X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (3177) 3177
Publication (565) 565
Book Chapter (115) 115
Book Review (84) 84
Conference Proceeding (17) 17
Dissertation (5) 5
Government Document (2) 2
Reference (2) 2
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
pleckstrin homology domain (1794) 1794
animals (1541) 1541
biochemistry & molecular biology (1501) 1501
humans (1448) 1448
cell biology (1108) 1108
index medicus (1053) 1053
signal transduction (704) 704
pleckstrin homology domains (618) 618
phosphorylation (592) 592
mice (559) 559
protein binding (494) 494
amino acid sequence (468) 468
proteins (467) 467
protein structure, tertiary (456) 456
activation (452) 452
molecular sequence data (449) 449
plasma-membrane (382) 382
binding (366) 366
cell membrane - metabolism (340) 340
biophysics (339) 339
phosphatidylinositol 3-kinase (321) 321
cell line (299) 299
article (296) 296
mutation (276) 276
ph domain (276) 276
binding sites (262) 262
phosphatidylinositol 3-kinases - metabolism (259) 259
research (250) 250
pleckstrin (238) 238
physiological aspects (235) 235
signal-transduction (230) 230
enzyme activation (229) 229
crystal-structure (228) 228
cells (227) 227
lipids (221) 221
models, molecular (219) 219
oncology (217) 217
phosphatidylinositols - metabolism (214) 214
phosphoinositides (209) 209
cancer (207) 207
protein (207) 207
sequence homology, amino acid (207) 207
rats (205) 205
phosphatidylinositol 4,5-bisphosphate (201) 201
phosphatidylinositol phosphates - metabolism (201) 201
pleckstrin-homology-domain (198) 198
signal transduction - physiology (197) 197
homology (196) 196
research article (191) 191
protein-kinase-b (189) 189
multidisciplinary sciences (186) 186
phosphoinositide 3-kinase (186) 186
kinases (184) 184
models, biological (184) 184
proto-oncogene proteins c-akt - metabolism (183) 183
transfection (182) 182
apoptosis (175) 175
akt (173) 173
analysis (171) 171
expression (171) 171
pleckstrin homology (167) 167
molecular-cloning (165) 165
protein-kinase-c (158) 158
in-vivo (157) 157
recombinant fusion proteins - metabolism (157) 157
identification (156) 156
proto-oncogene proteins c-akt (153) 153
protein-serine-threonine kinases - metabolism (152) 152
structural basis (150) 150
immunology (149) 149
biology (148) 148
cos cells (147) 147
female (140) 140
proto-oncogene proteins - metabolism (140) 140
protein conformation (137) 137
phosphoproteins - metabolism (135) 135
guanine nucleotide exchange factors - metabolism (134) 134
male (134) 134
genetics & heredity (133) 133
membrane proteins - metabolism (132) 132
phosphatidylinositol 4,5-diphosphate - metabolism (132) 132
localization (131) 131
protein transport (128) 128
carrier proteins - metabolism (127) 127
kinase (127) 127
cell line, tumor (126) 126
pleckstrin-homology domains (126) 126
cells, cultured (125) 125
actin (124) 124
membrane (123) 123
gene expression (122) 122
tyrosine kinase (122) 122
endocytosis (121) 121
insulin (120) 120
beta-gamma-subunits (118) 118
protein-tyrosine kinases - metabolism (118) 118
brutons tyrosine kinase (117) 117
kinetics (116) 116
proteins - metabolism (114) 114
isoenzymes - metabolism (113) 113
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (3230) 3230
French (5) 5
Japanese (5) 5
Chinese (3) 3
Korean (2) 2
Russian (2) 2
Polish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Biochemical Journal, ISSN 0264-6021, 01/2005, Volume 385, Issue 2, pp. 399 - 408
We developed a high-throughput HTRF (homogeneous time-resolved fluorescence) assay for Akt kinase activity and screened approx. 270000 compounds for their... 
Allosteric inhibitor | Protein kinase B (PKB) | Inhibitor | Pleckstrin homology domain | Akt | Kinase | PROTEIN-KINASE-B | INDUCED APOPTOSIS | TYROSINE KINASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | pleckstrin homology domain | allosteric inhibitor | COWDEN-DISEASE | kinase | inhibitor | STRUCTURAL BASIS | protein kinase B (PKB) | TUMOR-SUPPRESSOR | MOLECULAR-CLONING | CELL-LINE LNCAP | HUMAN CANCER | Phosphoproteins - immunology | Prostatic Neoplasms - chemistry | Humans | Peptides - genetics | Blood Proteins - immunology | Male | Isoenzymes - chemistry | Phosphoproteins - chemistry | Carcinoma - chemistry | Peptides - metabolism | TNF-Related Apoptosis-Inducing Ligand | Blood Proteins - genetics | Adenosine Triphosphate - metabolism | Phosphorylation - drug effects | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Peptides - immunology | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Cell Line, Tumor | Prostatic Neoplasms - metabolism | Uterine Cervical Neoplasms - pathology | Quinoxalines - pharmacology | Caspases - metabolism | Uterine Cervical Neoplasms - metabolism | Cloning, Molecular | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Molecular Structure | Carcinoma - pathology | Binding, Competitive | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Prostatic Neoplasms - pathology | Proto-Oncogene Proteins - antagonists & inhibitors | Peptides - chemistry | Membrane Glycoproteins - pharmacology | Blood Proteins - chemistry | Phosphoproteins - genetics | Enzyme Activation - drug effects | Proto-Oncogene Proteins c-akt | Sequence Homology, Amino Acid | Apoptosis Regulatory Proteins | Signal Transduction - physiology | Uterine Cervical Neoplasms - chemistry | Carcinoma - metabolism | Benzylamines - pharmacology | Isoenzymes - antagonists & inhibitors | cdk2, cyclin-dependent kinase 2 | FGFR, fibroblast growth factor receptor | MEK, MAPK | SH, Src homology | PI3K, phosphoinositide 3-kinase | DOPS, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine | ERK kinase | DOPC, 1,2-dioleoyl-sn-glycero-3-phosphocholine | DTT, dithiothreitol | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | PEG, poly(ethylene glycol) | PKC, protein kinase C | FLT, Fms-related tyrosine kinase | lymphoma 1 | GSK3, glycogen synthase kinase 3 | TRAIL, tumour-necrosis-factor-related apoptosis-inducing ligand | HTRF, homogeneous time-resolved fluorescence | PH, pleckstrin homology | MAPKK1, MAPK kinase 1 | FBS, foetal bovine serum | PDK, phosphoinositide-dependent kinase | TCL1, T-cell leukaemia | MAPK, mitogen-activated protein kinase | PKA, protein kinase A | SGK, serum- and glucocorticoid-inducible kinase
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 10/2019, Volume 116, Issue 43, pp. 21539 - 21544
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2017, Volume 474, Issue 4, pp. 539 - 556
Kindlins co-activate integrins alongside talin. They possess, like talin, a FERM domain (4.1-erythrin-radixin-moiesin domain) comprising F0-F3 subdomains, but... 
PERIPHERAL MEMBRANE-PROTEINS | GRP1 PH DOMAIN | INTEGRIN ALPHA-IIB-BETA-3 | MOLECULAR-DYNAMICS | MODEL MEMBRANES | ACTIVATION | COMPLEX | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FORCE-FIELD | CELL-ADHESION | Cytoskeletal Proteins - genetics | Crystallography, X-Ray | Phosphatidylcholines - metabolism | Receptors, Cytoplasmic and Nuclear - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Cytoskeletal Proteins - metabolism | Phosphatidylinositols - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Pleckstrin Homology Domains | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Phosphatidylinositols - chemistry | Phosphatidylserines - metabolism | Phosphatidylserines - chemistry | Recombinant Proteins - chemistry | Receptors, Cytoplasmic and Nuclear - genetics | Recombinant Proteins - genetics | Cytoskeletal Proteins - chemistry | Phosphatidylcholines - chemistry | Molecular Dynamics Simulation | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Protein Conformation, beta-Strand | Escherichia coli - genetics | Protein Binding | Mice | Kinetics | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | X-ray crystallography | lipid clustering | molecular dynamics | surface plasmon resonance | PH domain
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2000, Volume 351, Issue 1, pp. 19 - 31
Journal Article
Biochemistry, ISSN 0006-2960, 06/2017, Volume 56, Issue 23, pp. 2938 - 2949
Journal Article