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Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2019, Volume 1834, pp. 143 - 152
Evaluating cell death is essential when investigating neurodegeneration and neuroprotection in the retina. Cell death assays provide us with a means to... 
Retinal explant | Flow cytometry | TUNEL | Fluorescence microscopy | Photoreceptor-like cell line | 661W | Immunohistochemistry - methods | Cell Line | Retina - metabolism | Animals | Cell Survival | Cell Death | Biomarkers | Mice | Photoreceptor Cells, Vertebrate - metabolism | Microscopy, Fluorescence | Organ Culture Techniques | Apoptosis | Index Medicus
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 09/2009, Volume 186, Issue 5, pp. 703 - 711
Target of rapamycin (TOR) signaling is a regulator of cell growth. TOR activity can also enhance cell death, and the TOR inhibitor rapamycin protects cells... 
RETINAL DEGENERATION | SURVIVAL | APOPTOSIS | POLYGLUTAMINE | TUBEROUS SCLEROSIS COMPLEX | GROWTH | AGGREGATE-PRONE PROTEINS | TOXICITY | SUPPRESSION | NF-KAPPA-B | CELL BIOLOGY | Drosophila melanogaster - physiology | Ras Homolog Enriched in Brain Protein | Autophagy - physiology | Phosphatidylinositol 3-Kinases - metabolism | Drosophila Proteins - metabolism | Photoreceptor Cells, Invertebrate - ultrastructure | Autophagy-Related Protein-1 Homolog | Neuropeptides - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Neurodegenerative Diseases - pathology | Animals, Genetically Modified | Drosophila melanogaster - cytology | Protein-Serine-Threonine Kinases - genetics | Neuropeptides - metabolism | Monomeric GTP-Binding Proteins - genetics | Phosphatidylinositol 3-Kinases - genetics | Autophagy-Related Protein 7 | Animals | Neurodegenerative Diseases - physiopathology | Cell Death - physiology | Monomeric GTP-Binding Proteins - metabolism | Protein Kinases | Signal Transduction - physiology | TOR Serine-Threonine Kinases | Drosophila Proteins - genetics | Photoreceptor Cells, Invertebrate - metabolism | Cellular proteins | Physiological aspects | Nervous system | Cellular signal transduction | Degeneration | Genetic aspects | Research | Risk factors | Apoptosis | Cell growth | Insects | Cells | Neurological disorders | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, pp. e112142 - e112142
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, pp. e24248 - e24248
Glioblastoma is a highly aggressive malignant tumor involving glial cells in the human brain. We used high-throughput sequencing to comprehensively profile the... 
MALIGNANT GLIOMA | STEM-CELLS | THERAPY | HUMAN CYTOMEGALOVIRUS | BIOLOGY | RECEPTOR | PROLIFERATION | DIFFERENTIATION | CANCER | TUMORS | SIGNATURE | Genetic Therapy | Neurons - pathology | RNA Editing | Humans | MicroRNAs - metabolism | DNA Primers - genetics | Brain - metabolism | Cell Death - genetics | Glioblastoma - genetics | Base Sequence | Neurons - metabolism | Reproducibility of Results | Genes, Transgenic, Suicide - genetics | Thymidine Kinase - genetics | Transcriptome - genetics | Organ Specificity | Down-Regulation - genetics | Genetic Vectors - genetics | Glioblastoma - therapy | Herpesvirus 1, Human - enzymology | Glioblastoma - pathology | Brain - pathology | Cell Line, Tumor | Genetic Variation - genetics | High-Throughput Nucleotide Sequencing | MicroRNAs - genetics | MicroRNA | Gliomas | Cell death | Analysis | Genes | Brain tumors | Biochemistry | Genetic aspects | Gene therapy | Cancer | Enrichment | Cluster analysis | Brain | Post-transcription | Brain cancer | Glioblastoma | Herpes simplex | Viruses | Nervous system | Genomes | Thymidine | Glial cells | Kinases | Suicide | Tissues | Cancer therapies | Gene sequencing | Ganciclovir | Next-generation sequencing | Epidermal growth factor | Cell cycle | Suicide genes | Killing | Thymidine kinase | Medical research | MiRNA | Gene expression | Virology | Brain research | Insects | MicroRNAs | Medical prognosis | Stem cells | Photoreceptors | Glioblastoma cells | Cocaine | Mutation | Apoptosis | Tumors | Transcription | Gene regulation | Data processing | miRNA | glioblastoma cells | Expression vectors | suicide genes | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2012, Volume 109, Issue 36, pp. 14598 - 14603
Retinitis pigmentosa comprises a group of inherited retinal photoreceptor degenerations that lead to progressive loss of vision. Although in most cases rods,... 
Cell death | Retinitis pigmentosa | Retinal degeneration | Photoreceptors | Retina | Retinal cones | Inflammation | Genetic mutation | Apoptosis | Necrosis | Neuroprotection | Oxidation | Neurodegeneration | RETINAL DEGENERATION | ACTIVATION | NECROPTOSIS | MULTIDISCIPLINARY SCIENCES | neurodegeneration | oxidation | PROGRAMMED NECROSIS | apoptosis | inflammation | PATHWAY | neuroprotection | TNF-ALPHA | INHIBITOR | RETINITIS-PIGMENTOSA | Electroretinography | In Situ Nick-End Labeling | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Microscopy, Electron, Transmission | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Retinitis Pigmentosa - genetics | Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics | DNA Primers - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Analysis of Variance | Retina - ultrastructure | Retinal Cone Photoreceptor Cells - enzymology | Mice, Mutant Strains | Retinal Cone Photoreceptor Cells - pathology | Statistics, Nonparametric | Mice | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Real-Time Polymerase Chain Reaction | Retinitis Pigmentosa - pathology | Physiological aspects | Development and progression | Research | Protein kinases | Health aspects | Macular degeneration | Gangrene | Mutation | Kinases | Gene expression | Index Medicus | Biological Sciences
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, pp. e24361 - e24361
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 03/2009, Volume 46, Issue 5, pp. 672 - 679
Age-related macular degeneration (AMD) is a complex disease that has potential involvement of inflammatory and oxidative stress-related pathways in its... 
AMD | Photoreceptors | Retina | Curcumin | Light-induced retinal degeneration | OXIDATIVE DAMAGE | LIPID-PEROXIDATION | ALBINO-RATS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACULAR DEGENERATION | TRANSGENIC RATS | RESPONSIVE ELEMENT | COLON-CANCER CELLS | TRANSCRIPTION FACTOR EGR-1 | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | NF-KAPPA-B | Rats, Wistar | Apoptosis - drug effects | Humans | Oxidative Stress - physiology | Transcriptional Activation - drug effects | Gene Expression Profiling | Cytoprotection - physiology | Curcumin - administration & dosage | Macular Degeneration - drug therapy | Protein Processing, Post-Translational - drug effects | Retinal Cone Photoreceptor Cells - pathology | Macular Degeneration - enzymology | Phytotherapy | Disease Models, Animal | Electroretinography | Macular Degeneration - etiology | NF-kappa B - antagonists & inhibitors | Light - adverse effects | Cells, Cultured | Curcumin - pharmacology | Retinal Cone Photoreceptor Cells - physiology | Rats | Animals | Retinal Cone Photoreceptor Cells - drug effects | Mice | Apoptosis - physiology | Dietary Supplements | Macular Degeneration - pathology | Antigens | Diabetic retinopathy | Hydrogen peroxide | RNA | Streptozocin | Lactate dehydrogenase | Superoxide dismutase | Superoxide | Macular degeneration | Proteins | Methyl aspartate | Cell death | Analysis | Heme | Ophthalmology | Vascular endothelial growth factor | Index Medicus | photoreceptors | light-induced retinal degeneration
Journal Article