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British Journal of Pharmacology, ISSN 0007-1188, 08/2005, Volume 145, Issue 8, pp. 1093 - 1102
Journal Article
NeuroMolecular Medicine, ISSN 1535-1084, 9/2017, Volume 19, Issue 2, pp. 271 - 285
We have demonstrated that arginine-rich and poly-arginine peptides possess potent neuroprotective properties with arginine content and peptide positive charge... 
Neurology | Neuroprotection | Neurosciences | Stroke | Biomedicine | Protamine | Excitotoxicity | Middle cerebral artery occlusion (MCAO) | Tryptophan | Internal Medicine | Poly-arginine | NMDA RECEPTOR | MOLECULAR-WEIGHT PROTAMINE | EFFICACY | CELL-PENETRATING PEPTIDES | TOXICITY | NEUROSCIENCES | INTERNALIZATION | NEURONAL DEATH | POLYARGININE PEPTIDES | MEDIATOR PROTEIN-2 CRMP2 | Neuroprotective Agents - therapeutic use | Tryptophan - chemistry | Male | Peptides, Cyclic - pharmacology | Cerebral Cortex - cytology | Amino Acids - pharmacology | Oligopeptides - therapeutic use | Neuroprotective Agents - pharmacology | Infarction, Middle Cerebral Artery - drug therapy | Drug Evaluation, Preclinical | Neurons - drug effects | Astrocytes - drug effects | Oligopeptides - chemical synthesis | Protamines - chemistry | Cells, Cultured | Rats | Infarction, Middle Cerebral Artery - pathology | Rats, Sprague-Dawley | Arginine - chemistry | Neuroprotective Agents - chemical synthesis | Animals | Cerebral Cortex - embryology | Peptides, Cyclic - chemical synthesis | Calcium Signaling - drug effects | Peptides, Cyclic - therapeutic use | Glutamic Acid - toxicity | In Vitro Techniques | Oligopeptides - pharmacology | Amino acids | Nervous system diseases | Peptides | Glutamate | Occlusion | Glutamic acid | Animal models | In vitro testing | Leucine | Glycine | Calcium influx | Ischemia | Arginine | Cerebral blood flow | Rodents | Biocompatibility | Tyrosine | Edema | Effectiveness | Phenylalanine | Properties (attributes) | In vivo methods and tests | Index Medicus
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 05/2017, Volume 9, Issue 5, pp. 703 - 715
Alzheimer's disease ( AD ) is the most common neurodegenerative disease. Imbalance between the production and clearance of amyloid β (Aβ) peptides is... 
| peptide therapy | Alzheimer disease | polyarginine | polyethylenimine | MEDICINE, RESEARCH & EXPERIMENTAL | IMPROVES COGNITION | PROTEIN TRANSDUCTION | ENTORHINAL CORTEX | IN-VITRO | A beta | PRION-LIKE BEHAVIOR | REDUCTION | AMYLOID-BETA | MOUSE MODEL | DISEASE | INTRACELLULAR DELIVERY | Alzheimer Disease - complications | Amyloid - ultrastructure | Memory Disorders - complications | Peptides - administration & dosage | Alzheimer Disease - pathology | Amyloid beta-Peptides - ultrastructure | Female | Amyloid beta-Peptides - administration & dosage | Cognitive Dysfunction - complications | Memory Disorders - pathology | Disease Models, Animal | Cognitive Dysfunction - drug therapy | Peptide Fragments - ultrastructure | Amyloid - antagonists & inhibitors | Cell Line | Peptides - chemistry | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Alzheimer Disease - drug therapy | Cognitive Dysfunction - pathology | Cognition - drug effects | Administration, Intranasal | Brain - drug effects | Amyloid beta-Peptides - antagonists & inhibitors | Peptide Fragments - chemistry | Animals | Memory Disorders - drug therapy | Amyloid beta-Peptides - therapeutic use | Peptide Fragments - antagonists & inhibitors | Brain - pathology | Peptide Fragments - therapeutic use | Amyloid beta-Peptides - chemistry | Peptides - therapeutic use | Peptides | Neurodegenerative diseases | Memory | Cognitive ability | Transgenic mice | Intranasal administration | Amyloid precursor protein | Design | Transgenic animals | Presenilin 1 | Rodents | β-Amyloid | Alzheimers disease | Alzheimer's disease | Index Medicus | Pharmacology & Drug Discovery | Neuroscience
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2011, Volume 108, Issue 41, pp. 16883 - 16888
Cell-penetrating peptides (CPPs), such as the HIV TAT peptide, are able to translocate across cellular membranes efficiently. A number of mechanisms, from... 
Endocytosis | Receptors | Actins | Amino acids | Lipids | Cell membranes | Hydrophobicity | Curvature | Freight | P branes | Protein transduction domain | Polyarginine | Pore-forming peptide | Antimicrobial peptide | Peptide-lipid interactions | protein transduction domain | peptide-lipid interactions | MULTIDISCIPLINARY SCIENCES | pore-forming peptide | CELL-PENETRATING PEPTIDES | ANTIMICROBIAL PEPTIDES | MOLECULAR TRANSPORTERS | LOW-TEMPERATURE | LIPOSOME-DNA COMPLEXES | PROTEIN TRANSDUCTION DOMAINS | INTRACELLULAR DELIVERY | HEPARAN-SULFATE PROTEOGLYCANS | antimicrobial peptide | ARGININE-RICH PEPTIDES | polyarginine | FUSION PROTEINS | Amino Acid Sequence | Cell-Penetrating Peptides - genetics | tat Gene Products, Human Immunodeficiency Virus - genetics | Humans | Models, Molecular | Pinocytosis | tat Gene Products, Human Immunodeficiency Virus - chemistry | Unilamellar Liposomes - metabolism | Biological Transport, Active | Models, Biological | Cytoskeleton - metabolism | Hydrophobic and Hydrophilic Interactions | Cell Membrane - metabolism | HeLa Cells | In Vitro Techniques | Cell-Penetrating Peptides - chemistry | Cell-Penetrating Peptides - metabolism | tat Gene Products, Human Immunodeficiency Virus - metabolism | Physiological aspects | Cell receptors | Research | Viral proteins | HIV (Viruses) | Cytoskeleton | Membranes | Peptides | Human immunodeficiency virus--HIV | Cells | Index Medicus | Physical Sciences
Journal Article
ChemBioChem, ISSN 1439-4227, 04/2009, Volume 10, Issue 6, pp. 990 - 993
Journal Article
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 08/2012, Volume 161, Issue 3, pp. 735 - 745
The objective of the present study was to investigate the effect of polyarginine chain length on topical delivery of surface modified NLCs. Design of... 
Nanostructured lipid carriers (NLC) | Cell penetrating peptide (CPP) | Polyarginine peptide | Skin delivery | Allergic contact dermatitis (ACD) | DRUG-DELIVERY | CHITOSAN CROSS-LINKING | TRANSDERMAL DELIVERY | MEFLOQUINE HYDROCHLORIDE MICROPARTICLES | CELL-PENETRATING PEPTIDES | TACROLIMUS OINTMENT | CHEMISTRY, MULTIDISCIPLINARY | DERMAL DELIVERY | PHARMACOLOGY & PHARMACY | H-II MESOPHASES | SUBSTANCE-P | SPANTIDE-II | Nanoparticles - chemistry | Drug Carriers - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Drug Carriers - chemistry | Peptides - administration & dosage | Ketoprofen - chemistry | Allergens - administration & dosage | Lipids - chemistry | Rats, Hairless | Skin Absorption - drug effects | Substance P - analogs & derivatives | Oligopeptides - chemistry | Cell-Penetrating Peptides - chemistry | Dermatitis, Allergic Contact - drug therapy | Peptides - chemistry | Mice, Inbred C57BL | Ketoprofen - administration & dosage | Rats | Lipids - administration & dosage | Dinitrofluorobenzene - administration & dosage | Animals | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Mice | Nanoparticles - administration & dosage | Oligopeptides - administration & dosage | Cell-Penetrating Peptides - administration & dosage | Administration, Topical | Substance P - chemistry | Substance P - administration & dosage | Usage | Peptides | Dermatology | Analysis | Formulae, receipts, prescriptions | Dermatologic agents | Skin | Raman spectroscopy | Transdermal medication | Index Medicus | polyarginine peptide | cell penetrating peptide (CPP) | nanostructured lipid carriers (NLC) | allergic contact dermatitis (ACD)
Journal Article
Journal Article