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Clinical Cancer Research, ISSN 1078-0432, 01/2013, Volume 19, Issue 1, pp. 279 - 290
Journal Article
International Journal of Cancer, ISSN 0020-7136, 11/2013, Volume 133, Issue 9, pp. 2089 - 2101
The RAS/RAF/MEK/MAPK and the PTEN/PI3K/AKT/mTOR pathways are key regulators of proliferation and survival in human cancer cells. Selective inhibitors of... 
lung cancer | colorectal cancer | combination of molecular targeted therapies | MEK inhibitors | SIGNALING PATHWAYS | ACTIVATION | RAS | AZD6244 | ARRY-142886 | IDENTIFICATION | PI3K | ONCOLOGY | SELUMETINIB | KRAS | TUMOR-GROWTH | Lung Neoplasms - drug therapy | Oligonucleotide Array Sequence Analysis | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Gene Expression Profiling | TOR Serine-Threonine Kinases - antagonists & inhibitors | Colorectal Neoplasms - drug therapy | Biomarkers, Tumor - metabolism | Female | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Colorectal Neoplasms - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | PTEN Phosphohydrolase - metabolism | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Blotting, Western | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | MAP Kinase Kinase 2 - antagonists & inhibitors | Biomarkers, Tumor - genetics | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Phenylurea Compounds - pharmacology | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Cell Cycle - drug effects | Colorectal Neoplasms - pathology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Colorectal cancer | Tumors | Chemotherapy | Pharmacology | Kinases | Lung cancer | Index Medicus
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 05/2014, Volume 13, Issue 5, pp. 1044 - 1053
Journal Article
Blood, ISSN 0006-4971, 05/2014, Volume 123, Issue 22, pp. 3390 - 3397
Journal Article
Annals of Oncology, ISSN 0923-7534, 2017, Volume 28, Issue 3, pp. 512 - 518
Journal Article
Liver International, ISSN 1478-3223, 05/2013, Volume 33, Issue 5, pp. 780 - 793
Journal Article
BLOOD, ISSN 0006-4971, 07/2018, Volume 132, Issue 3, pp. 293 - 306
Because both phosphatidylinositol 3-kinase delta (PI3K delta) and Janus kinase (JAK)-signal transducer and activator of transcription pathways contribute to... 
SELECTIVE INHIBITOR | PI3K | SIGNALING PATHWAY | IL-10 LEVELS | IDELALISIB | SUBTYPES | INCB039110 | BLOCKADE | HEMATOLOGY | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 05/2017, Volume 77, Issue 10, pp. 2607 - 2619
Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations and a T-cell-inflamed phenotype. One... 
HEAD | RESPONSES | ONCOLOGY | IMMUNE SUPPRESSION | REGULATORY T-CELLS | PI3K-GAMMA | BLOCKADE | EXPRESSION | CARCINOMA | NECK-CANCER | TUMOR MICROENVIRONMENT | Neoplasms - metabolism | Immunomodulation - drug effects | Myeloid-Derived Suppressor Cells - drug effects | Lymphocyte Activation - immunology | Isoquinolines - pharmacology | Lymphocytes, Tumor-Infiltrating - metabolism | Antineoplastic Agents - pharmacology | Epitopes, T-Lymphocyte - immunology | Myeloid-Derived Suppressor Cells - metabolism | Disease Models, Animal | Myeloid-Derived Suppressor Cells - immunology | Purines - pharmacology | Antibodies, Monoclonal - pharmacology | Lymphocytes, Tumor-Infiltrating - drug effects | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Neoplasms - drug therapy | Tumor Microenvironment - immunology | Animals | B7-H1 Antigen - antagonists & inhibitors | Lymphocyte Activation - drug effects | Neoplasms - immunology | Survival Analysis | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Lymphocytes, Tumor-Infiltrating - immunology | Cell culture | Myeloid cells | Effectiveness | Cell survival | CD8 antigen | Effector cells | Lymphocytes T | Inflammation | Suppressor cells | Recruitment | Immune systems | Immunosuppression | Inhibitors | Immune checkpoint | Lymphocytes | PD-L1 protein | Isoforms | Head and neck | Neck | Head & neck cancer | Inhibition | Cancer | Index Medicus | immunosuppression | MDSC | IPI-145 | PI3K | head and neck cancer
Journal Article
Leukemia, ISSN 0887-6924, 09/2015, Volume 29, Issue 9, pp. 1811 - 1822
The functional relevance of the B-cell receptor (BCR) and the evolution of protein kinases as therapeutic targets have recently shifted the paradigm for... 
SURVIVAL | IN-VITRO | B-CELL | 3-KINASE P110-DELTA | ONCOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE-DELTA | P110-GAMMA | CHRONIC LYMPHOCYTIC-LEUKEMIA | TYROSINE KINASE INHIBITOR | PI3K-GAMMA | HEMATOLOGY | CUTTING EDGE | Chemokine CCL3 - secretion | Chemokine CCL4 - secretion | Leukocytes, Mononuclear - metabolism | Phosphorylation | Prognosis | Ribosomal Protein S6 Kinases - metabolism | Apoptosis - drug effects | Humans | Middle Aged | Male | Phosphatidylinositol 3-Kinases - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Receptors, Antigen, B-Cell - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Case-Control Studies | Isoquinolines - pharmacology | Aged, 80 and over | Female | Chemotaxis - immunology | Proto-Oncogene Proteins c-akt - metabolism | Quinazolinones - pharmacology | Pyrazoles - pharmacology | Cell Survival - drug effects | Leukocytes, Mononuclear - drug effects | Purines - pharmacology | Stromal Cells - metabolism | Chemotaxis - drug effects | Pyrimidines - pharmacology | Cell Survival - immunology | Signal Transduction - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Aged | Cell Proliferation - drug effects | Bone Marrow Cells - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis | Chronic lymphocytic leukemia | Development and progression | Genetic aspects | Cellular signal transduction | Properties | Health aspects | Phosphotransferases | Index Medicus | BCR | microenvironment | PI3Kinase | CLL | p110γ | IPI-145 | p110δ | apoptosis | Duvelisib
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2010, Volume 16, Issue 14, pp. 3670 - 3683
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 01/2018, Volume 364, Issue 1, pp. 120 - 130
Journal Article