCIPLINARY | gene delivery | TRANSFECTION PROPERTIES | nonviral gene carrier | CATIONIC LIPIDS | IN-VITRO | POLY(ETHYLENE GLYCOL) | pH-sensitive polymers | DIBLOCK COPOLYMER | PLASMID DNA | pH-sensitive lipids | POLYMER-MODIFIED LIPOSOMES | CARBOXYMETHYL POLY(L-HISTIDINE)
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 2006, Volume 1758, Issue 3, pp. 355 - 363
Protein transduction domains (PTDs) are peptides that afford the internalization of cargo macromolecules (including plasmid DNA, proteins, liposomes, and... 
ZINC SUPEROXIDE-DISMUTASE | BIOPHYSICS | POLY-L-LYSINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIV-1 TAT PROTEIN | IN-VIVO | FUSION PROTEIN | SINGLE-CHAIN FV | ED-B DOMAIN | DIFFERENTIAL SCANNING CALORIMETRY | PEPTIDE-MODIFIED LIPOSOMES | MAMMALIAN-CELLS | Dendrimers | Imports | Peptides | Tumor proteins | Heterocyclic compounds
Journal Article
高分子論文集, ISSN 0386-2186, 2008, Volume 65, Issue 2, pp. 132 - 139
材料表面の親水性⇔疎水性が可逆的に変化できる温度応答性ヒドロゲル材料を生医学材料へ応用する研究の一環として,大腸菌ランダムペプチドライブラリ(FliTrxTM, Invitrogen)法を応用した表面の評価法を検討した.用いた高分子材料は poly(N-isopropylacrylamide)を Ar... 
Poly(N-2-hydroxypropylmethacrylamide-co-methyl methacrylate) | Poly(N-isopropylacrylamide) | Biological Surface Evaluation | Bacterial Random Peptide Library
Journal Article
Acta Pharmaceutica Sinica B, ISSN 2211-3835, 03/2018, Volume 8, Issue 2, pp. 165 - 177
Mesoporous silica nanoparticles (MSNs) are attracting increasing interest for potential biomedical applications. With tailored mesoporous structure, huge... 
Mesoporous silica nanoparticles | Gene delivery | Poorly soluble drug | Cancer therapy | Multidrug resistance | CANCER-CELLS | OVERCOMING MULTIDRUG-RESISTANCE | PORE-SIZE | PHOTODYNAMIC THERAPY | CELLULAR UPTAKE | IN-VITRO | CO-DELIVERY | FACILE SYNTHESIS | ORAL BIOAVAILABILITY | PHARMACOLOGY & PHARMACY | TARGETED DELIVERY | GI, gastrointestinal | P-gp, P-glycoprotein | C dots, Cornell dots | GNRs@mSiO2, mesoporous silica-encapsulated gold nanorods | MSNs-TAT, TAT peptide-modified MSNs | PAMAM, polyamidoamine | Review | APTMS, amino propyl trimethoxysilane | TAT peptide-modified MSNs | MSNs-RGD | pDNA, plasmid DNA | PLL, poly-l-lysine | APTES, 3-aminopropyltriethoxysilane | BCS, Biopharmaceutical Classification System | LHRH, luteinising-hormone releasing hormone | EPR, enhanced permeability and retention | AO, acridine orange | MSNs, mesoporous silica nanoparticles | RGD, arginine-glycine-aspartate | PEG400, polyethylene glycol 400 | MDR, multi-drug resistance | MRP1, multidrug resistance protein 1 | NIR, near-infrared | PDEAEMA, poly (2-(diethylamino)ethylmethacrylate) | PTX, paclitaxel | FDA, Food and Drug Administration | Q-MSNs, quercetin encapsulated MSNs | MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide | MSNs@PDA-PEG-FA, poly(ethylene glycol)-folic acid-functionalized polydopamine-modified MSNs | CTAB, cetyltrimethyl ammonium bromide | PEI, polyethyleneimine | TMB, 1,3,5-trimethybenzene | BCL-2, B-cell lymphoma-2 | CMC, critical micelle concentration | MSNs-HA, hyaluronic acid-conjugated MSNs | TAT, trans-activating transcriptor | Bio-TEM, biological transmission electron microscopy | CPT, camptothecin | TAT, RGD | PDMAEMA, poly(2-(dimethylamino)ethylmethacrylate) | MSN-Dox-G2, Dox-loaded and G2 PAMAM-modified MSNs
Journal Article
Shi yan sheng wu xue bao, ISSN 0001-5334, 12/1999, Volume 32, Issue 4, p. 409
The foreign Bt gene was transferred into protoplasts of soybean using PEG and PLO methods, respectively. The result indicated that the transformation frequency... 
Transformation, Genetic | Soybeans - drug effects | Plants, Genetically Modified | Polymerase Chain Reaction | Protoplasts - drug effects | Soybeans - genetics | Peptides - pharmacology
Journal Article
International Journal of Nanomedicine, ISSN 1176-9114, 06/2014, Volume 9, Issue 1, pp. 3091 - 3105
In the present study, we prepared a novel delivery system of iRGD (CRGDK/RGPD/EC)-modified sterically stabilized liposomes (SSLs) containing conjugated... 
In vivo | Peptide-modified liposome | CLA-PTX | IRGD | Antitumor effect | In vitro | FUNCTIONALIZED NANOPARTICLES | MOLECULAR-WEIGHT PROTAMINE | SOLID TUMORS | EFFICACY | DRUG-DELIVERY | DOXORUBICIN DELIVERY | NANOSCIENCE & NANOTECHNOLOGY | ENDOCYTOSIS | peptide-modified liposome | IN-VITRO | THERAPY | iRGD | PRODRUGS | antitumor effect | in vitro | PHARMACOLOGY & PHARMACY | in vivo | Paclitaxel - pharmacology | Antineoplastic Agents - therapeutic use | Paclitaxel - pharmacokinetics | Tissue Distribution | Paclitaxel - chemistry | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Neoplasms, Experimental - mortality | Oligopeptides - chemistry | Liposomes - therapeutic use | Mice, Inbred C57BL | Kaplan-Meier Estimate | Antineoplastic Agents - chemistry | Paclitaxel - therapeutic use | Xenograft Model Antitumor Assays | Liposomes - chemistry | Animals | Melanoma - drug therapy | Cell Line, Tumor | Linoleic Acids, Conjugated - chemistry | Mice | Liposomes - pharmacology | Neoplasms, Experimental - drug therapy | Liposomes - pharmacokinetics | Melanoma - mortality | Complications and side effects | Usage | Linoleic acids | Paclitaxel | Melanoma | Physiological aspects | Dosage and administration | Liposomes | Research | Properties | Drug therapy | Peptides | Quantum dots | Brain cancer | Cytotoxicity | Permeability | Fatty acids | Cholesterol | Molecular weight | Nanoparticles | Biomedical materials | Polyethylene glycol | Penicillin | Ligands | Microemulsions | Laboratory animals | Tumors | Index Medicus
Journal Article
Biomaterials, ISSN 0142-9612, 2012, Volume 33, Issue 12, pp. 3375 - 3387
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 6/2013, Volume 30, Issue 6, pp. 1663 - 1676
To test the hypothesis that thrombus-specific tissue plasminogen activator (tPA)-loaded nanocarriers enhance thrombolytic efficacy and attenuate hemorrhagic... 
Biochemistry, general | Biomedical Engineering | Biomedicine | tissue plasminogen activator | localized fibrinolysis | protein delivery | Pharmacy | Medical Law | targeted delivery | Pharmacology/Toxicology | peptide-modified-liposomes | DRUG-DELIVERY | RABBIT MODEL | T-PA | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY-SYSTEM | TISSUE-PLASMINOGEN-ACTIVATOR | MOLECULAR-WEIGHT HEPARIN | ACCELERATED THROMBOLYSIS | IN-VIVO | ACUTE MYOCARDIAL-INFARCTION | PHARMACOLOGY & PHARMACY | LIPOSOMES | Chemistry, Pharmaceutical - methods | Tissue Plasminogen Activator - metabolism | Liposomes - administration & dosage | Humans | Drug Carriers - administration & dosage | Fibrinolytic Agents - metabolism | Half-Life | Male | Peptides - metabolism | Nanoparticles - metabolism | Platelet Glycoprotein GPIIb-IIIa Complex - metabolism | Thrombolytic Therapy - methods | Blood Platelets - drug effects | Drug Carriers - metabolism | Rats | Hemorrhage - metabolism | Rats, Sprague-Dawley | Hemorrhage - drug therapy | Thrombosis - metabolism | Animals | Tissue Plasminogen Activator - pharmacology | Blood Coagulation - drug effects | Blood Platelets - metabolism | Fibrinogen - metabolism | Liposomes - metabolism | Fibrinolytic Agents - administration & dosage | Nanoparticles - administration & dosage | Thrombosis - drug therapy | Fibrin - metabolism | Complications and side effects | Fibrin | Peptides | Tissue plasminogen activator | Analysis | Thrombosis | Blood clot | Proteins | Drug delivery systems | Hemorrhage | Pharmaceutical sciences | Nanotechnology | Blood clots | Index Medicus
Journal Article
Journal Article