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Biochemical journal, ISSN 0264-6021, 08/2011, Volume 438, Issue 1, pp. 53 - 62
Phosphoinositide 4-kinase (PI4K) | Pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PIK3CA | p110α E545k mutation | PIK3CA H1047R mutation | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Humans | Neoplasms, Experimental - prevention & control | Enzyme Inhibitors - therapeutic use | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Mice, Knockout | Neoplasms, Experimental - pathology | Tissue Distribution | Animals | Enzyme Inhibitors - pharmacokinetics | Signal Transduction - drug effects | Protein Isoforms | Mice | Neoplasms, Experimental - metabolism | Tumor Cells, Cultured | Homeodomain Proteins - physiology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | PI3K, phosphoinositide 3-kinase | phosphoinositide 4-kinase (PI4K) | BID, twice daily dosing | p110α E545K mutation | mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | pan-phosphoinositide 3kinase (PI3K) | PI4K, phosphoinositide 4-kinase | QD, once daily dosing | mTOR, mammalian target of rapamycin | TGI, tumour growth inhibition
Journal Article
Biochemical journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 2, pp. 145 - 156
Phospholipid | Signalling | Plant | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Plant Proteins - genetics | Plants - metabolism | Oxidative Stress | Signal Transduction | Calcium - metabolism | Models, Biological | Gene Expression Regulation, Plant | Phosphatidylinositols - metabolism | Plant Proteins - metabolism | Phospholipids - metabolism | Inositol Phosphates - metabolism | Plant Roots - growth & development | Index Medicus | PLC, phospholipase C | LPP, lipid phosphate phosphatase | PI3K, phosphoinositide 3-kinase | 5PTase, inositol polyphosphate 5-phosphatase | AVR4, avirulence 4 | PIPK, phosphoinositide phosphate kinase | Review | ABA, abscisic acid | DGK, DAG kinase | AtIPK2, Arabidopsis thaliana inositol polyphosphate kinase 2 | SNX1, sorting nexin 1 | PDK1, phosphoinositide-dependent kinase 1 | ZmPLC1, Zea mays PLC1 | F-actin, filamentous actin | LOX2, lipoxygenase 2 | IAA, indoleacetic acid | signalling | OsPIPK, Oryza sativa phosphoinositide phosphate kinase | PA, phosphatidic acid | CTR1, constitutive triple response 1 | DAG, diacylglycerol | PIP5K, phosphoinositide phosphate 5-kinase | PP2A, protein phosphatase 2A | AtCP, actin-capping protein | RACK1, receptor for activated C-kinase 1 | IP3R, Ins(1,4,5)P3 receptor | plant | PI4K, phosphoinositide 4-kinase | PLD, phospholipase D | phospholipid | MAPK, mitogen-activated protein kinase
Journal Article
Biochimie, ISSN 0300-9084, 01/2014, Volume 96, Issue 1, pp. 144 - 157
Phosphoinositides | Lipid signalling | Inositol-phosphate | Phospholipase C | Phosphatidic acid | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Adaptation, Physiological | Catalytic Domain | Humans | Lipid Metabolism | Phylogeny | Organ Specificity | Plants - enzymology | Plant Proteins - genetics | Animals | Phosphoinositide Phospholipase C - genetics | Plants - genetics | Plant Proteins - chemistry | Gene Expression Regulation, Plant | Phosphoinositide Phospholipase C - metabolism | Phosphoinositide Phospholipase C - chemistry | Plant Proteins - metabolism | Protein Processing, Post-Translational | Proteins | Phosphates | Inositol | Phospholipases | Phosphotransferases | Index Medicus | Plants | Phosphoinositide Phospholipase C | Life Sciences | Plant Proteins
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Allergy and Immunology | Recurrence | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Class I Phosphatidylinositol 3-Kinases/antagonists & inhibitors | Young Adult | Immunoglobulins, Intravenous/therapeutic use | Enzyme Inhibitors/therapeutic use | Lymphoproliferative Disorders/genetics | Adult | Female | Surveys and Questionnaires | Child | Respiratory Tract Infections/genetics | Mutation/genetics | Hematopoietic Stem Cell Transplantation | International Cooperation | Herpesviridae Infections/genetics | Animals | Adolescent | Survival Analysis | Mice | Immunologic Deficiency Syndromes/genetics | Cohort Studies | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Herpesviridae Infections - genetics | Immunologic Deficiency Syndromes - therapy | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Immunologic Deficiency Syndromes - genetics | Index Medicus | Abridged Index Medicus | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
The FEBS journal, ISSN 1742-464X, 01/2020, Volume 287, Issue 2, pp. 222 - 238
autophagy | phosphoinositide kinase | phosphoinositide phosphatase | lysosome | mTORC1 | phosphoinositide | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Phosphoinositides | Deregulation | Starvation | Homeostasis | Lipids | Phospholipids | Sphingolipids | Kinases | Metabolism | Autophagy | Neuromodulation | Modulators | Sterols | Neurodegeneration | Phagocytosis | Index Medicus
Journal Article