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Journal Article
2010, 1. Aufl., Wiley series in drug discovery and development, ISBN 0470044918, x, 289
Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluationIt is believed that selecting the 'right' drug... 
Drugs | standards | Drug Industry | methods | Pharmacology | Pharmaceutical Preparations | Pharmacokinetics | Drug Evaluation, Preclinical | Drug development | Metabolism | Drug Discovery | MEDICAL
Book
2009, ISBN 9780471751588, xii, 389
This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical... 
Science | Spectroscopy & Spectrum Analysis | Drugs | Design | Methodology | Research | Metabolism | Pharmacokinetics | Mass spectrometry | Pharmacokinetcs
Book
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 10/2011, Volume 100, Issue 10, pp. 4127 - 4157
Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 10/2015, Volume 76, Issue 4, pp. 803 - 811
5-Fluoro-2′-deoxycytidine (FdCyd; NSC48006), a fluoropyrimidine nucleoside inhibitor of DNA methylation, is degraded by cytidine deaminase (CD).... 
Toxicokinetics | Medicine & Public Health | Toxicity | Oncology | Cancer Research | Monkeys | Pharmacology/Toxicology | Tetrahydrouridine | DNA methylation inhibitor | Fluorodeoxycytidine | 5-FLUORODEOXYCYTIDINE | CYTIDINE DEAMINASE INHIBITOR | TETRAHYDROURIDINE THU | PLASMA | METABOLISM | ONCOLOGY | 5-FLUORO-2-DEOXYCYTIDINE | DNA METHYLTRANSFERASE | PHARMACOLOGY & PHARMACY | MICE | METHYLTRANSFERASE INHIBITOR 5-FLUORO-2'-DEOXYCYTIDINE | MYELODYSPLASTIC SYNDROMES | Cytidine Deaminase - antagonists & inhibitors | Antimetabolites, Antineoplastic - pharmacokinetics | Enzyme Inhibitors - blood | Humans | Half-Life | Macaca fascicularis | Biological Availability | Male | Metabolic Clearance Rate | Deoxycytidine - blood | Antimetabolites, Antineoplastic - administration & dosage | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Deoxycytidine - pharmacokinetics | Antimetabolites, Antineoplastic - blood | Enzyme Inhibitors - pharmacokinetics | Biotransformation | Female | Drug Evaluation, Preclinical | Tetrahydrouridine - pharmacokinetics | Administration, Oral | Tetrahydrouridine - blood | Deoxycytidine - administration & dosage | Tetrahydrouridine - administration & dosage | Pilot Projects | Animals | Infusions, Intravenous | Deoxycytidine - analogs & derivatives | Drug Combinations | Cohort Studies | Metabolites | Methylation | Analysis | Index Medicus | toxicity | monkeys | toxicokinetics | fluorodeoxycytidine | tetrahydouridine
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 7/2014, Volume 74, Issue 1, pp. 95 - 115
This study evaluated the preclinical pharmacokinetics (PK) and disposition of Fruquintinib (HMPL-013), a small molecule vascular endothelial growth factor... 
Fruquintinib | Medicine & Public Health | Disposition | Oncology | Cancer Research | HMPL-013 | Pharmacology/Toxicology | Pharmacokinetics | Allometric scaling | Modeling | HALF-LIFE | NONSPECIFIC-BINDING | CLEARANCE | FACTOR RECEPTORS | PROTEIN-BINDING | IN-VITRO | POTENT | ONCOLOGY | DRUGS | TYROSINE KINASE INHIBITOR | PHARMACOLOGY & PHARMACY | ENDOTHELIAL GROWTH-FACTOR | Inactivation, Metabolic | Drugs, Investigational - pharmacology | Cytochrome P-450 Enzyme Inhibitors | Bile - chemistry | Humans | Microsomes, Liver - metabolism | Drugs, Investigational - pharmacokinetics | Cytochrome P-450 Enzyme System - metabolism | Quinazolines - pharmacokinetics | Benzofurans - administration & dosage | Benzofurans - pharmacology | Biological Availability | Male | Drugs, Investigational - metabolism | Intestinal Absorption | Benzofurans - pharmacokinetics | Dose-Response Relationship, Drug | Angiogenesis Inhibitors - administration & dosage | Drug Interactions | Quinazolines - metabolism | Microsomes, Liver - drug effects | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Female | Quinazolines - administration & dosage | Microsomes, Liver - enzymology | Drug Evaluation, Preclinical | Caco-2 Cells | Protein Kinase Inhibitors - pharmacokinetics | Food-Drug Interactions | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | Angiogenesis Inhibitors - pharmacokinetics | Random Allocation | Protein Kinase Inhibitors - administration & dosage | Angiogenesis Inhibitors - metabolism | Animals | Models, Biological | Drugs, Investigational - administration & dosage | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Benzofurans - metabolism | Protein Kinase Inhibitors - metabolism | Physiological aspects | Permeability | Metabolites | Vascular endothelial growth factor | Gastrointestinal system | Protein binding
Journal Article
Journal Article