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Trends in Molecular Medicine, ISSN 1471-4914, 2012, Volume 18, Issue 11, pp. 679 - 688
Ten percent of inherited diseases are caused by premature termination codon (PTC) mutations that lead to degradation of the mRNA template and to the production... 
Pathology | genetic diseases | translational readthrough | nonsense mutations | aminoglycosides | nonsense mediated decay | cancer | premature termination codon suppression | Nonsense mediated decay | Aminoglycosides | Premature termination codon suppression | Genetic diseases | Nonsense mutations | Cancer | Translational readthrough | MEDICINE, RESEARCH & EXPERIMENTAL | EPITHELIAL-CELL LINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTAL-STRUCTURES | READ-THROUGH | AMINOGLYCOSIDE ANTIBIOTICS | RELEASE FACTOR ERF1 | CELL BIOLOGY | EUKARYOTIC TRANSLATION TERMINATION | CYSTIC-FIBROSIS PATIENTS | HUMAN GENETIC-DISEASES | DUCHENNE MUSCULAR-DYSTROPHY | MESSENGER-RNA DECAY | Humans | Genetic Diseases, Inborn - genetics | Nonsense Mediated mRNA Decay - drug effects | Models, Molecular | Antineoplastic Agents - therapeutic use | Codon, Nonsense | Peptide Chain Termination, Translational - drug effects | RNA Stability | Peptide Termination Factors - metabolism | Neoplasms - drug therapy | Animals | Neoplasms - genetics | Antineoplastic Agents - adverse effects | Antineoplastic Agents - pharmacology | Peptide Termination Factors - chemistry | Aminoglycosides - adverse effects | Aminoglycosides - pharmacology | Genetic Diseases, Inborn - drug therapy | Aminoglycosides - therapeutic use | Genetic disorders | Messenger RNA | Codon | Genetic translation | Analysis
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 03/2019, Volume 431, Issue 6, pp. 1088 - 1097
We show here that the specific use of fast or slowly translated codons in the early coding region of a gene may influence both the mRNA stability and premature... 
premature transcription termination | mRNA half-life | synonymous codons | translation velocity | DECAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE | USAGE | ELONGATION | IN-VIVO | SEQUENCE | RIBOSOMES | SECONDARY STRUCTURE | START | EFFICIENCY | Messenger RNA | Codon | Genetic transcription | Genetic translation | Analysis | Escherichia coli
Journal Article
Journal Article