X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (9443) 9443
Publication (1327) 1327
Book Chapter (250) 250
Newsletter (163) 163
Book Review (113) 113
Dissertation (103) 103
Conference Proceeding (57) 57
Book / eBook (20) 20
Magazine Article (6) 6
Web Resource (4) 4
Newspaper Article (3) 3
Data Set (2) 2
Paper (2) 2
Reference (1) 1
Trade Publication Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (4253) 4253
polyketides (3279) 3279
biosynthesis (3212) 3212
polyketide synthase (2154) 2154
biochemistry & molecular biology (2109) 2109
polyketide (1650) 1650
microbiology (1632) 1632
biotechnology & applied microbiology (1268) 1268
chemistry, organic (1218) 1218
analysis (1207) 1207
molecular structure (1201) 1201
polyketide synthases - metabolism (1201) 1201
metabolites (1196) 1196
chemistry, medicinal (1168) 1168
molecular sequence data (1128) 1128
research (1078) 1078
physiological aspects (1072) 1072
antibiotics (1065) 1065
chemistry, multidisciplinary (1044) 1044
enzymes (1040) 1040
polyketide synthases - genetics (1040) 1040
natural products (945) 945
natural-products (940) 940
multigene family (910) 910
gene-cluster (873) 873
genes (871) 871
animals (847) 847
amino acid sequence (837) 837
identification (833) 833
fungi (816) 816
escherichia-coli (807) 807
humans (807) 807
article (802) 802
plant sciences (750) 750
streptomyces - genetics (707) 707
streptomyces (701) 701
phylogeny (641) 641
pharmacology & pharmacy (601) 601
bacteria (600) 600
streptomyces - metabolism (592) 592
polyketides - chemistry (585) 585
secondary metabolites (585) 585
chemical properties (577) 577
proteins (575) 575
polyketide synthases (572) 572
gene expression (571) 571
polyketide synthases - chemistry (568) 568
bacterial proteins - genetics (567) 567
bacterial proteins - metabolism (563) 563
plant metabolites (554) 554
biotechnology (547) 547
genetic aspects (526) 526
cloning (521) 521
expression (516) 516
life sciences (513) 513
catalysis (504) 504
multidisciplinary sciences (493) 493
biochemistry (482) 482
models, molecular (482) 482
substrate specificity (480) 480
genomics (479) 479
synthase (471) 471
stereoisomerism (467) 467
gene (463) 463
polyketides - metabolism (459) 459
cloning, molecular (455) 455
peptides (450) 450
genomes (441) 441
anti-bacterial agents - biosynthesis (439) 439
heterologous expression (425) 425
derivatives (419) 419
base sequence (412) 412
streptomyces - enzymology (407) 407
secondary metabolism (404) 404
crystal-structure (401) 401
mutation (400) 400
drug discovery (385) 385
biosynthetic gene-cluster (378) 378
sequence analysis, dna (377) 377
macrolides - chemistry (374) 374
anti-bacterial agents - chemistry (370) 370
biology (368) 368
chemistry (362) 362
biosynthese (359) 359
genetic engineering (359) 359
macrolides - metabolism (353) 353
protein structure, tertiary (353) 353
escherichia coli - genetics (349) 349
genes, bacterial (342) 342
metabolism (339) 339
synthesis (335) 335
mass spectrometry (334) 334
genetic research (326) 326
pathway (323) 323
fermentation (320) 320
biological products - chemistry (319) 319
peptide synthases - metabolism (319) 319
sequence alignment (312) 312
organic chemistry (311) 311
magnetic resonance spectroscopy (310) 310
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (9770) 9770
Japanese (127) 127
Chinese (63) 63
Korean (45) 45
German (28) 28
Portuguese (16) 16
Russian (11) 11
Croatian (6) 6
Spanish (5) 5
French (2) 2
Ukrainian (2) 2
Persian (1) 1
Polish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature Chemical Biology, ISSN 1552-4450, 09/2015, Volume 11, Issue 9, pp. 705 - 712
Actin-targeting macrolides comprise a large, structurally diverse group of cytotoxins isolated from remarkably dissimilar micro- and macroorganisms. In spite... 
BACTERIAL SYMBIONT | GENE-CLUSTER | CYTOTOXIC MACROLIDES | NATURAL-PRODUCT DISCOVERY | CYANOBACTERIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNTHASES | IN-SITU HYBRIDIZATION | SPONGE THEONELLA-SWINHOEI | IDENTIFICATION | ANTIFUNGAL MACROLIDE | Cyanobacteria - genetics | Deltaproteobacteria - metabolism | Multigene Family | Peptides | Actins - metabolism | Bacterial Proteins - chemistry | Cyanobacteria - metabolism | Molecular Sequence Data | Polyketides - chemistry | Small Molecule Libraries - metabolism | Polyketides - metabolism | Polyketide Synthases - metabolism | Macrolides - chemistry | Pyrans - chemistry | Pyrans - metabolism | Base Sequence | Actins - chemistry | Symbiosis | Gene Expression | Bacterial Proteins - genetics | Macrolides - metabolism | Biological Evolution | Small Molecule Libraries - chemistry | Polyketide Synthases - chemistry | Animals | Deltaproteobacteria - genetics | Theonella - microbiology | Protein Binding | Bacterial Proteins - metabolism | Polyketide Synthases - genetics | Enzymes | Bacteria | Biosynthesis | Metabolism | Polyketide Synthases/metabolism | Actins/metabolism | Macrolides/chemistry | Polyketide Synthases/chemistry | Life Sciences | Cyanobacteria/metabolism | Deltaproteobacteria/genetics | Bacterial Proteins/chemistry | Macrolides/metabolism | Actins/chemistry | Polyketide Synthases/genetics | Deltaproteobacteria/metabolism | Small Molecule Libraries/metabolism | Theonella/microbiology | Cyanobacteria/genetics | Pyrans/metabolism | Small Molecule Libraries/chemistry | Microbiology and Parasitology | Bacterial Proteins/metabolism | Polyketides/chemistry | Polyketides/metabolism | Bacterial Proteins/genetics | Pyrans/chemistry
Journal Article
Science, ISSN 0036-8075, 9/2013, Volume 341, Issue 6150, pp. 1089 - 1094
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2014, Volume 111, Issue 34, pp. 12354 - 12359
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 06/2017, Volume 139, Issue 23, pp. 7913 - 7920
Journal Article
Molecular Plant Pathology, ISSN 1464-6722, 08/2011, Volume 12, Issue 6, pp. 564 - 579
Journal Article
Biochemistry, ISSN 0006-2960, 12/2014, Volume 53, Issue 49, pp. 7854 - 7865
Lactimidomycin (LTM, 1) and iso-migrastatin (iso-MGS, 2) belong to the glutarimide-containing polyketide family of natural products. We previously cloned and... 
STREPTOMYCES-PLATENSIS | GENE-CLUSTER | CYTOCHROME-P450 ENZYMES | CELL-MIGRATION INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGICAL-ACTIVITY | TUMOR-METASTASIS | ANTIFUNGAL ANTIBIOTICS | TRANSFORMED NIH/3T3 CELLS | PHOSPHOPANTETHEINYL TRANSFERASE | POTENT INHIBITORS | Multigene Family | Macrolides - isolation & purification | Antibiotics, Antineoplastic - pharmacology | Stereoisomerism | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Polyketides - chemistry | Antibiotics, Antineoplastic - isolation & purification | Structure-Activity Relationship | Polyketides - metabolism | Polyketide Synthases - metabolism | Antibiotics, Antineoplastic - chemistry | Macrolides - chemistry | Base Sequence | Drug Design | Protein Engineering | Macrolides - pharmacology | Molecular Structure | Piperidones - isolation & purification | Recombinant Proteins - metabolism | Bacterial Proteins - antagonists & inhibitors | Cell Survival - drug effects | Polyketide Synthases - antagonists & inhibitors | Streptomyces - genetics | Bacterial Proteins - genetics | Gene Silencing | Antibiotics, Antineoplastic - biosynthesis | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Macrolides - metabolism | Piperidones - pharmacology | Neoplasms - drug therapy | Piperidones - chemistry | Polyketide Synthases - chemistry | Bioreactors | Models, Biological | Mutant Proteins - chemistry | Polyketides - isolation & purification | Cell Line, Tumor | Bacterial Proteins - metabolism | Streptomyces - enzymology | Piperidones - metabolism | Polyketide Synthases - genetics | Polyketides - pharmacology | Streptomyces | Physiological aspects | Biosynthesis | Analysis
Journal Article