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Journal of Biological Chemistry, ISSN 0021-9258, 10/2002, Volume 277, Issue 42, pp. 39594 - 39598
Huntington's disease (HD) is caused by a polyglutamine expansion in the amino-terminal region of huntingtin. Mutant huntingtin is proteolytically cleaved by... 
polyglutamine
Journal Article
NATURE REVIEWS NEUROSCIENCE, ISSN 1471-003X, 06/2010, Volume 11, Issue 6, pp. 436 - 449
In ageing populations, neurodegenerative diseases increase in prevalence, exacting an enormous toll on individuals and their communities. Multiple... 
EXPANDED POLYGLUTAMINE | TRANSGENIC MOUSE | ALPHA-SYNUCLEIN TOXICITY | MUTANT HUNTINGTIN | ENDOPLASMIC-RETICULUM STRESS | PRPSC-LIKE CONFORMATION | POLYGLUTAMINE AGGREGATION | HUNTINGTONS-DISEASE | NEUROSCIENCES | PARKINSONS-DISEASE | CELLULAR TOXICITY
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2002, Volume 277, Issue 8, pp. 6703 - 6707
We reported previously that normal Huntingtin is associated with epidermal growth factor receptor (EGF) signaling complex (Liu, Y. F., Deth, C. R., and Devys,... 
polyglutamine
Journal Article
by Zhou, H and Li, S and Li, X
Journal of Biological Chemistry, ISSN 0021-9258, 12/2001, Volume 276, Issue 51, pp. 48417 - 48424
Polyglutamine protein aggregation is associated with eight inherited neurodegenerative disorders. In Huntington's disease, N-terminal fragments of mutant... 
polyglutamine
Journal Article
Nature, ISSN 0028-0836, 10/2001, Volume 413, Issue 6857, pp. 691 - 694
Close to the start of the huntingtin gene lies a repetitive sequence of nucleotides, CAGCAGCAG..., that is potentially deadly. This sequence codes for a... 
polyglutamine
Journal Article
Trends in Neurosciences, ISSN 0166-2236, 11/2001, Volume 24, Issue 11, pp. S32 - S38
Huntington's disease (HD) is one of eight progressive neurodegenerative disorders in which the underlying mutation is a CAG expansion encoding a polyglutamine... 
polyglutamine
Journal Article
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 08/2001, Volume 10, Issue 17, pp. 1829 - 1845
Huntington's disease (HD) is one of 10 known diseases caused by a (CAG) sub(n) trinucleotide repeat expansion that is translated into an abnormally long... 
polyglutamine
Journal Article
Brain Research, ISSN 0006-8993, 10/2018, Volume 1697, pp. 21 - 33
Huntington’s disease (HD) is a fatal neurodegenerative disorder characterized by progressive movement disorders and cognitive deficits, which is caused by a... 
Intravenous immunoglobulin | Huntingtin protein | Huntington’s disease | Polyglutamine
Journal Article
Cell, ISSN 0092-8674, 5/2018, Volume 173, Issue 4, pp. 989 - 1002.e13
Huntington’s disease (HD) is characterized by the preferential loss of the medium spiny neurons in the striatum. Using CRISPR-Cas9 and somatic nuclear transfer... 
neurodegeneration | large animal | polyglutamine | Knock-in
Journal Article
Nature Medicine, ISSN 1078-8956, 05/2001, Volume 7, Issue 5, pp. 528 - 530
The mutant proteins that cause polyglutamine disease bind CREB-binding protein (CBP), a key transcriptional coactivator for neuronal survival factors. This... 
polyglutamine
Journal Article
PLOS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0145333
Huntington’s disease is the result of a long polyglutamine tract in the gene encoding huntingtin protein, which in turn causes a large number of cellular... 
Huntingtons disease | Biotechnology | Bortezomib | Polyglutamine | Peptides | Huntingtin | Amino acids | Pharmacology | Kinases | Proteasome inhibitors | Proteins | Medicine | Studies | Signal transduction | Reduction | Neurodegeneration | MicroRNAs | Cell lines | Cell cycle | Neostriatum | Cleavage | Trinucleotide repeat diseases | Apoptosis
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2001, Volume 7, Issue 4, pp. 419 - 423
Polyglutamine diseases comprise a class of familial neurodegenerative disorders caused by expression of proteins containing expanded polyglutamine tracts.... 
polyglutamine
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 04/2018, Volume 465, Issue C, pp. 113 - 121
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 08/2001, Volume 65, Issue 4, pp. 289 - 297
Huntington's disease (HD) is a neurodegenerative disorder characterized by the expansion of CAG repeats in exon 1 of the HD gene. To clarify the instability of... 
polyglutamine
Journal Article