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2018, ISBN 0444632336, Volume 147
More than 40 diseases, most of which primarily affect the nervous system, are caused by expansions of simple sequence repeats dispersed throughout the human... 
myotonic dystrophy | repeat instability | expanded repeats | trinucleotide | anticipation | polyglutamine diseases | C9ORF72 | spinocerebellar ataxia | Nervous System Diseases - genetics | Repetitive Sequences, Nucleic Acid - genetics | Humans | Trinucleotide | Spinocerebellar ataxia
Book Chapter
PLoS One, ISSN 1932-6203, 2011, Volume 6, Issue 9, p. e24308
To date there are 9 known diseases caused by an expanded polyglutamine repeat, with the most prevalent being Huntington's disease. Huntington's disease is a... 
NEURODEGENERATIVE DISEASE | RNA INTERFERENCE | POLYGLUTAMINE | REPEAT LENGTH | MULTIDISCIPLINARY SCIENCES | MACHADO-JOSEPH-DISEASE | MUTANT HUNTINGTIN | MUSCULAR-DYSTROPHY | NORMAL HUNTINGTIN FUNCTION | BINDING PROTEIN | ALLELE-SELECTIVE INHIBITION | Ataxin-1 | Ataxin-3 | Humans | Molecular Targeted Therapy | RNA, Messenger - metabolism | Ataxins | Peptides - metabolism | Myoclonic Epilepsies, Progressive - genetics | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Fibroblasts - metabolism | Spinocerebellar Ataxias - genetics | Cell Line | Oligonucleotides, Antisense - pharmacology | RNA, Messenger - genetics | Mutant Proteins - genetics | Repressor Proteins - genetics | Mutant Proteins - metabolism | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - therapy | Nuclear Proteins - metabolism | Fibroblasts - pathology | Nerve Tissue Proteins - genetics | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Fibroblasts - drug effects | Trinucleotide Repeat Expansion - genetics | RNA | Nervous system diseases | Glutamine | Huntingtons disease | Transcription | Huntingtin | Dentatorubral-pallidoluysian atrophy | Oligonucleotides | Genomes | Muscular dystrophy | Proteins | Atrophy | Ataxin | Neurodegeneration | Rodents | Spinocerebellar ataxia | Fibroblasts | Ataxia | Phosphorothioate | Mathematical models | Expansion | Trinucleotide repeat diseases | Lymphoblasts | Polyglutamine | Neurodegenerative diseases | Trinucleotide repeats | Antisense oligonucleotides | Huntington's disease | Hereditary diseases | Machado-Joseph disease | Acids | MicroRNAs | trinucleotide repeat diseases | phosphorothioate
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