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Cancer Discovery, ISSN 2159-8274, 11/2015, Volume 5, Issue 11, pp. 1194 - 11209
Journal Article
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2015, Volume 128, Issue 18, pp. 3456 - 3465
Journal Article
JOURNAL OF CELL SCIENCE, ISSN 0021-9533, 09/2015, Volume 128, Issue 18, pp. 3456 - 3465
PKB/Akt activation is a common step in tumour growth, proliferation and survival. Akt activation is understood to occur at the plasma membrane of cells in... 
LOCALIZATION | Phosphoinositide | P110-ALPHA | Protein kinase B | PROTEIN-KINASE-B | NUCLEAR | SPECIFICITY | PHOSPHORYLATION | PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE | Akt | Rapalogue dimerisation | PHOSPHOINOSITIDES | CELL BIOLOGY | PLECKSTRIN HOMOLOGY DOMAIN | Subcellular compartment | MORPHOLOGY
Journal Article
Journal of Cell Science, ISSN 0021-9533, 10/2010, Volume 123, Issue 20, pp. 3525 - 3534
Phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P₃] is a key regulator of cell signaling that acts by recruiting proteins to the cell membrane, such... 
PtdIns(3,4,5)P | Myosin-X | Endosome | Filopodia | PH domain | Immunoprecipitation | Phosphatidylinositol Phosphates - metabolism | Humans | Cercopithecus aethiops | Protein Structure, Tertiary - genetics | Endosomes - metabolism | Animals | Pseudopodia - metabolism | Protein Binding | Myosins - metabolism | HeLa Cells | COS Cells | Protein Structure, Tertiary - physiology
Journal Article
Journal Article
NEURON, ISSN 0896-6273, 03/2013, Volume 77, Issue 6, pp. 1097 - 1108
PI(3,4,5)P-3 is a low-abundance lipid thought to play a role in the regulation of synaptic activity; however, the mechanism remains obscure. We have... 
ACTIVE ZONE | PROTEIN | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | SNARE COMPLEX | DROSOPHILA-MELANOGASTER | PI(4,5)P-2 | NEUROMUSCULAR-JUNCTION | ENDOCYTOSIS | PLASMA-MEMBRANE | HOMOLOGY | NEUROSCIENCES
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2005, Volume 7, Issue 8, pp. 797 - 807
The evolutionarily conserved DOCK180 protein has an indispensable role in cell migration by functioning as an exchange factor for Rac GTPase via its DOCK... 
CRKII/DOCK180/RAC PATHWAY | PROTEIN | CELL-MIGRATION | PHOSPHATIDYLINOSITOL 3-KINASE | C2 DOMAIN | FOCAL ADHESION KINASE | BINDING | MEMBRANE ASSOCIATION | MYOBLAST CITY | LIVING CELLS | CELL BIOLOGY
Journal Article
Journal Article