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PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e21225
Background: The safety and immunogenicity of a vaccine regimen consisting of a 6-plasmid HIV-1 DNA prime (envA, envB, envC, gagB, polB, nefB) boosted by a... 
RESPONSES | IMMUNITY | ASSAY | SAFETY | MULTIDISCIPLINARY SCIENCES | ANTIBODY | IMMUNOGENICITY EVALUATION | CANDIDATE | INFECTION | STEP | MEMORY T-CELLS | env Gene Products, Human Immunodeficiency Virus - immunology | Immunization, Secondary - adverse effects | Immunoglobulin G - blood | Human Immunodeficiency Virus Proteins - immunology | Humans | Middle Aged | AIDS Vaccines - immunology | Vaccines, DNA - immunology | pol Gene Products, Human Immunodeficiency Virus - immunology | Male | Antibodies, Viral - blood | Vaccines, DNA - administration & dosage | Young Adult | env Gene Products, Human Immunodeficiency Virus - genetics | T-Lymphocytes - metabolism | Immunoglobulin G - immunology | Adenoviridae - genetics | Adult | Female | gag Gene Products, Human Immunodeficiency Virus - genetics | pol Gene Products, Human Immunodeficiency Virus - genetics | Immunization - adverse effects | Enzyme-Linked Immunosorbent Assay | Immunization - methods | Anemia - chemically induced | Immunization, Secondary - methods | HIV-1 - genetics | HIV-1 - immunology | nef Gene Products, Human Immunodeficiency Virus - genetics | nef Gene Products, Human Immunodeficiency Virus - immunology | Interferon-gamma - immunology | Adolescent | Antibodies, Viral - immunology | Human Immunodeficiency Virus Proteins - genetics | T-Lymphocytes - immunology | AIDS Vaccines - administration & dosage | gag Gene Products, Human Immunodeficiency Virus - immunology | Interferon-gamma - blood | Cohort Studies | Oligomers | AIDS vaccines | Adenoviruses | Immunotherapy | DNA | Clinical trials | Product development | Interferon | Biological response modifiers | T cells | HIV (Viruses) | Antigenic determinants | Health care | CD8 antigen | Antibodies | Lymphocytes T | Infections | Vaccines | Epidemiology | Randomization | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Inserts | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Binding | Medical research | Immunoglobulins | Cytokines | Epitopes | Immune response (humoral) | CD4 antigen | Disease prevention | Hospitals | Infectious diseases | Immunogenicity | γ-Interferon | Adults | Cancer | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | Human immunodeficiency virus
Journal Article
PLoS ONE, ISSN 1932-6203, 2012, Volume 7, Issue 4, p. e34723
.... Subtle modifications were introduced into the GPN gene to increase Gag expression, modify the expression ratio of Gag to PolNef and support budding of virus-like particles. I. m... 
AIDS RESEARCH | IMMUNIZATION | T-CELL RESPONSES | VIRUS | PHASE-I TRIAL | IMMUNE-RESPONSES | BIOLOGY | ENVELOPE PROTEIN | INFECTION | NYVAC-C | EXPRESSION | env Gene Products, Human Immunodeficiency Virus - immunology | Humans | Vaccines, DNA - immunology | pol Gene Products, Human Immunodeficiency Virus - immunology | Vaccines, Synthetic - immunology | Vaccines, DNA - administration & dosage | Clinical Trials, Phase III as Topic | env Gene Products, Human Immunodeficiency Virus - genetics | pol Gene Products, Human Immunodeficiency Virus - biosynthesis | HEK293 Cells | Female | pol Gene Products, Human Immunodeficiency Virus - genetics | Gene Products, gag - immunology | Gene Products, gag - genetics | Vaccines, Synthetic - genetics | nef Gene Products, Human Immunodeficiency Virus - biosynthesis | HIV-1 - genetics | Gene Products, gag - biosynthesis | HIV-1 - immunology | Animals | env Gene Products, Human Immunodeficiency Virus - biosynthesis | nef Gene Products, Human Immunodeficiency Virus - genetics | nef Gene Products, Human Immunodeficiency Virus - immunology | Vaccines, Virus-Like Particle - immunology | Mice | Mice, Inbred BALB C | Vaccines, Synthetic - administration & dosage | AIDS vaccines | Viral proteins | Vaccination | DNA | Amino acids | T cells | HIV (Viruses) | Antigenic determinants | Competition | CD8 antigen | Clinical trials | Viruses | Lymphocytes T | DNA vaccines | Histocompatibility antigen H-2 | Vaccines | Virus-like particles | Proteins | Clonal deletion | Gag protein | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Combined vaccines | Deoxyribonucleic acid--DNA | Medical research | Cytomegalovirus | Envelope protein | Gene expression | Nef protein | Immunogenicity | γ-Interferon | Budding | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | Human immunodeficiency virus
Journal Article
Molecular therapy, ISSN 1525-0016, 2017, Volume 25, Issue 5, pp. 1168 - 1186
...; however, gene delivery efficiency in vivo remains an obstacle to overcome. Here, we demonstrate the feasibility and efficiency of excising the HIV-1 provirus in three different animal models using an all-in-one adeno-associated virus (AAV... 
genome editing | humanized BLT mice | animal models | viral latency | HIV | AAV | Tg26 mice | gene therapy | Cas9 | gRNA | EFFICIENT DELIVERY | MEDICINE, RESEARCH & EXPERIMENTAL | GENE EDITING TECHNOLOGIES | PACKAGING CAPACITY | LENTIVIRAL VECTORS | ADENOASSOCIATED VIRAL VECTORS | STAPHYLOCOCCUS-AUREUS CAS9 | CRISPR-CAS9 NUCLEASES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CRISPR/CAS9 SYSTEM | GENETICS & HEREDITY | MODULATES PROLIFERATION | NEURAL PRECURSOR CELLS | Oligonucleotides - genetics | Dependovirus - genetics | Endonucleases - genetics | Staphylococcus aureus - enzymology | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | HIV Long Terminal Repeat | pol Gene Products, Human Immunodeficiency Virus - metabolism | Endonucleases - metabolism | gag Gene Products, Human Immunodeficiency Virus - metabolism | HIV Infections - pathology | Proviruses - genetics | Base Sequence | Clustered Regularly Interspaced Short Palindromic Repeats | gag Gene Products, Human Immunodeficiency Virus - genetics | pol Gene Products, Human Immunodeficiency Virus - genetics | Disease Models, Animal | Genome, Viral | HIV-1 - metabolism | Dependovirus - metabolism | Genetic Vectors - chemistry | HIV Infections - virology | Bacterial Proteins - genetics | Genetic Vectors - metabolism | Mice, Transgenic | HIV-1 - genetics | Proviruses - metabolism | Staphylococcus aureus - chemistry | Oligonucleotides - metabolism | Animals | CRISPR-Cas Systems | HIV Infections - therapy | Bacterial Proteins - metabolism | Gene Editing - methods | Mice | Genetic Therapy - methods | Neuroimaging | Animal models | Bioluminescence | Intravenous administration | Genes | Liver | Clinical trials | Chronic infection | Infections | Genomes | Thymus | Acquired immune deficiency syndrome--AIDS | Efficiency | Transgenic animals | Human immunodeficiency virus--HIV | Bone marrow | Colon | Deoxyribonucleic acid--DNA | Spleen | CRISPR | Gene transfer | Advisors | Transgenic mice | Ribonucleic acid--RNA | Progenitor cells | Polymerase chain reaction | Studies | Genotyping | Neural stem cells | Original
Journal Article
Journal of virology, ISSN 1098-5514, 2018, Volume 93, Issue 1
Journal Article
Journal of Virology, ISSN 0022-538X, 2015, Volume 89, Issue 10, pp. 5330 - 5339
Journal Article
Scientific reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, p. 9021
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 9, pp. 1 - 16
Background: We conducted a double-blind, randomized, placebo-controlled Phase I study of a recombinant replication-defective adenovirus type 5 (rAd5) vector... 
IMMUNITY | NEUTRALIZING ANTIBODIES | ASSAY | REPLICATION | MULTIDISCIPLINARY SCIENCES | CLINICAL-TRIALS | PHASE-1 SAFETY | CANDIDATE | INFECTION | GAG | T-CELLS | HIV Infections - prevention & control | Humans | Middle Aged | AIDS Vaccines - immunology | Vaccines, DNA - immunology | pol Gene Products, Human Immunodeficiency Virus - immunology | Genetic Vectors - adverse effects | Male | AIDS Vaccines - adverse effects | Young Adult | HIV Infections - immunology | Immunization, Secondary | Drug-Related Side Effects and Adverse Reactions | Adenoviridae - genetics | Adult | gag Gene Products, Human Immunodeficiency Virus - genetics | Adenoviridae - immunology | pol Gene Products, Human Immunodeficiency Virus - genetics | pol Gene Products, Human Immunodeficiency Virus - adverse effects | Double-Blind Method | Genetic Vectors - immunology | HIV Infections - virology | HIV-1 - genetics | Genetic Vectors - genetics | HIV-1 - classification | HIV-1 - immunology | Vaccines, DNA - adverse effects | Adolescent | gag Gene Products, Human Immunodeficiency Virus - adverse effects | Antibodies, Viral - immunology | gag Gene Products, Human Immunodeficiency Virus - immunology | HIV antigens | Medical research | AIDS vaccines | Safety and security measures | Biological response modifiers | HIV (Viruses) | Adenoviruses | DNA | Medicine, Experimental | Genetic research | Interferon | Health aspects | HIV infection | Laboratories | Antibodies | Infections | DNA vaccines | Vaccines | Dosage | Immunity | Epidemiology | Proteins | Randomization | Immunology | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Safety | Public health | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Immune system | Antigens | Immunoglobulins | Immune response | Priming | Immune response (humoral) | Infectious diseases | Nef protein | Immunogenicity | γ-Interferon | Adults | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | Human immunodeficiency virus
Journal Article
Molecular Therapy, ISSN 1525-0016, 03/2015, Volume 23, Issue 3, pp. 591 - 601
.... HIV infected individuals whose virus was effectively suppressed using highly active antiretroviral therapy (HAART... 
MEDICINE, RESEARCH & EXPERIMENTAL | ELECTROPORATION | RESERVOIR | ELIMINATION | ANTIRETROVIRAL THERAPY | CD8(+) T-CELLS | REPLICATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | LYMPHOID-TISSUE | GENETICS & HEREDITY | FULL REPERTOIRE | EXPRESSION | LYMPHOCYTES | Consensus Sequence | Perforin - genetics | env Gene Products, Human Immunodeficiency Virus - immunology | Humans | Middle Aged | Vaccination | AIDS Vaccines - immunology | pol Gene Products, Human Immunodeficiency Virus - immunology | Male | Granzymes - genetics | Leukocytes, Mononuclear - virology | HIV Infections - immunology | env Gene Products, Human Immunodeficiency Virus - genetics | HIV Infections - pathology | Leukocytes, Mononuclear - immunology | Adult | Female | Granzymes - biosynthesis | gag Gene Products, Human Immunodeficiency Virus - genetics | pol Gene Products, Human Immunodeficiency Virus - genetics | env Gene Products, Human Immunodeficiency Virus - chemistry | HIV Infections - virology | Interferon-gamma - secretion | gag Gene Products, Human Immunodeficiency Virus - chemistry | pol Gene Products, Human Immunodeficiency Virus - chemistry | Enzyme-Linked Immunospot Assay | AIDS Vaccines - chemistry | Antiretroviral Therapy, Highly Active | Leukocytes, Mononuclear - pathology | HIV-1 - immunology | HIV Infections - therapy | Vaccines, Synthetic | AIDS Vaccines - genetics | AIDS Vaccines - administration & dosage | gag Gene Products, Human Immunodeficiency Virus - immunology | Immunity, Cellular | Interferon-gamma - biosynthesis | Perforin - biosynthesis | Original
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2010, Volume 207, Issue 1, pp. 51 - 59
...). To examine the extent of active immune response to virally encoded CEs, we analyzed human leukocyte antigen class I-associated polymorphisms in HIV-1 gag, pol, and nef genes from a large cohort... 
VIRAL LOAD | MEDICINE, RESEARCH & EXPERIMENTAL | CHALLENGE | ASSOCIATIONS | RNA | VACCINE | IMMUNODEFICIENCY-VIRUS TYPE-1 | CLASS-I | INFECTION | IMMUNOLOGY | EXPRESSION | LYMPHOCYTES | Epitopes, T-Lymphocyte - biosynthesis | Humans | pol Gene Products, Human Immunodeficiency Virus - immunology | Epitopes, T-Lymphocyte - genetics | Male | pol Gene Products, Human Immunodeficiency Virus - metabolism | HIV Infections - immunology | RNA, Viral - genetics | Genes, MHC Class I - immunology | CD8-Positive T-Lymphocytes - metabolism | nef Gene Products, Human Immunodeficiency Virus - metabolism | Female | RNA, Viral - metabolism | Epitopes, T-Lymphocyte - immunology | pol Gene Products, Human Immunodeficiency Virus - genetics | Cell Line | Gene Products, gag - immunology | HIV-1 - metabolism | Gene Products, gag - genetics | HIV Infections - genetics | Genes, MHC Class I - genetics | RNA, Antisense - immunology | HIV-1 - genetics | Gene Products, gag - metabolism | Polymorphism, Genetic | HIV-1 - immunology | nef Gene Products, Human Immunodeficiency Virus - genetics | nef Gene Products, Human Immunodeficiency Virus - immunology | RNA, Antisense - metabolism | Transcription, Genetic - immunology | RNA, Viral - immunology | South Africa | CD8-Positive T-Lymphocytes - immunology | Chronic Disease | Cohort Studies | Evolution, Molecular | RNA, Antisense - genetics | Brief Definitive Report
Journal Article
Journal Article