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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2017, Volume 114, Issue 16, pp. 4213 - 4218
Duchenne muscular dystrophy (DMD) is a lethal genetic disorder caused by an absence of the dystrophin protein in bodywide muscles, including the heart.... 
Cardiac Purkinje fibers | Dystrophic dog model | Peptide-conjugated morpholinos | Duchenne muscular dystrophy | Exon skipping | MUSCLE PATHOLOGY | MULTIDISCIPLINARY SCIENCES | DMD GENE | CARDIOMYOPATHY | BODYWIDE | dystrophic dog model | peptide-conjugated morpholinos | MDX52 MICE | OLIGONUCLEOTIDES | RESCUE | exon skipping | LABORATORY-ANIMALS | cardiac Purkinje fibers | EXPRESSION | EXONS 45-55 | Genetic Therapy | Muscular Dystrophy, Animal - genetics | Exons | Male | Muscle, Skeletal - metabolism | Muscular Dystrophy, Animal - complications | Muscular Dystrophy, Duchenne - complications | Cardiomyopathies - etiology | Cardiomyopathies - therapy | Cell-Penetrating Peptides - pharmacology | Animals | Dogs | Morpholinos - pharmacology | Female | Muscular Dystrophy, Animal - therapy | Muscle, Skeletal - pathology | Muscular Dystrophy, Duchenne - genetics | Muscular Dystrophy, Duchenne - therapy | Dystrophin - metabolism | Disease Models, Animal | Heart | Physiological aspects | Health aspects | Conduction | Intravenous administration | Peptides | Toxicity | Cardiomyopathy | Effects | Muscular dystrophy | Fibers | Oligomers | Nerve conduction | Arginine | Duchenne's muscular dystrophy | Degeneration | Polymers | Heart diseases | Dystrophin | EKG | Cardiac muscle | Abnormalities | Muscles | Skeletal muscle | Purkinje fibers | Myocardium | Dystrophy | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2015, Volume 112, Issue 38, pp. 11935 - 11940
Identification and genetic validation of new targets from available genome sequences are critical steps toward the development of new potent and selective... 
Vivo morpholino oligomer | Malaria | Gene expression | Peptide conjugated morpholino oligomer | Intraerythrocytic development | vivo morpholino oligomer | EXTERNAL GUIDE SEQUENCES | MULTIDISCIPLINARY SCIENCES | peptide conjugated morpholino oligomer | intraerythrocytic development | malaria | MALARIA PARASITES | MOLECULAR TRANSPORTERS | CHLOROQUINE RESISTANCE | CELLULAR UPTAKE | GENOME | DELIVERY | PHOSPHATIDYLCHOLINE BIOSYNTHESIS | FUNCTIONAL-ANALYSIS | GENE-EXPRESSION | gene expression | Luciferases - metabolism | Plasmodium falciparum - drug effects | RNA, Messenger - metabolism | Organophosphorus Compounds - metabolism | Parasites - genetics | Chloroquine - pharmacology | Proteolysis - drug effects | Artemisinins - pharmacology | Hemiterpenes - metabolism | Parasites - drug effects | Flow Cytometry | Plasmodium falciparum - genetics | Genes, Reporter | Parasites - growth & development | RNA Splicing - drug effects | RNA, Messenger - genetics | Drug Resistance - drug effects | Down-Regulation - drug effects | Sequence Analysis, DNA | Antimalarials - pharmacology | Peptides - pharmacology | Animals | Morpholinos - pharmacology | Protein Biosynthesis - drug effects | Plasmodium falciparum - growth & development | Physiology, Pathological | Plasmodium falciparum | Usage | Knots and splices | Analysis | Genetic aspects | Genetic engineering | Research | Proteins | Biosynthesis | Genomes | Parasites | Ribonucleic acid--RNA | Genes | Index Medicus | Biological Sciences
Journal Article
Molecular Therapy - Nucleic Acids, ISSN 2162-2531, 2013, Volume 2, Issue 9, pp. e124 - e124
Journal Article
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1828, pp. 365 - 379
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1828, pp. 263 - 273
Journal Article
ACS Infectious Diseases, ISSN 2373-8227, 2019, Volume 5, Issue 8, pp. 1446 - 1455
Overexpression of bacterial efflux pumps is a driver of increasing antibiotic resistance in Gram-negative pathogens. The AcrAB-TolC efflux pump has been... 
peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) | Pseudomonas aeruginosa | bacterial efflux pumps | Escherichia coli | Klebsiella pneumoniae | antisense | Index Medicus
Journal Article
ACS INFECTIOUS DISEASES, ISSN 2373-8227, 05/2018, Volume 4, Issue 5, pp. 806 - 814
Journal Article
ACS Infectious Diseases, ISSN 2373-8227, 05/2018, Volume 4, Issue 5, pp. 806 - 814
The Burkholderia cepacia complex is a group of Gram-negative bacteria that are opportunistic pathogens in immunocompromised individuals, such as those with... 
artificial sputum | Burkholaderia cepacia complex (Bcc) | pneumonia | peptide-conjugated phosphorodiamidate morpholino oligomers (PPMO) | antisense
Journal Article
International Journal of Peptide Research and Therapeutics, ISSN 1573-3149, 12/2009, Volume 15, Issue 4, pp. 323 - 337
A series of novel, potent and selective muscarinic receptor 1 agonists (M1 receptor agonists) that employ a key N-substituted morpholine arecoline moiety has... 
M1 agonists | Morpholino arecolines | Alzheimer's disease | Peptide conjugates | PRESENILE-DEMENTIA | ACTIVATION | TASK PARADIGM | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE-C | AMYLOID PRECURSOR PROTEIN | CHOLINERGIC AGONISTS | INHIBITION | DISEASE | MICE | BINDING | Peptides | Neurosciences | Amino acids | Alzheimers disease | Molecular biology | Neurons
Journal Article
Current Genetics, ISSN 0172-8083, 12/2017, Volume 63, Issue 6, pp. 973 - 976
Antibiotic resistance is a worldwide public health problem (Bush et al. in Nat Rev Microbiol 9:894–896, 2011). The lack of effective therapies against... 
Life Sciences | Biochemistry, general | Gene silencing | Microbiology | Microbial Genetics and Genomics | Proteomics | Antibiotic resistance | Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) | Evolution | Plant Sciences | Microbial evolution | Cell Biology | BACTERIA | ENVIRONMENTS | ESCHERICHIA-COLI | HOSPITALS | PURE CULTURE | COMPLEXITY | GENES | GENETICS & HEREDITY | SELECTION | Klebsiella pneumoniae - drug effects | Lipoproteins - genetics | Morpholinos - chemical synthesis | Escherichia coli - drug effects | Salmonella enterica - genetics | Drug Resistance, Microbial - genetics | Lipoproteins - antagonists & inhibitors | Microbial Sensitivity Tests | Salmonella enterica - drug effects | Membrane Transport Proteins - genetics | Klebsiella pneumoniae - genetics | Lipoproteins - metabolism | Membrane Transport Proteins - metabolism | Escherichia coli - growth & development | Escherichia coli Proteins - antagonists & inhibitors | Drug Resistance, Microbial - drug effects | Peptides - chemistry | Gene Silencing | Escherichia coli Proteins - metabolism | Salmonella enterica - growth & development | Peptides - pharmacology | Anti-Bacterial Agents - chemical synthesis | Escherichia coli - genetics | Morpholinos - pharmacology | Escherichia coli Proteins - genetics | Klebsiella pneumoniae - growth & development | Anti-Bacterial Agents - pharmacology | Gene Expression Regulation, Bacterial | Evolution, Molecular | Oligomers | Drug resistance in microorganisms | Peptides | Mortality | Bacteria | Genetic engineering | Public health | Medical care, Cost of | Health care | Drugs | Fighting | Antibiotics | Antimicrobial agents | Drug resistance | Inflating | Antiinfectives and antibacterials | Index Medicus
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1828, pp. 57 - 68
Journal Article
EBioMedicine, ISSN 2352-3964, 07/2019, Volume 45, pp. 630 - 645
Duchenne muscular dystrophy (DMD) is an X-linked disorder characterized by progressive muscle degeneration, caused by the absence of dystrophin. Exon skipping... 
MEDICINE, RESEARCH & EXPERIMENTAL | OLIGONUCLEOTIDE THERAPY | IN-VIVO DELIVERY | MORPHOLINO OLIGOMERS | NITRIC-OXIDE SYNTHASE | CELL-PENETRATING PEPTIDES | CARDIAC-MUSCLE | EXON-SKIPPING THERAPY | RECEPTOR-MEDIATED UPTAKE | MOUSE MODELS | MDX MICE
Journal Article