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Annual review of biochemistry, ISSN 0066-4154, 6/2017, Volume 86, Issue 1, pp. 225 - 244
Autophagy is the process of cellular self-eating by a double-membrane organelle, the autophagosome. A range of signaling processes converge on two protein... 
COPII | Atg1 | membrane remodeling | vesicle | tethering complex | nanoscale biology | ULK1 | Vps34 | membrane fusion | phosphatidylinositol 3-kinase | Vesicle | Membrane fusion | Membrane remodeling | Phosphatidylinositol 3-kinase | Nanoscale biology | Tethering complex | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHAGOPHORE ASSEMBLY SITE | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES | REGULATES AUTOPHAGY | MAMMALIAN AUTOPHAGY | BECLIN 1 PHOSPHORYLATION | SACCHAROMYCES-CEREVISIAE | SELECTIVE AUTOPHAGY | ATG1 KINASE COMPLEX | ENDOPLASMIC-RETICULUM | ULK1 COMPLEX | Humans | Protein Multimerization | Eukaryotic Cells - metabolism | Autophagy-Related Protein-1 Homolog - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Eukaryotic Cells - ultrastructure | Class III Phosphatidylinositol 3-Kinases - chemistry | Phagosomes - ultrastructure | Cell Membrane - metabolism | Autophagy - genetics | Intracellular Signaling Peptides and Proteins - genetics | Phosphatidylinositol 3-Kinase - metabolism | COP-Coated Vesicles - ultrastructure | Gene Expression | Signal Transduction | Phagosomes - metabolism | Gene Expression Regulation | COP-Coated Vesicles - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Cell Membrane - ultrastructure | Autophagy-Related Protein-1 Homolog - chemistry | Phosphatidylinositol 3-Kinase - chemistry | Phosphatidylinositol 3-Kinase - genetics | Class III Phosphatidylinositol 3-Kinases - genetics | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | Autophagy-Related Protein-1 Homolog - genetics | Physiological aspects | Autophagy (Cytology) | Genetic aspects | Research | Gene expression
Journal Article
Biochemical journal, ISSN 1470-8728, 2014, Volume 463, Issue 3, pp. 413 - 427
We characterize VPS34-IN, a potent and selective inhibitor of class III Vps34 PI3K. Using VPS34-IN1, we demonstrate that PtdIns(3)P, produced by Vps34 controls... 
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene-1 (NDRG1) | Protein Structure, Tertiary | Cell Line | Phosphorylation | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Class II Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Humans | Inositol Polyphosphate 5-Phosphatases | Class III Phosphatidylinositol 3-Kinases - metabolism | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Endosomes - metabolism | Amino Acid Motifs | Aminopyridines - pharmacology | Hydrophobic and Hydrophilic Interactions | Protein Binding | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | SGK3, serum- and glucocorticoid-regulated kinase-3 | signal transduction inhibitor | PI3K, phosphoinositide 3-kinase | ITC, isothermal titration calorimetry | SHIP1 | mTORC, mammalian target of rapamycin complex | EEA1, early endosome antigen 1 | INPP4B, inositol polyphosphate 4-phosphatase type II | TSC2, tuberous sclerosis complex 2 | phosphoinositide 3-kinase (PI3K) | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | DMEM, Dulbecco's modified Eagle's medium | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | IP1, inositol phosphate | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | PX, Phox homology | mammalian target of rapamycin (mTOR) | Accelerated Publication | PH, pleckstrin homology | PtdIns, phosphatidylinositol | PRAS40, proline-rich Akt substrate 40 kDa | protein kinase inhibitor | 2, Src homology 2-domain-containing inositol phosphatase 1 | Vps34, vacuolar protein sorting 34 | VSV-G, vesicular stomatitis virus glycoprotein
Journal Article
PLoS Genetics, ISSN 1553-7390, 10/2011, Volume 7, Issue 10, p. e1002319
We previously reported that autosomal recessive demyelinating Charcot-Marie-Tooth (CMT) type 4B1 neuropathy with myelin outfoldings is caused by loss of MTMR2... 
CELLS | PIKFYVE | MYOTUBULARIN-RELATED PROTEIN-2 | PHOSPHOINOSITIDE PHOSPHATASE | DISEASE | GENETICS & HEREDITY | NEURODEGENERATION | PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE | GROWTH-FACTOR | MYOPATHY | FAMILY | Axons - enzymology | Phosphatidylinositol Phosphates - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Charcot-Marie-Tooth Disease - enzymology | Humans | Phosphatidylinositol 3-Kinases - metabolism | Charcot-Marie-Tooth Disease - genetics | Myelin Sheath - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Neurons - metabolism | Peripheral Nerves - metabolism | Phospholipids - metabolism | Charcot-Marie-Tooth Disease - metabolism | Flavoproteins - metabolism | Flavoproteins - genetics | Mice, Inbred C57BL | Axons - metabolism | Rats | Schwann Cells - metabolism | Phospholipids - genetics | Phosphatidylinositol Phosphates - genetics | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Peripheral Nerves - enzymology | Animals | Aminopyridines - pharmacology | Myelin Sheath - genetics | Neurons - enzymology | Protein Tyrosine Phosphatases, Non-Receptor - metabolism | Phosphoinositide Phosphatases | Mice | Mutation | Peripheral Nerves - growth & development | Schwann Cells - enzymology | Phosphatases | Gene mutations | Charcot-Marie-Tooth disease | Physiological aspects | Genetic aspects | Research | Health aspects | Risk factors | Aminopyridines | Heterocyclic Compounds, 3-Ring | Peripheral Nerves | Schwann Cells | Neurons | Phospholipids | Phosphatidylinositol Phosphates | Protein Tyrosine Phosphatases, Non-Receptor | Phosphatidylinositol 3-Kinases | Charcot-Marie-Tooth Disease | Life Sciences | Axons | Myelin Sheath | Genetics | Flavoproteins | Proteins | Yeast | Homeostasis | Kinases | Experiments | Evacuations & rescues
Journal Article
Journal Article
Nature reviews. Immunology, ISSN 1474-1741, 2016, Volume 16, Issue 11, pp. 702 - 714
Primary immunodeficiencies are inherited disorders of the immune system, often caused by the mutation of genes required for lymphocyte development and... 
Signal Transduction | Humans | Gene Expression Regulation | Lymphocytes/cytology | Immune System/cytology | Molecular Targeted Therapy | Immunity | Immunologic Deficiency Syndromes/etiology | Cellular Senescence/genetics | Phosphatidylinositol 3-Kinases/antagonists & inhibitors | Animals | Lymphocyte Activation/genetics | Protein Subunits/genetics | Cell Differentiation/genetics | Enzyme Activation | Mutation | T-CELL RESPONSES | IMPAIRED B-CELL | GAIN-OF-FUNCTION | TRANSCRIPTION FACTOR FOXO1 | PHOSPHATIDYLINOSITOL 3-KINASE | PHOSPHOINOSITIDE 3-KINASE P110-DELTA | HYPER IGM SYNDROME | P85-ALPHA SUBUNIT | IMMUNOLOGY | CLASS-IA PI3K | CUTTING EDGE | Immunologic Deficiency Syndromes - etiology | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Protein Subunits - metabolism | Cell Differentiation - genetics | Cellular Senescence - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Lymphocytes - immunology | Immune System - immunology | Protein Subunits - genetics | Lymphocytes - metabolism | Cellular Senescence - genetics | Immunologic Deficiency Syndromes - therapy | Phosphatidylinositol 3-Kinases - chemistry | Lymphocytes - cytology | Immune System - cytology | Phosphatidylinositol 3-Kinases - genetics | Cell Differentiation - immunology | Immune System - metabolism | Immunologic Deficiency Syndromes - metabolism
Journal Article
Leukemia & lymphoma, ISSN 1029-2403, 2015, Volume 56, Issue 10, pp. 2779 - 2786
Idelalisib is a first-in-class selective, oral, phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor approved for the treatment of several types of blood...