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1. Full Text The elusive endogenous adipogenic PPARγ agonists: Lining up the suspects
by Hallenborg, Philip and Petersen, Rasmus K and Kouskoumvekaki, Irene and Newman, John W and Madsen, Lise and Kristiansen, Karsten
Progress in Lipid Research, ISSN 0163-7827, 01/2016, Volume 61, pp. 149 - 162
The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is the key decisive factor controlling the development of adipocytes. Ligand-mediated... 
Lipoxygenases | Cyclooxygenases | Reactive oxygen species | Polyunsaturated fatty acids | PPARγ | Adipogenesis | AF-1 ligand-independent activation function | NOS nitric oxide synthase | ADH alcohol dehydrogenase | ELOVL3 elongation of very long chain fatty acids 3 | FFA free fatty acid | DPEP dipeptidase | LNO | RXR retinoic X receptor | PTM post-translational modification | prostaglandin J | NOX4 NADPH oxidase 4 | azPC azelayol phosphatidylcholine | HPETE hydroperoxyeicosatetraenoic acid | GGT gamma-glutamyltransferase | MEF mouse embryonic fibroblast | C/EBP CCAAT/enhancer binding protein | TZD thiazolidinedione | Mo-Co molybdenum cofactor | CBR carbonyl reductase | HPODE hydroperoxyoctadecadienoic acid | AA arachidonic acid | HETE hydroxyeicosatrienoic acid | MAPK mitogen-activated protein kinase | PL phospholipase | pRB retinoblastoma protein | Abbreviations NO nitric oxide | cPLA | PTGR prostaglandin reductase | EET epoxyeicosatrienoic | PPARγ peroxisome proliferator-activated receptor γ | ROS reactive oxygen species | cytosolic PLA | EH epoxide hydrolase | BAT Brown adipose tissue | HODE hydroxyoctdecenonic acid | PTGES prostaglandin E synthase | LOX lipoxygenase | Epac exchange protein directly activated by cAMP | LPA lysophosphatidic acid | ChREBP carbohydrate element binding protein | NR nuclear receptor | LA linoleic acid | XOR xanthine oxidoreductase | CPA cyclic phosphatidic acid | AF-2 ligand-dependent activation function | TX thromboxane | 15-deoxy-Δ | PGDH 15-hydroxyprostaglandin dehydrogenase | PGFS prostaglandin F synthase | KETE ketoeicosatetraenoic acid | SREBP-1c sterol-regulatory element binding protein 1c | eLOX3 epidermis lipoxygenase type 3 | GPC glycerophosphocholine | LBD ligand binding domain | nitrolinoleic acid | PTGIS prostacyclin synthase | ONO | PG prostaglandin | RetSat retinol saturase | dioxide radical | EPA eicosapentaenoic acid | MUFA monounsaturated fatty acid | GPx glutathione peroxidase | LTC4S leukotriene C4 synthase | COX cyclooxygenase | IBMX isobutyl-methylxanthine | peroxynitrite | PPRE peroxisome proliferator response element | HPGD 15-hydroxyprostaglandin dehydrogenase | 15-dPGJ | DHET dihydroxyeicosatrienoic acid | FAS fatty acid synthase | PTGDS prostaglandin D2 synthase | sEH soluble epoxide hydrolase | UCP1 uncoupling protein 1 | CYP cytochrome P450 monooxygenase | WAT white adipose tissue | superoxide | FAD flavin adenine dinucleotide | PUFA polyunsaturated fatty acid | TBXAS thromboxane A synthase | INHIBITS ADIPOCYTE DIFFERENTIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOMINANT-NEGATIVE MUTATIONS | CELL-DERIVED ADIPOCYTES | MITOTIC CLONAL EXPANSION | PROLIFERATOR-ACTIVATED-RECEPTOR | PPAR gamma | WHITE ADIPOSE-TISSUE | NUTRITION & DIETETICS | 3T3-L1 PREADIPOCYTE DIFFERENTIATION | POLYUNSATURATED FATTY-ACIDS | LIGAND-BINDING DOMAIN | PROSTAGLANDIN F-2 ALPHA | PPAR gamma - physiology | Prostaglandins | Animals | Oxidation-Reduction | Humans | Lipid Metabolism | Adipocytes - physiology | Fatty Acids - metabolism
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2. Full Text Signaling functions of phosphatidic acid
by Wang, Xuemin and Devaiah, Shivakumar Pattada and Zhang, Wenhua and Welti, Ruth
Progress in Lipid Research, ISSN 0163-7827, 2006, Volume 45, Issue 3, pp. 250 - 278
Phosphatidic acid (PA) has emerged as a new class of lipid mediators involved in diverse cellular functions in plants, animals, and microorganisms.... 
Lipid signaling | Reactive oxygen species | Protein kinase | Roots | Abscisic acid | Guard cells | Protein phosphatase | Plant stress response | G proteins | Phospholipase D | Phosphatidic acid | phospholipase D | PROTEIN-KINASE TARGET | ARABIDOPSIS-THALIANA | guard cells | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | D ACTIVATION | roots | PLASMA-MEMBRANE | protein kinase | protein phosphatase | PHOSPHOLIPASE-D-ALPHA | DIACYLGLYCEROL KINASE | NUTRITION & DIETETICS | CASTOR BEAN-LEAVES | CULTURED RICE CELLS | reactive oxygen species | abscisic acid | plant stress response | phosphatidic acid | ABSCISIC-ACID | lipid signaling | Phosphorylation | Plants - metabolism | Animals | Oxidative Stress - physiology | Cell Physiological Phenomena | Cytoplasmic Vesicles - metabolism | Signal Transduction - physiology | Phosphatidic Acids - biosynthesis | Phosphatidic Acids - physiology | Lipid Metabolism - physiology | Phosphates | Oxidases | Niacinamide | Coenzymes | Phosphatases | Adenine | Proteins | Phosphatidylinositol | Ionization | Sphingosine | Physiological aspects | Phospholipases | Protein kinases | Mass spectrometry
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3. Full Text Phosphatidic acid synthesis in bacteria
by Yao, Jiangwei and Rock, Charles O
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 03/2013, Volume 1831, Issue 3, pp. 495 - 502
Membrane phospholipid synthesis is a vital facet of bacterial physiology. Although the spectrum of phospholipid headgroup structures produced by bacteria is... 
Bacteria | Coenzyme A | Acyltransferase | Acyl carrier protein | Diacylglycerol | Phosphatidic acid | PHENETHYL ALCOHOL | SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE | MEMBRANE PHOSPHOLIPID-SYNTHESIS | UNSATURATED FATTY-ACIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SN-GLYCEROL 3-PHOSPHATE | CELL BIOLOGY | L-ALPHA-GLYCEROPHOSPHATE | BIOPHYSICS | BACILLUS-SUBTILIS | ESCHERICHIA-COLI K-12 | GRAM-POSITIVE PATHOGENS | Acetyltransferases - metabolism | Acyl Carrier Protein - metabolism | Humans | Glycerophosphates - metabolism | Escherichia coli Proteins - metabolism | Phosphatidic Acids - biosynthesis | Drug Discovery | 1-Acylglycerol-3-Phosphate O-Acyltransferase - metabolism | Animals | Diglycerides - metabolism | Escherichia coli - metabolism | Glycolysis | Bacterial Proteins - metabolism | Acyl Coenzyme A - metabolism | Fatty Acids - metabolism | Glycerin | Phosphates | Glucose metabolism | Synthesis | Physiological aspects | Glycerol | Lipids | Phosphotransferases | Fatty acids | Acylation
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4. Full Text Phosphatidic acid-mediated signaling
by Liu, Yu and Su, Yuan and Wang, Xuemin
Advances in Experimental Medicine and Biology, ISSN 0065-2598, 2013, Volume 991, pp. 159 - 176
Phosphatidic acid (PA) is recognized as an important class of lipid messengers. The cellular PA levels are dynamic; PA is produced and metabolized by several... 
Lipid signaling | Diacylglycerol kinase | Stress response | Phospholipase D | Phosphatidic acid | Phospholipase C | Animals | Cell Proliferation | Transport Vesicles - physiology | Diacylglycerol Kinase - metabolism | Humans | Lipid Metabolism | Signal Transduction - physiology | Phosphatidic Acids - physiology | Phospholipase D - metabolism
Conference Proceeding
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5. Phosphatidic Acid-Mediated Signaling
by Liu, Y and Su, Y and Wang, XM
2013, Advances in Experimental Medicine and Biology, Volume 991, 18
Phosphatidic acid (PA) is recognized as an important class of lipid messengers. The cellular PA levels are dynamic; PA is produced and metabolized by several... 
Lipid signaling | MEDICINE, RESEARCH & EXPERIMENTAL | ARABIDOPSIS-THALIANA | CAMP-SPECIFIC PHOSPHODIESTERASE | PROTEIN-KINASE | BINDING-PROTEIN | Diacylglycerol kinase | PLASMA-MEMBRANE | Phospholipase D | Phospholipase C | LYSOPHOSPHATIDIC ACID | PHOSPHOLIPASE-D ACTIVITY | BIOLOGY | Stress response | ABSCISIC-ACID | SPHINGOSINE KINASE | Phosphatidic acid
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6. Full Text 2-O-Carba-oleoyl cyclic phosphatidic acid induces glial proliferation through the activation of lysophosphatidic acid receptor
by Nakajima, Shingo and Gotoh, Mari and Fukasawa, Keiko and Murofushi, Hiromu and Murakami-Murofushi, Kimiko
Brain Research, ISSN 0006-8993, 02/2018, Volume 1681, pp. 44 - 51
Lysophosphatidic acid (LPA) and cyclic phosphatidic acid (cPA) are one of the lipid mediators regulating cell proliferation and differentiation through the... 
2-O-Carba-cyclic phosphatidic acid | Proliferation | Lysophosphatidic acid | Astrocytes | Oligodendrocyte precursor cells | NERVOUS-SYSTEM | OXIDATIVE STRESS | NEUROSCIENCES | PATHOPHYSIOLOGY | OLIGODENDROCYTE DIFFERENTIATION | MULTIPLE-SCLEROSIS | DEMYELINATION | LPA | SIGNAL-REGULATED KINASE | AUTOTAXIN
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7. Full Text A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids
by Eto, Miki and Shindou, Hideo and Shimizu, Takao
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2014, Volume 443, Issue 2, pp. 718 - 724
Glycerophospholipids are important components of cellular membranes, required for constructing structural barriers, and for providing precursors of bioactive... 
Brain | Lysophosphatidic acyltransferase | Docosahexaenoic acid | Glycerophospholipid | Phosphatidic acid | SUBSTRATE PREFERENCE | ALZHEIMER-DISEASE | BIOPHYSICS | METABOLISM | BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEINS | Brain - metabolism | Glycerophospholipids - metabolism | Tissue Distribution | Animals | Mice, Inbred C57BL | Mice | Acyltransferases - metabolism | Organ Specificity | Docosahexaenoic Acids - metabolism | Enzymes | Unsaturated fatty acids | Lipids | Omega-3 fatty acids
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8. Full Text Creatine kinase muscle type specifically interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids
by Hoshino, Fumi and Murakami, Chiaki and Sakai, Hiromichi and Satoh, Mamoru and Sakane, Fumio
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2019, Volume 513, Issue 4, pp. 1035 - 1040
Diacylglycerol kinase (DGK) δ, which is a key enzyme in the pathogenesis of type 2 diabetes (T2D), preferentially generates saturated fatty acid (SFA)- and/or... 
Diabetes | Diacylglycerol kinase | Creatine kinase | Saturated fatty acid | Phosphatidic acid | DOMAIN | PROTEIN | DELTA | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIACYLGLYCEROL-KINASE | INSULIN | BIOPHYSICS | KAPPA | CLONING | GLUCOSE | BINDING
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9. Full Text Phosphatidic acid in membrane rearrangements
by Zhukovsky, Mikhail A and Filograna, Angela and Luini, Alberto and Corda, Daniela and Valente, Carmen
FEBS Letters, ISSN 0014-5793, 09/2019, Volume 593, Issue 17, pp. 2428 - 2451
Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique biophysical properties: a small headgroup; negative charge; and a... 
membrane curvature | lysophosphatidic acid | phosphatidic acid | membrane fission | diacylglycerol | membrane fusion | PROTEIN-KINASE-C | MOLECULAR-DYNAMICS | PHOSPHOLIPASE-D | TRANSBILAYER MOVEMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPONTANEOUS CURVATURE | PLASMA-MEMBRANE | CELL BIOLOGY | IN-VITRO | MITOCHONDRIAL DYNAMICS | BIOPHYSICS | SECONDARY STRUCTURE | LIPID-COMPOSITION
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10. Full Text Two pathways for lysophosphatidic acid production
by Aoki, Junken and Inoue, Asuka and Okudaira, Shinichi
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 2008, Volume 1781, Issue 9, pp. 513 - 518
Lysophosphatidic acid (LPA, 1- or 2-acyl- -glycerol 3-phosphate) is a simple phospholipid but displays an intriguing cell biology that is mediated via... 
G protein-coupled receptor | Lysophosphatidic acid | Autotaxin | LPA receptor | P2Y5 | LPA | mPA-PLA 1α/LIPH | mPA-PLA | α/LIPH | CANCER CELLS | autotaxin | LYSOPHOSPHOLIPASE-D ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPASE A | ACTIVATED PLATELETS | CELL BIOLOGY | NEUROPATHIC PAIN | BOVINE BRAIN | lysophosphatidic acid | mPA-PLA 1 alpha/LIPH | BIOPHYSICS | PROTEIN-COUPLED RECEPTOR | HUMAN HAIR-GROWTH | PHOSPHATIDIC-ACID | MOLECULAR-CLONING | Glycerin | Phosphates | Isoenzymes | Nuclear radiation | Genetic research | Glycerol | Family | Phospholipases | Neovascularization | G proteins | Cells | Membrane proteins
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