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Cell Stem Cell, ISSN 1934-5909, 08/2018, Volume 23, Issue 2, pp. 226 - 238.e4
The enhancer landscape of pluripotent stem cells undergoes extensive reorganization during early mammalian development. The functions and mechanisms behind... 
transcriptional control | gene regulation | enhancer regulation | early mammalian development | naive pluripotency | formative pluripotency | epigenetics | EPITHELIAL-MESENCHYMAL TRANSITION | CHROMATIN | MOUSE | STATE | PRIMED PLURIPOTENCY | GENOMIC FEATURES | EXPRESSION | EFFICIENT | NEURAL-TUBE CLOSURE | WEB SERVER | CELL & TISSUE ENGINEERING | CELL BIOLOGY | naïve pluripotency
Journal Article
Nature cell biology, ISSN 1465-7392, 05/2019, Volume 21, Issue 7, pp. 911 - 912
In the version of the article originally published, extra lines were displayed in Fig. 7. Fig. 7a contained a solid black line that extended into panel b, and... 
Black line | Chromatin | Pluripotency
Journal Article
Development (Cambridge), ISSN 0950-1991, 04/2017, Volume 144, Issue 7, pp. 1221 - 1234
Mouse embryonic stem (ES) cells are locked into self- renewal by shielding from inductive cues. Release from this ground state in minimal conditions offers a... 
Methylome | Rex1 | ES cells | Epiblast | Pluripotency | Transcriptome | DNA METHYLATION | NAIVE PLURIPOTENCY | TRANSCRIPTIONAL NETWORK | SELF-RENEWAL | DEVELOPMENTAL BIOLOGY | SPECIFICATION | GENOME | SUPER-ENHANCERS | EPIBLAST CELLS | PRIMED PLURIPOTENCY | GASTRULATING MOUSE EMBRYO | DNA methylation | Genomes | Methylation | Extinction | Stem cells | 203 | Stem Cells and Regeneration
Journal Article
06/2013
“The scientist, by the very nature of his commitment, creates more and more questions, never fewer. Indeed the measure of our intellectual maturity, one... 
0369 | Lineage specification | Imprinting | Pluripotency
Dissertation
Development (Cambridge), ISSN 0950-1991, 01/2017, Volume 144, Issue 2, pp. 175 - 186
Journal Article
Cell Stem Cell, ISSN 1934-5909, 04/2016, Volume 18, Issue 4, pp. 481 - 494
The interconversion between naive and primed pluripotent states is accompanied by drastic epigenetic rearrangements. However, it is unclear whether intrinsic... 
methylation is sufficient to drive reprogramming to | are instead simply a reflection of discrete pluripotent | we show that blocking histone H3K4 | with more | findings show that discrete perturbation of H3K4 | it is unclear whether | determinant factors and EpiSC markers | indirectly regulate ESC transcription circuitry. These | naive embryonic stem cells (ESCs) within 3 days. Reverted | INDUCTION | naive pluripotency | The interconversion between naive and primed | competent chimeras | CELL BIOLOGY | generating germline | GROUND-STATE PLURIPOTENCY | ESCs reactivate the silenced X chromosome | PRIMED PLURIPOTENCY | pluripotent states is accompanied by drastic epigenetic | Importantly | H3K4 METHYLTRANSFERASE ACTIVITY | is highly efficient and synchronized | than 50% of treated EpiSCs exhibiting features of | which | of H3K4me1 at enhancers and represses lineage | and contribute to embryos following blastocyst injection | MOUSE EMBRYOS | inhibitor MM-401 reprograms mouse epiblast | to naive pluripotency or if distinct chromatin states | SELF-RENEWAL | states. Here | ACETYLTRANSFERASE MOF | CELL & TISSUE ENGINEERING | rearrangements. However | PRIMITIVE STREAK | CORE TRANSCRIPTIONAL NETWORK | methyltransferase MLL1 activity with the small | intrinsic epigenetic events can drive reprogramming | blocking MLL1 leads to global redistribution | X-CHROMOSOME INACTIVATION | molecule | stem cells (EpiSCs) to naive pluripotency. This reversion | Cell Line | Small Molecule Libraries - pharmacology | Germ Layers - drug effects | Myeloid-Lymphoid Leukemia Protein - metabolism | Myeloid-Lymphoid Leukemia Protein - deficiency | Histone-Lysine N-Methyltransferase - deficiency | Mouse Embryonic Stem Cells - drug effects | Mouse Embryonic Stem Cells - metabolism | Cellular Reprogramming - drug effects | Pluripotent Stem Cells - metabolism | Histone-Lysine N-Methyltransferase - antagonists & inhibitors | Animals | Histone-Lysine N-Methyltransferase - metabolism | Pluripotent Stem Cells - drug effects | Mice | Oligopeptides - pharmacology | Myeloid-Lymphoid Leukemia Protein - antagonists & inhibitors
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 12, p. e0210042
[This corrects the article DOI: 10.1371/journal.pone.0206844.]. 
Clustering | Regulators | Pluripotency
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 8411 - 11
Pleomorphic adenoma gene 1 (PLAG1) is a transcription factor involved in cancer and growth. We discovered a de novo DNA motif containing a PLAG1 binding site... 
Journal Article
Chromosoma, ISSN 0009-5915, 07/2019, pp. 1 - 3
The recent report of X-chromosome dampening in human preimplantation embryos remains controversial. Subsequently, Sahakyan et al. found evidence of... 
Chromosomes | Embryos | Pluripotency | Stem cells
Journal Article
Cell Reports, ISSN 2211-1247, 07/2018, Volume 24, Issue 2, pp. 489 - 502
The genetic basis of naive pluripotency maintenance and loss is a central question in embryonic stem cell biology. Here, we deploy CRISPR-knockout-based... 
CRISPR | screening | exit from pluripotency | GATOR1 | Nprl2 | Tsc2 | Akt | naive pluripotency | mTORC2 | mTORC1 | GAP ACTIVITY | TRANSITION | TARGET | COMPLEX | GROUND-STATE PLURIPOTENCY | EMBRYONIC STEM-CELLS | GENETIC SCREENS | SELF-RENEWAL | DIFFERENTIATION | MTORC1 PATHWAY | CELL BIOLOGY
Journal Article
Development (Cambridge), ISSN 0950-1991, 03/2018, Volume 145, Issue 6, pp. dev157420 - dev157420
Tissue-specific transcription factors primarily act to define the phenotype of the cell. The power of a single transcription factor to alter cell fate is often... 
Reprogramming | Differentiation | Embryonic stem cells | Transcription factor | SIGNALING PATHWAYS | MAMMALIAN EMBRYOGENESIS | NAIVE PLURIPOTENCY | SELF-RENEWAL | DEVELOPMENTAL BIOLOGY | MOUSE EPIBLAST | GROUND-STATE PLURIPOTENCY | RECEPTOR ERR-BETA | MAINTAINS PLURIPOTENCY | ES CELLS | GENE REGULATORY NETWORKS | Phenotypes | Transcription factors | Enhancers | Cell fate | Stem cells
Journal Article