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09/2000, Volume 39, Issue 3, 17
Obesity is a worldwide problem, with major health, social and economic implications. The adaptation of drug dosages to obese patients is a subject of concern,... 
Beta adrenoceptor antagonists, pharmacokinetics | Bisoprolol, pharmacokinetics | Propranolol, pharmacokinetics | Gentamicin, pharmacokinetics | Dexfenfluramine, pharmacokinetics | Clinical pharmacokinetics | Nicotine, pharmacokinetics | Sotalol, pharmacokinetics | Antineoplastics, pharmacokinetics | Remifentanil, pharmacokinetics | Antihyperglycaemics, pharmacokinetics | Vecuronium bromide, pharmacokinetics | Theophylline, pharmacokinetics | Phenytoin, pharmacokinetics | Antibacterials, pharmacokinetics | Anaesthetics, pharmacokinetics | Doxorubicin, pharmacokinetics | Propofol, pharmacokinetics | Rocuronium bromide, pharmacokinetics | Anticonvulsants, pharmacokinetics | Carbamazepine, pharmacokinetics | Nebivolol, pharmacokinetics | Obesity | Sufentanil, pharmacokinetics | Vancomycin, pharmacokinetics | Anorectics, pharmacokinetics | Neuropsychotherapeutics, pharmacokinetics | Caffeine, pharmacokinetics | Interferon alpha, pharmacokinetics | Neuromuscular blocking agents, pharmacokinetics | Antifungals, pharmacokinetics | Cyclophosphamide, pharmacokinetics | Xanthines, pharmacokinetics | Ciprofloxacin, pharmacokinetics | General anaesthesia | Glibenclamide, pharmacokinetics | Labetalol, pharmacokinetics | Busulfan, pharmacokinetics | Glipizide, pharmacokinetics | Ifosfamide, pharmacokinetics | Lithium, pharmacokinetics | Opioids, pharmacokinetics | Carboplatin, pharmacokinetics | Phenazone, pharmacokinetics | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | LEAN BODY-MASS | VANCOMYCIN | METABOLISM | NORMAL VOLUNTEERS | PHARMACOLOGY & PHARMACY | PHARMACODYNAMICS | PATIENT | CLINICAL PHARMACOKINETICS | SIGNIFICANT WEIGHT-REDUCTION | CREATININE CLEARANCE | DISPOSITION | Adrenergic beta-Antagonists - pharmacokinetics | Anesthetics - pharmacokinetics | Anticonvulsants - pharmacokinetics | Hypoglycemic Agents - pharmacokinetics | Obesity - drug therapy | Antifungal Agents - pharmacokinetics | Humans | Anti-Bacterial Agents - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Obesity - metabolism
Book Review
Clinical Pharmacokinetics, ISSN 0312-5963, 05/2000, Volume 38, Issue 5, pp. 377 - 392
Effective use of the growing number of nonsteroidal anti-inflammatory drugs (NSAIDs), a group that has recently been augmented by the introduction of the... 
Research and development | Suprofen, pharmacokinetics | Sulindac, pharmacokinetics | Mefenamic acid, pharmacokinetics | Carprofen, pharmacokinetics | Indobufen, pharmacokinetics | Ketorolac, pharmacokinetics | Pirprofen, pharmacokinetics | Celecoxib, pharmacokinetics | Oxaprozin, pharmacokinetics | Oxyphenbutazone, pharmacokinetics | Azapropazone, pharmacokinetics | Nabumetone, pharmacokinetics | Bermoprofen, pharmacokinetics | Diclofenac, pharmacokinetics | Ibuprofen, pharmacokinetics | Benoxaprofen, pharmacokinetics | Diflunisal, pharmacokinetics | Flunoxaprofen, pharmacokinetics | Ketoprofen, pharmacokinetics | Loxoprofen, pharmacokinetics | Alminoprofen, pharmacokinetics | Flobufen, pharmacokinetics | Ximoprofen, pharmacokinetics | Butibufen, pharmacokinetics | Tenoxicam, pharmacokinetics | Meloxicam, pharmacokinetics | Naproxen, pharmacokinetics | Rofecoxib, pharmacokinetics | Piroxicam, pharmacokinetics | Tiaprofenic acid, pharmacokinetics | Flurbiprofen, pharmacokinetics | Indomethacin, pharmacokinetics | Pranoprofen, pharmacokinetics | Fenoprofen, pharmacokinetics | Indoprofen, pharmacokinetics | Etodolac, pharmacokinetics | Nonsteroidal antiinflammatories, pharmacokinetics | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | RHEUMATOID-ARTHRITIS | SYNOVIAL-FLUID | HEALTHY-SUBJECTS | NAPROXEN PHARMACOKINETICS | CIRCADIAN CHANGES | ELDERLY PATIENTS | PHARMACOLOGY & PHARMACY | CLINICAL PHARMACOKINETICS | ANTIINFLAMMATORY DRUGS | INTESTINAL PERMEABILITY | PURE ENANTIOMERS | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Pharmacokinetics | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Humans | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Journal Article
2001, Volume 15, Issue 6, 26
Many psychiatric patients smoke, and are believed to be heavier smokers than those without psychiatric disorders. Cigarette smoking is one of the environmental... 
Chlordiazepoxide, pharmacokinetics | Risperidone, pharmacokinetics | Amitriptyline, pharmacokinetics | Lorazepam, pharmacokinetics | Serotonin reuptake inhibitors, pharmacokinetics | Amfebutamone, pharmacokinetics | Haloperidol, pharmacokinetics | Fluphenazine, pharmacokinetics | Diazepam, pharmacokinetics | Trazodone, pharmacokinetics | Imipramine, pharmacokinetics | Clozapine, pharmacokinetics | Trifluoperazine, pharmacokinetics | Tricyclic antidepressants, pharmacokinetics | Clomipramine, pharmacokinetics | Zotepine, pharmacokinetics | Tiotixene, pharmacokinetics | Alprazolam, pharmacokinetics | Nortriptyline, pharmacokinetics | Fluvoxamine, pharmacokinetics | Venlafaxine, pharmacokinetics | Antidepressants, pharmacokinetics | Triazolam, pharmacokinetics | Chlorpromazine, pharmacokinetics | Olanzapine, pharmacokinetics | Antipsychotics, pharmacokinetics | Anxiolytics, pharmacokinetics | Smoking | Pharmacotherapy | Neurology | Neurosciences | Medicine & Public Health | Psychiatry | Psychopharmacology | VARIABILITY FACTORS | TOBACCO SMOKING | CIGARETTE-SMOKING | REDUCED HALOPERIDOL | PSYCHIATRIC POPULATION | DEPRESSED-PATIENTS | PLASMA-CONCENTRATIONS | DRUG-INTERACTIONS | CYP1A2 GENE | PHARMACOLOGY & PHARMACY | TARDIVE-DYSKINESIA | NEUROSCIENCES | Smoking - metabolism | Animals | Drug Interactions | Mental Disorders - drug therapy | Psychotropic Drugs - pharmacokinetics | Humans | Mental Disorders - metabolism | Smoking - psychology
Book Review
Clinical pharmacokinetics, ISSN 0312-5963, 2008, Volume 47, Issue 10, pp. 635 - 654
Journal Article
2003, Volume 42, Issue 14, 30
Modifications to bodily functions and physiology are known to occur with age. These changes can have a considerable impact on the pharmacokinetic processes of... 
Melphalan, pharmacokinetics | Vinblastine, pharmacokinetics | Cytarabine, pharmacokinetics | Antimetabolites, pharmacokinetics | Gemcitabine, pharmacodynamics | Vinca alkaloids, pharmacodynamics | Fluorouracil, pharmacokinetics | Ifosfamide, pharmacodynamics | Methotrexate, pharmacokinetics | Topotecan, pharmacodynamics | Capecitabine, pharmacodynamics | Irinotecan, pharmacokinetics | Vinca alkaloids, pharmacokinetics | Alkylating agents, pharmacokinetics | Chlorambucil, pharmacokinetics | Cyclophosphamide, pharmacodynamics | Vincristine, pharmacokinetics | Carboplatin, pharmacodynamics | Fludarabine, pharmacodynamics | Cisplatin, pharmacokinetics | Vinorelbine, pharmacodynamics | Capecitabine, pharmacokinetics | Platinum complexes, pharmacokinetics | Topotecan, pharmacokinetics | Cytarabine, pharmacodynamics | DNA topoisomerase inhibitors, pharmacodynamics | Chlorambucil, pharmacodynamics | Fluorouracil, pharmacodynamics | Fludarabine, pharmacokinetics | Cyclophosphamide, pharmacokinetics | Antimetabolites, pharmacodynamics | Gemcitabine, pharmacokinetics | Melphalan, pharmacodynamics | Oxaliplatin, pharmacokinetics | Vinblastine, pharmacodynamics | Vinorelbine, pharmacokinetics | Cisplatin, pharmacodynamics | Vincristine, pharmacodynamics | Oxaliplatin, pharmacodynamics | Irinotecan, pharmacodynamics | Ifosfamide, pharmacokinetics | Methotrexate, pharmacodynamics | Alkylating agents, pharmacodynamics | Platinum complexes, pharmacodynamics | Carboplatin, pharmacokinetics | Elderly | DNA topoisomerase inhibitors, pharmacokinetics | Cancer | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | CELL LUNG-CANCER | LEUKEMIA GROUP-B | DOXORUBICIN-BASED CHEMOTHERAPY | COLONY-STIMULATING FACTOR | RANDOMIZED PHASE-III | METASTATIC BREAST-CANCER | NON-HODGKINS-LYMPHOMA | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHARMACOLOGY & PHARMACY | ACUTE MYELOID-LEUKEMIA | PLASMA-PROTEIN BINDING | Drug Interactions | Antineoplastic Agents - adverse effects | Humans | Aged, 80 and over | Aging | Aged | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Frail Elderly | Patient Compliance | Neoplasms - drug therapy | Randomized Controlled Trials as Topic
Book Review
2004, Volume 43, Issue 12, 18
Topiramate is a new antiepileptic drug (AED) that has been approved worldwide (in more than 80 countries) for the treatment of various kinds of epilepsy. It is... 
Haloperidol, drug interactions | Topiramate, drug interactions | Carbamazepine, drug interactions | Risperidone, pharmacokinetics | Valproic acid, drug interactions | Topiramate, pharmacokinetics | Propranolol, pharmacokinetics | Sumatriptan, pharmacokinetics | Valproic acid, pharmacokinetics | Haloperidol, pharmacokinetics | Phenytoin, drug interactions | Antimigraines, drug interactions | Phenytoin, pharmacokinetics | Lithium, drug interactions | Carbamazepine, pharmacokinetics | Antiepileptic drugs, drug interactions | Drug interactions | Risperidone, drug interactions | Antimigraines, pharmacokinetics | Sumatriptan, drug interactions | Antiepileptic drugs, pharmacokinetics | Antipsychotics, drug interactions | Lithium, pharmacokinetics | Propranolol, drug interactions | Antipsychotics, pharmacokinetics | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | STEADY-STATE PHARMACOKINETICS | NORETHINDRONE | ETHINYL ESTRADIOL | COMBINATION THERAPY | LAMOTRIGINE | CARBAMAZEPINE | VALPROATE | PHARMACOLOGY & PHARMACY | EPILEPSY | BIOAVAILABILITY | REPETITIVE MONOTHERAPY | Anticonvulsants - pharmacokinetics | Fructose - pharmacokinetics | Area Under Curve | Psychotropic Drugs - pharmacokinetics | Humans | Sumatriptan - therapeutic use | Lithium - pharmacokinetics | Anticonvulsants - therapeutic use | Half-Life | Metabolic Clearance Rate | Fructose - therapeutic use | Fructose - analogs & derivatives | Serotonin Receptor Agonists - therapeutic use | Drug Interactions | Lithium - metabolism | Serotonin Receptor Agonists - pharmacokinetics | Sumatriptan - pharmacokinetics | Epilepsy - drug therapy | Contraceptives, Oral - pharmacokinetics
Book Review
07/1998, Volume 35, Issue 1, 28
Stimulating cardiac -adrenoceptors with oxyfedrine causes dilatation of coronary vessels and positive inotropic effects on the myocardium. -adrenergic agonists... 
Reviews-on-treatment | Hypertension | Calcium-antagonists, pharmacokinetics | Clinical-pharmacokinetics | Alpha-blockers, pharmacokinetics | ACE-inhibitors, pharmacokinetics | Phosphodiesterase-inhibitors, pharmacokinetics | Bioavailability | Pregnancy | Xanthines, pharmacokinetics | Coronary-disorders | Children | Angiotensin-antagonists, pharmacokinetics | Vasodilators, pharmacokinetics | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | THEOPHYLLINE PHARMACOKINETICS | INTRAVENOUS NITROGLYCERIN | POPULATION PHARMACOKINETICS | RENAL-FAILURE | ISOSORBIDE DINITRATE | PHARMACOLOGY & PHARMACY | ESSENTIAL-HYPERTENSION | CONGESTIVE-HEART-FAILURE | ARTERIAL OCCLUSIVE DISEASE | CHRONIC CARDIAC-FAILURE | BLOOD-PRESSURE | Nitroprusside - pharmacokinetics | Enoximone - pharmacokinetics | Isosorbide Dinitrate - analogs & derivatives | Labetalol - pharmacokinetics | Vasodilator Agents - pharmacokinetics | Humans | Milrinone | Imidazoles - pharmacokinetics | Propanolamines - pharmacokinetics | Theophylline - pharmacokinetics | Nitroglycerin - pharmacokinetics | Prazosin - pharmacokinetics | Female | Adrenergic alpha-Antagonists - pharmacokinetics | Piperazines - pharmacokinetics | Isosorbide Dinitrate - pharmacokinetics | Indoramin - pharmacokinetics | Alprostadil - pharmacokinetics | Phosphodiesterase Inhibitors - pharmacokinetics | Pyridones - pharmacokinetics | Iloprost - pharmacokinetics | Pentaerythritol Tetranitrate - pharmacokinetics | Adrenergic beta-Agonists - pharmacokinetics | Amrinone - pharmacokinetics | Oxyfedrine - pharmacokinetics | Molsidomine - pharmacokinetics | Carbazoles - pharmacokinetics | Trapidil - pharmacokinetics
Book Review
Anaesthesia and intensive care, ISSN 0310-057X, 06/2005, Volume 33, Issue 3, pp. 311 - 322
The clinical utility of most analgesic drugs is altered in the presence of patients with impaired renal or hepatic function not simply because of altered... 
Analgesia: renal failure, renal function, hepatic failure, hepatic function, review | Acute pain | acute pain | MORPHINE | hepatic function | GLUCURONIDES | DISPOSITION | PLASMA | PHARMACOKINETICS | METABOLISM | hepatic failure | review | LIVER-FAILURE | renal function | ANESTHESIOLOGY | REMIFENTANIL | HEPATOTOXICITY | analgesia : renal failure | FENTANYL | CRITICAL CARE MEDICINE | Kidney Failure, Chronic - physiopathology | Analgesics - therapeutic use | Pain - drug therapy | Humans | Half-Life | Biological Availability | Metabolic Clearance Rate | Analgesics - pharmacokinetics | Liver Diseases - physiopathology | Liver Diseases - metabolism | Contraindications | Kidney Failure, Chronic - metabolism | Methadone, pharmacokinetics | Anti-Inflammatory Agents, Non-Steroidal, adverse effects | Piperidines, pharmacokinetics | Hydrocodone, pharmacokinetics | Fentanyl, pharmacokinetics | Pain, complications | Buprenorphine, pharmacokinetics | Hydrocodone, administration and dosage | Carbamazepine, pharmacokinetics | Acute Disease | Ketamine, pharmacokinetics | Sufentanil, pharmacokinetics | Propoxyphene, pharmacokinetics | Acetaminophen, adverse effects | Clonidine, administration and dosage | Morphine, administration and dosage | Oxycodone, administration and dosage | Propoxyphene, administration and dosage | Hydromorphone, administration and dosage | Methadone, administration and dosage | Alfentanil, pharmacokinetics | Buprenorphine, administration and dosage | Codeine, pharmacokinetics | Meperidine, pharmacokinetics | Sufentanil, administration and dosage | Anesthetics, Local, therapeutic use | Codeine, administration and dosage | Mexiletine, pharmacokinetics | Mexiletine, administration and dosage | Anti-Inflammatory Agents, Non-Steroidal, therapeutic use | Liver Failure, complications | Alfentanil, administration and dosage | Piperidines, administration and dosage | Pain, drug therapy | Ketamine, administration and dosage | Fentanyl, administration and dosage | Carbamazepine, administration and dosage | Hydromorphone, pharmacokinetics | Ketorolac, pharmacokinetics | Analgesics, Opioid, therapeutic use | Ketorolac, administration and dosage | Tramadol, administration and dosage | Morphine, pharmacokinetics | Valproic Acid, pharmacokinetics | Acetaminophen, administration and dosage | Valproic Acid, administration and dosage | Tramadol, pharmacokinetics | Acetic Acids | Kidney Failure, complications | Antidepressive Agents, Tricyclic, therapeutic use | Meperidine, administration and dosage | Clonidine, pharmacokinetics | Analgesics, Non-Narcotic, therapeutic use | Oxycodone, pharmacokinetics | Valproic Acid, adverse effects
Journal Article