X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (1096) 1096
Publication (157) 157
Book Review (11) 11
Book Chapter (9) 9
Conference Proceeding (3) 3
Dissertation (3) 3
Book / eBook (2) 2
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
phosphoinositide 3-kinase (670) 670
index medicus (599) 599
animals (504) 504
humans (474) 474
mice (288) 288
signal transduction (281) 281
phosphatidylinositol 3-kinases - metabolism (267) 267
phosphatidylinositol 3-kinase (249) 249
kinases (238) 238
biochemistry & molecular biology (223) 223
cell biology (220) 220
activation (219) 219
oncology (192) 192
phosphorylation (180) 180
immunology (173) 173
phosphatidylinositol 3-kinases - antagonists & inhibitors (164) 164
proteins (163) 163
research (155) 155
cancer (154) 154
pi3k (148) 148
apoptosis (145) 145
1-phosphatidylinositol 3-kinase (123) 123
male (122) 122
female (118) 118
inflammation (118) 118
proto-oncogene proteins c-akt - metabolism (114) 114
research article (114) 114
physiological aspects (108) 108
health aspects (107) 107
expression (106) 106
gene expression (104) 104
genetic aspects (104) 104
akt (100) 100
cell line, tumor (100) 100
signal transduction - drug effects (100) 100
phosphatidylinositol 3-kinases - genetics (98) 98
multidisciplinary sciences (94) 94
enzyme inhibitors - pharmacology (92) 92
mutation (92) 92
cells, cultured (91) 91
phosphoinositides (89) 89
rats (86) 86
article (85) 85
care and treatment (82) 82
pharmacology & pharmacy (82) 82
biology (81) 81
protein kinase inhibitors - pharmacology (81) 81
hematology (80) 80
medicine, research & experimental (80) 80
cell line (79) 79
medicine (76) 76
pathway (76) 76
kinase (75) 75
akt protein (73) 73
inhibition (72) 72
cells (71) 71
b-cell (70) 70
science (70) 70
signaling (70) 70
cell proliferation (69) 69
development and progression (68) 68
rodents (68) 68
signal transduction - physiology (68) 68
protein kinases (66) 66
analysis (65) 65
cell growth (65) 65
studies (65) 65
cellular signal transduction (64) 64
chemistry, medicinal (64) 64
physiology (64) 64
cell cycle (62) 62
mice, knockout (61) 61
p110-delta (61) 61
nf-kappa-b (60) 60
enzymes (59) 59
articles (57) 57
in-vivo (56) 56
mice, inbred c57bl (56) 56
proliferation (56) 56
lipids (55) 55
chronic lymphocytic-leukemia (54) 54
phosphoinositide 3-kinase p110-delta (54) 54
enzyme activation (53) 53
morpholines - pharmacology (53) 53
phosphatidylinositol 3-kinases - physiology (53) 53
phosphoinositide 3-kinase delta (53) 53
p110 delta (52) 52
tumors (51) 51
antineoplastic agents - pharmacology (48) 48
growth (48) 48
insulin (48) 48
receptor (48) 48
signaling pathway (48) 48
gene-expression (47) 47
protein binding (47) 47
signaling pathways (47) 47
differentiation (46) 46
protein-kinase (46) 46
metastasis (45) 45
protein-kinase-c (45) 45
more...
Library Location Library Location
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


by Coulter, Tanya I., MRCPI and Chandra, Anita, PhD, FRCPath and Bacon, Chris M., PhD, FRCPath and Babar, Judith, MRCP, FRCR and Curtis, James, PhD and Screaton, Nick, FRCP, FRCR and Goodlad, John R., MD, FRCPath and Farmer, George, MD and Steele, Cathal Laurence, MB and Leahy, Timothy Ronan, MRCPI and Doffinger, Rainer, PhD, FRCPath and Baxendale, Helen, PhD, FRCPath and Bernatoniene, Jolanta, PhD and Edgar, J. David M., FRCP, FRCPath and Longhurst, Hilary J., PhD, FRCPath and Ehl, Stephan, MD, PhD and Speckmann, Carsten, MD and Grimbacher, Bodo, MD, PhD and Sediva, Anna, MD, PhD and Milota, Tomas, MD and Faust, Saul N., PhD, FRCPCH and Williams, Anthony P., PhD, FRCPath and Hayman, Grant, FRCP, FRCPath and Kucuk, Zeynep Yesim, MD and Hague, Rosie, MRCP, FRCPH and French, Paul, MD, MRCS, DipFMS, FRCPath and Brooker, Richard, FRCPCH and Forsyth, Peter, FRCPath and Herriot, Richard, FRCP, FRCPath and Cancrini, Caterina, MD, PhD and Palma, Paolo, MD, PhD and Ariganello, Paola, MD and Conlon, Niall, PhD, FRCPath and Feighery, Conleth, PhD, FRCPath and Gavin, Patrick J., MD and Jones, Alison, PhD, FRCPCH and Imai, Kohsuke, MD, PhD and Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath and Markelj, Gašper, MD and Abinun, Mario, MD, PhD and Rieux-Laucat, Frédéric, PhD and Latour, Sylvain, PhD and Pellier, Isabelle, MD, PhD and Fischer, Alain, MD, PhD and Touzot, Fabien, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Durandy, Anne, MD, PhD and Burns, Siobhan O., MD, PhD and Savic, Sinisa, PhD, FRCPath and Kumararatne, D.S., FRCPath, DPhil (Oxon) and Moshous, Despina, MD, PhD and Kracker, Sven, PhD and Vanhaesebroeck, Bart, PhD, FMedSci and Okkenhaug, Klaus, PhD and Picard, Capucine, MD, PhD and Nejentsev, Sergey, MD, PhD and Condliffe, Alison M., PhD, FRCP and Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Recurrence | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Young Adult | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Adult | Female | Surveys and Questionnaires | Herpesviridae Infections - genetics | Child | Immunologic Deficiency Syndromes - therapy | Hematopoietic Stem Cell Transplantation | International Cooperation | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Animals | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Survival Analysis | Immunologic Deficiency Syndromes - genetics | Mice | Cohort Studies | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 1, pp. 210 - 218.e9
Journal Article
Journal Article
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 03/2018, Volume 9
Activated phosphoinositide 3-kinase (PI3K) delta Syndrome (APDS), caused by autosomal dominant mutations in PIK3CD (APDS1) or PIK3R1 (APDS2), is a... 
registry | MUTATION | PIK3CD | PIK3R1 | IMMUNOLOGY | activated phosphoinositide 3-kinase delta syndrome | natural history | rapamycin | SIROLIMUS
Journal Article
by Jeong, JS and Kim, JS and Kim, SR and Lee, YC
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1661-6596, 07/2019, Volume 20, Issue 14, p. 3525
Journal Article
Clinical Immunology, ISSN 1521-6616, 2016, Volume 171, pp. 38 - 40
Highlights • Activated phosphoinositide 3-kinase δ syndrome may be complicated by refractory autoimmune hemolytic anemia. • Sirolimus presents a precision... 
Allergy and Immunology | Sirolimus | Autoimmune hemolytic anemia | Activated phosphoinositide 3-kinase δ syndrome | Activated phosphoinositide 3-kinase delta syndrome | GENOMICS | IMMUNOLOGY
Journal Article
by Wang, Y and Wang, WJ and Liu, LY and Hou, J and Ying, WJ and Hui, XY and Zhou, QH and Liu, DR and Yao, HL and Sun, JQ and Wang, XC
JOURNAL OF CLINICAL IMMUNOLOGY, ISSN 0271-9142, 11/2018, Volume 38, Issue 8, pp. 854 - 863
PurposeWe aimed to report the clinical manifestations and immunological features of activated phosphatidylinositol 3-kinase syndrome 1 (APDS1) in a Chinese... 
primary immunodeficiency | PIK3CD | MUTATIONS | IMMUNOLOGY | PIK3CD gene | Activated phosphoinositide 3-kinase syndrome | MTOR | rapamycin | FEATURES | Medicine, Experimental | Medical research | B cells | T cells | Health aspects | Immunodeficiency
Journal Article
ISSN 0091-6749, 2016
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 03/2018, Volume 9, p. 446
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 2012, Volume 38, Issue 4, pp. 381 - 391
Abstract Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by the production of autoantibodies against nuclear components.... 
Allergy and Immunology | Lyn tyrosine kinase | Autoimmune disease | Systemic lupus erythematosus | Phosphoinositide 3-kinase p110δ | Autoimmune disease therapy | B-CELL DEVELOPMENT | SYSTEMIC-LUPUS-ERYTHEMATOSUS | PHOSPHATIDYLINOSITOL 3-KINASE | TYROSINE KINASE | ALLERGIC AIRWAY INFLAMMATION | IMMUNOLOGY | NEGATIVE REGULATOR | MUTANT MICE | Phosphoinositide 3-kinase p110 delta | LYN(-/-) MICE | T-CELLS | LYN-DEFICIENT MICE | Kidney - pathology | Antibodies, Antinuclear - immunology | Hyperplasia | Autoimmune Diseases - mortality | Phosphatidylinositol 3-Kinases - metabolism | src-Family Kinases - deficiency | Autoimmune Diseases - genetics | Kidney - metabolism | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | Myeloid Cells - immunology | Proto-Oncogene Proteins c-akt - metabolism | B-Lymphocytes - metabolism | Haploinsufficiency - genetics | Signal Transduction | Mice, Inbred C57BL | Autoimmune Diseases - immunology | Genotype | Receptors, Antigen, B-Cell - immunology | Mice, Knockout | Antibodies, Antinuclear - genetics | Phosphatidylinositol 3-Kinases - genetics | Animals | B-Lymphocytes - immunology | Alleles | Myeloid Cells - metabolism | T-Lymphocytes - immunology | Mice | Myeloid Cells - pathology | src-Family Kinases - genetics | Plasma Cells - cytology | Haploinsufficiency - immunology | Mitogen-Activated Protein Kinases - metabolism | Plasma Cells - immunology | Glomerulonephritis | Enzymes | Animal models | Immunoglobulins | Autoantibodies | Inflammation | Lymphocytes T | Kidney | phosphoinositides | 1-Phosphatidylinositol 3-kinase | Cell activation | haploinsufficiency | Lymphocytes B | Plasma cells | Lyn protein | Autoimmune diseases
Journal Article
Pharmacological Reports, ISSN 1734-1140, 04/2018, Volume 70, Issue 2, pp. 346 - 349
Catalytic subunit delta of phosphoinositide 3-kinase, p110δ, encoded by the gene, was recently proposed as a target for pharmacological treatment of... 
Schizophrenia | Phosphoinositide 3-kinase delta | Antipsychotic drugs | Mechanism of action | Kinase assay | MESSENGER-RNA | PATHWAY | PHARMACOLOGY & PHARMACY | ISOFORM | RECEPTORS | EXPRESSION
Journal Article